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The map label for this gene is argH

Identifier: 110678897

GI number: 110678897

Start: 1536952

End: 1538352

Strand: Direct

Name: argH

Synonym: RD1_1591

Alternate gene names: 110678897

Gene position: 1536952-1538352 (Clockwise)

Preceding gene: 110678891

Following gene: 110678898

Centisome position: 37.19

GC content: 60.53

Gene sequence:

>1401_bases
ATGACAGACACGCAAAACCCGAAATCTTCCAATCAGATGTGGGGCGGCCGTTTTGCGGACGGACCCGATGCGATCATGGA
AGCAATTAATGCCTCAATCGGGTTCGACAAGCGTATGGCTGCACAAGATATTGCAGGGTCGCGAGCACATGCCGCGATGC
TGGGCGCGACAGGCATTGTTGAGCCTAGCGATGCGCAGGCCATGGGGGAAGGGCTACTCACGGTCTTGTCAGAAATCGAG
GCGGGAAATTTCCCGTTTTCGACCGCGCTGGAAGATATTCACATGAATGTGGAGGCGCGCCTGAAGGAGATCATCGGCGA
GCCTGCCGGGCGCTTGCACACGGGCCGCAGTCGCAACGATCAGGTCGCCACGGATTTCAAACTCTGGGTGCGCGATCAGT
TGGATGCGTGTGAGGCCGGATTGCTGGCGCTGATCCGTGCGTTGCTCGATCAGGCCGAAGCCGGGGCAGATTGGGTCATG
CCCGGCTTTACCCATTTACAGACCGCGCAACCTGTGACTTGGGGCCATCACATGATGGCCTATGTGGAGATGTTCGGACG
CGACCTGAGCCGTGTGCGTGATGCGCGCGCGCGCATGAATGAAAGCCCGCTTGGGGCGGCGGCGCTGGCGGGTACGTCCT
TTCCGATTGACCGTCACATGACCGCGCAGGCGCTGGGGTTTGACCGGCCTGCGGCCAATTCCCTCGACGCCGTGAGCGAT
CGTGACTTTGCCCTCGAATTCCTGAGCACGGCGAGCATCTGCGCCATGCACCTCAGTCGTTTTGCCGAGGAACTGGTGAT
CTGGTCCTCTGCTCAGTTCCGCTTTGTGGCGCTGTCGGACCGCTTTTCCACTGGCTCTTCGATCATGCCGCAAAAGAAGA
ACCCGGACGCCGCTGAACTGATCCGCGCCAAGGTTGGTCGCATTTTCGGTGCCAATACGGCGCTGATGATGGTGATGAAG
GGGCTGCCGCTGGCCTATTCCAAGGACATGCAGGAGGATAAAGAGCAAGTCTTTGATGCCGCCGACAACCTCATGCTCGC
GCTGGCGGCGATGACCGGCATGGTCAGCGACATGACGGCCAACCGCGAGAGCCTTGCGCAGGCGGCGGGTTCGGGCTTTT
CAACGGCCACGGACCTTGCGGACTGGTTGGTGCGCGTACTTGGCCTGCCGTTCCGCGAGGCACATCACGTCACTGGCGCA
TTGGTCGCACTGGCCGAAGCGAAACACTGCGACCTGCCGGACCTCACGCTGGAAGATATGCGCGGCGTACATGCTGGCAT
CACGGGGGATGTCTTTGATGTGCTCGGGGTGGAAAACTCGGTTCAAAGCCGTATATCATACGGTGGAACGGCACCCGTGC
GGGTGCGCGAACAAATCGCTCGGTGGAGGGCACTCCTGTGA

Upstream 100 bases:

>100_bases
CATGGGCCGTCGTGCCCACGGTGATTGCACCCAAGGAAAGGGCCGTATAAACGAGCGCGGAAACAATATTTTTCATTTTC
CCTCCAAAGGGTGAACACAG

Downstream 100 bases:

>100_bases
TGATCCGAAGTGTTGCGGTGTTGGTTTTGATCGGTACGCTATCCGCCTGTGGTGTGGATGGTGAGCCGGTGCGCCCGTCC
GTCGGAGCATCCGTCGCGAT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MTDTQNPKSSNQMWGGRFADGPDAIMEAINASIGFDKRMAAQDIAGSRAHAAMLGATGIVEPSDAQAMGEGLLTVLSEIE
AGNFPFSTALEDIHMNVEARLKEIIGEPAGRLHTGRSRNDQVATDFKLWVRDQLDACEAGLLALIRALLDQAEAGADWVM
PGFTHLQTAQPVTWGHHMMAYVEMFGRDLSRVRDARARMNESPLGAAALAGTSFPIDRHMTAQALGFDRPAANSLDAVSD
RDFALEFLSTASICAMHLSRFAEELVIWSSAQFRFVALSDRFSTGSSIMPQKKNPDAAELIRAKVGRIFGANTALMMVMK
GLPLAYSKDMQEDKEQVFDAADNLMLALAAMTGMVSDMTANRESLAQAAGSGFSTATDLADWLVRVLGLPFREAHHVTGA
LVALAEAKHCDLPDLTLEDMRGVHAGITGDVFDVLGVENSVQSRISYGGTAPVRVREQIARWRALL

Sequences:

>Translated_466_residues
MTDTQNPKSSNQMWGGRFADGPDAIMEAINASIGFDKRMAAQDIAGSRAHAAMLGATGIVEPSDAQAMGEGLLTVLSEIE
AGNFPFSTALEDIHMNVEARLKEIIGEPAGRLHTGRSRNDQVATDFKLWVRDQLDACEAGLLALIRALLDQAEAGADWVM
PGFTHLQTAQPVTWGHHMMAYVEMFGRDLSRVRDARARMNESPLGAAALAGTSFPIDRHMTAQALGFDRPAANSLDAVSD
RDFALEFLSTASICAMHLSRFAEELVIWSSAQFRFVALSDRFSTGSSIMPQKKNPDAAELIRAKVGRIFGANTALMMVMK
GLPLAYSKDMQEDKEQVFDAADNLMLALAAMTGMVSDMTANRESLAQAAGSGFSTATDLADWLVRVLGLPFREAHHVTGA
LVALAEAKHCDLPDLTLEDMRGVHAGITGDVFDVLGVENSVQSRISYGGTAPVRVREQIARWRALL
>Mature_465_residues
TDTQNPKSSNQMWGGRFADGPDAIMEAINASIGFDKRMAAQDIAGSRAHAAMLGATGIVEPSDAQAMGEGLLTVLSEIEA
GNFPFSTALEDIHMNVEARLKEIIGEPAGRLHTGRSRNDQVATDFKLWVRDQLDACEAGLLALIRALLDQAEAGADWVMP
GFTHLQTAQPVTWGHHMMAYVEMFGRDLSRVRDARARMNESPLGAAALAGTSFPIDRHMTAQALGFDRPAANSLDAVSDR
DFALEFLSTASICAMHLSRFAEELVIWSSAQFRFVALSDRFSTGSSIMPQKKNPDAAELIRAKVGRIFGANTALMMVMKG
LPLAYSKDMQEDKEQVFDAADNLMLALAAMTGMVSDMTANRESLAQAAGSGFSTATDLADWLVRVLGLPFREAHHVTGAL
VALAEAKHCDLPDLTLEDMRGVHAGITGDVFDVLGVENSVQSRISYGGTAPVRVREQIARWRALL

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=457, Percent_Identity=44.6389496717724, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI68303542, Length=457, Percent_Identity=44.6389496717724, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI68303549, Length=457, Percent_Identity=42.6695842450766, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI68303547, Length=457, Percent_Identity=42.4507658643326, Blast_Score=362, Evalue=1e-100,
Organism=Escherichia coli, GI1790398, Length=449, Percent_Identity=46.1024498886414, Blast_Score=388, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6321806, Length=460, Percent_Identity=42.8260869565217, Blast_Score=374, Evalue=1e-104,
Organism=Drosophila melanogaster, GI221473854, Length=456, Percent_Identity=40.5701754385965, Blast_Score=340, Evalue=2e-93,
Organism=Drosophila melanogaster, GI78706858, Length=456, Percent_Identity=40.5701754385965, Blast_Score=340, Evalue=2e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_ROSDO (Q169X5)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_681904.1
- ProteinModelPortal:   Q169X5
- SMR:   Q169X5
- STRING:   Q169X5
- GeneID:   4197124
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_1591
- NMPDR:   fig|375451.6.peg.1490
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- PhylomeDB:   Q169X5
- ProtClustDB:   PRK00855
- BioCyc:   RDEN375451:RD1_1591-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 50353; Mature: 50222

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTQNPKSSNQMWGGRFADGPDAIMEAINASIGFDKRMAAQDIAGSRAHAAMLGATGIV
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHCCCCCC
EPSDAQAMGEGLLTVLSEIEAGNFPFSTALEDIHMNVEARLKEIIGEPAGRLHTGRSRND
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCC
QVATDFKLWVRDQLDACEAGLLALIRALLDQAEAGADWVMPGFTHLQTAQPVTWGHHMMA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHHHHH
YVEMFGRDLSRVRDARARMNESPLGAAALAGTSFPIDRHMTAQALGFDRPAANSLDAVSD
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCC
RDFALEFLSTASICAMHLSRFAEELVIWSSAQFRFVALSDRFSTGSSIMPQKKNPDAAEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHH
IRAKVGRIFGANTALMMVMKGLPLAYSKDMQEDKEQVFDAADNLMLALAAMTGMVSDMTA
HHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NRESLAQAAGSGFSTATDLADWLVRVLGLPFREAHHVTGALVALAEAKHCDLPDLTLEDM
CHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
RGVHAGITGDVFDVLGVENSVQSRISYGGTAPVRVREQIARWRALL
CCHHCCCCHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDTQNPKSSNQMWGGRFADGPDAIMEAINASIGFDKRMAAQDIAGSRAHAAMLGATGIV
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHCCCCCC
EPSDAQAMGEGLLTVLSEIEAGNFPFSTALEDIHMNVEARLKEIIGEPAGRLHTGRSRND
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCC
QVATDFKLWVRDQLDACEAGLLALIRALLDQAEAGADWVMPGFTHLQTAQPVTWGHHMMA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHHHHH
YVEMFGRDLSRVRDARARMNESPLGAAALAGTSFPIDRHMTAQALGFDRPAANSLDAVSD
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCC
RDFALEFLSTASICAMHLSRFAEELVIWSSAQFRFVALSDRFSTGSSIMPQKKNPDAAEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHH
IRAKVGRIFGANTALMMVMKGLPLAYSKDMQEDKEQVFDAADNLMLALAAMTGMVSDMTA
HHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NRESLAQAAGSGFSTATDLADWLVRVLGLPFREAHHVTGALVALAEAKHCDLPDLTLEDM
CHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
RGVHAGITGDVFDVLGVENSVQSRISYGGTAPVRVREQIARWRALL
CCHHCCCCHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA