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The map label for this gene is nadC [H]

Identifier: 110678839

GI number: 110678839

Start: 1450054

End: 1450869

Strand: Direct

Name: nadC [H]

Synonym: RD1_1527

Alternate gene names: 110678839

Gene position: 1450054-1450869 (Clockwise)

Preceding gene: 110678838

Following gene: 110678840

Centisome position: 35.08

GC content: 58.09

Gene sequence:

>816_bases
ATGAACCAACTCATCGACCTTTGGCTGGATGAGGACGTCAACTATTATGACCTTACCGCAAAGATCATGGTGGATGATGA
CGCGGTGGCCAAATTCGGGATGAACGCGCGCGAACCGATCACCCTTTCGGGGTTGAAGCTGGCGGAAATGGTGTTTCGCA
AAATGGACCCCGAGTGCACGTTTGAGACTTCGCGAAAGGATGGCGAGCGCGTTGAAACAGGCGAGACATTTGCCGTGATC
ACCGGGAATGCGCAGGCACTGCTGACGGCGGAGCGGGTTGCGCTGAACCTCGTCCAACGGATGTGCGGCATTGCCGGTCT
GACAGCGCAATATGTCAAGGAGATCGAAGGCACTGGCGCGATCTTGCTGGATTCGCGCAAGACAACGCCTGGTCTGCGCA
TGATCGAAAAGTATGCCGTGGTCTGTGGGGGCGGGCGCAGCCACCGGCTGGGACTGGATAGCGGCATCATGCTGAAAGAC
AACCACATCGCCGTCGCAGGCAGCATTGCCGCAGCCGTCCAGCGCGCCAAGGCCAAAGCCCCGATGCTGACCAAGATCGA
AGTTGAGGCGGACCGTCTGGATCAGGTCCGCGAAGCACTTGATGCAGGCGTGGATGTCATCATGCTGGACAACATGAGCA
ATGACGATATGCGCAAAGCCGTTAAAATCGTGGACAAACGCATTCCGCTGGAATGTTCGGGCGGTGTGCGGCTCGATACG
ATCCGCGCGAAAGCCGAAACCGGCGTGGATTTTGTGTCGGTGGGCCGCATCACGCAGTCAGCGACCTGTGTTGATATCGG
CCTCGACGACCTCTGA

Upstream 100 bases:

>100_bases
TTCAAAGACCAATACGGACGCCTCGTTACCTCATGAAACAAACAACCCGTGATCTGGCCGTCTAAAGAAAGGCATGAATA
TGCTCCTCGACCTGCGAAAA

Downstream 100 bases:

>100_bases
TCTGGACCAGGAAAGGGTTAATCGTGCCGGGTACGCTGTTTCTCATTGTCGGTCCAAGTGGCGTTGGCAAGGACACCTTG
CTGGAGGGCGCGCGCGATCG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MNQLIDLWLDEDVNYYDLTAKIMVDDDAVAKFGMNAREPITLSGLKLAEMVFRKMDPECTFETSRKDGERVETGETFAVI
TGNAQALLTAERVALNLVQRMCGIAGLTAQYVKEIEGTGAILLDSRKTTPGLRMIEKYAVVCGGGRSHRLGLDSGIMLKD
NHIAVAGSIAAAVQRAKAKAPMLTKIEVEADRLDQVREALDAGVDVIMLDNMSNDDMRKAVKIVDKRIPLECSGGVRLDT
IRAKAETGVDFVSVGRITQSATCVDIGLDDL

Sequences:

>Translated_271_residues
MNQLIDLWLDEDVNYYDLTAKIMVDDDAVAKFGMNAREPITLSGLKLAEMVFRKMDPECTFETSRKDGERVETGETFAVI
TGNAQALLTAERVALNLVQRMCGIAGLTAQYVKEIEGTGAILLDSRKTTPGLRMIEKYAVVCGGGRSHRLGLDSGIMLKD
NHIAVAGSIAAAVQRAKAKAPMLTKIEVEADRLDQVREALDAGVDVIMLDNMSNDDMRKAVKIVDKRIPLECSGGVRLDT
IRAKAETGVDFVSVGRITQSATCVDIGLDDL
>Mature_271_residues
MNQLIDLWLDEDVNYYDLTAKIMVDDDAVAKFGMNAREPITLSGLKLAEMVFRKMDPECTFETSRKDGERVETGETFAVI
TGNAQALLTAERVALNLVQRMCGIAGLTAQYVKEIEGTGAILLDSRKTTPGLRMIEKYAVVCGGGRSHRLGLDSGIMLKD
NHIAVAGSIAAAVQRAKAKAPMLTKIEVEADRLDQVREALDAGVDVIMLDNMSNDDMRKAVKIVDKRIPLECSGGVRLDT
IRAKAETGVDFVSVGRITQSATCVDIGLDDL

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=273, Percent_Identity=32.2344322344322, Blast_Score=147, Evalue=9e-36,
Organism=Escherichia coli, GI1786299, Length=253, Percent_Identity=40.7114624505929, Blast_Score=171, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6321162, Length=275, Percent_Identity=36, Blast_Score=155, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29451; Mature: 29451

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQLIDLWLDEDVNYYDLTAKIMVDDDAVAKFGMNAREPITLSGLKLAEMVFRKMDPECT
CCCCEEEEECCCCCEEEEEEEEEECCHHHHHHCCCCCCCEEECCHHHHHHHHHHCCCCCE
FETSRKDGERVETGETFAVITGNAQALLTAERVALNLVQRMCGIAGLTAQYVKEIEGTGA
EECCCCCCCEEECCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCE
ILLDSRKTTPGLRMIEKYAVVCGGGRSHRLGLDSGIMLKDNHIAVAGSIAAAVQRAKAKA
EEEECCCCCCHHHHHHHHHEEECCCCCCCCCCCCCEEEECCCEEEEHHHHHHHHHHHCCC
PMLTKIEVEADRLDQVREALDAGVDVIMLDNMSNDDMRKAVKIVDKRIPLECSGGVRLDT
CCEEEEEECHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCEEECCCEEEEE
IRAKAETGVDFVSVGRITQSATCVDIGLDDL
EEEHHHCCCCEEEECCCCCCCEEEECCCCCC
>Mature Secondary Structure
MNQLIDLWLDEDVNYYDLTAKIMVDDDAVAKFGMNAREPITLSGLKLAEMVFRKMDPECT
CCCCEEEEECCCCCEEEEEEEEEECCHHHHHHCCCCCCCEEECCHHHHHHHHHHCCCCCE
FETSRKDGERVETGETFAVITGNAQALLTAERVALNLVQRMCGIAGLTAQYVKEIEGTGA
EECCCCCCCEEECCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCE
ILLDSRKTTPGLRMIEKYAVVCGGGRSHRLGLDSGIMLKDNHIAVAGSIAAAVQRAKAKA
EEEECCCCCCHHHHHHHHHEEECCCCCCCCCCCCCEEEECCCEEEEHHHHHHHHHHHCCC
PMLTKIEVEADRLDQVREALDAGVDVIMLDNMSNDDMRKAVKIVDKRIPLECSGGVRLDT
CCEEEEEECHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCEEECCCEEEEE
IRAKAETGVDFVSVGRITQSATCVDIGLDDL
EEEHHHCCCCEEEECCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]