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The map label for this gene is capL [H]

Identifier: 110678805

GI number: 110678805

Start: 1417874

End: 1419202

Strand: Direct

Name: capL [H]

Synonym: RD1_1493

Alternate gene names: 110678805

Gene position: 1417874-1419202 (Clockwise)

Preceding gene: 110678804

Following gene: 110678811

Centisome position: 34.31

GC content: 55.15

Gene sequence:

>1329_bases
ATGTCCGAACGTGTCAATTCCACACCACTGGAGACCATTTTAAGCAGGATAACGCAAAAAAAGGCCGTCATCGGCATAAT
CGGGATGGGGTATGTCGGTATTCCTCTCGCGGTGGCCGTGGGGCGGGCGGGGTATCCTGTTATCGGATTTGATGTCCTTG
ATGCGCGCATTGAACAGCTGAACACCTGCCAGAGCCCGATTGGTCAAATCCCGAATTCAGCATTGGAAGAGATTTCAAAG
ACCGGTTTTGTCGCCACGGGTGATTTCGCGCGCGTCTGTGAATGCGACGCGCTTATGATCTGTGTGCCGACACCGCTGGA
CAAGATGCGCGAACCTGACCTGAGTTTTATCATATCCACGATGGAAACGATTGCGCCCCACCTGAGGGCCGGTCAGATAT
TGGCGTTGGAAAGCACCACGTGGCCTGGCACCACGTATGAGGTTCTAAAGCCCTACATCGCGCGCACCGGCCTGACTGTG
GGTACTGATTTCTTCCTTGTCTATTCGCCGGAACGCGAGGATCCGGGCAATGCCGATTTCAACACGCAGTCAATCCCCAA
AGTACTGGGGGGCGATACGCAGGCGTGCCGTGACGTGGGCGTCGCCCTTTACAGCGCATTCATCGACCAGGTTGTTCCGG
TCAGTTCCACCAAGGCCGCGGAAATGACCAAACTGCTTGAGAACATTCAGCGGGCCGTGAACATCGGGCTGATGAACGAG
ATGAAAGTCGTCGCGGATGCGATGGACCTTGATATCCACGAAGTCATTGATGCCGCTGCGACCAAACCATTCGGGTTTGT
CCCGTATTATCCCGGTCCCGGCATTGGCGGGCATTGCATCCCGATTGACCCGTTTTATCTGACGTGGAAAGCGCGGGAAT
TTGGTCTGCACACACGATTTATCGAGCTTGCGGGTGAGATCAACGCATCGATGCCGTCCTATGTTGTCAACAAACTCATC
CGAGCCTTATCCGAGCGTGGCAAGGCGTTGAAGGGCGCAAAAGTCATGGTTCTGGGGATCGCCTACAAACGCGATATCGA
AGATGTGCGCGAAAGCCCCTCCGTGCTGATCATGGAGTTGTTGCGCGACTGGCATGTCGACCTTTCCTATTCCGACCCGC
ATGTGCCGGTATTCCCCGTGATGCGTGAACATCAATTCGATCTGTCATCGACACCTTTGACCCCTGAAACCCTTGCAGAG
CAGGATGCCGTTCTGCTGCTGACGGATCACACGGGTTTCGACTATGATATGATCGCCGAACATGCGCCTTTGCTGATCGA
CACACGGGGCGTTTATCGCCGTCGCGGCCAAAACGTTCCCACGGCGTAA

Upstream 100 bases:

>100_bases
GCGGATTGGGCATCTGCCAGTGGTCAATGTGGTTGCTTCATATCATTGCCTGCACTAACGCTGGGACAGGTTTCTGCTTA
ATCCCCGAACAAGGCTCGCT

Downstream 100 bases:

>100_bases
TGGCGCGCAGTCGGCGCCATACCCCAACCCATCTGGTGCGTAGCAGCTATCGCCACTACCCCAAGGCAGATTTCGGGAAG
TAGAAGCTTACCACCCAATT

Product: UDP-glucose/GDP-mannose dehydrogenase, putative

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MSERVNSTPLETILSRITQKKAVIGIIGMGYVGIPLAVAVGRAGYPVIGFDVLDARIEQLNTCQSPIGQIPNSALEEISK
TGFVATGDFARVCECDALMICVPTPLDKMREPDLSFIISTMETIAPHLRAGQILALESTTWPGTTYEVLKPYIARTGLTV
GTDFFLVYSPEREDPGNADFNTQSIPKVLGGDTQACRDVGVALYSAFIDQVVPVSSTKAAEMTKLLENIQRAVNIGLMNE
MKVVADAMDLDIHEVIDAAATKPFGFVPYYPGPGIGGHCIPIDPFYLTWKAREFGLHTRFIELAGEINASMPSYVVNKLI
RALSERGKALKGAKVMVLGIAYKRDIEDVRESPSVLIMELLRDWHVDLSYSDPHVPVFPVMREHQFDLSSTPLTPETLAE
QDAVLLLTDHTGFDYDMIAEHAPLLIDTRGVYRRRGQNVPTA

Sequences:

>Translated_442_residues
MSERVNSTPLETILSRITQKKAVIGIIGMGYVGIPLAVAVGRAGYPVIGFDVLDARIEQLNTCQSPIGQIPNSALEEISK
TGFVATGDFARVCECDALMICVPTPLDKMREPDLSFIISTMETIAPHLRAGQILALESTTWPGTTYEVLKPYIARTGLTV
GTDFFLVYSPEREDPGNADFNTQSIPKVLGGDTQACRDVGVALYSAFIDQVVPVSSTKAAEMTKLLENIQRAVNIGLMNE
MKVVADAMDLDIHEVIDAAATKPFGFVPYYPGPGIGGHCIPIDPFYLTWKAREFGLHTRFIELAGEINASMPSYVVNKLI
RALSERGKALKGAKVMVLGIAYKRDIEDVRESPSVLIMELLRDWHVDLSYSDPHVPVFPVMREHQFDLSSTPLTPETLAE
QDAVLLLTDHTGFDYDMIAEHAPLLIDTRGVYRRRGQNVPTA
>Mature_441_residues
SERVNSTPLETILSRITQKKAVIGIIGMGYVGIPLAVAVGRAGYPVIGFDVLDARIEQLNTCQSPIGQIPNSALEEISKT
GFVATGDFARVCECDALMICVPTPLDKMREPDLSFIISTMETIAPHLRAGQILALESTTWPGTTYEVLKPYIARTGLTVG
TDFFLVYSPEREDPGNADFNTQSIPKVLGGDTQACRDVGVALYSAFIDQVVPVSSTKAAEMTKLLENIQRAVNIGLMNEM
KVVADAMDLDIHEVIDAAATKPFGFVPYYPGPGIGGHCIPIDPFYLTWKAREFGLHTRFIELAGEINASMPSYVVNKLIR
ALSERGKALKGAKVMVLGIAYKRDIEDVRESPSVLIMELLRDWHVDLSYSDPHVPVFPVMREHQFDLSSTPLTPETLAEQ
DAVLLLTDHTGFDYDMIAEHAPLLIDTRGVYRRRGQNVPTA

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=372, Percent_Identity=25.5376344086022, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI48994968, Length=432, Percent_Identity=32.1759259259259, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1788340, Length=266, Percent_Identity=25.187969924812, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17560350, Length=374, Percent_Identity=25.4010695187166, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17136908, Length=375, Percent_Identity=25.3333333333333, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 48497; Mature: 48366

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERVNSTPLETILSRITQKKAVIGIIGMGYVGIPLAVAVGRAGYPVIGFDVLDARIEQL
CCCCCCCCCHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHCCCCCCEEEHHHHHHHHHHH
NTCQSPIGQIPNSALEEISKTGFVATGDFARVCECDALMICVPTPLDKMREPDLSFIIST
HHHHHHHHHCCHHHHHHHHHCCCEEECCHHHHHCCCEEEEEECCCHHHHCCCCHHHHHHH
METIAPHLRAGQILALESTTWPGTTYEVLKPYIARTGLTVGTDFFLVYSPEREDPGNADF
HHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCEECCEEEEEECCCCCCCCCCCC
NTQSIPKVLGGDTQACRDVGVALYSAFIDQVVPVSSTKAAEMTKLLENIQRAVNIGLMNE
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
MKVVADAMDLDIHEVIDAAATKPFGFVPYYPGPGIGGHCIPIDPFYLTWKAREFGLHTRF
HHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCEEEEEEHHHHCHHHHH
IELAGEINASMPSYVVNKLIRALSERGKALKGAKVMVLGIAYKRDIEDVRESPSVLIMEL
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHCCHHHHHHHH
LRDWHVDLSYSDPHVPVFPVMREHQFDLSSTPLTPETLAEQDAVLLLTDHTGFDYDMIAE
HHHHCCCCCCCCCCCCEECCHHCCCCCCCCCCCCHHHHCCCCCEEEEECCCCCCHHHHHC
HAPLLIDTRGVYRRRGQNVPTA
CCCEEEECCHHHHHCCCCCCCC
>Mature Secondary Structure 
SERVNSTPLETILSRITQKKAVIGIIGMGYVGIPLAVAVGRAGYPVIGFDVLDARIEQL
CCCCCCCCHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHCCCCCCEEEHHHHHHHHHHH
NTCQSPIGQIPNSALEEISKTGFVATGDFARVCECDALMICVPTPLDKMREPDLSFIIST
HHHHHHHHHCCHHHHHHHHHCCCEEECCHHHHHCCCEEEEEECCCHHHHCCCCHHHHHHH
METIAPHLRAGQILALESTTWPGTTYEVLKPYIARTGLTVGTDFFLVYSPEREDPGNADF
HHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCEECCEEEEEECCCCCCCCCCCC
NTQSIPKVLGGDTQACRDVGVALYSAFIDQVVPVSSTKAAEMTKLLENIQRAVNIGLMNE
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
MKVVADAMDLDIHEVIDAAATKPFGFVPYYPGPGIGGHCIPIDPFYLTWKAREFGLHTRF
HHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCEEEEEEHHHHCHHHHH
IELAGEINASMPSYVVNKLIRALSERGKALKGAKVMVLGIAYKRDIEDVRESPSVLIMEL
HHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHCCHHHHHHHH
LRDWHVDLSYSDPHVPVFPVMREHQFDLSSTPLTPETLAEQDAVLLLTDHTGFDYDMIAE
HHHHCCCCCCCCCCCCEECCHHCCCCCCCCCCCCHHHHCCCCCEEEEECCCCCCHHHHHC
HAPLLIDTRGVYRRRGQNVPTA
CCCEEEECCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]