Click here to switch to the map view.

The map label for this gene is adk [H]

Identifier: 110678750

GI number: 110678750

Start: 1363359

End: 1364006

Strand: Direct

Name: adk [H]

Synonym: RD1_1433

Alternate gene names: 110678750

Gene position: 1363359-1364006 (Clockwise)

Preceding gene: 110678749

Following gene: 110678752

Centisome position: 32.99

GC content: 58.64

Gene sequence:

>648_bases
ATGAATATAATACTGTTGGGGCCACCAGGGGCCGGTAAAGGAACACAGGCCCGGATGCTCGAACAAGAGCGCGGCATGGT
CCAGTTGAGCACCGGTGATATGCTGCGCGAGGCCAAGGACAGCGGCACGGAGATGGGAAAGGTTGTCGCCGATGTGATGG
CGCGCGGTGCCCTGGTGACGGATGAGATCGTGATCGGTCTGATCAAGGAAAAGCTGGATACGGTCGAGGCGTCGGGTTTC
ATCTTTGACGGTTTCCCACGCACTTTGGCGCAGGCCGATGCCTTGGGTGCTTTGATGGAAGAAACGGGCCAGACGCTGGA
TAAAGTGGTTGAGATGCGCGTTGATGATGCAGCCCTTGTGGCGCGGATCACGGCACGGTCGACCTGCGCGGGCTGCGGTG
AGGTCTACAACGATCAAACCAAGCCAATCCCGGCCGACGGGGTGTGCACCAATTGCGGGCAGGCCAAGGAATTCAAGCGT
CGCGCGGATGACAATGAGGAAAGCCTCAAGACGCGTCTGATGGAATATTACAAACAGACCTCGCCGCTGATCGGGTATTA
CTATGCCAAGGGCATGCTGTCGCGGGTCGACGGTCTGGGCGCGATTGATGCGGTGCAGGGCGAAATCAAGGCTGTGTTGG
ACGCGTAA

Upstream 100 bases:

>100_bases
AAAGCCATTTGCTGGCCCACCAATACGAAGGCCTGCTGGAGAAGTCGCAACTGCGCGGCAAAAGCGGCAAGGGCCGCAAG
AAACGGAGCCCTGTGCGTCG

Downstream 100 bases:

>100_bases
ACGCCGACACCGGCTAAGATCCCGACTTAAACTTCGTCAGGCTTTCTGATCTGGGCCGCGAAGCTGGGAATCCGGTGCAG
GATGAAGTCATAAAAGGCAG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MNIILLGPPGAGKGTQARMLEQERGMVQLSTGDMLREAKDSGTEMGKVVADVMARGALVTDEIVIGLIKEKLDTVEASGF
IFDGFPRTLAQADALGALMEETGQTLDKVVEMRVDDAALVARITARSTCAGCGEVYNDQTKPIPADGVCTNCGQAKEFKR
RADDNEESLKTRLMEYYKQTSPLIGYYYAKGMLSRVDGLGAIDAVQGEIKAVLDA

Sequences:

>Translated_215_residues
MNIILLGPPGAGKGTQARMLEQERGMVQLSTGDMLREAKDSGTEMGKVVADVMARGALVTDEIVIGLIKEKLDTVEASGF
IFDGFPRTLAQADALGALMEETGQTLDKVVEMRVDDAALVARITARSTCAGCGEVYNDQTKPIPADGVCTNCGQAKEFKR
RADDNEESLKTRLMEYYKQTSPLIGYYYAKGMLSRVDGLGAIDAVQGEIKAVLDA
>Mature_215_residues
MNIILLGPPGAGKGTQARMLEQERGMVQLSTGDMLREAKDSGTEMGKVVADVMARGALVTDEIVIGLIKEKLDTVEASGF
IFDGFPRTLAQADALGALMEETGQTLDKVVEMRVDDAALVARITARSTCAGCGEVYNDQTKPIPADGVCTNCGQAKEFKR
RADDNEESLKTRLMEYYKQTSPLIGYYYAKGMLSRVDGLGAIDAVQGEIKAVLDA

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=211, Percent_Identity=42.654028436019, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI4502013, Length=211, Percent_Identity=42.654028436019, Blast_Score=163, Evalue=9e-41,
Organism=Homo sapiens, GI310110345, Length=195, Percent_Identity=31.2820512820513, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI53832003, Length=195, Percent_Identity=31.2820512820513, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI8051579, Length=195, Percent_Identity=31.2820512820513, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI53832001, Length=195, Percent_Identity=31.2820512820513, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI19923437, Length=198, Percent_Identity=31.8181818181818, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI4502011, Length=217, Percent_Identity=30.4147465437788, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI28144899, Length=215, Percent_Identity=29.7674418604651, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI28144897, Length=215, Percent_Identity=29.7674418604651, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI7706497, Length=218, Percent_Identity=26.605504587156, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI22749187, Length=187, Percent_Identity=27.807486631016, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1786680, Length=219, Percent_Identity=43.8356164383562, Blast_Score=172, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17552384, Length=216, Percent_Identity=40.7407407407407, Blast_Score=153, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17567503, Length=215, Percent_Identity=32.093023255814, Blast_Score=106, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17533833, Length=216, Percent_Identity=31.9444444444444, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17550688, Length=215, Percent_Identity=28.3720930232558, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17537943, Length=192, Percent_Identity=30.2083333333333, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=199, Percent_Identity=41.2060301507538, Blast_Score=158, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6321018, Length=197, Percent_Identity=35.5329949238579, Blast_Score=120, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6322828, Length=198, Percent_Identity=28.2828282828283, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI22026816, Length=199, Percent_Identity=43.21608040201, Blast_Score=164, Evalue=3e-41,
Organism=Drosophila melanogaster, GI17737899, Length=195, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24645822, Length=195, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI221459597, Length=215, Percent_Identity=28.3720930232558, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21356893, Length=215, Percent_Identity=28.3720930232558, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17647141, Length=192, Percent_Identity=28.125, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24663208, Length=192, Percent_Identity=28.125, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23090; Mature: 23090

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIILLGPPGAGKGTQARMLEQERGMVQLSTGDMLREAKDSGTEMGKVVADVMARGALVT
CEEEEECCCCCCCCHHHHHHHHHCCEEEECCHHHHHHHHHCHHHHHHHHHHHHHCCCHHH
DEIVIGLIKEKLDTVEASGFIFDGFPRTLAQADALGALMEETGQTLDKVVEMRVDDAALV
HHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ARITARSTCAGCGEVYNDQTKPIPADGVCTNCGQAKEFKRRADDNEESLKTRLMEYYKQT
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHC
SPLIGYYYAKGMLSRVDGLGAIDAVQGEIKAVLDA
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNIILLGPPGAGKGTQARMLEQERGMVQLSTGDMLREAKDSGTEMGKVVADVMARGALVT
CEEEEECCCCCCCCHHHHHHHHHCCEEEECCHHHHHHHHHCHHHHHHHHHHHHHCCCHHH
DEIVIGLIKEKLDTVEASGFIFDGFPRTLAQADALGALMEETGQTLDKVVEMRVDDAALV
HHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ARITARSTCAGCGEVYNDQTKPIPADGVCTNCGQAKEFKRRADDNEESLKTRLMEYYKQT
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHC
SPLIGYYYAKGMLSRVDGLGAIDAVQGEIKAVLDA
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9862211; 2537726 [H]