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The map label for this gene is folK [H]

Identifier: 110678678

GI number: 110678678

Start: 1306678

End: 1307292

Strand: Direct

Name: folK [H]

Synonym: RD1_1357

Alternate gene names: 110678678

Gene position: 1306678-1307292 (Clockwise)

Preceding gene: 110678667

Following gene: 110678679

Centisome position: 31.61

GC content: 56.91

Gene sequence:

>615_bases
TTGACTGTGCCGCAAGTGACAAGACAGGGGAAAATTGGCAAAAAATCGCCACAATTACGGTCACTTGCACTGATTGCCGT
TGGGTCAAACCAAGGCTTACGCAACGGAACCCCACACGATACCGTACTGAATGCATTGAAAGAATTTCCCGTTAAGGTTG
GATCGATTCGGGCTTTCAGCAGGCTGTTTCGCACGGCTGCCTTCCCGGCGGGATCCGGCCCGGATTTCGTCAATGCGGCC
TTTGCCCTTGAGACGGAACTGGATGCAGCCGACCTTTTGAGCCATCTTCACGAGGTTGAATCACTGTTCAGGCGCAACCG
GACCAAGCGGTGGGGGCCGCGCACTCTGGACCTTGATCTGATCGCGATGGCGGATCAGGTTTTGCCTGATCGCGAGACAT
TCGATCACTGGGCGCAGTTGCCGATCGATCAACAGATGACCACATCGCCGGAGCGGTTGATCCTGCCGCACCCGCGTGTG
CATGAGCGGGCATTTGTCCTGATCCCGCTGGCGGATGTGGCACCGGAATGGCGTCACCCGGTCCGCGGTGTCAGCGTTCA
GGAGATGGTCGATGCCTTGCCGGAAAACCTCAAAAACGAAGTCGAACCGCTGTAA

Upstream 100 bases:

>100_bases
TGTAAAACATCTAAGTGTCCTTTCGATTGGTCAGGCGCTGGTGCTCGTAAAAAGTTGTGATAAAATTTCTGCACCCGACA
ATTGAACAAAATAGGGTTTT

Downstream 100 bases:

>100_bases
TTCTTTGCTTGTAAAGCGGTGCCAACCGACCTAAATAACGGACTTCCGCCCCTACTCTGTCTGATGGAGATGTTTCATGG
CCCGCGTCACAGTCGAAGAT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MTVPQVTRQGKIGKKSPQLRSLALIAVGSNQGLRNGTPHDTVLNALKEFPVKVGSIRAFSRLFRTAAFPAGSGPDFVNAA
FALETELDAADLLSHLHEVESLFRRNRTKRWGPRTLDLDLIAMADQVLPDRETFDHWAQLPIDQQMTTSPERLILPHPRV
HERAFVLIPLADVAPEWRHPVRGVSVQEMVDALPENLKNEVEPL

Sequences:

>Translated_204_residues
MTVPQVTRQGKIGKKSPQLRSLALIAVGSNQGLRNGTPHDTVLNALKEFPVKVGSIRAFSRLFRTAAFPAGSGPDFVNAA
FALETELDAADLLSHLHEVESLFRRNRTKRWGPRTLDLDLIAMADQVLPDRETFDHWAQLPIDQQMTTSPERLILPHPRV
HERAFVLIPLADVAPEWRHPVRGVSVQEMVDALPENLKNEVEPL
>Mature_203_residues
TVPQVTRQGKIGKKSPQLRSLALIAVGSNQGLRNGTPHDTVLNALKEFPVKVGSIRAFSRLFRTAAFPAGSGPDFVNAAF
ALETELDAADLLSHLHEVESLFRRNRTKRWGPRTLDLDLIAMADQVLPDRETFDHWAQLPIDQQMTTSPERLILPHPRVH
ERAFVLIPLADVAPEWRHPVRGVSVQEMVDALPENLKNEVEPL

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=162, Percent_Identity=33.9506172839506, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 22811; Mature: 22680

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVPQVTRQGKIGKKSPQLRSLALIAVGSNQGLRNGTPHDTVLNALKEFPVKVGSIRAFS
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHH
RLFRTAAFPAGSGPDFVNAAFALETELDAADLLSHLHEVESLFRRNRTKRWGPRTLDLDL
HHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
IAMADQVLPDRETFDHWAQLPIDQQMTTSPERLILPHPRVHERAFVLIPLADVAPEWRHP
HHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCEEEEEEHHHCCHHHCCC
VRGVSVQEMVDALPENLKNEVEPL
CCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TVPQVTRQGKIGKKSPQLRSLALIAVGSNQGLRNGTPHDTVLNALKEFPVKVGSIRAFS
CCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHH
RLFRTAAFPAGSGPDFVNAAFALETELDAADLLSHLHEVESLFRRNRTKRWGPRTLDLDL
HHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
IAMADQVLPDRETFDHWAQLPIDQQMTTSPERLILPHPRVHERAFVLIPLADVAPEWRHP
HHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCEEEEEEHHHCCHHHCCC
VRGVSVQEMVDALPENLKNEVEPL
CCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]