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The map label for this gene is fmt

Identifier: 110678660

GI number: 110678660

Start: 1288429

End: 1289346

Strand: Direct

Name: fmt

Synonym: RD1_1339

Alternate gene names: 110678660

Gene position: 1288429-1289346 (Clockwise)

Preceding gene: 110678659

Following gene: 110678661

Centisome position: 31.17

GC content: 66.45

Gene sequence:

>918_bases
ATGCGTTTGGTTTTCATGGGAACACCCGATTTTTCGGTCCCTGTGCTTGAGGCACTGGTGGCGGCAGGACATGAGATCGC
CTGTGTCTACAGCCAGCCGCCACGCCCGGCGGGGCGGGGCAAGAAAGACCGGCCCTCGCCCGTGCAGGCGCGGGCAGAGG
CGCTTGGGCTCCCGGTGCGCCACCCGGTGTCCTTGCGTAGCGATGAGGCGCTGGCGGATTTCGCGGGGCTGCAGGCCGAG
GTCGCCGTGGTCGTGGCCTATGGGCTGATCCTGCCGCAGGCCATTCTGGATGCGCCGACGCGCGGCTGTCTGAACATTCA
CGCCAGTTTACTGCCGCGCTGGCGGGGGGCTGCGCCGATCCACCGCGCCATCATGGCGGGGGATGCGCAGACCGGTGTGT
GCATCATGCAGATGGAAGCAGGCCTTGATACCGGCCCCGTGCTTGCGCGTGAAGCTGTCGACATCGGACCCGAGGAGACA
ACAGCGCAGTTGCATGACCGGCTGAGCGCCTTGGGGGCCGCGTTGATAGTCGACACGCTGGCGCGGCTCGATCAGCTTGA
GGCGGTCCCACAACCGGAAGACGGTGTGACCTATGCGGCCAAGATCGACAAGGCGGAGGCGCAGGTGGATTGGGACCAGC
CCGCCGAAGACGTGGATCGGCTGATCCGTGGGCTGTCGCCGTTTCCGGGTGCCTGGACCTTGCTGGGCGACACGCGCGTC
AAACTGCTCGGGTCGCGCATTGCCGAGGCGTCGGGGGTGCCGGGCACGGTCCGGCTGAACCCGCTGCGGGTGGTCTGTGG
GACGGGGGCGGTGGAACTCACGCAGGTGCAGCGCGCGGGCAAAGCGGTGCAGAGTGCGGCTGATTTTCTGAACGGCAGCG
CAATTGAAGACGGCACCCTTTTCAAAGGAAAAAGCTGA

Upstream 100 bases:

>100_bases
GCAGGGAAAGATGTATTTCGACAATCTCAGCAAGGTGAAACGGGATATGCTGCTGCGCAAGGCGCGTAAACTGAACGGCT
AGTGCCCTCTGGAGGATAAG

Downstream 100 bases:

>100_bases
TGTTCCCGACGTTGATAGGTACGGTTGTGATCGCGGGCCTTGTGGGGTTCTTTTCCGAACGGTCGGGGTTTACGCACAAC
GGCTATGTGCAGAGCATCAT

Product: methionyl-tRNA formyltransferase, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MRLVFMGTPDFSVPVLEALVAAGHEIACVYSQPPRPAGRGKKDRPSPVQARAEALGLPVRHPVSLRSDEALADFAGLQAE
VAVVVAYGLILPQAILDAPTRGCLNIHASLLPRWRGAAPIHRAIMAGDAQTGVCIMQMEAGLDTGPVLAREAVDIGPEET
TAQLHDRLSALGAALIVDTLARLDQLEAVPQPEDGVTYAAKIDKAEAQVDWDQPAEDVDRLIRGLSPFPGAWTLLGDTRV
KLLGSRIAEASGVPGTVRLNPLRVVCGTGAVELTQVQRAGKAVQSAADFLNGSAIEDGTLFKGKS

Sequences:

>Translated_305_residues
MRLVFMGTPDFSVPVLEALVAAGHEIACVYSQPPRPAGRGKKDRPSPVQARAEALGLPVRHPVSLRSDEALADFAGLQAE
VAVVVAYGLILPQAILDAPTRGCLNIHASLLPRWRGAAPIHRAIMAGDAQTGVCIMQMEAGLDTGPVLAREAVDIGPEET
TAQLHDRLSALGAALIVDTLARLDQLEAVPQPEDGVTYAAKIDKAEAQVDWDQPAEDVDRLIRGLSPFPGAWTLLGDTRV
KLLGSRIAEASGVPGTVRLNPLRVVCGTGAVELTQVQRAGKAVQSAADFLNGSAIEDGTLFKGKS
>Mature_305_residues
MRLVFMGTPDFSVPVLEALVAAGHEIACVYSQPPRPAGRGKKDRPSPVQARAEALGLPVRHPVSLRSDEALADFAGLQAE
VAVVVAYGLILPQAILDAPTRGCLNIHASLLPRWRGAAPIHRAIMAGDAQTGVCIMQMEAGLDTGPVLAREAVDIGPEET
TAQLHDRLSALGAALIVDTLARLDQLEAVPQPEDGVTYAAKIDKAEAQVDWDQPAEDVDRLIRGLSPFPGAWTLLGDTRV
KLLGSRIAEASGVPGTVRLNPLRVVCGTGAVELTQVQRAGKAVQSAADFLNGSAIEDGTLFKGKS

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI21614513, Length=262, Percent_Identity=32.0610687022901, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI238814322, Length=263, Percent_Identity=31.9391634980989, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI164663775, Length=318, Percent_Identity=30.5031446540881, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1789683, Length=298, Percent_Identity=46.9798657718121, Blast_Score=263, Evalue=7e-72,
Organism=Escherichia coli, GI1788589, Length=283, Percent_Identity=27.5618374558304, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI133930964, Length=270, Percent_Identity=29.2592592592593, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319458, Length=363, Percent_Identity=25.068870523416, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550868, Length=304, Percent_Identity=33.8815789473684, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI28571984, Length=227, Percent_Identity=37.0044052863436, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24585660, Length=268, Percent_Identity=27.6119402985075, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_ROSDO (Q16AL2)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_681667.1
- ProteinModelPortal:   Q16AL2
- SMR:   Q16AL2
- STRING:   Q16AL2
- GeneID:   4197352
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_1339
- NMPDR:   fig|375451.6.peg.1253
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   VVAYGAI
- PhylomeDB:   Q16AL2
- ProtClustDB:   CLSK934096
- BioCyc:   RDEN375451:RD1_1339-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 32087; Mature: 32087

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVFMGTPDFSVPVLEALVAAGHEIACVYSQPPRPAGRGKKDRPSPVQARAEALGLPVR
CEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCC
HPVSLRSDEALADFAGLQAEVAVVVAYGLILPQAILDAPTRGCLNIHASLLPRWRGAAPI
CCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHH
HRAIMAGDAQTGVCIMQMEAGLDTGPVLAREAVDIGPEETTAQLHDRLSALGAALIVDTL
HHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
ARLDQLEAVPQPEDGVTYAAKIDKAEAQVDWDQPAEDVDRLIRGLSPFPGAWTLLGDTRV
HHHHHHHCCCCCCCCCEEEEEECCHHCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCHHH
KLLGSRIAEASGVPGTVRLNPLRVVCGTGAVELTQVQRAGKAVQSAADFLNGSAIEDGTL
HHHHHHHHHCCCCCCEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
FKGKS
CCCCC
>Mature Secondary Structure
MRLVFMGTPDFSVPVLEALVAAGHEIACVYSQPPRPAGRGKKDRPSPVQARAEALGLPVR
CEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCC
HPVSLRSDEALADFAGLQAEVAVVVAYGLILPQAILDAPTRGCLNIHASLLPRWRGAAPI
CCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHH
HRAIMAGDAQTGVCIMQMEAGLDTGPVLAREAVDIGPEETTAQLHDRLSALGAALIVDTL
HHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
ARLDQLEAVPQPEDGVTYAAKIDKAEAQVDWDQPAEDVDRLIRGLSPFPGAWTLLGDTRV
HHHHHHHCCCCCCCCCEEEEEECCHHCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCHHH
KLLGSRIAEASGVPGTVRLNPLRVVCGTGAVELTQVQRAGKAVQSAADFLNGSAIEDGTL
HHHHHHHHHCCCCCCEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
FKGKS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA