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The map label for this gene is prrA [H]

Identifier: 110678485

GI number: 110678485

Start: 1115576

End: 1116262

Strand: Reverse

Name: prrA [H]

Synonym: RD1_1155

Alternate gene names: 110678485

Gene position: 1116262-1115576 (Counterclockwise)

Preceding gene: 110678486

Following gene: 110678484

Centisome position: 27.01

GC content: 58.08

Gene sequence:

>687_bases
ATGCGTATGAGCACTTTGCTGATCATTGATGACGACCCTGAAATCACCTCTGCGCTGTCACGTGGGCTTGCCTTGCATGG
CTACGAAACTGAGGCTGAAAACCGGGCAGACCGGGCGCTGAGCAGGCTGCAAACGGGCCGCTATGACGGCGCGATTGTCG
ATGTGATGCTGGGCGCAGACAGCGGGGTCGATCTGGTGCGCTTGGCCCGTGCAGCTGGCGTAAGCATGCCAATCCTGATG
CTGTCCGCCCTGTCAGATGTCGAACATCGCGCCGCAGGCCTTGAGGCGGGTGCGGACGATTATGTGGTGAAACCTTTCAA
CTTTGATGAACTGGTGGCCCGCCTGCGTGTGCAGGAGCATCGTTCCGCGCAGCATCGCCCCCTGCCCCCACAGCTTGTAC
GCCGCACCCGCGAGTTAAGGAACGACTGCGCCAGCGTCACCTTGACCGAACGCGAATTTGCGCTTCTGGACCTTTTGGCC
AAACATGCCGGCACGCCCTTGTCACGCGGGGCGATCTTTGACGCACTCTGGGCGGGCGACGGGTCGAGTAACGAGAATGT
GGTTGACGTATACATCGGCTATTTGCGCAAAAAGCTCAAAAACTATGACTTTCATTTTGAAATCAAGACATTACGCAACC
AGGGGTTTAGTCTTGAGGGTCCCGCGCCGCAATTGAGCGACCTCTGA

Upstream 100 bases:

>100_bases
AGTATTACGCTGACAAGTCCCGTGCCCGTTGAGCAGGCACTTGGCGATGCACCCGGGACGAAAATCGCGGTTTGCCTGCC
GCGCCACAATACCTAATATA

Downstream 100 bases:

>100_bases
ACACCGATTAAAGTCGTATATGCTCTTATAAATTAAGAGTCGCGCAAACCGAGATCCTCTGTCAGAATGAAACGATAAAT
CAGTGGAGGAGACCCCCATG

Product: transcriptional regulatory protein PrrA, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MRMSTLLIIDDDPEITSALSRGLALHGYETEAENRADRALSRLQTGRYDGAIVDVMLGADSGVDLVRLARAAGVSMPILM
LSALSDVEHRAAGLEAGADDYVVKPFNFDELVARLRVQEHRSAQHRPLPPQLVRRTRELRNDCASVTLTEREFALLDLLA
KHAGTPLSRGAIFDALWAGDGSSNENVVDVYIGYLRKKLKNYDFHFEIKTLRNQGFSLEGPAPQLSDL

Sequences:

>Translated_228_residues
MRMSTLLIIDDDPEITSALSRGLALHGYETEAENRADRALSRLQTGRYDGAIVDVMLGADSGVDLVRLARAAGVSMPILM
LSALSDVEHRAAGLEAGADDYVVKPFNFDELVARLRVQEHRSAQHRPLPPQLVRRTRELRNDCASVTLTEREFALLDLLA
KHAGTPLSRGAIFDALWAGDGSSNENVVDVYIGYLRKKLKNYDFHFEIKTLRNQGFSLEGPAPQLSDL
>Mature_228_residues
MRMSTLLIIDDDPEITSALSRGLALHGYETEAENRADRALSRLQTGRYDGAIVDVMLGADSGVDLVRLARAAGVSMPILM
LSALSDVEHRAAGLEAGADDYVVKPFNFDELVARLRVQEHRSAQHRPLPPQLVRRTRELRNDCASVTLTEREFALLDLLA
KHAGTPLSRGAIFDALWAGDGSSNENVVDVYIGYLRKKLKNYDFHFEIKTLRNQGFSLEGPAPQLSDL

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=38.5964912280702, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=34.0909090909091, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1789809, Length=224, Percent_Identity=31.25, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=32.7272727272727, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1790860, Length=229, Percent_Identity=33.1877729257642, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=30.5936073059361, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=29.3577981651376, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=32.7586206896552, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1786911, Length=208, Percent_Identity=32.2115384615385, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=27.2321428571429, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=31.063829787234, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1788394, Length=205, Percent_Identity=28.780487804878, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI1788550, Length=198, Percent_Identity=25.2525252525253, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790437, Length=110, Percent_Identity=30.9090909090909, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25200; Mature: 25200

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMSTLLIIDDDPEITSALSRGLALHGYETEAENRADRALSRLQTGRYDGAIVDVMLGAD
CCCEEEEEECCCHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCC
SGVDLVRLARAAGVSMPILMLSALSDVEHRAAGLEAGADDYVVKPFNFDELVARLRVQEH
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHH
RSAQHRPLPPQLVRRTRELRNDCASVTLTEREFALLDLLAKHAGTPLSRGAIFDALWAGD
HCCCCCCCCHHHHHHHHHHHHHHHCEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCC
GSSNENVVDVYIGYLRKKLKNYDFHFEIKTLRNQGFSLEGPAPQLSDL
CCCCCCHHHHHHHHHHHHHHCCCEEEEEEEHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRMSTLLIIDDDPEITSALSRGLALHGYETEAENRADRALSRLQTGRYDGAIVDVMLGAD
CCCEEEEEECCCHHHHHHHHCCCEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCC
SGVDLVRLARAAGVSMPILMLSALSDVEHRAAGLEAGADDYVVKPFNFDELVARLRVQEH
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHH
RSAQHRPLPPQLVRRTRELRNDCASVTLTEREFALLDLLAKHAGTPLSRGAIFDALWAGD
HCCCCCCCCHHHHHHHHHHHHHHHCEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCC
GSSNENVVDVYIGYLRKKLKNYDFHFEIKTLRNQGFSLEGPAPQLSDL
CCCCCCHHHHHHHHHHHHHHCCCEEEEEEEHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]