Click here to switch to the map view.

The map label for this gene is acsA [H]

Identifier: 110678452

GI number: 110678452

Start: 1069311

End: 1071233

Strand: Reverse

Name: acsA [H]

Synonym: RD1_1117

Alternate gene names: 110678452

Gene position: 1071233-1069311 (Counterclockwise)

Preceding gene: 110678455

Following gene: 110678451

Centisome position: 25.92

GC content: 61.1

Gene sequence:

>1923_bases
ATGACCAGAACACCCCACGTCACCTTATCGCAATACGCGTCTCTTTATTCGGAGTCTGTTTCGGATTCTGAGGGGTTTTG
GCGGCGTGAGGGGGGGCGGGTTGACTGGATCAAGCCGTTCACCAAGGTCAGGGATGTGAACTTCGATCTCGGCTCTGTGT
CGATCAACTGGTACGGCGATGGGACGTTGAATGTGGCGGCCAATTGCGTCGATCGCCATCTGGCCACGCGCGCCGATCAG
ACCGCGATCATCTGGGAGCCGGATGACCCCAAGGATGCCGCCAAACATATCACCTACAAGCAATTGCATGTTTCGGTCTG
CAAGATGGCCAATGTGCTGGAAAGCCTTGGCGTGCGGCGCGGCGACCGGGTGGTGATCTACCTGCCGATGATCCCCGAGG
CGGCCTATGCGATGCTGGCCTGTGCGCGCATCGGCGCGATCCACTCCATCGTCTTTGCCGGGTTCTCGCCCGATGCACTT
GCCGCGCGGATCAATGGCAGTGACGCCAAAGTCGTCATCACCGCCGATCACGCCCCGCGCGGCGGGCGCGCCACAGCGCT
CAAGGCCAATACGGATGCGGCCCTGCTGCACTGCAAGGACAGCGTGAAGTGCCTCGTCGTCAAGCGCACAGGCGGGCAGA
CCACCTGGATCGACGGGCGCGATTTTGACTGCGGCGAGATGATGCTGGAGGCCTCCGATGTCTCCCACCCCGCCGAGATG
AACGCCGAAGACCCGCTGTTCATCCTCTATACCTCCGGCTCCACCGGGCAGCCCAAGGGCGTCGTGCACACCTCGGGCGG
CTATCTCACCTATGCCGCGATGACCCATGAGATCGTGTTTGATTACCACGATGGCGATGTGTTCTGGTGCACCGCCGATG
TGGGCTGGGTGACGGGCCACAGCTATATCGTCTACGGGCCGCTGGCCAATGGCGCGACCACCATCATGTTCGAGGGCGTG
CCGACCTACCCCGATGCCAGCCGCTTCTGGCAGGTCTGCGAAAAGCACAAAGTCAACCAGTTCTACACCGCCCCCACCGC
CATCCGCGCGCTGATGGGACAGGGCAAGGAGTTCGTCGAAAAATGCGATCTGAGTGATCTCAAGGTGCTGGGCACCGTGG
GCGAGCCGATCAACCCCGAGGCCTGGAACTGGTACAATGACGTGGTGGGCAAGGGCAAATGCCCCATCGTCGACACCTGG
TGGCAGACCGAAACAGGCGGGCATCTGATGACCCCTCTGCCCGGCGCGCATACCATGAAACCGGGCTCGGCGATGAAGCC
TTTCTTTGGCATCAAGCCGATGGTGCTGGAGCCTGCGTCAGGCGAGGTGCTGGAGGGCAACGACGTCGAGGGCGTGCTGG
TCATCGCCGACAGCTGGCCCGGCCAGATGCGCACCATCTGGGGCGATCACGAACGCTTCGAAAAGACCTACTTCTCTGAT
TACAAAGGCTATTACTTCACCGGAGATGGCTGCAAGCGCGACGCGGACGGCGATTACTGGATCACGGGACGGGTCGATGA
CGTGATCAACGTCTCGGGCCACCGCATGGGCACCGCAGAGGTCGAAAGCGCGCTGGTCGCCCACGCCAAAGTCGCCGAAG
CCGCCGTTGTCGGATACCCGCATGACATCAAGGGACAGGGCATCTATTGCTACGTCACCCTGATGAACGGCGAAGAACCC
AGCGATGAACTCTATCAGGAATTGCGCAAATGGGTCCGCGCAGAAATCGGCCCCATCGCATCCCCAGACCTCATCCAATG
GGCCCCCGGCCTGCCCAAAACACGCTCCGGCAAAATCATGCGCCGCATCCTGCGCAAAATCGCCGAAGACGACTTCGCAA
CCCTCGGAGACACCTCAACACTCGCAGACCCAACCGTCGTCGATGACCTCATCAAAAACAGAATGAACAAACAGGACGCT
TGA

Upstream 100 bases:

>100_bases
TTTTCAAAACTCACGTAAAAGTTATTCAACAAAGGCGCTGGGTAATTTTCTGACCCGCCCCGCGCTTCAACTGTCGAAAT
ACTACTGTGAGGAGAAAACA

Downstream 100 bases:

>100_bases
TAATATGGATGGTTCAACACACCCAAACACCGCACCGGTCCTGATCCTGCTTGGCCCTCCGGGAGCCGGCAAGGGCACGC
AAGCCCGCATGCTGCAGGAA

Product: acetyl-coenzyme A synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 640; Mature: 639

Protein sequence:

>640_residues
MTRTPHVTLSQYASLYSESVSDSEGFWRREGGRVDWIKPFTKVRDVNFDLGSVSINWYGDGTLNVAANCVDRHLATRADQ
TAIIWEPDDPKDAAKHITYKQLHVSVCKMANVLESLGVRRGDRVVIYLPMIPEAAYAMLACARIGAIHSIVFAGFSPDAL
AARINGSDAKVVITADHAPRGGRATALKANTDAALLHCKDSVKCLVVKRTGGQTTWIDGRDFDCGEMMLEASDVSHPAEM
NAEDPLFILYTSGSTGQPKGVVHTSGGYLTYAAMTHEIVFDYHDGDVFWCTADVGWVTGHSYIVYGPLANGATTIMFEGV
PTYPDASRFWQVCEKHKVNQFYTAPTAIRALMGQGKEFVEKCDLSDLKVLGTVGEPINPEAWNWYNDVVGKGKCPIVDTW
WQTETGGHLMTPLPGAHTMKPGSAMKPFFGIKPMVLEPASGEVLEGNDVEGVLVIADSWPGQMRTIWGDHERFEKTYFSD
YKGYYFTGDGCKRDADGDYWITGRVDDVINVSGHRMGTAEVESALVAHAKVAEAAVVGYPHDIKGQGIYCYVTLMNGEEP
SDELYQELRKWVRAEIGPIASPDLIQWAPGLPKTRSGKIMRRILRKIAEDDFATLGDTSTLADPTVVDDLIKNRMNKQDA

Sequences:

>Translated_640_residues
MTRTPHVTLSQYASLYSESVSDSEGFWRREGGRVDWIKPFTKVRDVNFDLGSVSINWYGDGTLNVAANCVDRHLATRADQ
TAIIWEPDDPKDAAKHITYKQLHVSVCKMANVLESLGVRRGDRVVIYLPMIPEAAYAMLACARIGAIHSIVFAGFSPDAL
AARINGSDAKVVITADHAPRGGRATALKANTDAALLHCKDSVKCLVVKRTGGQTTWIDGRDFDCGEMMLEASDVSHPAEM
NAEDPLFILYTSGSTGQPKGVVHTSGGYLTYAAMTHEIVFDYHDGDVFWCTADVGWVTGHSYIVYGPLANGATTIMFEGV
PTYPDASRFWQVCEKHKVNQFYTAPTAIRALMGQGKEFVEKCDLSDLKVLGTVGEPINPEAWNWYNDVVGKGKCPIVDTW
WQTETGGHLMTPLPGAHTMKPGSAMKPFFGIKPMVLEPASGEVLEGNDVEGVLVIADSWPGQMRTIWGDHERFEKTYFSD
YKGYYFTGDGCKRDADGDYWITGRVDDVINVSGHRMGTAEVESALVAHAKVAEAAVVGYPHDIKGQGIYCYVTLMNGEEP
SDELYQELRKWVRAEIGPIASPDLIQWAPGLPKTRSGKIMRRILRKIAEDDFATLGDTSTLADPTVVDDLIKNRMNKQDA
>Mature_639_residues
TRTPHVTLSQYASLYSESVSDSEGFWRREGGRVDWIKPFTKVRDVNFDLGSVSINWYGDGTLNVAANCVDRHLATRADQT
AIIWEPDDPKDAAKHITYKQLHVSVCKMANVLESLGVRRGDRVVIYLPMIPEAAYAMLACARIGAIHSIVFAGFSPDALA
ARINGSDAKVVITADHAPRGGRATALKANTDAALLHCKDSVKCLVVKRTGGQTTWIDGRDFDCGEMMLEASDVSHPAEMN
AEDPLFILYTSGSTGQPKGVVHTSGGYLTYAAMTHEIVFDYHDGDVFWCTADVGWVTGHSYIVYGPLANGATTIMFEGVP
TYPDASRFWQVCEKHKVNQFYTAPTAIRALMGQGKEFVEKCDLSDLKVLGTVGEPINPEAWNWYNDVVGKGKCPIVDTWW
QTETGGHLMTPLPGAHTMKPGSAMKPFFGIKPMVLEPASGEVLEGNDVEGVLVIADSWPGQMRTIWGDHERFEKTYFSDY
KGYYFTGDGCKRDADGDYWITGRVDDVINVSGHRMGTAEVESALVAHAKVAEAAVVGYPHDIKGQGIYCYVTLMNGEEPS
DELYQELRKWVRAEIGPIASPDLIQWAPGLPKTRSGKIMRRILRKIAEDDFATLGDTSTLADPTVVDDLIKNRMNKQDA

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=666, Percent_Identity=53.3033033033033, Blast_Score=692, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=679, Percent_Identity=52.4300441826215, Blast_Score=689, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=632, Percent_Identity=48.8924050632911, Blast_Score=629, Evalue=1e-180,
Organism=Homo sapiens, GI13375727, Length=643, Percent_Identity=37.6360808709176, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI38505220, Length=512, Percent_Identity=29.1015625, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI42544132, Length=515, Percent_Identity=29.126213592233, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI115511026, Length=504, Percent_Identity=28.3730158730159, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI122937307, Length=512, Percent_Identity=26.953125, Blast_Score=170, Evalue=5e-42,
Organism=Homo sapiens, GI31982927, Length=627, Percent_Identity=22.8070175438596, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI58082049, Length=519, Percent_Identity=25.8188824662813, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI157311624, Length=519, Percent_Identity=25.2408477842004, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI157311622, Length=519, Percent_Identity=25.2408477842004, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI42544134, Length=331, Percent_Identity=26.5861027190332, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI187761345, Length=404, Percent_Identity=26.2376237623762, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI187761343, Length=404, Percent_Identity=26.2376237623762, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI156151445, Length=591, Percent_Identity=22.8426395939086, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1790505, Length=630, Percent_Identity=62.3809523809524, Blast_Score=826, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=630, Percent_Identity=37.4603174603175, Blast_Score=397, Evalue=1e-111,
Organism=Escherichia coli, GI145693145, Length=514, Percent_Identity=24.9027237354086, Blast_Score=99, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71983001, Length=643, Percent_Identity=51.1664074650078, Blast_Score=615, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI71982997, Length=643, Percent_Identity=51.1664074650078, Blast_Score=614, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI17569507, Length=596, Percent_Identity=22.4832214765101, Blast_Score=129, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17559526, Length=556, Percent_Identity=23.7410071942446, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17558820, Length=552, Percent_Identity=22.463768115942, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17538037, Length=155, Percent_Identity=29.6774193548387, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17557194, Length=150, Percent_Identity=30, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323182, Length=643, Percent_Identity=47.900466562986, Blast_Score=605, Evalue=1e-174,
Organism=Saccharomyces cerevisiae, GI6319264, Length=643, Percent_Identity=47.7449455676516, Blast_Score=591, Evalue=1e-169,
Organism=Saccharomyces cerevisiae, GI6319699, Length=383, Percent_Identity=24.5430809399478, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24667955, Length=647, Percent_Identity=54.2503863987635, Blast_Score=684, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=564, Percent_Identity=57.9787234042553, Blast_Score=643, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=522, Percent_Identity=58.8122605363985, Blast_Score=600, Evalue=1e-172,
Organism=Drosophila melanogaster, GI21355225, Length=646, Percent_Identity=32.9721362229102, Blast_Score=344, Evalue=1e-94,
Organism=Drosophila melanogaster, GI21355181, Length=536, Percent_Identity=23.8805970149254, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI18859661, Length=188, Percent_Identity=30.8510638297872, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 70426; Mature: 70295

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRTPHVTLSQYASLYSESVSDSEGFWRREGGRVDWIKPFTKVRDVNFDLGSVSINWYGD
CCCCCCEEHHHHHHHHHHCCCCCCCCEECCCCEEEEECHHHHHEECCCEECEEEEEEECC
GTLNVAANCVDRHLATRADQTAIIWEPDDPKDAAKHITYKQLHVSVCKMANVLESLGVRR
CCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
GDRVVIYLPMIPEAAYAMLACARIGAIHSIVFAGFSPDALAARINGSDAKVVITADHAPR
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCCCC
GGRATALKANTDAALLHCKDSVKCLVVKRTGGQTTWIDGRDFDCGEMMLEASDVSHPAEM
CCCEEEEECCCCEEEEEECCCEEEEEEEECCCCEEEECCCCCCHHHHHEECCCCCCCCCC
NAEDPLFILYTSGSTGQPKGVVHTSGGYLTYAAMTHEIVFDYHDGDVFWCTADVGWVTGH
CCCCCEEEEEECCCCCCCCEEEECCCCEEEEEEEEEEEEEEEECCCEEEEECCCCEEECC
SYIVYGPLANGATTIMFEGVPTYPDASRFWQVCEKHKVNQFYTAPTAIRALMGQGKEFVE
CEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCEEECCHHHHHHHHHCCHHHHH
KCDLSDLKVLGTVGEPINPEAWNWYNDVVGKGKCPIVDTWWQTETGGHLMTPLPGAHTMK
HCCCCCEEEEECCCCCCCCCCCCHHHHHCCCCCCCEEECCCCCCCCCEEECCCCCCCCCC
PGSAMKPFFGIKPMVLEPASGEVLEGNDVEGVLVIADSWPGQMRTIWGDHERFEKTYFSD
CCCCCCCCCCCCCEEECCCCCCEECCCCCCEEEEEECCCCCCEEEECCCHHHHHHHHHHC
YKGYYFTGDGCKRDADGDYWITGRVDDVINVSGHRMGTAEVESALVAHAKVAEAAVVGYP
CCCEEEECCCCCCCCCCCEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHHEEECCC
HDIKGQGIYCYVTLMNGEEPSDELYQELRKWVRAEIGPIASPDLIQWAPGLPKTRSGKIM
CCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCHHH
RRILRKIAEDDFATLGDTSTLADPTVVDDLIKNRMNKQDA
HHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TRTPHVTLSQYASLYSESVSDSEGFWRREGGRVDWIKPFTKVRDVNFDLGSVSINWYGD
CCCCCEEHHHHHHHHHHCCCCCCCCEECCCCEEEEECHHHHHEECCCEECEEEEEEECC
GTLNVAANCVDRHLATRADQTAIIWEPDDPKDAAKHITYKQLHVSVCKMANVLESLGVRR
CCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
GDRVVIYLPMIPEAAYAMLACARIGAIHSIVFAGFSPDALAARINGSDAKVVITADHAPR
CCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEECCCCC
GGRATALKANTDAALLHCKDSVKCLVVKRTGGQTTWIDGRDFDCGEMMLEASDVSHPAEM
CCCEEEEECCCCEEEEEECCCEEEEEEEECCCCEEEECCCCCCHHHHHEECCCCCCCCCC
NAEDPLFILYTSGSTGQPKGVVHTSGGYLTYAAMTHEIVFDYHDGDVFWCTADVGWVTGH
CCCCCEEEEEECCCCCCCCEEEECCCCEEEEEEEEEEEEEEEECCCEEEEECCCCEEECC
SYIVYGPLANGATTIMFEGVPTYPDASRFWQVCEKHKVNQFYTAPTAIRALMGQGKEFVE
CEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCEEECCHHHHHHHHHCCHHHHH
KCDLSDLKVLGTVGEPINPEAWNWYNDVVGKGKCPIVDTWWQTETGGHLMTPLPGAHTMK
HCCCCCEEEEECCCCCCCCCCCCHHHHHCCCCCCCEEECCCCCCCCCEEECCCCCCCCCC
PGSAMKPFFGIKPMVLEPASGEVLEGNDVEGVLVIADSWPGQMRTIWGDHERFEKTYFSD
CCCCCCCCCCCCCEEECCCCCCEECCCCCCEEEEEECCCCCCEEEECCCHHHHHHHHHHC
YKGYYFTGDGCKRDADGDYWITGRVDDVINVSGHRMGTAEVESALVAHAKVAEAAVVGYP
CCCEEEECCCCCCCCCCCEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHHEEECCC
HDIKGQGIYCYVTLMNGEEPSDELYQELRKWVRAEIGPIASPDLIQWAPGLPKTRSGKIM
CCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCHHH
RRILRKIAEDDFATLGDTSTLADPTVVDDLIKNRMNKQDA
HHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9256491 [H]