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The map label for this gene is adk-2 [H]

Identifier: 110678451

GI number: 110678451

Start: 1068620

End: 1069306

Strand: Reverse

Name: adk-2 [H]

Synonym: RD1_1116

Alternate gene names: 110678451

Gene position: 1069306-1068620 (Counterclockwise)

Preceding gene: 110678452

Following gene: 110678450

Centisome position: 25.87

GC content: 60.84

Gene sequence:

>687_bases
ATGGATGGTTCAACACACCCAAACACCGCACCGGTCCTGATCCTGCTTGGCCCTCCGGGAGCCGGCAAGGGCACGCAAGC
CCGCATGCTGCAGGAAAAATTCGGCCTTGTGCAACTCTCCACCGGTGACCTGTTGCGCGCGGCTGTGGCCGCGGGCACCA
AGGCCGGGATCGAAGCCAAGGCCGTTATGGCCGCCGGCGGGCTGGTCAGTGACGAAATCGTCCTGCAAGTTCTTGCCGAC
CGCCTGTGCGAACCTGATTGCGCCGCTGGCGTGGTGCTTGACGGGTTTCCGCGCACAACCGGTCAGGCCGAGGCACTGGA
TCAGATGCTTGCGAAATCTGGCCAGCGCATCAATGCCGCAATCGCGCTGGAGGTCGACAACGTCAAGATGGTTCTGCGCA
TCGCGGGCCGCTTCACCTGTGCCGACTGCGGTGAAGGCTATCACGACAATTTCAAACCGACCCGGGCAGAGGGTGTTTGC
GATGGCTGCGGCAGCACCAAGATGACGCGCCGGGCCGACGACAATGCCCAGACCGTCATGTCACGCCTTGATGCATATCA
AGAACAAACCGAACCACTGATTGCATATTACGACGCTAAGGGATCGCTGCGTCGGGTCAATGCGATGGGCGACATCTCGG
CCATCGCCCAAAGCATCGCGCAAATCGTTTCGAGAGTTACAGCTTGA

Upstream 100 bases:

>100_bases
GACGACTTCGCAACCCTCGGAGACACCTCAACACTCGCAGACCCAACCGTCGTCGATGACCTCATCAAAAACAGAATGAA
CAAACAGGACGCTTGATAAT

Downstream 100 bases:

>100_bases
AAACACCTGCTGGCCACATCCGGCCCGCAACAGAACTTAAAAGGAGGAACGCCAAAATGGCAGAACAACAAACAAACACA
GACAGCCGGGCTGCGGAGGA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MDGSTHPNTAPVLILLGPPGAGKGTQARMLQEKFGLVQLSTGDLLRAAVAAGTKAGIEAKAVMAAGGLVSDEIVLQVLAD
RLCEPDCAAGVVLDGFPRTTGQAEALDQMLAKSGQRINAAIALEVDNVKMVLRIAGRFTCADCGEGYHDNFKPTRAEGVC
DGCGSTKMTRRADDNAQTVMSRLDAYQEQTEPLIAYYDAKGSLRRVNAMGDISAIAQSIAQIVSRVTA

Sequences:

>Translated_228_residues
MDGSTHPNTAPVLILLGPPGAGKGTQARMLQEKFGLVQLSTGDLLRAAVAAGTKAGIEAKAVMAAGGLVSDEIVLQVLAD
RLCEPDCAAGVVLDGFPRTTGQAEALDQMLAKSGQRINAAIALEVDNVKMVLRIAGRFTCADCGEGYHDNFKPTRAEGVC
DGCGSTKMTRRADDNAQTVMSRLDAYQEQTEPLIAYYDAKGSLRRVNAMGDISAIAQSIAQIVSRVTA
>Mature_228_residues
MDGSTHPNTAPVLILLGPPGAGKGTQARMLQEKFGLVQLSTGDLLRAAVAAGTKAGIEAKAVMAAGGLVSDEIVLQVLAD
RLCEPDCAAGVVLDGFPRTTGQAEALDQMLAKSGQRINAAIALEVDNVKMVLRIAGRFTCADCGEGYHDNFKPTRAEGVC
DGCGSTKMTRRADDNAQTVMSRLDAYQEQTEPLIAYYDAKGSLRRVNAMGDISAIAQSIAQIVSRVTA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=215, Percent_Identity=41.3953488372093, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI4502013, Length=214, Percent_Identity=41.588785046729, Blast_Score=175, Evalue=3e-44,
Organism=Homo sapiens, GI19923437, Length=190, Percent_Identity=36.8421052631579, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI310110345, Length=194, Percent_Identity=32.4742268041237, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI53832003, Length=194, Percent_Identity=32.4742268041237, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI8051579, Length=194, Percent_Identity=32.4742268041237, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI53832001, Length=194, Percent_Identity=32.4742268041237, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI4502011, Length=211, Percent_Identity=30.8056872037915, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI28144897, Length=200, Percent_Identity=30.5, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI28144899, Length=200, Percent_Identity=30.5, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI22749187, Length=154, Percent_Identity=35.0649350649351, Blast_Score=78, Evalue=5e-15,
Organism=Escherichia coli, GI1786680, Length=185, Percent_Identity=45.4054054054054, Blast_Score=165, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=40.6542056074766, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17567503, Length=220, Percent_Identity=28.6363636363636, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17550688, Length=216, Percent_Identity=27.3148148148148, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17537943, Length=218, Percent_Identity=27.5229357798165, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=197, Percent_Identity=46.7005076142132, Blast_Score=184, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6321018, Length=203, Percent_Identity=35.4679802955665, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322828, Length=203, Percent_Identity=29.5566502463054, Blast_Score=82, Evalue=5e-17,
Organism=Drosophila melanogaster, GI22026816, Length=212, Percent_Identity=44.811320754717, Blast_Score=190, Evalue=7e-49,
Organism=Drosophila melanogaster, GI17737899, Length=188, Percent_Identity=36.7021276595745, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24645822, Length=188, Percent_Identity=36.7021276595745, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24663208, Length=214, Percent_Identity=30.8411214953271, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17647141, Length=214, Percent_Identity=30.8411214953271, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221459597, Length=213, Percent_Identity=24.8826291079812, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21356893, Length=213, Percent_Identity=24.8826291079812, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23883; Mature: 23883

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGSTHPNTAPVLILLGPPGAGKGTQARMLQEKFGLVQLSTGDLLRAAVAAGTKAGIEAK
CCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHHHCCCCCCHHH
AVMAAGGLVSDEIVLQVLADRLCEPDCAAGVVLDGFPRTTGQAEALDQMLAKSGQRINAA
HHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCEEEEE
IALEVDNVKMVLRIAGRFTCADCGEGYHDNFKPTRAEGVCDGCGSTKMTRRADDNAQTVM
EEEEECCHHEEEHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHH
SRLDAYQEQTEPLIAYYDAKGSLRRVNAMGDISAIAQSIAQIVSRVTA
HHHHHHHHHCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDGSTHPNTAPVLILLGPPGAGKGTQARMLQEKFGLVQLSTGDLLRAAVAAGTKAGIEAK
CCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHHHCCCCCCHHH
AVMAAGGLVSDEIVLQVLADRLCEPDCAAGVVLDGFPRTTGQAEALDQMLAKSGQRINAA
HHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHHHHHCCCEEEEE
IALEVDNVKMVLRIAGRFTCADCGEGYHDNFKPTRAEGVCDGCGSTKMTRRADDNAQTVM
EEEEECCHHEEEHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHH
SRLDAYQEQTEPLIAYYDAKGSLRRVNAMGDISAIAQSIAQIVSRVTA
HHHHHHHHHCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA