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The map label for this gene is pbpC [H]

Identifier: 110678285

GI number: 110678285

Start: 907404

End: 909590

Strand: Direct

Name: pbpC [H]

Synonym: RD1_0938

Alternate gene names: 110678285

Gene position: 907404-909590 (Clockwise)

Preceding gene: 110678282

Following gene: 110678288

Centisome position: 21.95

GC content: 61.87

Gene sequence:

>2187_bases
ATGAGTGGTAAACCCAAAGGTAAAAAGCCCTTGGTCGCGGACAAACGCTATGTGTCCCGCAAGGCAAAGACGGCAAAACC
GCAGCCACGGCGCGCGAAGAAAAAGCCGCGCCGTGTCGCAAAGCAACGCGGTGGCATCATCGGTTTCTTTCAGCGGATCA
TCCGGTGGGTACTGCGGCTGATCTGGCGCATAACGTGGCGCGTGGGTCTGGTCGCTACGCTCATGCTGGCTCTGGCGGTC
GGATACTATTACACAACCTTGCCGCCGGTGGATCAACTGCTGGACGCGCGGGCCCGCGGTTCGGTCACATTGCTGGATCA
GGACGGACAGGTCTTTGCCTGGCGCGGCGATCAATTCGGGGGCGTGGTGACTGCGCAAACCGTGTCGCCGCATCTGAAAA
ACGCGATTATCGCCACCGAGGACCGCCGCTTTTATCGCCATTTCGGGCTTAGCCCGCGCGGTATCGCAAGTGCAGTGCGC
ATCAACCTGAGCGAAGGACGTGGCCCGCTGCAAGGACATGGCGGGTCAACGATTACACAGCAGGTGGCGAAACTCTTGTG
CCTTGGTGTGGCTTTTGATCCGGAGAAGCAGACCGAAGCGGAATATGAGCGCGAGTGCCGCCGCGGCACGGTAAAGCGCA
AGGCCAGCGAGGCGATCTACGCGCTGGCGATGGAGGCCAAGTATTCCAAAGATGAAATCCTGACCATCTACATGAACCGG
GTTTTTCTGGGCGCCGGGGCGCGCGGTTTTGAGGCGGCCAGCGAACGCTATTTCGGCAAATCCGCTGCCAACGTAGAACC
GGCGGAAGCTGCGATGCTGGCTGGTCTGTTGGTGGCGCCCACGCGTTTCGCGCCGACCAATGATCTGACCCGCTCGCAAC
GCCGGGCGGCAACCATTGTCCGGCTGATGAATGAGCAAGGATATCTGACCGACGCCCAGGCGCGGGACGCCCAAGAGAAT
CCCGCGCAGCTTTCGCAGGCGGCGGAGGCGCGTTCGGGGGGGTATTTTGCGGATTGGGTCATGTCGTCGGGGCCGGAGTT
CTTTACCCGCAAGACCACTGAGGATGTGATCATCAAGACGACTTTGGATCAGCGCATTCAGCGCAGCGCCGAAGAGGCGT
TGCAATGGGTCTTTGACAACAAGGTGCGCGCAGGCAGTGAGGCACAGGCCGCCATCGTCGTCATGTCCGCCGATGGTGCG
GTGCGCGCAATGGTCGGCGGACGCAACACGAGAGTATCCGGTGCCTTCAATCGCGCGGTCCAGGCCAAGCGGCAAACCGG
ATCGGCGTTCAAGCCATTCGTCTACGCCGCGGCACTGGATCTGGGCTATTCCCCCAATGATACCGTCACGGATGAACCGC
TCACGATTGATATCCCAGGGTCGGGCCCGTGGTCGCCGCGCAACTATACCAACAAGTATTATGGCAAGGTCACGCTGACC
CACGCGCTGCGCGACAGTCTGAACATCCCTGCGGTCAAAGTGTCCGAGTTTGTAGGACGCGACCTTGTGCGGCAGGTTGC
GAATGGCTTCGGATTGGAGAGCGACCTCGCCGCCGGGCCCGCGCTGGCGCTGGGTGCATCGGAAAGCACGTTGATCGAGA
TGACCGGGGCGTATGCCGGTATCCTCAACGGTGGCTCATCCGTGCAGCCCTACGGGTTGGTTGAGCTGCGGCTCTTGGGC
GATCAGGAGCCGTTGATGGGCACGGGCGGCGGTATCGGCGAACGGATCATCCAGGAAAAGGCCGCCCGTCAGTTGGTCTA
TATGATGGAAAAGGTTGTCTCTGAAGGCACCGGGCAGCGCGCGGCCTTTGGCGATCGGCAGGTGGCAGGTAAAACAGGCA
CAACGCAGGCCGCACGGGACGCTTGGTTTGTCGGGTTCTCGGCCGACTACGTGGCCGGTGTCTGGATGGGATATGATGAC
AACACCCCATTGACCGGCGTCACTGGCGGAGGCTTGCCCGCGGAGATATGGCGCGAAACCATGGCGCGCGTGCATGAGGG
AATACCCGCGCGACCGCTTCCCCTTGAAACGCCCGGCAATGATGGGCGCACGCGCGAGGATGAGCGTGATGACAACCGGA
ACAGCGGTGGTGCGGTGGGTCTGCTGGAGGGTCTGTTGCGCGATATTCTCGGCGGCACCGGCGAGGGCAGGCAGCCCCCG
CAGAATGTCAGCGGCTCAGATCGTTGA

Upstream 100 bases:

>100_bases
TTAATCACACAAATGATCAAAGTGACGTACCGGAGCGGGTCACAATCGGGCAAAAGCCGGTTAGAGTGTCGAAAACAACA
ATGGGCCGGGCAGGTTCTTT

Downstream 100 bases:

>100_bases
TCCTGAACAGATTACCCGGCGTTCTTGAGGTCATTCACCACGGCATTGATATCGCCACCACGCTTGTCCAGCATGGCACC
AATTTCTGTCCGCTCTGTCA

Product: 1A family penicillin-binding protein

Products: NA

Alternate protein names: PBP-2D; PBP2d [H]

Number of amino acids: Translated: 728; Mature: 727

Protein sequence:

>728_residues
MSGKPKGKKPLVADKRYVSRKAKTAKPQPRRAKKKPRRVAKQRGGIIGFFQRIIRWVLRLIWRITWRVGLVATLMLALAV
GYYYTTLPPVDQLLDARARGSVTLLDQDGQVFAWRGDQFGGVVTAQTVSPHLKNAIIATEDRRFYRHFGLSPRGIASAVR
INLSEGRGPLQGHGGSTITQQVAKLLCLGVAFDPEKQTEAEYERECRRGTVKRKASEAIYALAMEAKYSKDEILTIYMNR
VFLGAGARGFEAASERYFGKSAANVEPAEAAMLAGLLVAPTRFAPTNDLTRSQRRAATIVRLMNEQGYLTDAQARDAQEN
PAQLSQAAEARSGGYFADWVMSSGPEFFTRKTTEDVIIKTTLDQRIQRSAEEALQWVFDNKVRAGSEAQAAIVVMSADGA
VRAMVGGRNTRVSGAFNRAVQAKRQTGSAFKPFVYAAALDLGYSPNDTVTDEPLTIDIPGSGPWSPRNYTNKYYGKVTLT
HALRDSLNIPAVKVSEFVGRDLVRQVANGFGLESDLAAGPALALGASESTLIEMTGAYAGILNGGSSVQPYGLVELRLLG
DQEPLMGTGGGIGERIIQEKAARQLVYMMEKVVSEGTGQRAAFGDRQVAGKTGTTQAARDAWFVGFSADYVAGVWMGYDD
NTPLTGVTGGGLPAEIWRETMARVHEGIPARPLPLETPGNDGRTREDERDDNRNSGGAVGLLEGLLRDILGGTGEGRQPP
QNVSGSDR

Sequences:

>Translated_728_residues
MSGKPKGKKPLVADKRYVSRKAKTAKPQPRRAKKKPRRVAKQRGGIIGFFQRIIRWVLRLIWRITWRVGLVATLMLALAV
GYYYTTLPPVDQLLDARARGSVTLLDQDGQVFAWRGDQFGGVVTAQTVSPHLKNAIIATEDRRFYRHFGLSPRGIASAVR
INLSEGRGPLQGHGGSTITQQVAKLLCLGVAFDPEKQTEAEYERECRRGTVKRKASEAIYALAMEAKYSKDEILTIYMNR
VFLGAGARGFEAASERYFGKSAANVEPAEAAMLAGLLVAPTRFAPTNDLTRSQRRAATIVRLMNEQGYLTDAQARDAQEN
PAQLSQAAEARSGGYFADWVMSSGPEFFTRKTTEDVIIKTTLDQRIQRSAEEALQWVFDNKVRAGSEAQAAIVVMSADGA
VRAMVGGRNTRVSGAFNRAVQAKRQTGSAFKPFVYAAALDLGYSPNDTVTDEPLTIDIPGSGPWSPRNYTNKYYGKVTLT
HALRDSLNIPAVKVSEFVGRDLVRQVANGFGLESDLAAGPALALGASESTLIEMTGAYAGILNGGSSVQPYGLVELRLLG
DQEPLMGTGGGIGERIIQEKAARQLVYMMEKVVSEGTGQRAAFGDRQVAGKTGTTQAARDAWFVGFSADYVAGVWMGYDD
NTPLTGVTGGGLPAEIWRETMARVHEGIPARPLPLETPGNDGRTREDERDDNRNSGGAVGLLEGLLRDILGGTGEGRQPP
QNVSGSDR
>Mature_727_residues
SGKPKGKKPLVADKRYVSRKAKTAKPQPRRAKKKPRRVAKQRGGIIGFFQRIIRWVLRLIWRITWRVGLVATLMLALAVG
YYYTTLPPVDQLLDARARGSVTLLDQDGQVFAWRGDQFGGVVTAQTVSPHLKNAIIATEDRRFYRHFGLSPRGIASAVRI
NLSEGRGPLQGHGGSTITQQVAKLLCLGVAFDPEKQTEAEYERECRRGTVKRKASEAIYALAMEAKYSKDEILTIYMNRV
FLGAGARGFEAASERYFGKSAANVEPAEAAMLAGLLVAPTRFAPTNDLTRSQRRAATIVRLMNEQGYLTDAQARDAQENP
AQLSQAAEARSGGYFADWVMSSGPEFFTRKTTEDVIIKTTLDQRIQRSAEEALQWVFDNKVRAGSEAQAAIVVMSADGAV
RAMVGGRNTRVSGAFNRAVQAKRQTGSAFKPFVYAAALDLGYSPNDTVTDEPLTIDIPGSGPWSPRNYTNKYYGKVTLTH
ALRDSLNIPAVKVSEFVGRDLVRQVANGFGLESDLAAGPALALGASESTLIEMTGAYAGILNGGSSVQPYGLVELRLLGD
QEPLMGTGGGIGERIIQEKAARQLVYMMEKVVSEGTGQRAAFGDRQVAGKTGTTQAARDAWFVGFSADYVAGVWMGYDDN
TPLTGVTGGGLPAEIWRETMARVHEGIPARPLPLETPGNDGRTREDERDDNRNSGGAVGLLEGLLRDILGGTGEGRQPPQ
NVSGSDR

Specific function: Involved in the polymerization and cross-linking of spore peptidoglycan. May be required for synthesis of the spore germ cell wall, the first layer of peptidoglycan synthesized on the surface of the inner forespore membrane [H]

COG id: COG0744

COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=560, Percent_Identity=33.0357142857143, Blast_Score=208, Evalue=9e-55,
Organism=Escherichia coli, GI1786343, Length=550, Percent_Identity=33.2727272727273, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI87082258, Length=316, Percent_Identity=31.3291139240506, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1789601, Length=203, Percent_Identity=34.9753694581281, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 78953; Mature: 78821

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGKPKGKKPLVADKRYVSRKAKTAKPQPRRAKKKPRRVAKQRGGIIGFFQRIIRWVLRL
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
IWRITWRVGLVATLMLALAVGYYYTTLPPVDQLLDARARGSVTLLDQDGQVFAWRGDQFG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCEEEECCCCCC
GVVTAQTVSPHLKNAIIATEDRRFYRHFGLSPRGIASAVRINLSEGRGPLQGHGGSTITQ
CEEEECCCCHHHHCCEEEECCHHHHHHCCCCCHHCCCEEEEEECCCCCCCCCCCCCHHHH
QVAKLLCLGVAFDPEKQTEAEYERECRRGTVKRKASEAIYALAMEAKYSKDEILTIYMNR
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHH
VFLGAGARGFEAASERYFGKSAANVEPAEAAMLAGLLVAPTRFAPTNDLTRSQRRAATIV
HHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
RLMNEQGYLTDAQARDAQENPAQLSQAAEARSGGYFADWVMSSGPEFFTRKTTEDVIIKT
HHHHCCCCEECCHHCCCCCCHHHHHHHHHHHCCCEEEHHHHCCCCHHHHCCCCCCEEEEH
TLDQRIQRSAEEALQWVFDNKVRAGSEAQAAIVVMSADGAVRAMVGGRNTRVSGAFNRAV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCEECHHHHHHH
QAKRQTGSAFKPFVYAAALDLGYSPNDTVTDEPLTIDIPGSGPWSPRNYTNKYYGKVTLT
HHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEECEEEEH
HALRDSLNIPAVKVSEFVGRDLVRQVANGFGLESDLAAGPALALGASESTLIEMTGAYAG
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEECCCCCEEEEECCHHHH
ILNGGSSVQPYGLVELRLLGDQEPLMGTGGGIGERIIQEKAARQLVYMMEKVVSEGTGQR
HCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AAFGDRQVAGKTGTTQAARDAWFVGFSADYVAGVWMGYDDNTPLTGVTGGGLPAEIWRET
CCCCCCCCCCCCCCCHHHCCEEEEECCHHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHH
MARVHEGIPARPLPLETPGNDGRTREDERDDNRNSGGAVGLLEGLLRDILGGTGEGRQPP
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
QNVSGSDR
CCCCCCCC
>Mature Secondary Structure 
SGKPKGKKPLVADKRYVSRKAKTAKPQPRRAKKKPRRVAKQRGGIIGFFQRIIRWVLRL
CCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
IWRITWRVGLVATLMLALAVGYYYTTLPPVDQLLDARARGSVTLLDQDGQVFAWRGDQFG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCEEEECCCCCC
GVVTAQTVSPHLKNAIIATEDRRFYRHFGLSPRGIASAVRINLSEGRGPLQGHGGSTITQ
CEEEECCCCHHHHCCEEEECCHHHHHHCCCCCHHCCCEEEEEECCCCCCCCCCCCCHHHH
QVAKLLCLGVAFDPEKQTEAEYERECRRGTVKRKASEAIYALAMEAKYSKDEILTIYMNR
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHH
VFLGAGARGFEAASERYFGKSAANVEPAEAAMLAGLLVAPTRFAPTNDLTRSQRRAATIV
HHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
RLMNEQGYLTDAQARDAQENPAQLSQAAEARSGGYFADWVMSSGPEFFTRKTTEDVIIKT
HHHHCCCCEECCHHCCCCCCHHHHHHHHHHHCCCEEEHHHHCCCCHHHHCCCCCCEEEEH
TLDQRIQRSAEEALQWVFDNKVRAGSEAQAAIVVMSADGAVRAMVGGRNTRVSGAFNRAV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCEECHHHHHHH
QAKRQTGSAFKPFVYAAALDLGYSPNDTVTDEPLTIDIPGSGPWSPRNYTNKYYGKVTLT
HHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEECEEEEH
HALRDSLNIPAVKVSEFVGRDLVRQVANGFGLESDLAAGPALALGASESTLIEMTGAYAG
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEECCCCCEEEEECCHHHH
ILNGGSSVQPYGLVELRLLGDQEPLMGTGGGIGERIIQEKAARQLVYMMEKVVSEGTGQR
HCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
AAFGDRQVAGKTGTTQAARDAWFVGFSADYVAGVWMGYDDNTPLTGVTGGGLPAEIWRET
CCCCCCCCCCCCCCCHHHCCEEEEECCHHHHEEEEECCCCCCCCCCCCCCCCCHHHHHHH
MARVHEGIPARPLPLETPGNDGRTREDERDDNRNSGGAVGLLEGLLRDILGGTGEGRQPP
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
QNVSGSDR
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]