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The map label for this gene is fghA [H]

Identifier: 110678235

GI number: 110678235

Start: 864316

End: 865140

Strand: Direct

Name: fghA [H]

Synonym: RD1_0888

Alternate gene names: 110678235

Gene position: 864316-865140 (Clockwise)

Preceding gene: 110678234

Following gene: 110678236

Centisome position: 20.91

GC content: 58.18

Gene sequence:

>825_bases
ATGGAGCTGATATCAGAAAACCGGAGTTTTGGCGGCAGCCAGCAGGTCTTCAAGCACCCGTCGAACACGTGCGGCTGCGA
GATGACATTCGCGGCCTACCTGCCGCCTCAGGCGCAGGATGGACCTGTCCCGGTTTTGTGGTATCTCAGCGGTCTGACCT
GCACCCATGAAAACGCGATGACCAAGGGCGGTTTTCAGGAACACGCGGCCAAAAACGGTTTGGCGGTCATCTTTCCGGAT
ACGTCGCCGCGCGGTGCGGGTGTCAGTGATGACGAGGCCTATGACCTTGGCCAGGGGGCCGGGTTTTATGTCAATGCGAC
GCGGGACCCCTGGAAGACCAACTATCGCATGTATGATTACATCGTGAGCGAATTGCGCTCGATCATCGTGGATAATCTGC
CGGTGCAGGACAAACACGGCATCACCGGCCATTCCATGGGCGGGCATGGTGCGATCACGATCGCCATTCGCAACGCAGGC
CTGTTTGATTCCCTGTCTGCATTTGCGCCCATCGCCAATCCGACGCAGTCTGACTGGGGCCGCAAACAACTCAGCGCCTA
TCTGGGGGACGACGAAAGCAACTGGGCGGATCATGATGCCACGCTCTTGCTGGAAGAACACGGCTGGAAGGGTGATTTGC
TGGTGGATCAGGGGGCTGCCGATCAGTTCCTCGACCTGCTCAAACCCGAAGCGCTGGCAGACATGATGGCGCGTCGGCGT
CAACCCGGACAGCTCCGGATGCAAAGCGGCTATGATCATTCGTATTTCTTCGTGAACAGTTTTGCGCGGGATCATGTATC
ATGGCACGCGGAGCGACTACACTGA

Upstream 100 bases:

>100_bases
TGATCACCCACAAACTCAGCCTGGACGAAATCAACCACGGCTTCGACCTCATGCACCAGGGAAAATCAATCAGAGCCGTC
GTGGAGTTTTGAGAGCAGAG

Downstream 100 bases:

>100_bases
CTGTTCGACCAAGGTGAAACCAAGGAAGGTACTATATGCTAAAGAAATTTCTATCCGTCGCCTGCCTCATGGCACTGCCT
GCCGCTGGCTTTGCGGATGG

Product: S-formylglutathione hydrolase, putative

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MELISENRSFGGSQQVFKHPSNTCGCEMTFAAYLPPQAQDGPVPVLWYLSGLTCTHENAMTKGGFQEHAAKNGLAVIFPD
TSPRGAGVSDDEAYDLGQGAGFYVNATRDPWKTNYRMYDYIVSELRSIIVDNLPVQDKHGITGHSMGGHGAITIAIRNAG
LFDSLSAFAPIANPTQSDWGRKQLSAYLGDDESNWADHDATLLLEEHGWKGDLLVDQGAADQFLDLLKPEALADMMARRR
QPGQLRMQSGYDHSYFFVNSFARDHVSWHAERLH

Sequences:

>Translated_274_residues
MELISENRSFGGSQQVFKHPSNTCGCEMTFAAYLPPQAQDGPVPVLWYLSGLTCTHENAMTKGGFQEHAAKNGLAVIFPD
TSPRGAGVSDDEAYDLGQGAGFYVNATRDPWKTNYRMYDYIVSELRSIIVDNLPVQDKHGITGHSMGGHGAITIAIRNAG
LFDSLSAFAPIANPTQSDWGRKQLSAYLGDDESNWADHDATLLLEEHGWKGDLLVDQGAADQFLDLLKPEALADMMARRR
QPGQLRMQSGYDHSYFFVNSFARDHVSWHAERLH
>Mature_274_residues
MELISENRSFGGSQQVFKHPSNTCGCEMTFAAYLPPQAQDGPVPVLWYLSGLTCTHENAMTKGGFQEHAAKNGLAVIFPD
TSPRGAGVSDDEAYDLGQGAGFYVNATRDPWKTNYRMYDYIVSELRSIIVDNLPVQDKHGITGHSMGGHGAITIAIRNAG
LFDSLSAFAPIANPTQSDWGRKQLSAYLGDDESNWADHDATLLLEEHGWKGDLLVDQGAADQFLDLLKPEALADMMARRR
QPGQLRMQSGYDHSYFFVNSFARDHVSWHAERLH

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=279, Percent_Identity=49.4623655913978, Blast_Score=289, Evalue=2e-78,
Organism=Escherichia coli, GI1788477, Length=276, Percent_Identity=49.2753623188406, Blast_Score=270, Evalue=6e-74,
Organism=Escherichia coli, GI1786551, Length=275, Percent_Identity=44.3636363636364, Blast_Score=266, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI17510185, Length=277, Percent_Identity=53.7906137184115, Blast_Score=290, Evalue=6e-79,
Organism=Saccharomyces cerevisiae, GI6322393, Length=296, Percent_Identity=39.8648648648649, Blast_Score=201, Evalue=1e-52,
Organism=Drosophila melanogaster, GI45551932, Length=280, Percent_Identity=48.9285714285714, Blast_Score=280, Evalue=9e-76,
Organism=Drosophila melanogaster, GI24648347, Length=280, Percent_Identity=48.9285714285714, Blast_Score=279, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 30294; Mature: 30294

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELISENRSFGGSQQVFKHPSNTCGCEMTFAAYLPPQAQDGPVPVLWYLSGLTCTHENAM
CCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEEECCCCCCCCCEEEEEEECCCEEECCCHH
TKGGFQEHAAKNGLAVIFPDTSPRGAGVSDDEAYDLGQGAGFYVNATRDPWKTNYRMYDY
CCCCHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHH
IVSELRSIIVDNLPVQDKHGITGHSMGGHGAITIAIRNAGLFDSLSAFAPIANPTQSDWG
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHCCCCCCCCCHHH
RKQLSAYLGDDESNWADHDATLLLEEHGWKGDLLVDQGAADQFLDLLKPEALADMMARRR
HHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEEECCCHHHHHHHHCHHHHHHHHHHCC
QPGQLRMQSGYDHSYFFVNSFARDHVSWHAERLH
CCCCEEECCCCCCEEEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MELISENRSFGGSQQVFKHPSNTCGCEMTFAAYLPPQAQDGPVPVLWYLSGLTCTHENAM
CCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEEECCCCCCCCCEEEEEEECCCEEECCCHH
TKGGFQEHAAKNGLAVIFPDTSPRGAGVSDDEAYDLGQGAGFYVNATRDPWKTNYRMYDY
CCCCHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHH
IVSELRSIIVDNLPVQDKHGITGHSMGGHGAITIAIRNAGLFDSLSAFAPIANPTQSDWG
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHCCCCCCCCCHHH
RKQLSAYLGDDESNWADHDATLLLEEHGWKGDLLVDQGAADQFLDLLKPEALADMMARRR
HHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEEECCCHHHHHHHHCHHHHHHHHHHCC
QPGQLRMQSGYDHSYFFVNSFARDHVSWHAERLH
CCCCEEECCCCCCEEEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]