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The map label for this gene is mdlA [H]

Identifier: 110678065

GI number: 110678065

Start: 669838

End: 670938

Strand: Direct

Name: mdlA [H]

Synonym: RD1_0690

Alternate gene names: 110678065

Gene position: 669838-670938 (Clockwise)

Preceding gene: 110678064

Following gene: 110678068

Centisome position: 16.21

GC content: 59.22

Gene sequence:

>1101_bases
ATGAGCCGGATCGCCACGGTTCAGGCCCGGCTTTTCAATGTGCCCTTGGATGAGGTGTTGGTGGATGCCAAACACGGCAG
TCACAGCCACTTTCACCTCATCACGGCGACCATAACGCTGGAAGACGGGCGTCAGGGCACGGGTTATACCTATAACGGCG
GGCGCGGCGGGCATGCGACGGCGGCGATGATCACGCATGATCTGGCGCCCTTTCTCATCGGCAAGTACGCGCAGGACGTC
GAAGCGCTGAACGATGCGATGCAATGGCATATGCATTACGTGGGGCGTGGCGGCATCGTCAGCTTTGCGATCTCGGCGGT
CGATATCGCCCTGTGGGATTTGCGCTGCAAGGCGCATGGCGCGCCCCTCTGGCAACTGGCGGGTGGCGTGGATAACAGTT
GCAAAGCCTATGGCGGCGGCATTGATCTTGCCTTTCCGCTGCCCAAACTGCTCACGCATGTGCAGGGCTATCTCGATGCG
GGCCTGAATGCGGTCAAAATCAAGGTCGGCCAGCCAGATATGGCAGACGATATTGCCCGTATCCGTGCCGTGCGTCGCCA
TATCGGTCCCGACGCCGATTTCATGATCGACGCGAATTATGCGTTGACGGTGGAGCAGGCGATCACCCTCGCCAATGCGG
TGAAGGACCAGAATATCCTATGGTTTGAAGAGCCGATCATCCCGGACAATTACCCCGGATATGCGCAGATCACCAAAGCG
ACGGGCATGGCCGTGGCGCAGGGCGAAAACCTGCACACGATCCACGAGTTTGAAATGGCCGTGGCGCAGTCAGATCTGGG
CTTCATCCAGCCCGATGCATCTAATTGCGGTGGTATCACGGGGTGGTTGCAGGTTGCGGCGCTGACCGAACAAAGCGGCA
TCGCACTATGTTCGCATGGCATGCAGGAATTGCACGTGAGCCTTGTTTCCGCTCAGGCGCACGCCGGCTGGATCGAAGTG
CACAGCTTTCCAATCGACCGATACACGATGCGTCCGCTGGTGATTGAGGACGCACGCGCGGTTGCGCCGGATGAATCCGG
GATCGGCGTGACGTTCGATTGGCAAAGGTTGCAGGCCTTTGAGGTCGTGCAACCAGCTTAA

Upstream 100 bases:

>100_bases
ACGCGCGCCGCGATGGGGGCTTTGACCGTCGACAACCTGTTGCAGCACCTCTCCGATGGTAGCACCGTATCCCCGGTGCC
GGAATGCGCGGATATGTGAC

Downstream 100 bases:

>100_bases
ATCCTGAGGAACCGTTGCGCGATCTTCGGCAGCAGGCGGTCGAATTCCAGCGGCGCATCCGCAACTGCAAGGCAGATGCA
ATCCTCGTGGATGTCCGCAA

Product: racemase, putative

Products: NA

Alternate protein names: MR [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MSRIATVQARLFNVPLDEVLVDAKHGSHSHFHLITATITLEDGRQGTGYTYNGGRGGHATAAMITHDLAPFLIGKYAQDV
EALNDAMQWHMHYVGRGGIVSFAISAVDIALWDLRCKAHGAPLWQLAGGVDNSCKAYGGGIDLAFPLPKLLTHVQGYLDA
GLNAVKIKVGQPDMADDIARIRAVRRHIGPDADFMIDANYALTVEQAITLANAVKDQNILWFEEPIIPDNYPGYAQITKA
TGMAVAQGENLHTIHEFEMAVAQSDLGFIQPDASNCGGITGWLQVAALTEQSGIALCSHGMQELHVSLVSAQAHAGWIEV
HSFPIDRYTMRPLVIEDARAVAPDESGIGVTFDWQRLQAFEVVQPA

Sequences:

>Translated_366_residues
MSRIATVQARLFNVPLDEVLVDAKHGSHSHFHLITATITLEDGRQGTGYTYNGGRGGHATAAMITHDLAPFLIGKYAQDV
EALNDAMQWHMHYVGRGGIVSFAISAVDIALWDLRCKAHGAPLWQLAGGVDNSCKAYGGGIDLAFPLPKLLTHVQGYLDA
GLNAVKIKVGQPDMADDIARIRAVRRHIGPDADFMIDANYALTVEQAITLANAVKDQNILWFEEPIIPDNYPGYAQITKA
TGMAVAQGENLHTIHEFEMAVAQSDLGFIQPDASNCGGITGWLQVAALTEQSGIALCSHGMQELHVSLVSAQAHAGWIEV
HSFPIDRYTMRPLVIEDARAVAPDESGIGVTFDWQRLQAFEVVQPA
>Mature_365_residues
SRIATVQARLFNVPLDEVLVDAKHGSHSHFHLITATITLEDGRQGTGYTYNGGRGGHATAAMITHDLAPFLIGKYAQDVE
ALNDAMQWHMHYVGRGGIVSFAISAVDIALWDLRCKAHGAPLWQLAGGVDNSCKAYGGGIDLAFPLPKLLTHVQGYLDAG
LNAVKIKVGQPDMADDIARIRAVRRHIGPDADFMIDANYALTVEQAITLANAVKDQNILWFEEPIIPDNYPGYAQITKAT
GMAVAQGENLHTIHEFEMAVAQSDLGFIQPDASNCGGITGWLQVAALTEQSGIALCSHGMQELHVSLVSAQAHAGWIEVH
SFPIDRYTMRPLVIEDARAVAPDESGIGVTFDWQRLQAFEVVQPA

Specific function: Unknown

COG id: COG4948

COG function: function code MR; L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544119, Length=319, Percent_Identity=26.6457680250784, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI186972148, Length=252, Percent_Identity=28.1746031746032, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI42544117, Length=316, Percent_Identity=25, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI226510960, Length=310, Percent_Identity=28.0645161290323, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1787864, Length=391, Percent_Identity=25.3196930946292, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI48994953, Length=278, Percent_Identity=27.6978417266187, Blast_Score=92, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018110
- InterPro:   IPR015654
- InterPro:   IPR013342
- InterPro:   IPR013341
- InterPro:   IPR001354 [H]

Pfam domain/function: PF01188 MR_MLE; PF02746 MR_MLE_N [H]

EC number: =5.1.2.2 [H]

Molecular weight: Translated: 39622; Mature: 39491

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIATVQARLFNVPLDEVLVDAKHGSHSHFHLITATITLEDGRQGTGYTYNGGRGGHAT
CCCHHEEEHHHCCCCHHHHEEECCCCCCCEEEEEEEEEEEECCCCCCCEEECCCCCCCHH
AAMITHDLAPFLIGKYAQDVEALNDAMQWHMHYVGRGGIVSFAISAVDIALWDLRCKAHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEEEEEECCC
APLWQLAGGVDNSCKAYGGGIDLAFPLPKLLTHVQGYLDAGLNAVKIKVGQPDMADDIAR
CCHHHHCCCCCCCCHHCCCCEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHH
IRAVRRHIGPDADFMIDANYALTVEQAITLANAVKDQNILWFEEPIIPDNYPGYAQITKA
HHHHHHHCCCCCCEEEECCEEEEHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEHH
TGMAVAQGENLHTIHEFEMAVAQSDLGFIQPDASNCGGITGWLQVAALTEQSGIALCSHG
CCEEEECCCCCCHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHEEECCCCCCHHHHHCC
MQELHVSLVSAQAHAGWIEVHSFPIDRYTMRPLVIEDARAVAPDESGIGVTFDWQRLQAF
HHHHHHHHHHHHCCCCEEEEEECCCCCEEECCEEEECCCCCCCCCCCCEEEEEHHHHHHH
EVVQPA
HHCCCC
>Mature Secondary Structure 
SRIATVQARLFNVPLDEVLVDAKHGSHSHFHLITATITLEDGRQGTGYTYNGGRGGHAT
CCHHEEEHHHCCCCHHHHEEECCCCCCCEEEEEEEEEEEECCCCCCCEEECCCCCCCHH
AAMITHDLAPFLIGKYAQDVEALNDAMQWHMHYVGRGGIVSFAISAVDIALWDLRCKAHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEEEEEECCC
APLWQLAGGVDNSCKAYGGGIDLAFPLPKLLTHVQGYLDAGLNAVKIKVGQPDMADDIAR
CCHHHHCCCCCCCCHHCCCCEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHH
IRAVRRHIGPDADFMIDANYALTVEQAITLANAVKDQNILWFEEPIIPDNYPGYAQITKA
HHHHHHHCCCCCCEEEECCEEEEHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEHH
TGMAVAQGENLHTIHEFEMAVAQSDLGFIQPDASNCGGITGWLQVAALTEQSGIALCSHG
CCEEEECCCCCCHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHEEECCCCCCHHHHHCC
MQELHVSLVSAQAHAGWIEVHSFPIDRYTMRPLVIEDARAVAPDESGIGVTFDWQRLQAF
HHHHHHHHHHHHCCCCEEEEEECCCCCEEECCEEEECCCCCCCCCCCCEEEEEHHHHHHH
EVVQPA
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2831968; 2271624; 2215699; 1909893; 1892834; 7893689; 7893690 [H]