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The map label for this gene is gyaR [H]

Identifier: 110678064

GI number: 110678064

Start: 668907

End: 669836

Strand: Direct

Name: gyaR [H]

Synonym: RD1_0689

Alternate gene names: 110678064

Gene position: 668907-669836 (Clockwise)

Preceding gene: 110678063

Following gene: 110678065

Centisome position: 16.18

GC content: 60.11

Gene sequence:

>930_bases
ATGCCGGACCTGTTGCAAATCGGCGGTGTCACCGATGTCATGCGCGAAAGGCTGGAGGCGGCGTTTACCATCCACAAGCT
GGCCGACGGCGCCTACCCGGCGGAGGCGATCACGCATATTGCCACCAATGGGCATGACGGTGTGCCCGCCGATGTGATGA
GCGCGTTGCCCAACCTCAAGATGATCAGCTGCTATGGCGTTGGCTATGACGCGGTGGACGTCACGGTAGCAAAGGCGCGT
GGCATCGTCGTGACGCATACGCCGAATGTGTTGAACGGTGAAGTTGCCACCACGGCGGTGATGCTGATGATGGCCTGTTA
TCGTGAACTGTTGCGCGATGATGCCTGGGTCCGTTCCGGCGATTGGGAGGCGAAAGGCAATGCGCCGCTGACCCGTTCGG
TGGACAATCAGACGGTTGGAATTCTGGGCCTTGGACGCATTGGCCAGGCGATTGCTGACAAGCTCGCGCCCTTTGGCACG
ACGATCGTGTATCATTCCCGCACGCAGAAAGACGTGGCCTATCAATACTACGCTGATCTGACGGAAATGGCGGCCAACGT
GGATTGTCTGATCTGCATCACACCGGGTGGGCCAGCGACCAACAAGATCGTCAACAAAGACGTTCTGGACGCCTTGGGGC
CCAAGGGAACGCTGATCAATGTGAGCCGCGGGTCGGTCGTGGATGAGGCCGCGATGATTGCAGCCTTGCAGGAAAAACGC
CTTGGTTGGGCTGGGCTGGACGTCTTTGAGGCGGAACCCAAGGTGCCGCAGGCCCTGCGCGATCTGCCCAATGTCGTTCT
GTTACCCCATGTCGGCAGCGCTACGGTTGAAACGCGCGCCGCGATGGGGGCTTTGACCGTCGACAACCTGTTGCAGCACC
TCTCCGATGGTAGCACCGTATCCCCGGTGCCGGAATGCGCGGATATGTGA

Upstream 100 bases:

>100_bases
GATAAAGCCCGAACCCGTCTATCTGAAAAAAGGCGATGTGATGGAGTTGTGGATCGAAGGGTTGGGGACGCAGCGGCAGA
CCGTGACGGAGGACGCATAG

Downstream 100 bases:

>100_bases
CATGAGCCGGATCGCCACGGTTCAGGCCCGGCTTTTCAATGTGCCCTTGGATGAGGTGTTGGTGGATGCCAAACACGGCA
GTCACAGCCACTTTCACCTC

Product: putative D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MPDLLQIGGVTDVMRERLEAAFTIHKLADGAYPAEAITHIATNGHDGVPADVMSALPNLKMISCYGVGYDAVDVTVAKAR
GIVVTHTPNVLNGEVATTAVMLMMACYRELLRDDAWVRSGDWEAKGNAPLTRSVDNQTVGILGLGRIGQAIADKLAPFGT
TIVYHSRTQKDVAYQYYADLTEMAANVDCLICITPGGPATNKIVNKDVLDALGPKGTLINVSRGSVVDEAAMIAALQEKR
LGWAGLDVFEAEPKVPQALRDLPNVVLLPHVGSATVETRAAMGALTVDNLLQHLSDGSTVSPVPECADM

Sequences:

>Translated_309_residues
MPDLLQIGGVTDVMRERLEAAFTIHKLADGAYPAEAITHIATNGHDGVPADVMSALPNLKMISCYGVGYDAVDVTVAKAR
GIVVTHTPNVLNGEVATTAVMLMMACYRELLRDDAWVRSGDWEAKGNAPLTRSVDNQTVGILGLGRIGQAIADKLAPFGT
TIVYHSRTQKDVAYQYYADLTEMAANVDCLICITPGGPATNKIVNKDVLDALGPKGTLINVSRGSVVDEAAMIAALQEKR
LGWAGLDVFEAEPKVPQALRDLPNVVLLPHVGSATVETRAAMGALTVDNLLQHLSDGSTVSPVPECADM
>Mature_308_residues
PDLLQIGGVTDVMRERLEAAFTIHKLADGAYPAEAITHIATNGHDGVPADVMSALPNLKMISCYGVGYDAVDVTVAKARG
IVVTHTPNVLNGEVATTAVMLMMACYRELLRDDAWVRSGDWEAKGNAPLTRSVDNQTVGILGLGRIGQAIADKLAPFGTT
IVYHSRTQKDVAYQYYADLTEMAANVDCLICITPGGPATNKIVNKDVLDALGPKGTLINVSRGSVVDEAAMIAALQEKRL
GWAGLDVFEAEPKVPQALRDLPNVVLLPHVGSATVETRAAMGALTVDNLLQHLSDGSTVSPVPECADM

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=244, Percent_Identity=38.5245901639344, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI23308577, Length=285, Percent_Identity=31.9298245614035, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI145580578, Length=246, Percent_Identity=28.0487804878049, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4557499, Length=246, Percent_Identity=28.0487804878049, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI61743967, Length=244, Percent_Identity=27.4590163934426, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4557497, Length=244, Percent_Identity=27.4590163934426, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI145580575, Length=240, Percent_Identity=28.3333333333333, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI87082289, Length=311, Percent_Identity=35.6913183279743, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1789279, Length=324, Percent_Identity=27.4691358024691, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787645, Length=259, Percent_Identity=25.8687258687259, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87081824, Length=171, Percent_Identity=32.1637426900585, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=240, Percent_Identity=27.9166666666667, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI25147481, Length=225, Percent_Identity=27.5555555555556, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324055, Length=262, Percent_Identity=33.969465648855, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6320925, Length=280, Percent_Identity=26.7857142857143, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322116, Length=272, Percent_Identity=26.4705882352941, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6325144, Length=172, Percent_Identity=33.1395348837209, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321253, Length=166, Percent_Identity=30.1204819277108, Blast_Score=75, Evalue=9e-15,
Organism=Drosophila melanogaster, GI28571528, Length=268, Percent_Identity=37.6865671641791, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI45551003, Length=268, Percent_Identity=35.0746268656716, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI28574284, Length=268, Percent_Identity=35.0746268656716, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24585514, Length=268, Percent_Identity=35.0746268656716, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28574282, Length=268, Percent_Identity=35.0746268656716, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI45552429, Length=268, Percent_Identity=35.0746268656716, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28574286, Length=269, Percent_Identity=33.0855018587361, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24585516, Length=251, Percent_Identity=29.0836653386454, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI62472511, Length=224, Percent_Identity=29.4642857142857, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24646446, Length=230, Percent_Identity=28.695652173913, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24646448, Length=230, Percent_Identity=28.695652173913, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24646452, Length=230, Percent_Identity=28.695652173913, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24646450, Length=230, Percent_Identity=28.695652173913, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19921140, Length=240, Percent_Identity=27.9166666666667, Blast_Score=90, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 32758; Mature: 32627

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDLLQIGGVTDVMRERLEAAFTIHKLADGAYPAEAITHIATNGHDGVPADVMSALPNLK
CCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHCCCCE
MISCYGVGYDAVDVTVAKARGIVVTHTPNVLNGEVATTAVMLMMACYRELLRDDAWVRSG
EEEEECCCCCHHEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECC
DWEAKGNAPLTRSVDNQTVGILGLGRIGQAIADKLAPFGTTIVYHSRTQKDVAYQYYADL
CCCCCCCCCCEECCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
TEMAANVDCLICITPGGPATNKIVNKDVLDALGPKGTLINVSRGSVVDEAAMIAALQEKR
HHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHC
LGWAGLDVFEAEPKVPQALRDLPNVVLLPHVGSATVETRAAMGALTVDNLLQHLSDGSTV
CCCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
SPVPECADM
CCCCHHCCC
>Mature Secondary Structure 
PDLLQIGGVTDVMRERLEAAFTIHKLADGAYPAEAITHIATNGHDGVPADVMSALPNLK
CCCHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHHHCCCCE
MISCYGVGYDAVDVTVAKARGIVVTHTPNVLNGEVATTAVMLMMACYRELLRDDAWVRSG
EEEEECCCCCHHEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECC
DWEAKGNAPLTRSVDNQTVGILGLGRIGQAIADKLAPFGTTIVYHSRTQKDVAYQYYADL
CCCCCCCCCCEECCCCCEEEEEEHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHH
TEMAANVDCLICITPGGPATNKIVNKDVLDALGPKGTLINVSRGSVVDEAAMIAALQEKR
HHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHC
LGWAGLDVFEAEPKVPQALRDLPNVVLLPHVGSATVETRAAMGALTVDNLLQHLSDGSTV
CCCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
SPVPECADM
CCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA