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The map label for this gene is lpxK

Identifier: 110677698

GI number: 110677698

Start: 286208

End: 287203

Strand: Direct

Name: lpxK

Synonym: RD1_0294

Alternate gene names: 110677698

Gene position: 286208-287203 (Clockwise)

Preceding gene: 110677697

Following gene: 110677701

Centisome position: 6.92

GC content: 60.74

Gene sequence:

>996_bases
ATGCGCGCGCCTGACTTCTGGTATACGCCCCCGCAGGCGCCCGCTTTGCTGGCCCGGCTCCTGCAACCGTTTGGCAAAAT
CTATGGCATGGCGACGGCCCGGCGGCTCGCGAAAGGCACCCCCGTGAAACTGGATGTGCCCGTGATATGCGTCGGCAACC
TGAACGCAGGCGGAACCGGGAAAACGCCGACGGTCATTGCCGTTCTGACGACGCTGATGGATATGTTAGAAACGCCCCAT
GTGGTGACCCGTGGCTATGGCGGTTCGCTCAAAGGCCCGGTTCGGGTTGATCCATCGAAACATACGGCCAAACAGGTCGG
GGATGAACCTTTGCTGCTCGCCGCCTTTGCCGAAGTCTGGGTTGCGCGTGATCGTGCCGCAGGCTGCGCCGCTGCCGCGC
AAGGCGGGGCCAGTGTAGTCGTGCTGGATGATGGGTTTCAAAACCCGTCCGTCCACAAGGATTTCAGCCTGATCGTCGTG
GATGCCGAAAAGGGGTTTGGCAACGGACGATGCCTGCCGGCCGGCCCCCTGCGCGAACCGGTGGATATAGGCCTGAAACG
CGCGGATGCCTTGCTGTCTGTCGGGGCGGCTGAGGCACAGGCTCGGTTTGATAGCAGCACCCTGCCCACCGATCTGCCGC
ATATCCGGGGCGCATTGACGCCGCTGCAAACGGGTATGGACTGGTCTGATATGCGTGCAATTGCTTTTGCGGGTATCGCG
CATCCGGAAAAGTTCTTTGCGACCCTGCGCGCCTTGGGTGCCAATGTGGTACACAGTGAGCCGCTGGATGATCACCAACC
GCTGAGCACGGCACTAATGAGCCGCCTCGAAGCAGATGCCAAAAGGCAGAACGCCCAACTGGTGACAACCGAAAAAGACG
CCGCGCGCCTGCCGAACAGTTTCCGCACCAAAGTGATAACACTGCCCGTTCGTCTCAGCTTTGACGGTCAGGAAAACGCG
CTGGCAGACTTGTTGCGACCCGTTGTTAAATCCTGA

Upstream 100 bases:

>100_bases
GCGCACGCAGGCTGGGATGTCGTCAGCGAAGGTGCAGATGTGACGGACCGCGTCATTGATTTGGTGCAGGCCGCACTGGA
CGGGGAATTGGAGACCGCAC

Downstream 100 bases:

>100_bases
TCGGGCCAGCGTCACCGCCAGCCCAAGCAAATTCGTGAGTACCTGAAATCGCCGCGCCCCGGATCATTCCGCCGCGGCGT
CGATCAGTTCGGCCATTTCG

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MRAPDFWYTPPQAPALLARLLQPFGKIYGMATARRLAKGTPVKLDVPVICVGNLNAGGTGKTPTVIAVLTTLMDMLETPH
VVTRGYGGSLKGPVRVDPSKHTAKQVGDEPLLLAAFAEVWVARDRAAGCAAAAQGGASVVVLDDGFQNPSVHKDFSLIVV
DAEKGFGNGRCLPAGPLREPVDIGLKRADALLSVGAAEAQARFDSSTLPTDLPHIRGALTPLQTGMDWSDMRAIAFAGIA
HPEKFFATLRALGANVVHSEPLDDHQPLSTALMSRLEADAKRQNAQLVTTEKDAARLPNSFRTKVITLPVRLSFDGQENA
LADLLRPVVKS

Sequences:

>Translated_331_residues
MRAPDFWYTPPQAPALLARLLQPFGKIYGMATARRLAKGTPVKLDVPVICVGNLNAGGTGKTPTVIAVLTTLMDMLETPH
VVTRGYGGSLKGPVRVDPSKHTAKQVGDEPLLLAAFAEVWVARDRAAGCAAAAQGGASVVVLDDGFQNPSVHKDFSLIVV
DAEKGFGNGRCLPAGPLREPVDIGLKRADALLSVGAAEAQARFDSSTLPTDLPHIRGALTPLQTGMDWSDMRAIAFAGIA
HPEKFFATLRALGANVVHSEPLDDHQPLSTALMSRLEADAKRQNAQLVTTEKDAARLPNSFRTKVITLPVRLSFDGQENA
LADLLRPVVKS
>Mature_331_residues
MRAPDFWYTPPQAPALLARLLQPFGKIYGMATARRLAKGTPVKLDVPVICVGNLNAGGTGKTPTVIAVLTTLMDMLETPH
VVTRGYGGSLKGPVRVDPSKHTAKQVGDEPLLLAAFAEVWVARDRAAGCAAAAQGGASVVVLDDGFQNPSVHKDFSLIVV
DAEKGFGNGRCLPAGPLREPVDIGLKRADALLSVGAAEAQARFDSSTLPTDLPHIRGALTPLQTGMDWSDMRAIAFAGIA
HPEKFFATLRALGANVVHSEPLDDHQPLSTALMSRLEADAKRQNAQLVTTEKDAARLPNSFRTKVITLPVRLSFDGQENA
LADLLRPVVKS

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=314, Percent_Identity=34.7133757961783, Blast_Score=142, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_ROSDO (Q16DC4)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_680705.1
- STRING:   Q16DC4
- GeneID:   4198434
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_0294
- NMPDR:   fig|375451.6.peg.278
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   DEPVLIH
- PhylomeDB:   Q16DC4
- ProtClustDB:   PRK00652
- BioCyc:   RDEN375451:RD1_0294-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 35188; Mature: 35188

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAPDFWYTPPQAPALLARLLQPFGKIYGMATARRLAKGTPVKLDVPVICVGNLNAGGTG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEEEECCCCCCCC
KTPTVIAVLTTLMDMLETPHVVTRGYGGSLKGPVRVDPSKHTAKQVGDEPLLLAAFAEVW
CCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEECCCHHHHHHCCCCCHHHHHHHHHH
VARDRAAGCAAAAQGGASVVVLDDGFQNPSVHKDFSLIVVDAEKGFGNGRCLPAGPLREP
HHHHHCCCHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCH
VDIGLKRADALLSVGAAEAQARFDSSTLPTDLPHIRGALTPLQTGMDWSDMRAIAFAGIA
HHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCC
HPEKFFATLRALGANVVHSEPLDDHQPLSTALMSRLEADAKRQNAQLVTTEKDAARLPNS
CHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHCCCC
FRTKVITLPVRLSFDGQENALADLLRPVVKS
CCCEEEEEEEEEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MRAPDFWYTPPQAPALLARLLQPFGKIYGMATARRLAKGTPVKLDVPVICVGNLNAGGTG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEEEECCCCCCCC
KTPTVIAVLTTLMDMLETPHVVTRGYGGSLKGPVRVDPSKHTAKQVGDEPLLLAAFAEVW
CCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEECCCHHHHHHCCCCCHHHHHHHHHH
VARDRAAGCAAAAQGGASVVVLDDGFQNPSVHKDFSLIVVDAEKGFGNGRCLPAGPLREP
HHHHHCCCHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCH
VDIGLKRADALLSVGAAEAQARFDSSTLPTDLPHIRGALTPLQTGMDWSDMRAIAFAGIA
HHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCC
HPEKFFATLRALGANVVHSEPLDDHQPLSTALMSRLEADAKRQNAQLVTTEKDAARLPNS
CHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHCCCC
FRTKVITLPVRLSFDGQENALADLLRPVVKS
CCCEEEEEEEEEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA