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The map label for this gene is gyrB [H]

Identifier: 110677620

GI number: 110677620

Start: 209436

End: 211850

Strand: Direct

Name: gyrB [H]

Synonym: RD1_0212

Alternate gene names: 110677620

Gene position: 209436-211850 (Clockwise)

Preceding gene: 110677619

Following gene: 110677623

Centisome position: 5.07

GC content: 58.55

Gene sequence:

>2415_bases
ATGTCCGAAAACGATCAGACTCCCGAAGAATATGGCGCGAATTCCATCAAAGTTCTCAAGGGGTTAGAGGCTGTCCGAAA
ACGCCCCGGTATGTATATTGGCGATACGGATGATGGCTCCGGTCTGCACCATATGGTGTATGAGGTTGTCGACAACGGCA
TCGACGAGGCACTGGCGGGCCATGCGGATGCGGTGACGGTCAAAATCCACGCCGACAGTTCGGTGTCAGTGTCCGACAAC
GGGCGCGGCATTCCTGTGGGCATCCACGAAGAAGAGGGCGTGTCCGCCGCCGAAGTCATCATGACACAGCTGCATGCGGG
TGGTAAGTTTGACAGCAATTCCTACAAGGTGTCGGGCGGTTTGCACGGCGTCGGCGTTTCGGTTGTGAACGCGCTGTCGG
ACTGGCTGGAACTGCGCATCTGGCGCGAGGGTAAAGAGCACGTCGCCCGCTTTGAAGGCGGGTTTACGACCAGGCACCTC
GAAGTGGTCGGCGATACCGACCGCACGGGCACCGAGGTCCGCTTCATGGCCTCGACCGAGACGTTTTCCAACCTCGACTA
TTCGTTCGAGACGCTGGAAAAGCGCCTGCGCGAACTGGCCTTTCTGAATTCCGGTGTGCGCATCATTCTGATCGACGAGC
GCCCTGCCGAAGAACTGCGGTCCGATTTGTTCTACGAGGGGGGCGTCAAGGAATTCGTCAAATACCTCGATCGTTCGAAA
TCCTCGGTTATGCCCGAGCCGATTTTCATCACCGGGGAAAAAGACGACATCGGCGTCGAAGTCGCCATGTGGTGGAACGA
CAGCTATCACGAAAACGTCCTGCCGTTTACGAACAACATTCCGCAACGCGACGGCGGCACCCATATGGCGGGCTTTCGCG
GGGCGCTGACGCGCACGATCAACAATTATGCGCAGTCCTCCGGTATCGCACGCAAGGAAAAGGTCAGCTTTACCGGCGAT
GATGCACGCGAGGGGTTGACCTGCGTGCTGTCGGTCAAGGTGCCTGATCCGAAGTTCTCGTCGCAGACCAAGGACAAGCT
GGTATCCTCCGAAGTGCGCCCCGCTGTCGAAGGGTTGGTCAACGAAAAGCTGGCCGAATGGTTCGAAGAAAATCCGGCCG
AGGCCAAGATCGTCGTGGGCAAGATCATCGAAGCGGCGCACGCGCGTGAAGCGGCCCGCAAGGCACGCGACCTCACGCGT
CGCAAGACGGCGATGGATGTGAATTTTCTGGCCGGAAAGCTCAAGGATTGTTCCGAAAAGGACCCTTCCAAAACCGAAGT
CTTCCTTGTCGAGGGGGATTCAGCGGGCGGTTCTGCGCAGACTGGCCGCGACCGCCAGACACAGGCGATCCTGCCGCTGA
AGGGTAAGATCCTGAACGTGGAACGTGCGCGCTTTGACCGGATGCTGGGCAGTCAGGAGATTGGCAACCTCGTTATGGCG
CTCGGGACAGGGATCGGTCGCGACGAATTCAACATCGACAAATTGCGCTACCACAAGATCGTCATCATGACGGATGCGGA
CGTGGATGGCGCGCATATCCGGACGTTGTTGCTGACCTTCTTTTACCGGCAGATGCCGCAATTGATCGAACAGGGGCACC
TCTATATTGCGCAGCCGCCGCTTTACAAAGTCAGCCGTGGCAAGTCCGAGGTCTACCTCAAGGATGAGGCCGCGATGGAG
GAATACCTGATCCAACAGGGGATTGATGGCGCGATGCTACGTCAGGGCAACAACGAAGAAATCTCCGGTGCAGACCTCGC
CCGCGTGGTTGAACTGGCCCGCCAGATGCGCCGTGTGCTTGACGCTTTCCCGACACATTACCCGCGCCACATTTTGGAAC
AGGCCGCGATTGCGGGTGCCTTTACACCCGGTGCCGTGGATGCAGACCTGCAGGGCGTGGCGGACAAGGTCGCGGCACGG
CTGAACCTCATTGCGCTTGAATACGAACGGGGCTGGCAAGGGCGCATCACGCAGGATCACGGCATCCGTCTGGCGCGTAT
CCTGCGCGGAGTTGAAGAAGTGCGCACACTGGACGGGCGCATCCTGCGCGGCGGTGAAGCCAGCCGCAGTGGTTCCTTCA
CAGAGCACCTGCAGGAGGTCTACAACCTGCCCGCGACATTGGTGCGCAAGGATCGGACACAATTGATCCATGGTCCGATG
GACCTGTTGAATGCCATTCTGCAAGAAGGCGAAAAAGGGCTATCCCTGCAACGCTACAAGGGTTTGGGTGAAATGAACCC
GGACCAGCTGTGGGAAACCACGTTGGACCCGGATGCGCGCACACTGTTGCAGGTCAAGGTCGACGATATGGCCGAGGCGG
ACGATCTCTTTACCAAACTCATGGGCGATGTTGTGGAGCCGCGCCGCGAGTTCATTCAGCAAAACGCACTAAGCGTTGAG
AACCTCGATTTCTGA

Upstream 100 bases:

>100_bases
TGTGTTGATCCCTGTATTATAACACAAAATATTGTGTCGGCGGCGTGACAACCGGAGAGAAAAACCGTATAACTCGGTCA
AAATACGAAGGTATGACGAC

Downstream 100 bases:

>100_bases
CCAGCTGTAGGCTTGGTTTTCAACAGCTGCGGCCAGAGGAGAAACCATACTTCACTGTTCCCTCTGGCCGACACTGTTTG
TGCCGGGTGTTCAGGTCAGG

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 804; Mature: 803

Protein sequence:

>804_residues
MSENDQTPEEYGANSIKVLKGLEAVRKRPGMYIGDTDDGSGLHHMVYEVVDNGIDEALAGHADAVTVKIHADSSVSVSDN
GRGIPVGIHEEEGVSAAEVIMTQLHAGGKFDSNSYKVSGGLHGVGVSVVNALSDWLELRIWREGKEHVARFEGGFTTRHL
EVVGDTDRTGTEVRFMASTETFSNLDYSFETLEKRLRELAFLNSGVRIILIDERPAEELRSDLFYEGGVKEFVKYLDRSK
SSVMPEPIFITGEKDDIGVEVAMWWNDSYHENVLPFTNNIPQRDGGTHMAGFRGALTRTINNYAQSSGIARKEKVSFTGD
DAREGLTCVLSVKVPDPKFSSQTKDKLVSSEVRPAVEGLVNEKLAEWFEENPAEAKIVVGKIIEAAHAREAARKARDLTR
RKTAMDVNFLAGKLKDCSEKDPSKTEVFLVEGDSAGGSAQTGRDRQTQAILPLKGKILNVERARFDRMLGSQEIGNLVMA
LGTGIGRDEFNIDKLRYHKIVIMTDADVDGAHIRTLLLTFFYRQMPQLIEQGHLYIAQPPLYKVSRGKSEVYLKDEAAME
EYLIQQGIDGAMLRQGNNEEISGADLARVVELARQMRRVLDAFPTHYPRHILEQAAIAGAFTPGAVDADLQGVADKVAAR
LNLIALEYERGWQGRITQDHGIRLARILRGVEEVRTLDGRILRGGEASRSGSFTEHLQEVYNLPATLVRKDRTQLIHGPM
DLLNAILQEGEKGLSLQRYKGLGEMNPDQLWETTLDPDARTLLQVKVDDMAEADDLFTKLMGDVVEPRREFIQQNALSVE
NLDF

Sequences:

>Translated_804_residues
MSENDQTPEEYGANSIKVLKGLEAVRKRPGMYIGDTDDGSGLHHMVYEVVDNGIDEALAGHADAVTVKIHADSSVSVSDN
GRGIPVGIHEEEGVSAAEVIMTQLHAGGKFDSNSYKVSGGLHGVGVSVVNALSDWLELRIWREGKEHVARFEGGFTTRHL
EVVGDTDRTGTEVRFMASTETFSNLDYSFETLEKRLRELAFLNSGVRIILIDERPAEELRSDLFYEGGVKEFVKYLDRSK
SSVMPEPIFITGEKDDIGVEVAMWWNDSYHENVLPFTNNIPQRDGGTHMAGFRGALTRTINNYAQSSGIARKEKVSFTGD
DAREGLTCVLSVKVPDPKFSSQTKDKLVSSEVRPAVEGLVNEKLAEWFEENPAEAKIVVGKIIEAAHAREAARKARDLTR
RKTAMDVNFLAGKLKDCSEKDPSKTEVFLVEGDSAGGSAQTGRDRQTQAILPLKGKILNVERARFDRMLGSQEIGNLVMA
LGTGIGRDEFNIDKLRYHKIVIMTDADVDGAHIRTLLLTFFYRQMPQLIEQGHLYIAQPPLYKVSRGKSEVYLKDEAAME
EYLIQQGIDGAMLRQGNNEEISGADLARVVELARQMRRVLDAFPTHYPRHILEQAAIAGAFTPGAVDADLQGVADKVAAR
LNLIALEYERGWQGRITQDHGIRLARILRGVEEVRTLDGRILRGGEASRSGSFTEHLQEVYNLPATLVRKDRTQLIHGPM
DLLNAILQEGEKGLSLQRYKGLGEMNPDQLWETTLDPDARTLLQVKVDDMAEADDLFTKLMGDVVEPRREFIQQNALSVE
NLDF
>Mature_803_residues
SENDQTPEEYGANSIKVLKGLEAVRKRPGMYIGDTDDGSGLHHMVYEVVDNGIDEALAGHADAVTVKIHADSSVSVSDNG
RGIPVGIHEEEGVSAAEVIMTQLHAGGKFDSNSYKVSGGLHGVGVSVVNALSDWLELRIWREGKEHVARFEGGFTTRHLE
VVGDTDRTGTEVRFMASTETFSNLDYSFETLEKRLRELAFLNSGVRIILIDERPAEELRSDLFYEGGVKEFVKYLDRSKS
SVMPEPIFITGEKDDIGVEVAMWWNDSYHENVLPFTNNIPQRDGGTHMAGFRGALTRTINNYAQSSGIARKEKVSFTGDD
AREGLTCVLSVKVPDPKFSSQTKDKLVSSEVRPAVEGLVNEKLAEWFEENPAEAKIVVGKIIEAAHAREAARKARDLTRR
KTAMDVNFLAGKLKDCSEKDPSKTEVFLVEGDSAGGSAQTGRDRQTQAILPLKGKILNVERARFDRMLGSQEIGNLVMAL
GTGIGRDEFNIDKLRYHKIVIMTDADVDGAHIRTLLLTFFYRQMPQLIEQGHLYIAQPPLYKVSRGKSEVYLKDEAAMEE
YLIQQGIDGAMLRQGNNEEISGADLARVVELARQMRRVLDAFPTHYPRHILEQAAIAGAFTPGAVDADLQGVADKVAARL
NLIALEYERGWQGRITQDHGIRLARILRGVEEVRTLDGRILRGGEASRSGSFTEHLQEVYNLPATLVRKDRTQLIHGPMD
LLNAILQEGEKGLSLQRYKGLGEMNPDQLWETTLDPDARTLLQVKVDDMAEADDLFTKLMGDVVEPRREFIQQNALSVEN
LDF

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=588, Percent_Identity=24.6598639455782, Blast_Score=129, Evalue=9e-30,
Organism=Homo sapiens, GI19913408, Length=598, Percent_Identity=23.9130434782609, Blast_Score=125, Evalue=2e-28,
Organism=Escherichia coli, GI48994957, Length=806, Percent_Identity=58.0645161290323, Blast_Score=889, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=560, Percent_Identity=40.3571428571429, Blast_Score=385, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17535065, Length=585, Percent_Identity=24.4444444444444, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI212645845, Length=515, Percent_Identity=25.631067961165, Blast_Score=117, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI212645657, Length=144, Percent_Identity=31.9444444444444, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=592, Percent_Identity=25.6756756756757, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI17136538, Length=550, Percent_Identity=25.4545454545455, Blast_Score=130, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 89292; Mature: 89161

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENDQTPEEYGANSIKVLKGLEAVRKRPGMYIGDTDDGSGLHHMVYEVVDNGIDEALAG
CCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHCCHHHHHCC
HADAVTVKIHADSSVSVSDNGRGIPVGIHEEEGVSAAEVIMTQLHAGGKFDSNSYKVSGG
CCCEEEEEEECCCEEEECCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCC
LHGVGVSVVNALSDWLELRIWREGKEHVARFEGGFTTRHLEVVGDTDRTGTEVRFMASTE
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEECC
TFSNLDYSFETLEKRLRELAFLNSGVRIILIDERPAEELRSDLFYEGGVKEFVKYLDRSK
HHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHCCC
SSVMPEPIFITGEKDDIGVEVAMWWNDSYHENVLPFTNNIPQRDGGTHMAGFRGALTRTI
CCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
NNYAQSSGIARKEKVSFTGDDAREGLTCVLSVKVPDPKFSSQTKDKLVSSEVRPAVEGLV
HHHHHHCCCCCHHCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
NEKLAEWFEENPAEAKIVVGKIIEAAHAREAARKARDLTRRKTAMDVNFLAGKLKDCSEK
HHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DPSKTEVFLVEGDSAGGSAQTGRDRQTQAILPLKGKILNVERARFDRMLGSQEIGNLVMA
CCCCEEEEEEECCCCCCCCCCCCCCCCEEECCCCCCEECHHHHHHHHHHCHHHHHHHHHH
LGTGIGRDEFNIDKLRYHKIVIMTDADVDGAHIRTLLLTFFYRQMPQLIEQGHLYIAQPP
HHCCCCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
LYKVSRGKSEVYLKDEAAMEEYLIQQGIDGAMLRQGNNEEISGADLARVVELARQMRRVL
CCHHCCCCCEEEECHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
DAFPTHYPRHILEQAAIAGAFTPGAVDADLQGVADKVAARLNLIALEYERGWQGRITQDH
HHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEEEEEEECCCCCCCCCHHC
GIRLARILRGVEEVRTLDGRILRGGEASRSGSFTEHLQEVYNLPATLVRKDRTQLIHGPM
CHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCH
DLLNAILQEGEKGLSLQRYKGLGEMNPDQLWETTLDPDARTLLQVKVDDMAEADDLFTKL
HHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHH
MGDVVEPRREFIQQNALSVENLDF
HHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SENDQTPEEYGANSIKVLKGLEAVRKRPGMYIGDTDDGSGLHHMVYEVVDNGIDEALAG
CCCCCCHHHHCCCHHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHCCHHHHHCC
HADAVTVKIHADSSVSVSDNGRGIPVGIHEEEGVSAAEVIMTQLHAGGKFDSNSYKVSGG
CCCEEEEEEECCCEEEECCCCCCCEEECCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCC
LHGVGVSVVNALSDWLELRIWREGKEHVARFEGGFTTRHLEVVGDTDRTGTEVRFMASTE
CCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEECC
TFSNLDYSFETLEKRLRELAFLNSGVRIILIDERPAEELRSDLFYEGGVKEFVKYLDRSK
HHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHCCC
SSVMPEPIFITGEKDDIGVEVAMWWNDSYHENVLPFTNNIPQRDGGTHMAGFRGALTRTI
CCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
NNYAQSSGIARKEKVSFTGDDAREGLTCVLSVKVPDPKFSSQTKDKLVSSEVRPAVEGLV
HHHHHHCCCCCHHCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
NEKLAEWFEENPAEAKIVVGKIIEAAHAREAARKARDLTRRKTAMDVNFLAGKLKDCSEK
HHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DPSKTEVFLVEGDSAGGSAQTGRDRQTQAILPLKGKILNVERARFDRMLGSQEIGNLVMA
CCCCEEEEEEECCCCCCCCCCCCCCCCEEECCCCCCEECHHHHHHHHHHCHHHHHHHHHH
LGTGIGRDEFNIDKLRYHKIVIMTDADVDGAHIRTLLLTFFYRQMPQLIEQGHLYIAQPP
HHCCCCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
LYKVSRGKSEVYLKDEAAMEEYLIQQGIDGAMLRQGNNEEISGADLARVVELARQMRRVL
CCHHCCCCCEEEECHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
DAFPTHYPRHILEQAAIAGAFTPGAVDADLQGVADKVAARLNLIALEYERGWQGRITQDH
HHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEEEEEEECCCCCCCCCHHC
GIRLARILRGVEEVRTLDGRILRGGEASRSGSFTEHLQEVYNLPATLVRKDRTQLIHGPM
CHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCH
DLLNAILQEGEKGLSLQRYKGLGEMNPDQLWETTLDPDARTLLQVKVDDMAEADDLFTKL
HHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHH
MGDVVEPRREFIQQNALSVENLDF
HHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8226640 [H]