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The map label for this gene is flhA [H]

Identifier: 110677562

GI number: 110677562

Start: 149533

End: 151617

Strand: Direct

Name: flhA [H]

Synonym: RD1_0149

Alternate gene names: 110677562

Gene position: 149533-151617 (Clockwise)

Preceding gene: 110677561

Following gene: 110677563

Centisome position: 3.62

GC content: 55.73

Gene sequence:

>2085_bases
ATGGAAAACCTGACCGTCAAGGCCCTGTTCAACCCCACCATCCTGCTGGCGATCGCTCTGATGACGGTGATTGTCATGAT
GATCCTGCCTGTCCCGTCCTGGGTATTGGACGCCGGGCTTGCCGCATCATTCGCTTTGGCAATCCTGATTTTTACCGTGA
CCTTGTTCATCGAACGGCCTTTGGATTTTTCGGCCTTTCCGACGATTCTTCTCGCATCTTTGATGCTGCGGCTGTCCCTC
AACGTCTCATCAACCAAACTGATCATTGGACAGGGGCACACGGGCACTGATGCCGCCGGTGAAGTCATTGAGGGGTTCGC
GCAATTCGTGATGGGGGGCAGCGTGTTCCTTGGATTGGTGGTTTTCTCTGTTTTGCTGATCGTGAACTTCATGGTCATCA
CAAAAGGGGCCACGCGCATGGCGGAAGTCGGCGCACGCTTCGCATTGGACGGTATGCCCGGCAAACAACTCGCCATCGAC
AGCGATATGGCCGCGGGCGCCATTACGCACACGGAAGCCAAAGAGCGCAGAGAGCGCGAACAACAGGAAACGACGTTTTT
CGGCTCCCTTGACGGCGCGTCAAAGTTCGTGAAAGGCGACGCAATTGCGGGTCTTTTGATCACCTTGCTCAATCTGGTTG
CAGGACTGATCATGGGCATCGCCGTGCATGGAATGCCGCTTGGGCAGGCGTTCGAAACCTATGCAATCCTGACGGTCGGT
GACGGGCTGGTATCACAGATTCCCGCCGTCGTCATTTCCATTGCCTCGGCTCTTCTCTTGGCGCGCGGCGGCGCACAGGG
TGCAACAGACCTTGCGGTTTTCGCGCAGTTGGGACGGCATCCTTCTGCTCTGGCCACCGTTGGCGTTCTGATGGCTCTTT
TTGCCTTTTTCCCGGGGCTGCCGTTTGTGCCCTTCATCGTGGGGAGTCTGGCGCTCGGATTTGTGGCGTACCGTCTGCAT
GTAAAGCAAAAGGCGGAGCCGCAGGAAGTGCTGGCCTTGCAAGATGAAAGCGAGACACCGAAAGAGGCCGTCTTGGGCGA
CATTCTTGAAATTGATGACATCCACGTGGAGTTTTCCCAAGACCTGGTCAACATGGTGTTGGATCCCGGCACGGGTCTCG
ACGCACGCATTTCCAATATGAGAACACATGTGGCGACCGTTTACGGTTTGATCCTGCCCGAAATACGTCTGACCGATAAT
GCCGGACTGCCAGTTGGTACTTATGTTTTGAAAATACAAGGCGTTGAGCAGGCAAGAGCGCAACTGAACCCCGATCAGGT
ATTGGCGCTTGTCCCGGAAAACCCGGTAAATCTGCCAAGCGGCACAGATACGAACGAACCGGTCTATGGCGCACCGGCGC
GCTGGATCAACAGAAAGGATCAGGAAAGCGCTGCTCTGGACGGTCTGACGTTGGTAACGCCCGCGGAAATCCTCGCGACA
CATCTGCTGGAGACCGTCAAACGCAACTTCAGCCGCCTGCTGACACTGAAATCACTGAGGCGACTGCTTACAGAGATGAC
CAATATCTCGAACCCCGCGCGGGCGGAGGCAAATCGTAAACTTCTGGATGAAATGATACCGGACAAGGTGCCGATCGACG
TTTTGCATTCGGTATTGCGCCTGCTTCTGGACGAACAGGTCTCCATTCGCAATCTGCCACTGATCCTTGAAGCAACCGCG
GAAGCGCGCGGGCGAAACTCGCAGGTCGAAGCAATTTGCGAACATGTGCGTCAGCGCCTGGGCTTCCAACTGGTCGCTGA
AATGCGTCGAGAAGATGGGACGCTGCCACTGATCCAGCTCGCGCCGGAATGGGAAGATACGTTCACCATGTATCAGGTCG
AGGCAGATCGAGGTTTGGACATTGCCCTGCCACCAGACTTGTTCAACAAGCTCGCGGAAAATGTATCGGAAAAACTGCAG
ACGGCGAACCAGAACGGCATAAACGCAGCGCTCGTTACAAACACGAAGCGCCGCCGTTTCCTGAAGACAGTCATGCGCGC
CAAAGGCATCAACAATCCCGTTTTCTCATTTGAAGAAATCGGACTGGATGCGCGCCCCTCTTTGGTTGGAGTCGTCGCCC
AGTGA

Upstream 100 bases:

>100_bases
TGATTGGTCAACCCGCCGACTCAACGCGAGGCTCTTTGTTTCCGTTGGCGGCTTCATCCCGAGGCAACCTGCTCGTTTCC
TCCGGCAGAAAGAACTGAAG

Downstream 100 bases:

>100_bases
TCGCACTGCAGGAGTTCTTTCCATTCCTGAACTCGGCCATTTGGCATGGCTTTGTCGTGTTTTGTCGCGTGGCCGCTTTG
GCCGCTGTTTTACCCGCCTT

Product: flagellar biosynthesis protein FlhA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 694; Mature: 694

Protein sequence:

>694_residues
MENLTVKALFNPTILLAIALMTVIVMMILPVPSWVLDAGLAASFALAILIFTVTLFIERPLDFSAFPTILLASLMLRLSL
NVSSTKLIIGQGHTGTDAAGEVIEGFAQFVMGGSVFLGLVVFSVLLIVNFMVITKGATRMAEVGARFALDGMPGKQLAID
SDMAAGAITHTEAKERREREQQETTFFGSLDGASKFVKGDAIAGLLITLLNLVAGLIMGIAVHGMPLGQAFETYAILTVG
DGLVSQIPAVVISIASALLLARGGAQGATDLAVFAQLGRHPSALATVGVLMALFAFFPGLPFVPFIVGSLALGFVAYRLH
VKQKAEPQEVLALQDESETPKEAVLGDILEIDDIHVEFSQDLVNMVLDPGTGLDARISNMRTHVATVYGLILPEIRLTDN
AGLPVGTYVLKIQGVEQARAQLNPDQVLALVPENPVNLPSGTDTNEPVYGAPARWINRKDQESAALDGLTLVTPAEILAT
HLLETVKRNFSRLLTLKSLRRLLTEMTNISNPARAEANRKLLDEMIPDKVPIDVLHSVLRLLLDEQVSIRNLPLILEATA
EARGRNSQVEAICEHVRQRLGFQLVAEMRREDGTLPLIQLAPEWEDTFTMYQVEADRGLDIALPPDLFNKLAENVSEKLQ
TANQNGINAALVTNTKRRRFLKTVMRAKGINNPVFSFEEIGLDARPSLVGVVAQ

Sequences:

>Translated_694_residues
MENLTVKALFNPTILLAIALMTVIVMMILPVPSWVLDAGLAASFALAILIFTVTLFIERPLDFSAFPTILLASLMLRLSL
NVSSTKLIIGQGHTGTDAAGEVIEGFAQFVMGGSVFLGLVVFSVLLIVNFMVITKGATRMAEVGARFALDGMPGKQLAID
SDMAAGAITHTEAKERREREQQETTFFGSLDGASKFVKGDAIAGLLITLLNLVAGLIMGIAVHGMPLGQAFETYAILTVG
DGLVSQIPAVVISIASALLLARGGAQGATDLAVFAQLGRHPSALATVGVLMALFAFFPGLPFVPFIVGSLALGFVAYRLH
VKQKAEPQEVLALQDESETPKEAVLGDILEIDDIHVEFSQDLVNMVLDPGTGLDARISNMRTHVATVYGLILPEIRLTDN
AGLPVGTYVLKIQGVEQARAQLNPDQVLALVPENPVNLPSGTDTNEPVYGAPARWINRKDQESAALDGLTLVTPAEILAT
HLLETVKRNFSRLLTLKSLRRLLTEMTNISNPARAEANRKLLDEMIPDKVPIDVLHSVLRLLLDEQVSIRNLPLILEATA
EARGRNSQVEAICEHVRQRLGFQLVAEMRREDGTLPLIQLAPEWEDTFTMYQVEADRGLDIALPPDLFNKLAENVSEKLQ
TANQNGINAALVTNTKRRRFLKTVMRAKGINNPVFSFEEIGLDARPSLVGVVAQ
>Mature_694_residues
MENLTVKALFNPTILLAIALMTVIVMMILPVPSWVLDAGLAASFALAILIFTVTLFIERPLDFSAFPTILLASLMLRLSL
NVSSTKLIIGQGHTGTDAAGEVIEGFAQFVMGGSVFLGLVVFSVLLIVNFMVITKGATRMAEVGARFALDGMPGKQLAID
SDMAAGAITHTEAKERREREQQETTFFGSLDGASKFVKGDAIAGLLITLLNLVAGLIMGIAVHGMPLGQAFETYAILTVG
DGLVSQIPAVVISIASALLLARGGAQGATDLAVFAQLGRHPSALATVGVLMALFAFFPGLPFVPFIVGSLALGFVAYRLH
VKQKAEPQEVLALQDESETPKEAVLGDILEIDDIHVEFSQDLVNMVLDPGTGLDARISNMRTHVATVYGLILPEIRLTDN
AGLPVGTYVLKIQGVEQARAQLNPDQVLALVPENPVNLPSGTDTNEPVYGAPARWINRKDQESAALDGLTLVTPAEILAT
HLLETVKRNFSRLLTLKSLRRLLTEMTNISNPARAEANRKLLDEMIPDKVPIDVLHSVLRLLLDEQVSIRNLPLILEATA
EARGRNSQVEAICEHVRQRLGFQLVAEMRREDGTLPLIQLAPEWEDTFTMYQVEADRGLDIALPPDLFNKLAENVSEKLQ
TANQNGINAALVTNTKRRRFLKTVMRAKGINNPVFSFEEIGLDARPSLVGVVAQ

Specific function: Required for formation of the rod structure of the flagellar apparatus. May constitute the export apparatus of flagellin. The flagellum is required to cause a persistent disease in a murine model of infection [H]

COG id: COG1298

COG function: function code NU; Flagellar biosynthesis pathway, component FlhA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family [H]

Homologues:

Organism=Escherichia coli, GI1788187, Length=653, Percent_Identity=37.3660030627871, Blast_Score=377, Evalue=1e-105,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006301
- InterPro:   IPR001712 [H]

Pfam domain/function: PF00771 FHIPEP [H]

EC number: NA

Molecular weight: Translated: 75011; Mature: 75011

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENLTVKALFNPTILLAIALMTVIVMMILPVPSWVLDAGLAASFALAILIFTVTLFIERP
CCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LDFSAFPTILLASLMLRLSLNVSSTKLIIGQGHTGTDAAGEVIEGFAQFVMGGSVFLGLV
CCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VFSVLLIVNFMVITKGATRMAEVGARFALDGMPGKQLAIDSDMAAGAITHTEAKERRERE
HHHHHHHHHHHHHHCCHHHHHHHCCHHEECCCCCCCEEECCCCCCCCHHHHHHHHHHHHH
QQETTFFGSLDGASKFVKGDAIAGLLITLLNLVAGLIMGIAVHGMPLGQAFETYAILTVG
HHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEEC
DGLVSQIPAVVISIASALLLARGGAQGATDLAVFAQLGRHPSALATVGVLMALFAFFPGL
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
PFVPFIVGSLALGFVAYRLHVKQKAEPQEVLALQDESETPKEAVLGDILEIDDIHVEFSQ
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHH
DLVNMVLDPGTGLDARISNMRTHVATVYGLILPEIRLTDNAGLPVGTYVLKIQGVEQARA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEEEECHHHHHH
QLNPDQVLALVPENPVNLPSGTDTNEPVYGAPARWINRKDQESAALDGLTLVTPAEILAT
HCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCHHHHHCCEEECCHHHHHHH
HLLETVKRNFSRLLTLKSLRRLLTEMTNISNPARAEANRKLLDEMIPDKVPIDVLHSVLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LLLDEQVSIRNLPLILEATAEARGRNSQVEAICEHVRQRLGFQLVAEMRREDGTLPLIQL
HHHCCCCCCCCCCEEEEECHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
APEWEDTFTMYQVEADRGLDIALPPDLFNKLAENVSEKLQTANQNGINAALVTNTKRRRF
CCCCCCCEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHH
LKTVMRAKGINNPVFSFEEIGLDARPSLVGVVAQ
HHHHHHHCCCCCCCCCHHHCCCCCCCCCEEEECC
>Mature Secondary Structure
MENLTVKALFNPTILLAIALMTVIVMMILPVPSWVLDAGLAASFALAILIFTVTLFIERP
CCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LDFSAFPTILLASLMLRLSLNVSSTKLIIGQGHTGTDAAGEVIEGFAQFVMGGSVFLGLV
CCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VFSVLLIVNFMVITKGATRMAEVGARFALDGMPGKQLAIDSDMAAGAITHTEAKERRERE
HHHHHHHHHHHHHHCCHHHHHHHCCHHEECCCCCCCEEECCCCCCCCHHHHHHHHHHHHH
QQETTFFGSLDGASKFVKGDAIAGLLITLLNLVAGLIMGIAVHGMPLGQAFETYAILTVG
HHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEEC
DGLVSQIPAVVISIASALLLARGGAQGATDLAVFAQLGRHPSALATVGVLMALFAFFPGL
CHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
PFVPFIVGSLALGFVAYRLHVKQKAEPQEVLALQDESETPKEAVLGDILEIDDIHVEFSQ
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHH
DLVNMVLDPGTGLDARISNMRTHVATVYGLILPEIRLTDNAGLPVGTYVLKIQGVEQARA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEEEECHHHHHH
QLNPDQVLALVPENPVNLPSGTDTNEPVYGAPARWINRKDQESAALDGLTLVTPAEILAT
HCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCHHHHHCCEEECCHHHHHHH
HLLETVKRNFSRLLTLKSLRRLLTEMTNISNPARAEANRKLLDEMIPDKVPIDVLHSVLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LLLDEQVSIRNLPLILEATAEARGRNSQVEAICEHVRQRLGFQLVAEMRREDGTLPLIQL
HHHCCCCCCCCCCEEEEECHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
APEWEDTFTMYQVEADRGLDIALPPDLFNKLAENVSEKLQTANQNGINAALVTNTKRRRF
CCCCCCCEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHH
LKTVMRAKGINNPVFSFEEIGLDARPSLVGVVAQ
HHHHHHHCCCCCCCCCHHHCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]