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The map label for this gene is ribA [H]

Identifier: 110677461

GI number: 110677461

Start: 42577

End: 43665

Strand: Direct

Name: ribA [H]

Synonym: RD1_0043

Alternate gene names: 110677461

Gene position: 42577-43665 (Clockwise)

Preceding gene: 110677455

Following gene: 110677462

Centisome position: 1.03

GC content: 63.18

Gene sequence:

>1089_bases
ATGAGCTTCTCACCCGACCAAAATGAATTGATAGCCCGCGCGCGCGCGGACCTGCGGATGGGCGTACCCGTCGTGATTGA
CGGCGCGACGCCACTGCTTGCAGCCCCGGTGGAAACGCTCAATGCCGCGCGGCTGGGTGATGTGATGGCCCTGTCGCAAG
ATGCGGTTCTGGTCATTACCGCACGCCGCGCCGCGACGCTCAAGGCGGCCGCCTATGATGGCGATCTGGCCCGGGTGAAA
CTGTCCCCCGATGCGACACTGGCCTGGGTGAACGGGGTCGCGGACCCGGCGGGTGATCTGATGAACCCGATGAAAGGGCC
TCTGGCCTGCGCGCGCGGTGGGGACGCCGAAACGCACCGCTTTGCCATTCAACTGGCGAAAGCCGCGCGCTTGTTGCCAG
CGGTTGTCTGCGCCCCGGTGGACAATGCGCCGGCCTTTGCGCAGGCGCATAACCTCGTGTGTCTCGCGGCGCAAAGCGGA
CAGGCGATGCTGGATGCCTCAAGCCCCTTGCACGCGGTGATCAGCGCGCGCCTGCCGATGGAGGTATCAGAGGCCGGGCG
ATTGCATGTGTTCCGGCCCGAAGACGGCGGTGAAGAGCATTACGCCATTGAAATCGGCAGGCCGGATCGCGCCGCCCCGC
TGCTGACAAGGCTGCATTCCGCCTGTTTCACCGGGGATCTGATGGGATCGCTCAAATGCGACTGCGGTCCACAGTTGCGC
GCCGCCCTCGCGCAGATGGGAGCGGAGGGGAACGGCGTGCTTCTGTATATGAACCAGGAAGGGCGCGGCATTGGTCTGGC
CAATAAAATGCGGGCATATTCCTTGCAGGATCAAGGGTTTGACACGGTCGAAGCCAACCACCGGCTCGGGTTTGAGGATG
ACGAACGCGACTTTCGCCTCGGCGCCGCAATCCTGAAATCCATGGGGTTTTCCAAGGCGCGGCTGCTGACGAACAACCCG
CGCAAGGTCGCCATGATGTGCGAAAACGGCATCGACGTGACCGAACGTGTGCCGCTTCATGTGGGCGAGAACGCGCATAA
TCACGCCTATCTCGCGACGAAAGTCGCCAAATCGGGCCATCTGAAATGA

Upstream 100 bases:

>100_bases
GCAACCGCCTCACGGCCTCGTGTTACAAAGCCGTCCAAATGTTTCAATTCCGTCCGAATTACCCTAGATCGAGGCATGAA
ATGTCAGGCATTGTAACATC

Downstream 100 bases:

>100_bases
AGCCGGATGATATGGTTGTCACGCCTCGGGGCCTGCGGTTTCAGGGGCAGCTCTTTCCCTGCAGCATCGGGAAAACCGGC
ATCACCCGGCGCAAGAAAGA

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: GTP cyclohydrolase II [H]

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSFSPDQNELIARARADLRMGVPVVIDGATPLLAAPVETLNAARLGDVMALSQDAVLVITARRAATLKAAAYDGDLARVK
LSPDATLAWVNGVADPAGDLMNPMKGPLACARGGDAETHRFAIQLAKAARLLPAVVCAPVDNAPAFAQAHNLVCLAAQSG
QAMLDASSPLHAVISARLPMEVSEAGRLHVFRPEDGGEEHYAIEIGRPDRAAPLLTRLHSACFTGDLMGSLKCDCGPQLR
AALAQMGAEGNGVLLYMNQEGRGIGLANKMRAYSLQDQGFDTVEANHRLGFEDDERDFRLGAAILKSMGFSKARLLTNNP
RKVAMMCENGIDVTERVPLHVGENAHNHAYLATKVAKSGHLK

Sequences:

>Translated_362_residues
MSFSPDQNELIARARADLRMGVPVVIDGATPLLAAPVETLNAARLGDVMALSQDAVLVITARRAATLKAAAYDGDLARVK
LSPDATLAWVNGVADPAGDLMNPMKGPLACARGGDAETHRFAIQLAKAARLLPAVVCAPVDNAPAFAQAHNLVCLAAQSG
QAMLDASSPLHAVISARLPMEVSEAGRLHVFRPEDGGEEHYAIEIGRPDRAAPLLTRLHSACFTGDLMGSLKCDCGPQLR
AALAQMGAEGNGVLLYMNQEGRGIGLANKMRAYSLQDQGFDTVEANHRLGFEDDERDFRLGAAILKSMGFSKARLLTNNP
RKVAMMCENGIDVTERVPLHVGENAHNHAYLATKVAKSGHLK
>Mature_361_residues
SFSPDQNELIARARADLRMGVPVVIDGATPLLAAPVETLNAARLGDVMALSQDAVLVITARRAATLKAAAYDGDLARVKL
SPDATLAWVNGVADPAGDLMNPMKGPLACARGGDAETHRFAIQLAKAARLLPAVVCAPVDNAPAFAQAHNLVCLAAQSGQ
AMLDASSPLHAVISARLPMEVSEAGRLHVFRPEDGGEEHYAIEIGRPDRAAPLLTRLHSACFTGDLMGSLKCDCGPQLRA
ALAQMGAEGNGVLLYMNQEGRGIGLANKMRAYSLQDQGFDTVEANHRLGFEDDERDFRLGAAILKSMGFSKARLLTNNPR
KVAMMCENGIDVTERVPLHVGENAHNHAYLATKVAKSGHLK

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=165, Percent_Identity=58.1818181818182, Blast_Score=200, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6319438, Length=168, Percent_Identity=40.4761904761905, Blast_Score=120, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00925 GTP_cyclohydro2 [H]

EC number: =3.5.4.25 [H]

Molecular weight: Translated: 38423; Mature: 38291

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFSPDQNELIARARADLRMGVPVVIDGATPLLAAPVETLNAARLGDVMALSQDAVLVIT
CCCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHCCHHHHHHHHHCHHEEECCCEEEEEE
ARRAATLKAAAYDGDLARVKLSPDATLAWVNGVADPAGDLMNPMKGPLACARGGDAETHR
ECCCEEEEEEEECCCEEEEEECCCCEEEEECCCCCCHHHHHCCCCCCEEECCCCCCCHHH
FAIQLAKAARLLPAVVCAPVDNAPAFAQAHNLVCLAAQSGQAMLDASSPLHAVISARLPM
HHHHHHHHHHHHHHHEEECCCCCCCHHHHCCEEEEEECCCCEEEECCCCHHHHHHCCCCE
EVSEAGRLHVFRPEDGGEEHYAIEIGRPDRAAPLLTRLHSACFTGDLMGSLKCDCGPQLR
EECCCCCEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEECCCCHHHH
AALAQMGAEGNGVLLYMNQEGRGIGLANKMRAYSLQDQGFDTVEANHRLGFEDDERDFRL
HHHHHHCCCCCEEEEEECCCCCCCCCHHHHHEEECCCCCCCEEECCCCCCCCCCCHHHHH
GAAILKSMGFSKARLLTNNPRKVAMMCENGIDVTERVPLHVGENAHNHAYLATKVAKSGH
HHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCCCCEEECCCCCCCEEEEEECCCCCC
LK
CC
>Mature Secondary Structure 
SFSPDQNELIARARADLRMGVPVVIDGATPLLAAPVETLNAARLGDVMALSQDAVLVIT
CCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHCCHHHHHHHHHCHHEEECCCEEEEEE
ARRAATLKAAAYDGDLARVKLSPDATLAWVNGVADPAGDLMNPMKGPLACARGGDAETHR
ECCCEEEEEEEECCCEEEEEECCCCEEEEECCCCCCHHHHHCCCCCCEEECCCCCCCHHH
FAIQLAKAARLLPAVVCAPVDNAPAFAQAHNLVCLAAQSGQAMLDASSPLHAVISARLPM
HHHHHHHHHHHHHHHEEECCCCCCCHHHHCCEEEEEECCCCEEEECCCCHHHHHHCCCCE
EVSEAGRLHVFRPEDGGEEHYAIEIGRPDRAAPLLTRLHSACFTGDLMGSLKCDCGPQLR
EECCCCCEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEECCCCHHHH
AALAQMGAEGNGVLLYMNQEGRGIGLANKMRAYSLQDQGFDTVEANHRLGFEDDERDFRL
HHHHHHCCCCCEEEEEECCCCCCCCCHHHHHEEECCCCCCCEEECCCCCCCCCCCHHHHH
GAAILKSMGFSKARLLTNNPRKVAMMCENGIDVTERVPLHVGENAHNHAYLATKVAKSGH
HHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCCCCEEECCCCCCCEEEEEECCCCCC
LK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7883178 [H]