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The map label for this gene is ubiH [H]

Identifier: 110677455

GI number: 110677455

Start: 37491

End: 38753

Strand: Direct

Name: ubiH [H]

Synonym: RD1_0036

Alternate gene names: 110677455

Gene position: 37491-38753 (Clockwise)

Preceding gene: 110677450

Following gene: 110677461

Centisome position: 0.91

GC content: 61.52

Gene sequence:

>1263_bases
ATGGACAATCCCCCCGCCCCGGCCATATTCAGACACATGGCATTTGACAGCGACATTTTAATTGTAGGGGGCGGGCTGAA
CGGGCCGACGCTTGCCCTTGCTCTTGCACAGGCGGGGCACAGCGTGACGATGATTGACGCGGTGCCGCTGGGCAGTCGCA
AAAGCCCCGGCTTTGATGGCCGCTGCTATGCCATGGCGCTGACTTCCACCCGGCTGCTTGAGGCCGTTGGTATCTGGGAA
ACGCTCGAACCTGATGCGCAACCCATGCTCGACATCAAGGTTACCGATGGCCGCGCGGGAGAGGGACCATCGCCCTTTTT
CATGCATTTCGACCATGCCGAGATCGAAGAAGGCCCCATGGGCTATATGGTCGAAGACAGACACCTCAGGCCCGCCTTGC
TCAGCGCCTCGGACGCGCATGAAAACATCCAGACGCTGCACGGTGAAACGGTGGTTTCACAATCCGCAGAGGCAGGCAGC
GTATCGGTGACACTGGCAAGCGGGCGCGTCCTGACGGGCAGGTTGCTCGTGGGGTGCGACGGGCGCGGGTCCGGCACGGC
CATGCGCGCCGGGATCAAACGCACAGGCTGGGACTATGGCCAGACCGCACTGGTCTGCGCGGTTGAACACGCATTGCCCC
ATCACGGCGTCGCACATCAATTCTTTATGCCGCCGGGGCCGCTGGCGATCCTGCCCCTGACGGGCAACCGCTCCTCCATT
GTCTGGAGCGAAACCGCCGAAAACGCAGCACTGATCAACGAGATGCCGGACGAGGCCTATATCGACGTGCTCAAACCCAG
GTTCGGCAGTTTTCTGGGTGATATTACGCGCGTCGGTACGCGCTACACCTACCCTTTGTCGCTGTCGTTGGCGAATACGC
TGGTCGCGCCCCGGGTTGTTCTGGTCGGCGACGCAGCCCATGGCGTCCACCCGATTGCAGGTCAGGGACTGAACGCAGGC
GTTCGCGATATCGCCGCATTGGCCGAGGTCGTGACGGATGCAAAACGGCGCGGCGAAGACATCGGCGCCGAGGGCGTGCT
TTCGCGCTATCAGGAATGGCGACGGTTTGATAACACCACTCTGGCGCTGGCCACCGACACGTTCAACCGTCTGTTTTCAA
ATGATAACCCCGTGTTACGGGCGGTGCGCGACATTGGCATGGGGATTGTCGGAAACATGCCCGCCTTGCGTCGGAGTTTC
ATCCGCGAAGCCGCCGGTCTGACCGGAGACTTGCCCAAACTGCTGAAAGGTCAAAGGCTCTGA

Upstream 100 bases:

>100_bases
TGATCCCCCTGCCCAGATCCGCCGCTGTCAATTTAAGCCACGCCTGCATGCCATCCCCCATAAGCGTTCGATTTTGGCGA
CGGTAGCGACGCAACCGCGC

Downstream 100 bases:

>100_bases
AGCGTCATTCGAAAAACATCAATCACCTGACGCCGCATGAAATCAAAGATGCCAACGCGTCACCTGATACTTGATACATC
AGGTTTTTCGCCAGACGCTC

Product: 2-octaprenyl-6-methoxyphenol hydroxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MDNPPAPAIFRHMAFDSDILIVGGGLNGPTLALALAQAGHSVTMIDAVPLGSRKSPGFDGRCYAMALTSTRLLEAVGIWE
TLEPDAQPMLDIKVTDGRAGEGPSPFFMHFDHAEIEEGPMGYMVEDRHLRPALLSASDAHENIQTLHGETVVSQSAEAGS
VSVTLASGRVLTGRLLVGCDGRGSGTAMRAGIKRTGWDYGQTALVCAVEHALPHHGVAHQFFMPPGPLAILPLTGNRSSI
VWSETAENAALINEMPDEAYIDVLKPRFGSFLGDITRVGTRYTYPLSLSLANTLVAPRVVLVGDAAHGVHPIAGQGLNAG
VRDIAALAEVVTDAKRRGEDIGAEGVLSRYQEWRRFDNTTLALATDTFNRLFSNDNPVLRAVRDIGMGIVGNMPALRRSF
IREAAGLTGDLPKLLKGQRL

Sequences:

>Translated_420_residues
MDNPPAPAIFRHMAFDSDILIVGGGLNGPTLALALAQAGHSVTMIDAVPLGSRKSPGFDGRCYAMALTSTRLLEAVGIWE
TLEPDAQPMLDIKVTDGRAGEGPSPFFMHFDHAEIEEGPMGYMVEDRHLRPALLSASDAHENIQTLHGETVVSQSAEAGS
VSVTLASGRVLTGRLLVGCDGRGSGTAMRAGIKRTGWDYGQTALVCAVEHALPHHGVAHQFFMPPGPLAILPLTGNRSSI
VWSETAENAALINEMPDEAYIDVLKPRFGSFLGDITRVGTRYTYPLSLSLANTLVAPRVVLVGDAAHGVHPIAGQGLNAG
VRDIAALAEVVTDAKRRGEDIGAEGVLSRYQEWRRFDNTTLALATDTFNRLFSNDNPVLRAVRDIGMGIVGNMPALRRSF
IREAAGLTGDLPKLLKGQRL
>Mature_420_residues
MDNPPAPAIFRHMAFDSDILIVGGGLNGPTLALALAQAGHSVTMIDAVPLGSRKSPGFDGRCYAMALTSTRLLEAVGIWE
TLEPDAQPMLDIKVTDGRAGEGPSPFFMHFDHAEIEEGPMGYMVEDRHLRPALLSASDAHENIQTLHGETVVSQSAEAGS
VSVTLASGRVLTGRLLVGCDGRGSGTAMRAGIKRTGWDYGQTALVCAVEHALPHHGVAHQFFMPPGPLAILPLTGNRSSI
VWSETAENAALINEMPDEAYIDVLKPRFGSFLGDITRVGTRYTYPLSLSLANTLVAPRVVLVGDAAHGVHPIAGQGLNAG
VRDIAALAEVVTDAKRRGEDIGAEGVLSRYQEWRRFDNTTLALATDTFNRLFSNDNPVLRAVRDIGMGIVGNMPALRRSF
IREAAGLTGDLPKLLKGQRL

Specific function: Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=393, Percent_Identity=29.0076335877863, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI32967307, Length=348, Percent_Identity=30.4597701149425, Blast_Score=152, Evalue=7e-37,
Organism=Escherichia coli, GI1789274, Length=375, Percent_Identity=37.8666666666667, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1789273, Length=406, Percent_Identity=32.2660098522167, Blast_Score=187, Evalue=8e-49,
Organism=Escherichia coli, GI1786883, Length=395, Percent_Identity=32.4050632911392, Blast_Score=187, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI25146631, Length=424, Percent_Identity=26.8867924528302, Blast_Score=144, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6321694, Length=464, Percent_Identity=26.9396551724138, Blast_Score=119, Evalue=9e-28,
Organism=Drosophila melanogaster, GI19920760, Length=425, Percent_Identity=25.4117647058824, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971
- InterPro:   IPR011295 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.-

Molecular weight: Translated: 44839; Mature: 44839

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNPPAPAIFRHMAFDSDILIVGGGLNGPTLALALAQAGHSVTMIDAVPLGSRKSPGFDG
CCCCCCCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCC
RCYAMALTSTRLLEAVGIWETLEPDAQPMLDIKVTDGRAGEGPSPFFMHFDHAEIEEGPM
EEEEEEEHHHHHHHHHCCHHHCCCCCCCEEEEEEECCCCCCCCCCEEEECCCCCCCCCCC
GYMVEDRHLRPALLSASDAHENIQTLHGETVVSQSAEAGSVSVTLASGRVLTGRLLVGCD
CCEEECCCCCHHHHCCCCHHHHHHHHCCCHHHHCCCCCCEEEEEEECCEEEEEEEEEEEC
GRGSGTAMRAGIKRTGWDYGQTALVCAVEHALPHHGVAHQFFMPPGPLAILPLTGNRSSI
CCCCCHHHHCCCHHCCCCCCCHHHEEEHHHHCCCCCCCEEEECCCCCEEEEEECCCCCEE
VWSETAENAALINEMPDEAYIDVLKPRFGSFLGDITRVGTRYTYPLSLSLANTLVAPRVV
EEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHCCEEE
LVGDAAHGVHPIAGQGLNAGVRDIAALAEVVTDAKRRGEDIGAEGVLSRYQEWRRFDNTT
EEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCE
LALATDTFNRLFSNDNPVLRAVRDIGMGIVGNMPALRRSFIREAAGLTGDLPKLLKGQRL
EEEEEHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHCCCCC
>Mature Secondary Structure
MDNPPAPAIFRHMAFDSDILIVGGGLNGPTLALALAQAGHSVTMIDAVPLGSRKSPGFDG
CCCCCCCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCC
RCYAMALTSTRLLEAVGIWETLEPDAQPMLDIKVTDGRAGEGPSPFFMHFDHAEIEEGPM
EEEEEEEHHHHHHHHHCCHHHCCCCCCCEEEEEEECCCCCCCCCCEEEECCCCCCCCCCC
GYMVEDRHLRPALLSASDAHENIQTLHGETVVSQSAEAGSVSVTLASGRVLTGRLLVGCD
CCEEECCCCCHHHHCCCCHHHHHHHHCCCHHHHCCCCCCEEEEEEECCEEEEEEEEEEEC
GRGSGTAMRAGIKRTGWDYGQTALVCAVEHALPHHGVAHQFFMPPGPLAILPLTGNRSSI
CCCCCHHHHCCCHHCCCCCCCHHHEEEHHHHCCCCCCCEEEECCCCCEEEEEECCCCCEE
VWSETAENAALINEMPDEAYIDVLKPRFGSFLGDITRVGTRYTYPLSLSLANTLVAPRVV
EEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHCCEEE
LVGDAAHGVHPIAGQGLNAGVRDIAALAEVVTDAKRRGEDIGAEGVLSRYQEWRRFDNTT
EEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCE
LALATDTFNRLFSNDNPVLRAVRDIGMGIVGNMPALRRSFIREAAGLTGDLPKLLKGQRL
EEEEEHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]