Click here to switch to the map view.

The map label for this gene is gppA [H]

Identifier: 108810259

GI number: 108810259

Start: 127968

End: 128474

Strand: Reverse

Name: gppA [H]

Synonym: YPN_0093

Alternate gene names: 108810259

Gene position: 128474-127968 (Counterclockwise)

Preceding gene: 108810260

Following gene: 108810258

Centisome position: 2.83

GC content: 51.87

Gene sequence:

>507_bases
ATGATGCTAAGTTCCACCTCACTTTATGCTGCCATCGATCTTGGCTCCAATAGTTTTCATATGTTGGTAGTACGTGAGGT
GGCTGGCAGTATCCAAACGCTGGCACGTATTAAGCGGAAGGTCCGCCTGGCGGCTGGTCTGGATAACCAAAATCATCTAT
CGCAGGAAGCGATGGAACGAGGCTGGCAATGCCTAAAACTTTTCTCAGAGCGTTTACAGGATATTCCTCTGGATCAAATC
CGCGTGGTCGCAACGGCAACCTTGCGCCTGGCCTCTAATGCCGACGAATTCTTGCGTACTGCAACCGAGATCCTCGGCTG
CCCTATTCAAGTCATCAGTGGCGAAGAAGAAGCCCGTCTGATTTATCATGGCGTAGCGCATACGACTGGCGGGCCAGAAC
AGCGGTTGGTCGTCGATATTGGGGGGGCAGCACTGAGTTGGTTACAGGCAATGGGGCTCAGGCGAATATTTTGGTCAGCC
TATCAATGGGTTGTGTTACCTGGTTAG

Upstream 100 bases:

>100_bases
ACGCCTAGCCCGTACCCGCACCGGGAATGGCCCACGCCGTAATTCTGCCCCACGCCGCAGTGGAGCACCACGGAATAACC
GTAAGCGACCAGGCTGATAA

Downstream 100 bases:

>100_bases
AACGTTATTTTGGTGACCGCCATCTGGCAAAGGAAAATTTTGAACGCGCTGAATTGGCCGCTCATGAGATGATCAAGCCC
GTCGCCCAACGTTTTCGTGA

Product: hypothetical protein

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 168; Mature: 168

Protein sequence:

>168_residues
MMLSSTSLYAAIDLGSNSFHMLVVREVAGSIQTLARIKRKVRLAAGLDNQNHLSQEAMERGWQCLKLFSERLQDIPLDQI
RVVATATLRLASNADEFLRTATEILGCPIQVISGEEEARLIYHGVAHTTGGPEQRLVVDIGGAALSWLQAMGLRRIFWSA
YQWVVLPG

Sequences:

>Translated_168_residues
MMLSSTSLYAAIDLGSNSFHMLVVREVAGSIQTLARIKRKVRLAAGLDNQNHLSQEAMERGWQCLKLFSERLQDIPLDQI
RVVATATLRLASNADEFLRTATEILGCPIQVISGEEEARLIYHGVAHTTGGPEQRLVVDIGGAALSWLQAMGLRRIFWSA
YQWVVLPG
>Mature_168_residues
MMLSSTSLYAAIDLGSNSFHMLVVREVAGSIQTLARIKRKVRLAAGLDNQNHLSQEAMERGWQCLKLFSERLQDIPLDQI
RVVATATLRLASNADEFLRTATEILGCPIQVISGEEEARLIYHGVAHTTGGPEQRLVVDIGGAALSWLQAMGLRRIFWSA
YQWVVLPG

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=151, Percent_Identity=78.8079470198676, Blast_Score=239, Evalue=6e-65,
Organism=Escherichia coli, GI1788848, Length=136, Percent_Identity=51.4705882352941, Blast_Score=143, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 18574; Mature: 18574

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLSSTSLYAAIDLGSNSFHMLVVREVAGSIQTLARIKRKVRLAAGLDNQNHLSQEAMER
CCCCCCCEEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
GWQCLKLFSERLQDIPLDQIRVVATATLRLASNADEFLRTATEILGCPIQVISGEEEARL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEECCCCHHEE
IYHGVAHTTGGPEQRLVVDIGGAALSWLQAMGLRRIFWSAYQWVVLPG
EEECHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHEEEEECC
>Mature Secondary Structure
MMLSSTSLYAAIDLGSNSFHMLVVREVAGSIQTLARIKRKVRLAAGLDNQNHLSQEAMER
CCCCCCCEEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
GWQCLKLFSERLQDIPLDQIRVVATATLRLASNADEFLRTATEILGCPIQVISGEEEARL
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEECCCCHHEE
IYHGVAHTTGGPEQRLVVDIGGAALSWLQAMGLRRIFWSAYQWVVLPG
EEECHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA