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The map label for this gene is gppA [H]

Identifier: 108810258

GI number: 108810258

Start: 126979

End: 128037

Strand: Reverse

Name: gppA [H]

Synonym: YPN_0092

Alternate gene names: 108810258

Gene position: 128037-126979 (Counterclockwise)

Preceding gene: 108810259

Following gene: 108810256

Centisome position: 2.82

GC content: 49.76

Gene sequence:

>1059_bases
TTGGTTACAGGCAATGGGGCTCAGGCGAATATTTTGGTCAGCCTATCAATGGGTTGTGTTACCTGGTTAGAACGTTATTT
TGGTGACCGCCATCTGGCAAAGGAAAATTTTGAACGCGCTGAATTGGCCGCTCATGAGATGATCAAGCCCGTCGCCCAAC
GTTTTCGTGAACATGGCTGGCAAGTTTGTGTCGGCGCTTCAGGCACCGTTCAGGCACTACAAGAGATCATGGTCGCTCAA
GGTATGGACGAGCTGATCACCTTAGCCAAGCTGCAACAGCTCAAACAAAGAGCGATTCAGTGTGGCAAATTAGAAGAGTT
GGAAATCCCTGGTTTAACCTTGGAACGAGCGCTGGTCTTCCCCAGTGGTCTGTCCATCTTAATTGCGATATTCCAGGAGT
TGTCCATTGAAAGCATGACACTGGCAGGTGGCGCACTGCGCGAAGGGCTGGTCTATGGCATGCTCCATTTACCGGTCGAG
CAAGATATTCGCCGCCGGACACTACGTAATTTACAGCGCCGCTATTTACTGGATACCGAGCAAGCTAAGCGCGTCAGTTG
TTTGGCGGATAACTTTTTCCTACAAGTGGAAAAAGAGTGGCATCTCGATGGCCGATGTCGCGAATTTTTGCAAAACGCCT
GTTTGATCCATGAAATTGGCCTCAGTGTCGATTTTAAACATGCTCCGCAACATGCCGCTTATCTGATCCGTAATCTGGAT
CTACCCGGTTTTACTCCTGCACAAAAGCTGCTGCTTTCTGCTCTGTTACAAAACCAGAGTGACACTATCGATCTATCGCT
CTTGAACCAGCAGAATGCATTACCTGCCGACATGGCACAGCATTTGTGTCGTCTACTGCGCTTGGCCATTATTTTTTCCA
GCCGTCGCCGGGATGATACCCTGCCAGCAGTCAGGTTGCGGGCCGATAATAATGCGCTTTATGTGCTGGTCCCCCAAGGT
TGGTTGGAACAGCACCCCTACCGCGCCGAAGCGTTAGAACAAGAGAGTCACTGGCAAAGTTATGTTCAATGGCCACTGCT
ATTGGAAGAGCTTAGCTAA

Upstream 100 bases:

>100_bases
GTGGCGAAGAAGAAGCCCGTCTGATTTATCATGGCGTAGCGCATACGACTGGCGGGCCAGAACAGCGGTTGGTCGTCGAT
ATTGGGGGGGCAGCACTGAG

Downstream 100 bases:

>100_bases
GTGTGTTGGTGGGGATTACCCATAGCATTTCAGCGACGTTAAAAACGTCACGGTTGATGGTCAATCAGTCGCGCCTTAAT
GCATGGCTAACGGGCAATAG

Product: guanosine-5'-triphosphate,3'-diphosphate diphosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MVTGNGAQANILVSLSMGCVTWLERYFGDRHLAKENFERAELAAHEMIKPVAQRFREHGWQVCVGASGTVQALQEIMVAQ
GMDELITLAKLQQLKQRAIQCGKLEELEIPGLTLERALVFPSGLSILIAIFQELSIESMTLAGGALREGLVYGMLHLPVE
QDIRRRTLRNLQRRYLLDTEQAKRVSCLADNFFLQVEKEWHLDGRCREFLQNACLIHEIGLSVDFKHAPQHAAYLIRNLD
LPGFTPAQKLLLSALLQNQSDTIDLSLLNQQNALPADMAQHLCRLLRLAIIFSSRRRDDTLPAVRLRADNNALYVLVPQG
WLEQHPYRAEALEQESHWQSYVQWPLLLEELS

Sequences:

>Translated_352_residues
MVTGNGAQANILVSLSMGCVTWLERYFGDRHLAKENFERAELAAHEMIKPVAQRFREHGWQVCVGASGTVQALQEIMVAQ
GMDELITLAKLQQLKQRAIQCGKLEELEIPGLTLERALVFPSGLSILIAIFQELSIESMTLAGGALREGLVYGMLHLPVE
QDIRRRTLRNLQRRYLLDTEQAKRVSCLADNFFLQVEKEWHLDGRCREFLQNACLIHEIGLSVDFKHAPQHAAYLIRNLD
LPGFTPAQKLLLSALLQNQSDTIDLSLLNQQNALPADMAQHLCRLLRLAIIFSSRRRDDTLPAVRLRADNNALYVLVPQG
WLEQHPYRAEALEQESHWQSYVQWPLLLEELS
>Mature_352_residues
MVTGNGAQANILVSLSMGCVTWLERYFGDRHLAKENFERAELAAHEMIKPVAQRFREHGWQVCVGASGTVQALQEIMVAQ
GMDELITLAKLQQLKQRAIQCGKLEELEIPGLTLERALVFPSGLSILIAIFQELSIESMTLAGGALREGLVYGMLHLPVE
QDIRRRTLRNLQRRYLLDTEQAKRVSCLADNFFLQVEKEWHLDGRCREFLQNACLIHEIGLSVDFKHAPQHAAYLIRNLD
LPGFTPAQKLLLSALLQNQSDTIDLSLLNQQNALPADMAQHLCRLLRLAIIFSSRRRDDTLPAVRLRADNNALYVLVPQG
WLEQHPYRAEALEQESHWQSYVQWPLLLEELS

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=346, Percent_Identity=71.0982658959538, Blast_Score=511, Evalue=1e-146,
Organism=Escherichia coli, GI1788848, Length=361, Percent_Identity=32.1329639889197, Blast_Score=187, Evalue=8e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 40018; Mature: 40018

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTGNGAQANILVSLSMGCVTWLERYFGDRHLAKENFERAELAAHEMIKPVAQRFREHGW
CCCCCCCCEEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QVCVGASGTVQALQEIMVAQGMDELITLAKLQQLKQRAIQCGKLEELEIPGLTLERALVF
EEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHC
PSGLSILIAIFQELSIESMTLAGGALREGLVYGMLHLPVEQDIRRRTLRNLQRRYLLDTE
CCHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCH
QAKRVSCLADNFFLQVEKEWHLDGRCREFLQNACLIHEIGLSVDFKHAPQHAAYLIRNLD
HHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHCC
LPGFTPAQKLLLSALLQNQSDTIDLSLLNQQNALPADMAQHLCRLLRLAIIFSSRRRDDT
CCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
LPAVRLRADNNALYVLVPQGWLEQHPYRAEALEQESHWQSYVQWPLLLEELS
CCEEEEEECCCEEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVTGNGAQANILVSLSMGCVTWLERYFGDRHLAKENFERAELAAHEMIKPVAQRFREHGW
CCCCCCCCEEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QVCVGASGTVQALQEIMVAQGMDELITLAKLQQLKQRAIQCGKLEELEIPGLTLERALVF
EEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHC
PSGLSILIAIFQELSIESMTLAGGALREGLVYGMLHLPVEQDIRRRTLRNLQRRYLLDTE
CCHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCH
QAKRVSCLADNFFLQVEKEWHLDGRCREFLQNACLIHEIGLSVDFKHAPQHAAYLIRNLD
HHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHCC
LPGFTPAQKLLLSALLQNQSDTIDLSLLNQQNALPADMAQHLCRLLRLAIIFSSRRRDDT
CCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
LPAVRLRADNNALYVLVPQGWLEQHPYRAEALEQESHWQSYVQWPLLLEELS
CCEEEEEECCCEEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA