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The map label for this gene is gloB [H]

Identifier: 108801782

GI number: 108801782

Start: 5102409

End: 5103188

Strand: Reverse

Name: gloB [H]

Synonym: Mmcs_4819

Alternate gene names: 108801782

Gene position: 5103188-5102409 (Counterclockwise)

Preceding gene: 108801783

Following gene: 108801779

Centisome position: 89.44

GC content: 69.23

Gene sequence:

>780_bases
GTGAGCGCACCCGAGCATCCGGCATACGGGCTACTGCGCCCGGTGACCGAGACCGCCTCGGTGCTGTTGTGCAACAACCC
GGGGCTGATGACGCTCGACGGTACGAACACCTGGGTGCTGCGCGCACCGGGCAGTGACGAACTGGTGATCGTCGACCCCG
GGCCCGACGACGACGAACACATCGCGAAGGTCGCCGAACTCGGCCGGATCGCGCTGGTCCTGATCAGCCACAAACACGAG
GACCACACCGGCGGGATCGACAAGATCGTCGACCGTACCGGTGCGGTCGTCCGGTCGGTCGGCAGCGGATTCCTGCGCGG
TCTCGGAGGTCCGCTCACCGACGGTGAGGTCATCGACGCGGCGGGGCTGCGGATCGTCGTGATGGCCACGCCCGGCCACA
CCGCCGACTCGCTGTCGTTCGTCCTCGACGACGCGGTGCTGACCGCCGACACCGTGCTCGGGCGCGGCACCACCGTCATC
GATACCGAGGACGGCAGCCTGCGCGACTACCTCGAATCCCTACACCGCCTGCAGGGCCTGGGCCGGCGGACGGTGCTGCC
CGGGCACGGCCCCGACCTGCCCGACCTCGAGGCCGTCACGGCCATGTATCTCACCCACCGCGAGGAGCGGCTCGAACAGG
TGCGGGCGGCGTTGCGCGAACTCGGTGACGACGCGACGGCGCGCCAGGTCGTCGAACACGTCTACACCGATGTCGACGAG
AAGCTGTGGGACGCCGCGGAGAAGTCGGTCGAAGCCCAGCTCGACTACCTGCGCACGTGA

Upstream 100 bases:

>100_bases
GGCGACGCCGGCGCGCACGCCCGATCCGCGGTCGGGGTGTCGGAGTTGCCGCGCAACGCCCCGGTCGAGGTCGAGATCGT
CGTCGAGGTCGGTTAGGGCG

Downstream 100 bases:

>100_bases
TTTCGGCGTGTTCAGTCGCGCCAGGCGCGACCGGCCACGCCGAAATCACCGGGACTAGCGAGCGCGGCGGGCCAGCCGTT
CGGAGTCGCTGATCAGCACG

Product: beta-lactamase-like protein

Products: NA

Alternate protein names: Glyoxalase II; Glx II [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MSAPEHPAYGLLRPVTETASVLLCNNPGLMTLDGTNTWVLRAPGSDELVIVDPGPDDDEHIAKVAELGRIALVLISHKHE
DHTGGIDKIVDRTGAVVRSVGSGFLRGLGGPLTDGEVIDAAGLRIVVMATPGHTADSLSFVLDDAVLTADTVLGRGTTVI
DTEDGSLRDYLESLHRLQGLGRRTVLPGHGPDLPDLEAVTAMYLTHREERLEQVRAALRELGDDATARQVVEHVYTDVDE
KLWDAAEKSVEAQLDYLRT

Sequences:

>Translated_259_residues
MSAPEHPAYGLLRPVTETASVLLCNNPGLMTLDGTNTWVLRAPGSDELVIVDPGPDDDEHIAKVAELGRIALVLISHKHE
DHTGGIDKIVDRTGAVVRSVGSGFLRGLGGPLTDGEVIDAAGLRIVVMATPGHTADSLSFVLDDAVLTADTVLGRGTTVI
DTEDGSLRDYLESLHRLQGLGRRTVLPGHGPDLPDLEAVTAMYLTHREERLEQVRAALRELGDDATARQVVEHVYTDVDE
KLWDAAEKSVEAQLDYLRT
>Mature_258_residues
SAPEHPAYGLLRPVTETASVLLCNNPGLMTLDGTNTWVLRAPGSDELVIVDPGPDDDEHIAKVAELGRIALVLISHKHED
HTGGIDKIVDRTGAVVRSVGSGFLRGLGGPLTDGEVIDAAGLRIVVMATPGHTADSLSFVLDDAVLTADTVLGRGTTVID
TEDGSLRDYLESLHRLQGLGRRTVLPGHGPDLPDLEAVTAMYLTHREERLEQVRAALRELGDDATARQVVEHVYTDVDEK
LWDAAEKSVEAQLDYLRT

Specific function: Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family [H]

Homologues:

Organism=Homo sapiens, GI7705793, Length=248, Percent_Identity=31.8548387096774, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI193205216, Length=241, Percent_Identity=30.2904564315353, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17537503, Length=241, Percent_Identity=30.2904564315353, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI20129357, Length=263, Percent_Identity=29.6577946768061, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR017782 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.2.6 [H]

Molecular weight: Translated: 27875; Mature: 27743

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPEHPAYGLLRPVTETASVLLCNNPGLMTLDGTNTWVLRAPGSDELVIVDPGPDDDEH
CCCCCCCCCHHHHHHHHCCEEEEECCCCEEEECCCCEEEEECCCCCCEEEECCCCCCHHH
IAKVAELGRIALVLISHKHEDHTGGIDKIVDRTGAVVRSVGSGFLRGLGGPLTDGEVIDA
HHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEC
AGLRIVVMATPGHTADSLSFVLDDAVLTADTVLGRGTTVIDTEDGSLRDYLESLHRLQGL
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCC
GRRTVLPGHGPDLPDLEAVTAMYLTHREERLEQVRAALRELGDDATARQVVEHVYTDVDE
CCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
KLWDAAEKSVEAQLDYLRT
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SAPEHPAYGLLRPVTETASVLLCNNPGLMTLDGTNTWVLRAPGSDELVIVDPGPDDDEH
CCCCCCCCHHHHHHHHCCEEEEECCCCEEEECCCCEEEEECCCCCCEEEECCCCCCHHH
IAKVAELGRIALVLISHKHEDHTGGIDKIVDRTGAVVRSVGSGFLRGLGGPLTDGEVIDA
HHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEC
AGLRIVVMATPGHTADSLSFVLDDAVLTADTVLGRGTTVIDTEDGSLRDYLESLHRLQGL
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCC
GRRTVLPGHGPDLPDLEAVTAMYLTHREERLEQVRAALRELGDDATARQVVEHVYTDVDE
CCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
KLWDAAEKSVEAQLDYLRT
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA