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The map label for this gene is folE [H]

Identifier: 108801732

GI number: 108801732

Start: 5044761

End: 5045366

Strand: Reverse

Name: folE [H]

Synonym: Mmcs_4769

Alternate gene names: 108801732

Gene position: 5045366-5044761 (Counterclockwise)

Preceding gene: 108801733

Following gene: 108801731

Centisome position: 88.43

GC content: 67.66

Gene sequence:

>606_bases
ATGACGCGGTCGTACGATTCGGCCACGGTCAAGATCGCCGATTTCGACCAGCCGCGTGCGGAGGCGGCGGTGCGCGAACT
GCTGATCGCGATCGGGGAGGATCCGGACCGGCACGGGCTGGTGGACACCCCGGCCCGGGTGGCGCGGGCCTACCGGGAGA
TGTTCGCGGGGCTGTACACCGATCCCGACGACGTCCTCAACACGACGTTCGACGAACAGCACGACGAGATGGTGCTGGTC
AAGGACATCCCGATGTACTCCACGTGCGAACACCACCTCGTGGCGTTCCACGGAGTGGCGCACGTGGGGTACATCCCGGG
CGTCGACGGCCGGGTGACGGGGTTGTCGAAGCTCGCGCGGGTGGTCGACCTGTACGCGAAGCGTCCGCAGGTGCAGGAGC
GGCTGACCGCCCAGGTCGCCGACGCGCTGATGCGCAAACTCGACCCGCGCGGGGTGATCGTGGTGATGGAAGCCGAGCAC
CTCTGCATGGCCATGCGCGGGATCCGCAAACCCGGCGCCACCACCACCACCTCCGCGGTCCGCGGTCAGTTCAAGACCGA
CAAAGCTTCGCGGGCCGAGGCGCTGGATCTGATCTTGCGCAAGTGA

Upstream 100 bases:

>100_bases
CCACGCGACCCGCAGCAGGAGCGGGGCCGCGACGGCGACCGTCCCGGTGACCGTCCGAACCCGCCTGCGCAGCACTGACA
ACTTCACAAGGGAGGCCTCG

Downstream 100 bases:

>100_bases
GCGCCACCGCGGTCCAGGTGATGGGGGTCGTCAACGTCACCGACGACTCCTTCTCCGACGGAGGCCAGTTCCTCGACCCG
GGTCACGCCGTCGCACACGG

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 201; Mature: 200

Protein sequence:

>201_residues
MTRSYDSATVKIADFDQPRAEAAVRELLIAIGEDPDRHGLVDTPARVARAYREMFAGLYTDPDDVLNTTFDEQHDEMVLV
KDIPMYSTCEHHLVAFHGVAHVGYIPGVDGRVTGLSKLARVVDLYAKRPQVQERLTAQVADALMRKLDPRGVIVVMEAEH
LCMAMRGIRKPGATTTTSAVRGQFKTDKASRAEALDLILRK

Sequences:

>Translated_201_residues
MTRSYDSATVKIADFDQPRAEAAVRELLIAIGEDPDRHGLVDTPARVARAYREMFAGLYTDPDDVLNTTFDEQHDEMVLV
KDIPMYSTCEHHLVAFHGVAHVGYIPGVDGRVTGLSKLARVVDLYAKRPQVQERLTAQVADALMRKLDPRGVIVVMEAEH
LCMAMRGIRKPGATTTTSAVRGQFKTDKASRAEALDLILRK
>Mature_200_residues
TRSYDSATVKIADFDQPRAEAAVRELLIAIGEDPDRHGLVDTPARVARAYREMFAGLYTDPDDVLNTTFDEQHDEMVLVK
DIPMYSTCEHHLVAFHGVAHVGYIPGVDGRVTGLSKLARVVDLYAKRPQVQERLTAQVADALMRKLDPRGVIVVMEAEHL
CMAMRGIRKPGATTTTSAVRGQFKTDKASRAEALDLILRK

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=186, Percent_Identity=50, Blast_Score=180, Evalue=7e-46,
Organism=Homo sapiens, GI4503949, Length=186, Percent_Identity=50, Blast_Score=180, Evalue=7e-46,
Organism=Homo sapiens, GI66932970, Length=146, Percent_Identity=51.3698630136986, Blast_Score=144, Evalue=7e-35,
Organism=Homo sapiens, GI66932972, Length=146, Percent_Identity=51.3698630136986, Blast_Score=143, Evalue=1e-34,
Organism=Escherichia coli, GI1788476, Length=159, Percent_Identity=44.0251572327044, Blast_Score=116, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17560486, Length=180, Percent_Identity=50, Blast_Score=186, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6321706, Length=185, Percent_Identity=51.8918918918919, Blast_Score=182, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24656782, Length=185, Percent_Identity=48.1081081081081, Blast_Score=167, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24656796, Length=185, Percent_Identity=48.1081081081081, Blast_Score=166, Evalue=8e-42,
Organism=Drosophila melanogaster, GI24656791, Length=185, Percent_Identity=48.1081081081081, Blast_Score=166, Evalue=1e-41,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 22303; Mature: 22172

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSYDSATVKIADFDQPRAEAAVRELLIAIGEDPDRHGLVDTPARVARAYREMFAGLYT
CCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
DPDDVLNTTFDEQHDEMVLVKDIPMYSTCEHHLVAFHGVAHVGYIPGVDGRVTGLSKLAR
CHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
VVDLYAKRPQVQERLTAQVADALMRKLDPRGVIVVMEAEHLCMAMRGIRKPGATTTTSAV
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHCCCCCCCCHHHHH
RGQFKTDKASRAEALDLILRK
HCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TRSYDSATVKIADFDQPRAEAAVRELLIAIGEDPDRHGLVDTPARVARAYREMFAGLYT
CCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
DPDDVLNTTFDEQHDEMVLVKDIPMYSTCEHHLVAFHGVAHVGYIPGVDGRVTGLSKLAR
CHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
VVDLYAKRPQVQERLTAQVADALMRKLDPRGVIVVMEAEHLCMAMRGIRKPGATTTTSAV
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHCCCCCCCCHHHHH
RGQFKTDKASRAEALDLILRK
HCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA