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The map label for this gene is folP1 [H]

Identifier: 108801731

GI number: 108801731

Start: 5043937

End: 5044764

Strand: Reverse

Name: folP1 [H]

Synonym: Mmcs_4768

Alternate gene names: 108801731

Gene position: 5044764-5043937 (Counterclockwise)

Preceding gene: 108801732

Following gene: 108801730

Centisome position: 88.42

GC content: 71.62

Gene sequence:

>828_bases
GTGAGCGCCACCGCGGTCCAGGTGATGGGGGTCGTCAACGTCACCGACGACTCCTTCTCCGACGGAGGCCAGTTCCTCGA
CCCGGGTCACGCCGTCGCACACGGTATGGCGCTGGCGGCCGAGGGGGCGGCGATCATCGACGTCGGTGGTGAGTCCACCC
GGCCCGGCGCCACCCGGGTCGATCCCGAAGTCGAAGCGGCCCGCATCATCCCGGTGGTCGAAGCGCTCGCCGCGGCCGGC
ATCACGGTCAGCATCGACACGATGCGCGCCCGGGTGGCGAGCGCCGCCCTGGAACACGGCGCCGCGATCGTCAACGACGT
GTCCGGCGGCAGGGCCGACCCCGACATGGCGCGCGTGGTCGCCGACGCCCGGGTGCCGTGGATCCTCATGCACTGGCGGT
CGGTCGCCGCCGAACGCCCGCACCAGGTGCCCGTATACGACGACGTCGTCGGCGAGGTGCGTACGGAACTGCTGGCCAGT
GTGGACGCCGCGGTCGCCGCGGGCGTGGACCCGATGAACCTGATCATCGACCCGGGCCTCGGATTCGCCAAGACCGGACA
ACACAATTGGGCACTGCTGCACGCACTGCCCGAGCTGGTGGCGACCGAGATCCCGGTGCTGGTGGGTGCGTCACGCAAAC
GTTTTCTCGGTGCGCTGCTCGCCGACGCCTACGGTGCGGTGCGTCCCCCCGACGGCCGGGAGACGGCCACCGCGGTGATC
TCCGCGCTGGCCGCGCTGCACGGTGCGTGGGGTGTGCGCGTGCACGACGTGCGCGCCTCGGTGGATGCCGTCAAAGTGGT
GGGGGCGTGGGAGCGAGGTGGGGAGTGA

Upstream 100 bases:

>100_bases
TCCGCAAACCCGGCGCCACCACCACCACCTCCGCGGTCCGCGGTCAGTTCAAGACCGACAAAGCTTCGCGGGCCGAGGCG
CTGGATCTGATCTTGCGCAA

Downstream 100 bases:

>100_bases
GCGACCGGATCGAGTTGCGCGGGCTGACCGTGCGGGGCAACCACGGCGTCTTCGACCATGAGCGCCGCGACGGGCAGGAC
TTCGTGATCGACCTGACCGT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS 1; Dihydropteroate pyrophosphorylase 1 [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MSATAVQVMGVVNVTDDSFSDGGQFLDPGHAVAHGMALAAEGAAIIDVGGESTRPGATRVDPEVEAARIIPVVEALAAAG
ITVSIDTMRARVASAALEHGAAIVNDVSGGRADPDMARVVADARVPWILMHWRSVAAERPHQVPVYDDVVGEVRTELLAS
VDAAVAAGVDPMNLIIDPGLGFAKTGQHNWALLHALPELVATEIPVLVGASRKRFLGALLADAYGAVRPPDGRETATAVI
SALAALHGAWGVRVHDVRASVDAVKVVGAWERGGE

Sequences:

>Translated_275_residues
MSATAVQVMGVVNVTDDSFSDGGQFLDPGHAVAHGMALAAEGAAIIDVGGESTRPGATRVDPEVEAARIIPVVEALAAAG
ITVSIDTMRARVASAALEHGAAIVNDVSGGRADPDMARVVADARVPWILMHWRSVAAERPHQVPVYDDVVGEVRTELLAS
VDAAVAAGVDPMNLIIDPGLGFAKTGQHNWALLHALPELVATEIPVLVGASRKRFLGALLADAYGAVRPPDGRETATAVI
SALAALHGAWGVRVHDVRASVDAVKVVGAWERGGE
>Mature_274_residues
SATAVQVMGVVNVTDDSFSDGGQFLDPGHAVAHGMALAAEGAAIIDVGGESTRPGATRVDPEVEAARIIPVVEALAAAGI
TVSIDTMRARVASAALEHGAAIVNDVSGGRADPDMARVVADARVPWILMHWRSVAAERPHQVPVYDDVVGEVRTELLASV
DAAVAAGVDPMNLIIDPGLGFAKTGQHNWALLHALPELVATEIPVLVGASRKRFLGALLADAYGAVRPPDGRETATAVIS
ALAALHGAWGVRVHDVRASVDAVKVVGAWERGGE

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=264, Percent_Identity=39.7727272727273, Blast_Score=175, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6324073, Length=331, Percent_Identity=30.5135951661631, Blast_Score=125, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 28347; Mature: 28216

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATAVQVMGVVNVTDDSFSDGGQFLDPGHAVAHGMALAAEGAAIIDVGGESTRPGATRV
CCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCC
DPEVEAARIIPVVEALAAAGITVSIDTMRARVASAALEHGAAIVNDVSGGRADPDMARVV
CCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHH
ADARVPWILMHWRSVAAERPHQVPVYDDVVGEVRTELLASVDAAVAAGVDPMNLIIDPGL
HHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
GFAKTGQHNWALLHALPELVATEIPVLVGASRKRFLGALLADAYGAVRPPDGRETATAVI
CCCCCCCCCHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
SALAALHGAWGVRVHDVRASVDAVKVVGAWERGGE
HHHHHHHCCCCCEEEEHHHCHHHHHEEECCCCCCC
>Mature Secondary Structure 
SATAVQVMGVVNVTDDSFSDGGQFLDPGHAVAHGMALAAEGAAIIDVGGESTRPGATRV
CCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCC
DPEVEAARIIPVVEALAAAGITVSIDTMRARVASAALEHGAAIVNDVSGGRADPDMARVV
CCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHH
ADARVPWILMHWRSVAAERPHQVPVYDDVVGEVRTELLASVDAAVAAGVDPMNLIIDPGL
HHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
GFAKTGQHNWALLHALPELVATEIPVLVGASRKRFLGALLADAYGAVRPPDGRETATAVI
CCCCCCCCCHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
SALAALHGAWGVRVHDVRASVDAVKVVGAWERGGE
HHHHHHHCCCCCEEEEHHHCHHHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10474189; 10542185; 11234002 [H]