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The map label for this gene is folK [H]

Identifier: 108801729

GI number: 108801729

Start: 5043036

End: 5043566

Strand: Reverse

Name: folK [H]

Synonym: Mmcs_4766

Alternate gene names: 108801729

Gene position: 5043566-5043036 (Counterclockwise)

Preceding gene: 108801730

Following gene: 108801728

Centisome position: 88.4

GC content: 71.37

Gene sequence:

>531_bases
GTGACACGAGTCGTGTTGTCCATCGGGTCGAATGTGGGTGACCGCCTGGCACGCCTGCAGTCCGTCGTCGACGGTCTCGG
GGAGGCCGTGCGCGCGGTGTCGCCGGTGTACGAGACCGCGGCGTGGGGCGGTGTCGAACAGGGCGCCTTCCTCAACGCGG
TGCTGATCGCCGACGACCCCGACCTCGACTGCCACGGCTGGCTGCGCCGCGGTCAGCAGTTGGAGCAGGAGGCCGACCGG
GTCCGCGGACAGCGGTGGGGGCCCCGCACCCTCGACGTCGACATCGTCACCTGCCACGACGGGGACACCGAAGTGCGTTC
CGCGACTGCGGAGCTCACGCTGCCGCATCCGTACGCACATCTGCGGGGGTTCGTCCTGATGCCGTGGCTGGCGGCCGAAC
CGGAGGCGACGCTGACGGTGGCGGACACGACACGGCCGGTCTCGCTGTGGCTGGAGGAACTCGACTACGCCGAGCGCGCG
GGTGTGCGGCGCACCGACCTGGCCCTGCGCACGGAGATCGCGGCCGACTGA

Upstream 100 bases:

>100_bases
CCGTCGAGGTGGTCGTGCACAAACCGGAGGCGCCGATCCCGCTGACCTTCGCGGACGTCGCCGTGGTGGCGCGTAGGACG
CGCGCACGCGAGGAGCGCAA

Downstream 100 bases:

>100_bases
TGGGGCCCACCCGGAAACGCGACCTGGCGGCCGCGGTGCTCATCGCAGGCATCGTCGGATATCTCGCCGCACTGCTGGCC
TACCCGCGGTACTTCCCGCC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 176; Mature: 175

Protein sequence:

>176_residues
MTRVVLSIGSNVGDRLARLQSVVDGLGEAVRAVSPVYETAAWGGVEQGAFLNAVLIADDPDLDCHGWLRRGQQLEQEADR
VRGQRWGPRTLDVDIVTCHDGDTEVRSATAELTLPHPYAHLRGFVLMPWLAAEPEATLTVADTTRPVSLWLEELDYAERA
GVRRTDLALRTEIAAD

Sequences:

>Translated_176_residues
MTRVVLSIGSNVGDRLARLQSVVDGLGEAVRAVSPVYETAAWGGVEQGAFLNAVLIADDPDLDCHGWLRRGQQLEQEADR
VRGQRWGPRTLDVDIVTCHDGDTEVRSATAELTLPHPYAHLRGFVLMPWLAAEPEATLTVADTTRPVSLWLEELDYAERA
GVRRTDLALRTEIAAD
>Mature_175_residues
TRVVLSIGSNVGDRLARLQSVVDGLGEAVRAVSPVYETAAWGGVEQGAFLNAVLIADDPDLDCHGWLRRGQQLEQEADRV
RGQRWGPRTLDVDIVTCHDGDTEVRSATAELTLPHPYAHLRGFVLMPWLAAEPEATLTVADTTRPVSLWLEELDYAERAG
VRRTDLALRTEIAAD

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=152, Percent_Identity=32.8947368421053, Blast_Score=70, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 19326; Mature: 19195

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRVVLSIGSNVGDRLARLQSVVDGLGEAVRAVSPVYETAAWGGVEQGAFLNAVLIADDP
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCC
DLDCHGWLRRGQQLEQEADRVRGQRWGPRTLDVDIVTCHDGDTEVRSATAELTLPHPYAH
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCHHHHHCEEEEECCCCHHH
LRGFVLMPWLAAEPEATLTVADTTRPVSLWLEELDYAERAGVRRTDLALRTEIAAD
HCCHHEECEECCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
TRVVLSIGSNVGDRLARLQSVVDGLGEAVRAVSPVYETAAWGGVEQGAFLNAVLIADDP
CEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCC
DLDCHGWLRRGQQLEQEADRVRGQRWGPRTLDVDIVTCHDGDTEVRSATAELTLPHPYAH
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCHHHHHCEEEEECCCCHHH
LRGFVLMPWLAAEPEATLTVADTTRPVSLWLEELDYAERAGVRRTDLALRTEIAAD
HCCHHEECEECCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]