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The map label for this gene is mhpF [C]

Identifier: 108801623

GI number: 108801623

Start: 4937320

End: 4938252

Strand: Reverse

Name: mhpF [C]

Synonym: Mmcs_4660

Alternate gene names: 108801623

Gene position: 4938252-4937320 (Counterclockwise)

Preceding gene: 108801624

Following gene: 108801622

Centisome position: 86.55

GC content: 66.77

Gene sequence:

>933_bases
ATGCCGGAGAAGCTTCAGGTCGCGATCGTCGGGTCCGGCAACATCAGCACCGATCTGCTGTACAAGCTGCAGCGCTCGGA
GTACCTCGAACCGCGTTGGATGATCGGAATCGATCCCGAGTCCGAAGGGCTCGCGCGCGCACGCAAACTCGGCCTCGAGA
CCTCGCACGAGGGCGTGGATTGGCTGCTCGCCCAGGACGACAAACCGGATCTGGTGTTCGAGGCCACCAGCGCCTACGTG
CACCGGGCGGCGGCACCGCGCTACGAGGAAGCGGGTATCCGCGCCATCGACCTCACCCCGGCCGCGGTGGGCCCGGCGGT
GATCCCGCCGGCCAACCTGCGCGAACACCTCGACGCACCGAACGTCAACATGATCACCTGTGGTGGGCAGGCCACCATCC
CCATCGTCTACGCGGTCACCCGCGCGGTCACCGAACAGGGCGGCACGGTGCCCTACGCCGAGATCGTCGCCTCGGTGTCG
TCGAGTTCGGCGGGTCCGGGTACCCGCGCCAACATCGACGAGTTCACCAAGACCACCAGCAAGGGTGTGCAGACCATCGG
CGGTGCCGCGCGGGGGAAGGCGATCATCATCCTCAACCCCGCCGATCCGCCGATGATCATGCGCGACACCATCTTCTGTG
CCATCCCCGAGGACGTCGACCGGGATGCGATCGCCCAGTCGATCCGCGACGTCGTCGCCGAGGTGCAGACCTACGTACCC
GGCTACCGCCTGCTCAACGACCCGCAGTTCGACGACCCCTCGATCAACTCCGGCGGACAGGCCGTGGTCACCACGTTCGT
GGAGGTGGAAGGCGCAGGCGACTACCTGCCGCCGTACGCGGGAAACCTCGACATCATGACCGCCGCGGCGGCCAAGGTGG
GCGAGGAGATCGCAAAGGAATCCCTTTCTCTGGCAGGAGGTGCGCAGGCATGA

Upstream 100 bases:

>100_bases
GATGCACCTCCCGGGAGCCATTTCGTCGCCGACTTCGCCGGGTTAGGTTCAGTACAACTCGCTTTCGAGTGAGCGCTTTT
CAGAAACCAGGGAGAGTCAT

Downstream 100 bases:

>100_bases
GCACCAAAGACATCTTCTTCAACCCGATCTGGGACGTCCGGATGACGGACACGTCGCTGCGCGACGGCTCGCACCACAAA
CGTCACCAGTTCACCAAGGA

Product: acetaldehyde dehydrogenase

Products: NA

Alternate protein names: Acetaldehyde dehydrogenase [acetylating] 1

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MPEKLQVAIVGSGNISTDLLYKLQRSEYLEPRWMIGIDPESEGLARARKLGLETSHEGVDWLLAQDDKPDLVFEATSAYV
HRAAAPRYEEAGIRAIDLTPAAVGPAVIPPANLREHLDAPNVNMITCGGQATIPIVYAVTRAVTEQGGTVPYAEIVASVS
SSSAGPGTRANIDEFTKTTSKGVQTIGGAARGKAIIILNPADPPMIMRDTIFCAIPEDVDRDAIAQSIRDVVAEVQTYVP
GYRLLNDPQFDDPSINSGGQAVVTTFVEVEGAGDYLPPYAGNLDIMTAAAAKVGEEIAKESLSLAGGAQA

Sequences:

>Translated_310_residues
MPEKLQVAIVGSGNISTDLLYKLQRSEYLEPRWMIGIDPESEGLARARKLGLETSHEGVDWLLAQDDKPDLVFEATSAYV
HRAAAPRYEEAGIRAIDLTPAAVGPAVIPPANLREHLDAPNVNMITCGGQATIPIVYAVTRAVTEQGGTVPYAEIVASVS
SSSAGPGTRANIDEFTKTTSKGVQTIGGAARGKAIIILNPADPPMIMRDTIFCAIPEDVDRDAIAQSIRDVVAEVQTYVP
GYRLLNDPQFDDPSINSGGQAVVTTFVEVEGAGDYLPPYAGNLDIMTAAAAKVGEEIAKESLSLAGGAQA
>Mature_309_residues
PEKLQVAIVGSGNISTDLLYKLQRSEYLEPRWMIGIDPESEGLARARKLGLETSHEGVDWLLAQDDKPDLVFEATSAYVH
RAAAPRYEEAGIRAIDLTPAAVGPAVIPPANLREHLDAPNVNMITCGGQATIPIVYAVTRAVTEQGGTVPYAEIVASVSS
SSAGPGTRANIDEFTKTTSKGVQTIGGAARGKAIIILNPADPPMIMRDTIFCAIPEDVDRDAIAQSIRDVVAEVQTYVPG
YRLLNDPQFDDPSINSGGQAVVTTFVEVEGAGDYLPPYAGNLDIMTAAAAKVGEEIAKESLSLAGGAQA

Specific function: Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds

COG id: COG4569

COG function: function code Q; Acetaldehyde dehydrogenase (acetylating)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetaldehyde dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1786547, Length=321, Percent_Identity=51.4018691588785, Blast_Score=296, Evalue=9e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACDH1_MYCSK (A1UM81)

Other databases:

- EMBL:   CP000518
- RefSeq:   YP_940729.1
- STRING:   A1UM81
- EnsemblBacteria:   EBMYCT00000058403
- GeneID:   4616163
- GenomeReviews:   CP000518_GR
- KEGG:   mkm:Mkms_4748
- eggNOG:   COG4569
- GeneTree:   EBGT00050000016468
- HOGENOM:   HBG300125
- OMA:   HAMVKEV
- ProtClustDB:   PRK08300
- BioCyc:   MSP189918:MKMS_4748-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01657
- InterPro:   IPR003361
- InterPro:   IPR015426
- InterPro:   IPR016040
- InterPro:   IPR000534
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR21123
- PIRSF:   PIRSF015689
- SMART:   SM00859
- TIGRFAMs:   TIGR03215

Pfam domain/function: PF09290 AcetDehyd-dimer; PF01118 Semialdhyde_dh

EC number: =1.2.1.10

Molecular weight: Translated: 32743; Mature: 32612

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: NA

Important sites: BINDING 282-282

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEKLQVAIVGSGNISTDLLYKLQRSEYLEPRWMIGIDPESEGLARARKLGLETSHEGVD
CCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCE
WLLAQDDKPDLVFEATSAYVHRAAAPRYEEAGIRAIDLTPAAVGPAVIPPANLREHLDAP
EEEECCCCCCEEEEHHHHHHHHHCCCCHHHCCCEEEECCCHHCCCCCCCCCHHHHHCCCC
NVNMITCGGQATIPIVYAVTRAVTEQGGTVPYAEIVASVSSSSAGPGTRANIDEFTKTTS
CCEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
KGVQTIGGAARGKAIIILNPADPPMIMRDTIFCAIPEDVDRDAIAQSIRDVVAEVQTYVP
HHHHHHCCCCCCCEEEEECCCCCCEEEECEEEEECCCCCCHHHHHHHHHHHHHHHHHHCC
GYRLLNDPQFDDPSINSGGQAVVTTFVEVEGAGDYLPPYAGNLDIMTAAAAKVGEEIAKE
CCEECCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SLSLAGGAQA
HHHCCCCCCC
>Mature Secondary Structure 
PEKLQVAIVGSGNISTDLLYKLQRSEYLEPRWMIGIDPESEGLARARKLGLETSHEGVD
CCEEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCE
WLLAQDDKPDLVFEATSAYVHRAAAPRYEEAGIRAIDLTPAAVGPAVIPPANLREHLDAP
EEEECCCCCCEEEEHHHHHHHHHCCCCHHHCCCEEEECCCHHCCCCCCCCCHHHHHCCCC
NVNMITCGGQATIPIVYAVTRAVTEQGGTVPYAEIVASVSSSSAGPGTRANIDEFTKTTS
CCEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
KGVQTIGGAARGKAIIILNPADPPMIMRDTIFCAIPEDVDRDAIAQSIRDVVAEVQTYVP
HHHHHHCCCCCCCEEEEECCCCCCEEEECEEEEECCCCCCHHHHHHHHHHHHHHHHHHCC
GYRLLNDPQFDDPSINSGGQAVVTTFVEVEGAGDYLPPYAGNLDIMTAAAAKVGEEIAKE
CCEECCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
SLSLAGGAQA
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA