| Definition | Mycobacterium sp. MCS chromosome, complete genome. |
|---|---|
| Accession | NC_008146 |
| Length | 5,705,448 |
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The map label for this gene is benD [H]
Identifier: 108801609
GI number: 108801609
Start: 4921824
End: 4922609
Strand: Reverse
Name: benD [H]
Synonym: Mmcs_4646
Alternate gene names: 108801609
Gene position: 4922609-4921824 (Counterclockwise)
Preceding gene: 108801610
Following gene: 108801608
Centisome position: 86.28
GC content: 64.89
Gene sequence:
>786_bases ATGGCGCTCGGGTTACTGAAGGACAAGGTCGTCGTCGTCAGCGGCGTCGGCCCGGCGCTCGGCACCACACTGGCCCGGCG CTGCGCGGAGGAGGGTGCCGACCTGGTGCTCGCCGCGCGCACGGTCGAACGCCTCGAGGACGTCGCCAAGCAGATCACCG ATCTGGGGCGACGCGCGGTGTCGGTGGGCACGGACATCACCGACGAGGCGCAGGTGGCCAACCTGGTCGACCAGTCGCTC GAGGCCTACGGCAGGGTCGACGTGTTGATCAACAACGCCTTCAGGGTGCCGTCGATGAAGCCGTTCGCGAACACCACCTT CGAGCACATGCGCGACGCCATCGAGTTGACCGTGTTCGGCGCCCTGCGCATGGTCCAGGCCTTCACCCCGGCGCTGGCCG AAGCCAAGGGGTCCGTCGTCAACGTGAACTCGATGGTGGTGCGGCACTCCCAGGCCAAATACGGCGCCTACAAGATGGCC AAATCCGCGCTGCTGGCGATGTCACAGACGCTGGCCACCGAGCTCGGTGAACAAGGCATTCGAGTGAATTCGGTTGCCCC CGGATATATCTGGGGTGAAACCCTGAAGAGTTACTTCAATCACCAGGCGGGTAAGTACGGGACGACCGTCGAGGAGATCT ACCAGGCGACCGCGGCGGCGTCCGACCTCAAGCGGTTGCCCACCGAGGACGAGGTGGCCTCGGCGATCCTGTTCATGGCC AGCGATCTGTCCAGCGGTATCACCGGGCAGACTCTGGATGTCAACTGCGGGGAGTACAAGGCATGA
Upstream 100 bases:
>100_bases GCGCTGCCGTACTACGCATCGAACAAGATTTCAGGAGAAGACTGGCGGGCACGGATCGCGCTACGCCAGAAACAGATCGG CGAGAGAATGGTGGGTTGAG
Downstream 100 bases:
>100_bases GTCCGGGCGGACGTACCGACGTGGGCACCGTCGAGGATCTGCACGCCTCGGCCGTGAAGGCCTGCGGTTTGGACGATTTC GGCTCCGATGACGACAACTA
Product: short chain dehydrogenase
Products: NA
Alternate protein names: 2-hydro-1,2-dihydroxybenzoate dehydrogenase; DHB dehydrogenase; Cis-1,2-dihydroxy-3,4-cyclohexadiene-1-carboxylate dehydrogenase; Cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase [H]
Number of amino acids: Translated: 261; Mature: 260
Protein sequence:
>261_residues MALGLLKDKVVVVSGVGPALGTTLARRCAEEGADLVLAARTVERLEDVAKQITDLGRRAVSVGTDITDEAQVANLVDQSL EAYGRVDVLINNAFRVPSMKPFANTTFEHMRDAIELTVFGALRMVQAFTPALAEAKGSVVNVNSMVVRHSQAKYGAYKMA KSALLAMSQTLATELGEQGIRVNSVAPGYIWGETLKSYFNHQAGKYGTTVEEIYQATAAASDLKRLPTEDEVASAILFMA SDLSSGITGQTLDVNCGEYKA
Sequences:
>Translated_261_residues MALGLLKDKVVVVSGVGPALGTTLARRCAEEGADLVLAARTVERLEDVAKQITDLGRRAVSVGTDITDEAQVANLVDQSL EAYGRVDVLINNAFRVPSMKPFANTTFEHMRDAIELTVFGALRMVQAFTPALAEAKGSVVNVNSMVVRHSQAKYGAYKMA KSALLAMSQTLATELGEQGIRVNSVAPGYIWGETLKSYFNHQAGKYGTTVEEIYQATAAASDLKRLPTEDEVASAILFMA SDLSSGITGQTLDVNCGEYKA >Mature_260_residues ALGLLKDKVVVVSGVGPALGTTLARRCAEEGADLVLAARTVERLEDVAKQITDLGRRAVSVGTDITDEAQVANLVDQSLE AYGRVDVLINNAFRVPSMKPFANTTFEHMRDAIELTVFGALRMVQAFTPALAEAKGSVVNVNSMVVRHSQAKYGAYKMAK SALLAMSQTLATELGEQGIRVNSVAPGYIWGETLKSYFNHQAGKYGTTVEEIYQATAAASDLKRLPTEDEVASAILFMAS DLSSGITGQTLDVNCGEYKA
Specific function: Degradation of 2-hydro-1,2-dihydroxy benzoate (DHB) to catechol [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI19923817, Length=273, Percent_Identity=27.8388278388278, Blast_Score=113, Evalue=2e-25, Organism=Homo sapiens, GI10190704, Length=261, Percent_Identity=30.6513409961686, Blast_Score=111, Evalue=7e-25, Organism=Homo sapiens, GI59889578, Length=184, Percent_Identity=29.8913043478261, Blast_Score=92, Evalue=6e-19, Organism=Homo sapiens, GI5031737, Length=255, Percent_Identity=25.4901960784314, Blast_Score=91, Evalue=1e-18, Organism=Homo sapiens, GI32483357, Length=253, Percent_Identity=26.4822134387352, Blast_Score=90, Evalue=2e-18, Organism=Homo sapiens, GI33667109, Length=191, Percent_Identity=28.7958115183246, Blast_Score=82, Evalue=4e-16, Organism=Homo sapiens, GI7706318, Length=189, Percent_Identity=30.6878306878307, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI40254992, Length=257, Percent_Identity=27.6264591439689, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI7705925, Length=258, Percent_Identity=27.1317829457364, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI20149619, Length=214, Percent_Identity=27.5700934579439, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI157739938, Length=196, Percent_Identity=28.0612244897959, Blast_Score=72, Evalue=5e-13, Organism=Homo sapiens, GI126723191, Length=181, Percent_Identity=25.9668508287293, Blast_Score=68, Evalue=9e-12, Organism=Homo sapiens, GI126723750, Length=256, Percent_Identity=23.828125, Blast_Score=66, Evalue=3e-11, Organism=Homo sapiens, GI15277342, Length=264, Percent_Identity=24.2424242424242, Blast_Score=65, Evalue=4e-11, Organism=Escherichia coli, GI1787905, Length=253, Percent_Identity=30.4347826086957, Blast_Score=107, Evalue=9e-25, Organism=Escherichia coli, GI87082100, Length=252, Percent_Identity=29.3650793650794, Blast_Score=100, Evalue=1e-22, Organism=Escherichia coli, GI1789378, Length=258, Percent_Identity=29.4573643410853, Blast_Score=100, Evalue=1e-22, Organism=Escherichia coli, GI1787335, Length=256, Percent_Identity=28.90625, Blast_Score=96, Evalue=2e-21, Organism=Escherichia coli, GI1789208, Length=261, Percent_Identity=26.8199233716475, Blast_Score=86, Evalue=2e-18, Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=26.0869565217391, Blast_Score=80, Evalue=1e-16, Organism=Escherichia coli, GI1788459, Length=252, Percent_Identity=25.7936507936508, Blast_Score=77, Evalue=1e-15, Organism=Escherichia coli, GI1787526, Length=257, Percent_Identity=26.4591439688716, Blast_Score=74, Evalue=7e-15, Organism=Escherichia coli, GI2367175, Length=258, Percent_Identity=27.5193798449612, Blast_Score=74, Evalue=8e-15, Organism=Escherichia coli, GI1789057, Length=258, Percent_Identity=26.3565891472868, Blast_Score=70, Evalue=1e-13, Organism=Escherichia coli, GI1787820, Length=247, Percent_Identity=23.8866396761134, Blast_Score=70, Evalue=1e-13, Organism=Escherichia coli, GI87082160, Length=260, Percent_Identity=25.3846153846154, Blast_Score=65, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17562904, Length=267, Percent_Identity=29.2134831460674, Blast_Score=101, Evalue=4e-22, Organism=Caenorhabditis elegans, GI17560332, Length=193, Percent_Identity=34.1968911917098, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17560676, Length=259, Percent_Identity=26.6409266409266, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI71994604, Length=252, Percent_Identity=29.3650793650794, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17562910, Length=263, Percent_Identity=27.7566539923954, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI71994600, Length=256, Percent_Identity=31.25, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17551412, Length=262, Percent_Identity=29.0076335877863, Blast_Score=94, Evalue=5e-20, Organism=Caenorhabditis elegans, GI17560150, Length=253, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=6e-19, Organism=Caenorhabditis elegans, GI17562906, Length=261, Percent_Identity=28.3524904214559, Blast_Score=91, Evalue=8e-19, Organism=Caenorhabditis elegans, GI17562908, Length=268, Percent_Identity=28.7313432835821, Blast_Score=91, Evalue=8e-19, Organism=Caenorhabditis elegans, GI193204405, Length=261, Percent_Identity=27.5862068965517, Blast_Score=91, Evalue=8e-19, Organism=Caenorhabditis elegans, GI17531453, Length=267, Percent_Identity=30.3370786516854, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17544670, Length=265, Percent_Identity=29.4339622641509, Blast_Score=89, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17561402, Length=253, Percent_Identity=26.0869565217391, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17565030, Length=265, Percent_Identity=28.6792452830189, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17559104, Length=261, Percent_Identity=27.2030651340996, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17538480, Length=265, Percent_Identity=27.1698113207547, Blast_Score=88, Evalue=5e-18, Organism=Caenorhabditis elegans, GI17560220, Length=269, Percent_Identity=28.996282527881, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17538486, Length=192, Percent_Identity=29.6875, Blast_Score=85, Evalue=3e-17, Organism=Caenorhabditis elegans, GI17536025, Length=269, Percent_Identity=27.5092936802974, Blast_Score=84, Evalue=6e-17, Organism=Caenorhabditis elegans, GI17562990, Length=254, Percent_Identity=27.5590551181102, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17555706, Length=255, Percent_Identity=25.8823529411765, Blast_Score=80, Evalue=7e-16, Organism=Caenorhabditis elegans, GI72000259, Length=258, Percent_Identity=27.906976744186, Blast_Score=78, Evalue=4e-15, Organism=Caenorhabditis elegans, GI17536651, Length=264, Percent_Identity=26.1363636363636, Blast_Score=78, Evalue=5e-15, Organism=Caenorhabditis elegans, GI115534694, Length=253, Percent_Identity=26.4822134387352, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI25147288, Length=261, Percent_Identity=25.2873563218391, Blast_Score=71, Evalue=7e-13, Organism=Caenorhabditis elegans, GI17538182, Length=208, Percent_Identity=27.8846153846154, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17563726, Length=189, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI71997402, Length=189, Percent_Identity=29.1005291005291, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI71982365, Length=194, Percent_Identity=26.8041237113402, Blast_Score=68, Evalue=4e-12, Organism=Caenorhabditis elegans, GI17508895, Length=189, Percent_Identity=25.3968253968254, Blast_Score=68, Evalue=5e-12, Organism=Caenorhabditis elegans, GI17561272, Length=249, Percent_Identity=26.1044176706827, Blast_Score=64, Evalue=7e-11, Organism=Caenorhabditis elegans, GI115534660, Length=232, Percent_Identity=23.2758620689655, Blast_Score=64, Evalue=8e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=261, Percent_Identity=27.9693486590038, Blast_Score=81, Evalue=2e-16, Organism=Saccharomyces cerevisiae, GI6322861, Length=195, Percent_Identity=28.7179487179487, Blast_Score=68, Evalue=1e-12, Organism=Saccharomyces cerevisiae, GI6323882, Length=194, Percent_Identity=28.3505154639175, Blast_Score=66, Evalue=4e-12, Organism=Saccharomyces cerevisiae, GI6322226, Length=183, Percent_Identity=26.775956284153, Blast_Score=63, Evalue=5e-11, Organism=Drosophila melanogaster, GI21357041, Length=255, Percent_Identity=31.7647058823529, Blast_Score=115, Evalue=3e-26, Organism=Drosophila melanogaster, GI28571526, Length=262, Percent_Identity=31.2977099236641, Blast_Score=111, Evalue=5e-25, Organism=Drosophila melanogaster, GI23397609, Length=255, Percent_Identity=30.5882352941176, Blast_Score=108, Evalue=3e-24, Organism=Drosophila melanogaster, GI24644339, Length=253, Percent_Identity=30.4347826086957, Blast_Score=101, Evalue=4e-22, Organism=Drosophila melanogaster, GI24644337, Length=228, Percent_Identity=30.7017543859649, Blast_Score=96, Evalue=2e-20, Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=24.4979919678715, Blast_Score=85, Evalue=4e-17, Organism=Drosophila melanogaster, GI24639444, Length=260, Percent_Identity=23.0769230769231, Blast_Score=83, Evalue=2e-16, Organism=Drosophila melanogaster, GI17737361, Length=196, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=6e-15, Organism=Drosophila melanogaster, GI21358495, Length=190, Percent_Identity=26.8421052631579, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI24643142, Length=261, Percent_Identity=27.2030651340996, Blast_Score=73, Evalue=1e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.3.1.25 [H]
Molecular weight: Translated: 27896; Mature: 27765
Theoretical pI: Translated: 5.15; Mature: 5.15
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 3.1 %Met (Translated Protein) 3.8 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MALGLLKDKVVVVSGVGPALGTTLARRCAEEGADLVLAARTVERLEDVAKQITDLGRRAV CCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH SVGTDITDEAQVANLVDQSLEAYGRVDVLINNAFRVPSMKPFANTTFEHMRDAIELTVFG HCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH ALRMVQAFTPALAEAKGSVVNVNSMVVRHSQAKYGAYKMAKSALLAMSQTLATELGEQGI HHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC RVNSVAPGYIWGETLKSYFNHQAGKYGTTVEEIYQATAAASDLKRLPTEDEVASAILFMA EECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH SDLSSGITGQTLDVNCGEYKA HHHCCCCCCCEEECCCCCCCC >Mature Secondary Structure ALGLLKDKVVVVSGVGPALGTTLARRCAEEGADLVLAARTVERLEDVAKQITDLGRRAV CCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHH SVGTDITDEAQVANLVDQSLEAYGRVDVLINNAFRVPSMKPFANTTFEHMRDAIELTVFG HCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH ALRMVQAFTPALAEAKGSVVNVNSMVVRHSQAKYGAYKMAKSALLAMSQTLATELGEQGI HHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC RVNSVAPGYIWGETLKSYFNHQAGKYGTTVEEIYQATAAASDLKRLPTEDEVASAILFMA EECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH SDLSSGITGQTLDVNCGEYKA HHHCCCCCCCEEECCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 1740120 [H]