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The map label for this gene is gltP [H]

Identifier: 108801514

GI number: 108801514

Start: 4827017

End: 4828315

Strand: Reverse

Name: gltP [H]

Synonym: Mmcs_4551

Alternate gene names: 108801514

Gene position: 4828315-4827017 (Counterclockwise)

Preceding gene: 108801515

Following gene: 108801513

Centisome position: 84.63

GC content: 63.9

Gene sequence:

>1299_bases
ATGAAGGTCTTGGCCCACCCCGCAGTCCAGATCGGCATCGCCGCAATCGCGGGACTGGCGTTCGGGCTGAGCGTCGGCGA
GTGGGCGGCGAACCTGAAGTTCATCGGGGACATGTTCATCCGACTCATCCAGATGTCGATCGTGCCGCTGGTGATGGCGT
CGGTGATCGTCGCGACCGGCTCGATGAACGGCGCAGGAACAGGCCGGATCGCACTGCGCACGTTCAAGTGGATGCTCGGT
TTCTCCGCCGTCGCAGCGGTCCTGGCCTGGCTGCTCGGCGAACTGATCCGGCCCGGCGCCGGCATGGTCTTCGACGGGGA
ACTGGACTCCGAGCTCGCGGGGTCGGCCGACGAGGCGCTGGGCTGGCAGGAGACGCTACTCAACTTCGTCTCGACGAACA
TCTTCGACGCGATGTCGACCGCGTCGATGGTGCCGATCATCGTGTTCTCGCTGCTGTTCGGACTCGCCCTGCGCACCCAG
ATCAACAAGACCGGCGACACCAGGGTCCTCACCCTCATCGATCAGATTCAGCAGGTCGTGCTCACCATGATCCGGCTGGT
CATGTACATCGCGCCGATCGGCGTGTTCTGTCTGCTGGCGGCGCTGGCCGGCGACGTCGGCTTCGCGGTCGTGACGTCGG
CGCTGAAGTACCTGGGCGCGACCCTGCTCGGCGTGCTCATCCTCTTCGCCTTGTTCGTCGTGGTCGTCACCCTGCGCACG
CGGCTGAACCCGGCGAAGCTGCCCGGCAAGCTCGCCGAGCAGACCGCGATCGCGATCACCACGACGAGTTCGGCGGTGAC
CTTCCCGACGGTGCTGAAGAACACCGTCGAAAAATTCGGGGTCAGCCAGAAGATCGCGAACTTCACGCTGTCGATCGGGT
TGACGATGGGGTCGTACGGAGCCGTGCTCAACTACGTGATCGTCGTCCTGTTCCTCGCCCAGGCGGGCGGCGTCGACTTG
AGTTTCGGTCAGATCGCGTTCGGCATGGGTCTCGCGATCCTGCTCAACATGGGAACGATCACTGTTCCGGGCGGCTTCCC
GGTTGTCGCCATGTTCCTCGCGACGTCACTTGATCTGCCGTTCGAGGCCGTCGGGTTGCTGATCGCCGTCGACTGGTTCG
CCGGCATCTTCCGCACGTTCCTCAACGTGAACGGCGACACCTTCGTCGCGATGCTGGTCGCCAACGCCGATGACGAAATC
GATCGCGACGTCTACAACGGGACGAAGACGATGATCGCCGATGAGATCGATCTCGAAGAGCTCGAAGGCGCGATGGCCCG
TGCCGACGATGCCGACTGA

Upstream 100 bases:

>100_bases
TGCCACCTGCCGGTAGTCACCTCGTCATAGTGTCCGCGCGGTAACACAATCGACGGACCGCGACGCCGGGCCCGTTTCGC
CGCGGTGTTCGGAGGTACGC

Downstream 100 bases:

>100_bases
ACGCCGAGTCGGGCGGGAATCGACCCTGACGCACGTTCGATCGGTTCGACCGTCAAGATGAAGAGATGCCAGCCAGCCCC
CAGAGCCTGTGCGCCTTCAT

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MKVLAHPAVQIGIAAIAGLAFGLSVGEWAANLKFIGDMFIRLIQMSIVPLVMASVIVATGSMNGAGTGRIALRTFKWMLG
FSAVAAVLAWLLGELIRPGAGMVFDGELDSELAGSADEALGWQETLLNFVSTNIFDAMSTASMVPIIVFSLLFGLALRTQ
INKTGDTRVLTLIDQIQQVVLTMIRLVMYIAPIGVFCLLAALAGDVGFAVVTSALKYLGATLLGVLILFALFVVVVTLRT
RLNPAKLPGKLAEQTAIAITTTSSAVTFPTVLKNTVEKFGVSQKIANFTLSIGLTMGSYGAVLNYVIVVLFLAQAGGVDL
SFGQIAFGMGLAILLNMGTITVPGGFPVVAMFLATSLDLPFEAVGLLIAVDWFAGIFRTFLNVNGDTFVAMLVANADDEI
DRDVYNGTKTMIADEIDLEELEGAMARADDAD

Sequences:

>Translated_432_residues
MKVLAHPAVQIGIAAIAGLAFGLSVGEWAANLKFIGDMFIRLIQMSIVPLVMASVIVATGSMNGAGTGRIALRTFKWMLG
FSAVAAVLAWLLGELIRPGAGMVFDGELDSELAGSADEALGWQETLLNFVSTNIFDAMSTASMVPIIVFSLLFGLALRTQ
INKTGDTRVLTLIDQIQQVVLTMIRLVMYIAPIGVFCLLAALAGDVGFAVVTSALKYLGATLLGVLILFALFVVVVTLRT
RLNPAKLPGKLAEQTAIAITTTSSAVTFPTVLKNTVEKFGVSQKIANFTLSIGLTMGSYGAVLNYVIVVLFLAQAGGVDL
SFGQIAFGMGLAILLNMGTITVPGGFPVVAMFLATSLDLPFEAVGLLIAVDWFAGIFRTFLNVNGDTFVAMLVANADDEI
DRDVYNGTKTMIADEIDLEELEGAMARADDAD
>Mature_432_residues
MKVLAHPAVQIGIAAIAGLAFGLSVGEWAANLKFIGDMFIRLIQMSIVPLVMASVIVATGSMNGAGTGRIALRTFKWMLG
FSAVAAVLAWLLGELIRPGAGMVFDGELDSELAGSADEALGWQETLLNFVSTNIFDAMSTASMVPIIVFSLLFGLALRTQ
INKTGDTRVLTLIDQIQQVVLTMIRLVMYIAPIGVFCLLAALAGDVGFAVVTSALKYLGATLLGVLILFALFVVVVTLRT
RLNPAKLPGKLAEQTAIAITTTSSAVTFPTVLKNTVEKFGVSQKIANFTLSIGLTMGSYGAVLNYVIVVLFLAQAGGVDL
SFGQIAFGMGLAILLNMGTITVPGGFPVVAMFLATSLDLPFEAVGLLIAVDWFAGIFRTFLNVNGDTFVAMLVANADDEI
DRDVYNGTKTMIADEIDLEELEGAMARADDAD

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=466, Percent_Identity=24.8927038626609, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI40254478, Length=434, Percent_Identity=24.1935483870968, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI21314632, Length=413, Percent_Identity=24.6973365617433, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI5032093, Length=429, Percent_Identity=27.039627039627, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI223468564, Length=280, Percent_Identity=28.2142857142857, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI223468566, Length=280, Percent_Identity=28.2142857142857, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI4827012, Length=320, Percent_Identity=27.8125, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI194239697, Length=295, Percent_Identity=27.7966101694915, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI66773030, Length=412, Percent_Identity=24.2718446601942, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI262359914, Length=379, Percent_Identity=23.2189973614776, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI301601644, Length=138, Percent_Identity=30.4347826086957, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790514, Length=380, Percent_Identity=30.5263157894737, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1789947, Length=406, Percent_Identity=26.6009852216749, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788024, Length=396, Percent_Identity=25.7575757575758, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17537407, Length=438, Percent_Identity=24.4292237442922, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI193206654, Length=473, Percent_Identity=26.4270613107822, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71983106, Length=425, Percent_Identity=24.9411764705882, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71983099, Length=425, Percent_Identity=24.9411764705882, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI193206505, Length=433, Percent_Identity=24.9422632794457, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71996953, Length=456, Percent_Identity=22.5877192982456, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17541374, Length=407, Percent_Identity=24.5700245700246, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24583025, Length=413, Percent_Identity=25.181598062954, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17137668, Length=413, Percent_Identity=25.181598062954, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24583023, Length=413, Percent_Identity=25.181598062954, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281360481, Length=317, Percent_Identity=29.3375394321767, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281360483, Length=317, Percent_Identity=29.3375394321767, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17137666, Length=317, Percent_Identity=29.3375394321767, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45622; Mature: 45622

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCCCC
>Mature Secondary Structure
MKVLAHPAVQIGIAAIAGLAFGLSVGEWAANLKFIGDMFIRLIQMSIVPLVMASVIVATG
CCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SMNGAGTGRIALRTFKWMLGFSAVAAVLAWLLGELIRPGAGMVFDGELDSELAGSADEAL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHCCCCHHHC
GWQETLLNFVSTNIFDAMSTASMVPIIVFSLLFGLALRTQINKTGDTRVLTLIDQIQQVV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LTMIRLVMYIAPIGVFCLLAALAGDVGFAVVTSALKYLGATLLGVLILFALFVVVVTLRT
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLNPAKLPGKLAEQTAIAITTTSSAVTFPTVLKNTVEKFGVSQKIANFTLSIGLTMGSYG
CCCHHCCCCHHHHCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHEEEECCCCHHH
AVLNYVIVVLFLAQAGGVDLSFGQIAFGMGLAILLNMGTITVPGGFPVVAMFLATSLDLP
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCC
FEAVGLLIAVDWFAGIFRTFLNVNGDTFVAMLVANADDEIDRDVYNGTKTMIADEIDLEE
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHCCCHHHHCCCCCHHH
LEGAMARADDAD
HHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7751298; 9384377 [H]