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The map label for this gene is purM [H]

Identifier: 108801501

GI number: 108801501

Start: 4810144

End: 4811217

Strand: Reverse

Name: purM [H]

Synonym: Mmcs_4538

Alternate gene names: 108801501

Gene position: 4811217-4810144 (Counterclockwise)

Preceding gene: 108801504

Following gene: 108801498

Centisome position: 84.33

GC content: 69.55

Gene sequence:

>1074_bases
ATGACCGAGCGCGCCGAACAACACGGCATTTCCTATGCGTCGGCCGGTGTAGACATCGAGGCCGGTGACCGCGCAGTCGA
ACTCTTCAAACCGCTGGCCGCGAAAGCCACCCGCCCGGAGGTGCGCGGAGGGCTCGGCGGGTTCGCCGGCCTGTTCGCCC
TGCGGGGCGGCTACCGCGAACCGGTGCTGGCGTCCTCGACGGACGGCGTGGGCACCAAGCTCGCCGTCGCACAGGCGATG
GACAAGCACGACACGGTCGGGCTCGACCTGGTCGCGATGGTGGTCGACGACCTGGTGGTCTGCGGCGCCGAACCGCTGTT
CCTGCAGGATTACATCGCCGTCGGGCGCACGGTTCCCGAGCGGGTCAGCCAGCTGGTCGCCGGGATCGCGGAGGGCTGCG
TGATCGCCGGCTGCGCGCTGCTCGGCGGGGAGACCGCCGAACACCCGGGCCTGATGGCGCCGGACCACTACGACATCTCG
GCGACCGGCATCGGCATCGTCGAGGCCGATGACGTGCTGGGCCCCGACCGGGTCCGCCCGGGTGACGTGATCATCGCGAT
GGGGTCCTCGGGCCTGCACTCCAACGGCTACTCACTGGCCCGCAAGGTGCTGCTGGAGATCGACCGGATGAACCTGGCCG
GCCACGTCGAGGAGTTCGGCCGCACCCTGGGCGAGGAACTTCTCGAACCCACGCGCATCTACGCCAAGGACTGCCTCGCG
CTGGCCGCCGAGACCCAGGTACGCACGTTCTGCCACGTCACCGGCGGTGGGCTGGCAGGAAACCTCGAACGCGTGGTCCC
CAACGGTCTGATGGCCGAACTCGACCGCGGCACGTGGACGCCGGCGCCGGTGTTCCAGATGATCGCCCAGCGCGGTCGCA
TCGAGCGCACCGAGATGGAGAAGACCTTCAACATGGGCATCGGCATGGTGGCCGTCGTCGCGCCGGAGGACACCGATCGC
GCGCTGGCCATCCTCACCGCCCGTCACATCGACTGCTGGACGCTCGGGACCGTCAAGAAGGGCGGCAAGGACGAGCCGCG
AGCGCTGCTGGTGGGTCAGCACCCGCGGTTCTGA

Upstream 100 bases:

>100_bases
AACGGTGTCACACCGGTCGCCCTGCTGCGGGGAAACGCGCAGGCAGCGATCGCCGATGGCGTTTACCGTCGCGAAGCCGC
GACCGGTAGCCTTTCCCTCG

Downstream 100 bases:

>100_bases
AACGCGTGGAGGCTAGCGGCGCCAGTCGTCCTCGGGCGCCCACGGGTCGTCGGCTACGCCGTCGCTGGGGTCCAAGTCGT
CGGACCCGCCGGCCAGCTCG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MTERAEQHGISYASAGVDIEAGDRAVELFKPLAAKATRPEVRGGLGGFAGLFALRGGYREPVLASSTDGVGTKLAVAQAM
DKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGRTVPERVSQLVAGIAEGCVIAGCALLGGETAEHPGLMAPDHYDIS
ATGIGIVEADDVLGPDRVRPGDVIIAMGSSGLHSNGYSLARKVLLEIDRMNLAGHVEEFGRTLGEELLEPTRIYAKDCLA
LAAETQVRTFCHVTGGGLAGNLERVVPNGLMAELDRGTWTPAPVFQMIAQRGRIERTEMEKTFNMGIGMVAVVAPEDTDR
ALAILTARHIDCWTLGTVKKGGKDEPRALLVGQHPRF

Sequences:

>Translated_357_residues
MTERAEQHGISYASAGVDIEAGDRAVELFKPLAAKATRPEVRGGLGGFAGLFALRGGYREPVLASSTDGVGTKLAVAQAM
DKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGRTVPERVSQLVAGIAEGCVIAGCALLGGETAEHPGLMAPDHYDIS
ATGIGIVEADDVLGPDRVRPGDVIIAMGSSGLHSNGYSLARKVLLEIDRMNLAGHVEEFGRTLGEELLEPTRIYAKDCLA
LAAETQVRTFCHVTGGGLAGNLERVVPNGLMAELDRGTWTPAPVFQMIAQRGRIERTEMEKTFNMGIGMVAVVAPEDTDR
ALAILTARHIDCWTLGTVKKGGKDEPRALLVGQHPRF
>Mature_356_residues
TERAEQHGISYASAGVDIEAGDRAVELFKPLAAKATRPEVRGGLGGFAGLFALRGGYREPVLASSTDGVGTKLAVAQAMD
KHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGRTVPERVSQLVAGIAEGCVIAGCALLGGETAEHPGLMAPDHYDISA
TGIGIVEADDVLGPDRVRPGDVIIAMGSSGLHSNGYSLARKVLLEIDRMNLAGHVEEFGRTLGEELLEPTRIYAKDCLAL
AAETQVRTFCHVTGGGLAGNLERVVPNGLMAELDRGTWTPAPVFQMIAQRGRIERTEMEKTFNMGIGMVAVVAPEDTDRA
LAILTARHIDCWTLGTVKKGGKDEPRALLVGQHPRF

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=341, Percent_Identity=43.9882697947214, Blast_Score=281, Evalue=7e-76,
Organism=Homo sapiens, GI209869995, Length=341, Percent_Identity=43.9882697947214, Blast_Score=281, Evalue=7e-76,
Organism=Homo sapiens, GI209869993, Length=341, Percent_Identity=43.9882697947214, Blast_Score=281, Evalue=7e-76,
Organism=Escherichia coli, GI1788845, Length=340, Percent_Identity=45.8823529411765, Blast_Score=302, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17567511, Length=346, Percent_Identity=35.2601156069364, Blast_Score=196, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6321203, Length=350, Percent_Identity=40.8571428571429, Blast_Score=266, Evalue=3e-72,
Organism=Drosophila melanogaster, GI24582400, Length=269, Percent_Identity=39.4052044609665, Blast_Score=192, Evalue=2e-49,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37818; Mature: 37687

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERAEQHGISYASAGVDIEAGDRAVELFKPLAAKATRPEVRGGLGGFAGLFALRGGYRE
CCCCHHHHCCEEHHCCCEECCCCHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHCCCCCC
PVLASSTDGVGTKLAVAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGRTVPE
CCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHH
RVSQLVAGIAEGCVIAGCALLGGETAEHPGLMAPDHYDISATGIGIVEADDVLGPDRVRP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCEEEEECCCCCCCCCCCC
GDVIIAMGSSGLHSNGYSLARKVLLEIDRMNLAGHVEEFGRTLGEELLEPTRIYAKDCLA
CCEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAETQVRTFCHVTGGGLAGNLERVVPNGLMAELDRGTWTPAPVFQMIAQRGRIERTEME
HHHHHHHHEEEEECCCCCCCCHHHHCCCCHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHH
KTFNMGIGMVAVVAPEDTDRALAILTARHIDCWTLGTVKKGGKDEPRALLVGQHPRF
HHHCCCCCEEEEECCCCCCCEEEEEEECCCCEEECCCCCCCCCCCCCEEEECCCCCC
>Mature Secondary Structure 
TERAEQHGISYASAGVDIEAGDRAVELFKPLAAKATRPEVRGGLGGFAGLFALRGGYRE
CCCHHHHCCEEHHCCCEECCCCHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHCCCCCC
PVLASSTDGVGTKLAVAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLQDYIAVGRTVPE
CCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHH
RVSQLVAGIAEGCVIAGCALLGGETAEHPGLMAPDHYDISATGIGIVEADDVLGPDRVRP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCEEEEECCCCCCCCCCCC
GDVIIAMGSSGLHSNGYSLARKVLLEIDRMNLAGHVEEFGRTLGEELLEPTRIYAKDCLA
CCEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAETQVRTFCHVTGGGLAGNLERVVPNGLMAELDRGTWTPAPVFQMIAQRGRIERTEME
HHHHHHHHEEEEECCCCCCCCHHHHCCCCHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHH
KTFNMGIGMVAVVAPEDTDRALAILTARHIDCWTLGTVKKGGKDEPRALLVGQHPRF
HHHCCCCCEEEEECCCCCCCEEEEEEECCCCEEECCCCCCCCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA