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The map label for this gene is arsB [H]

Identifier: 108801485

GI number: 108801485

Start: 4799538

End: 4800632

Strand: Reverse

Name: arsB [H]

Synonym: Mmcs_4522

Alternate gene names: 108801485

Gene position: 4800632-4799538 (Counterclockwise)

Preceding gene: 108801486

Following gene: 108801482

Centisome position: 84.14

GC content: 66.58

Gene sequence:

>1095_bases
ATGACTCGGCCGGTCGCGTCCACCGAGACGCCTCAGGTCGTCGCCAAACTCTCGACGCTGGACCGGTTGCTGCCACTGTG
GATCGGCATCGCGATGGCCGCGGGGCTGCTCCTCGGCCGCTGGGTCCCCGGCCTGAACACCGTGGTGGAAAGCATTGCCG
TCGACGGCGTTTCGCTACCCATTGCACTCGGGCTGCTGATCATGATGTACCCGGTGCTGGCCAAGGTCCGCTACGACAGG
CTCGACACCGTCACCGGTGACCGCAAACTCCTCGTGAGCTCGCTGCTCCTGAACTGGGTGCTCGGACCCGCGCTCATGTT
CGCGCTCGCCTGGCTCCTGCTGCCCGACCTGCCGGAGTACCGAACCGGGCTGATCATCGTCGGGCTCGCCCGGTGTATCG
CCATGGTGATCATCTGGAACGACCTCGCCTGCGGGGACCGCGAAGCCGCGGCGGTGCTGGTCGCGCTGAACTCCATCTTC
CAGGTCGTGATGTTCGCGGTGCTCGGATGGTTCTACCTGTCGGTGCTGCCGGGCTGGATCGGGTTGGCGCAGACCACGAT
CGCCACGTCCCCGTGGGACATCGCCAAGTCCGTGCTGATCTTCCTCGGGATTCCACTGCTGGCCGGATACCTGTCCCGGC
GGTTCGGTGAGAAGGCCAGGGGGCGCGAGTGGTACGAGTCGAGGTTCCTGCCGACCGTCGGGCCGTGGGCACTGTACGGT
CTGCTCTTCACCATCGTCATTCTCTTTGCGCTGCAAGGGGATCAGATCACCAACCGGCCACTCGACGTGGTGCGGATCGC
GCTACCCCTGCTGGCGTACTTCGCGATCATGTGGGGCGGCGGATACCTGCTGGGCGCCCTCCTCGGGCTGGGATACGAAC
GCACCACCACGCTGGCATTCACCGCCGCGGGCAACAACTTCGAACTCGCCATCGCCGTCGCGATCGCCACCTACGGGGCC
ACGTCGGGTCAGGCACTCGCCGGTGTTGTCGGTCCGCTCATCGAGGTGCCCGTCCTGGTCGCCCTGGTGTACGTCTCACT
CGCCCTGCGCCGCCGCTTCTCCCGGCCGGTCGGTGTTGTTCGACCGCCGGAGTGA

Upstream 100 bases:

>100_bases
GCGCGTCCTGGGTGTACTACGCCGTGGCCCCTGAGGCGCTGCGCAGTCTTGCGATGCTGTTCGCGATCGATACCCTCGAC
GCGACAGCAGGGGCGAACGC

Downstream 100 bases:

>100_bases
CCGCGAGGTTCACGCCTCGACGGTGACCCCGAGTTCGGCCAGCAGTCCGCGAACCCGGCGTTCGATGTCGTCGCGGATGG
GGCGTACCGCGTCGACTCCC

Product: arsenical-resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MTRPVASTETPQVVAKLSTLDRLLPLWIGIAMAAGLLLGRWVPGLNTVVESIAVDGVSLPIALGLLIMMYPVLAKVRYDR
LDTVTGDRKLLVSSLLLNWVLGPALMFALAWLLLPDLPEYRTGLIIVGLARCIAMVIIWNDLACGDREAAAVLVALNSIF
QVVMFAVLGWFYLSVLPGWIGLAQTTIATSPWDIAKSVLIFLGIPLLAGYLSRRFGEKARGREWYESRFLPTVGPWALYG
LLFTIVILFALQGDQITNRPLDVVRIALPLLAYFAIMWGGGYLLGALLGLGYERTTTLAFTAAGNNFELAIAVAIATYGA
TSGQALAGVVGPLIEVPVLVALVYVSLALRRRFSRPVGVVRPPE

Sequences:

>Translated_364_residues
MTRPVASTETPQVVAKLSTLDRLLPLWIGIAMAAGLLLGRWVPGLNTVVESIAVDGVSLPIALGLLIMMYPVLAKVRYDR
LDTVTGDRKLLVSSLLLNWVLGPALMFALAWLLLPDLPEYRTGLIIVGLARCIAMVIIWNDLACGDREAAAVLVALNSIF
QVVMFAVLGWFYLSVLPGWIGLAQTTIATSPWDIAKSVLIFLGIPLLAGYLSRRFGEKARGREWYESRFLPTVGPWALYG
LLFTIVILFALQGDQITNRPLDVVRIALPLLAYFAIMWGGGYLLGALLGLGYERTTTLAFTAAGNNFELAIAVAIATYGA
TSGQALAGVVGPLIEVPVLVALVYVSLALRRRFSRPVGVVRPPE
>Mature_363_residues
TRPVASTETPQVVAKLSTLDRLLPLWIGIAMAAGLLLGRWVPGLNTVVESIAVDGVSLPIALGLLIMMYPVLAKVRYDRL
DTVTGDRKLLVSSLLLNWVLGPALMFALAWLLLPDLPEYRTGLIIVGLARCIAMVIIWNDLACGDREAAAVLVALNSIFQ
VVMFAVLGWFYLSVLPGWIGLAQTTIATSPWDIAKSVLIFLGIPLLAGYLSRRFGEKARGREWYESRFLPTVGPWALYGL
LFTIVILFALQGDQITNRPLDVVRIALPLLAYFAIMWGGGYLLGALLGLGYERTTTLAFTAAGNNFELAIAVAIATYGAT
SGQALAGVVGPLIEVPVLVALVYVSLALRRRFSRPVGVVRPPE

Specific function: Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump [H]

COG id: COG0798

COG function: function code P; Arsenite efflux pump ACR3 and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ACR3 family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6325459, Length=380, Percent_Identity=35, Blast_Score=191, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004706
- InterPro:   IPR002657 [H]

Pfam domain/function: PF01758 SBF [H]

EC number: NA

Molecular weight: Translated: 39387; Mature: 39255

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPVASTETPQVVAKLSTLDRLLPLWIGIAMAAGLLLGRWVPGLNTVVESIAVDGVSLP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHH
IALGLLIMMYPVLAKVRYDRLDTVTGDRKLLVSSLLLNWVLGPALMFALAWLLLPDLPEY
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
RTGLIIVGLARCIAMVIIWNDLACGDREAAAVLVALNSIFQVVMFAVLGWFYLSVLPGWI
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLAQTTIATSPWDIAKSVLIFLGIPLLAGYLSRRFGEKARGREWYESRFLPTVGPWALYG
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHCCCCCCCHHHHHH
LLFTIVILFALQGDQITNRPLDVVRIALPLLAYFAIMWGGGYLLGALLGLGYERTTTLAF
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHEEEEE
TAAGNNFELAIAVAIATYGATSGQALAGVVGPLIEVPVLVALVYVSLALRRRFSRPVGVV
EECCCCEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
RPPE
CCCC
>Mature Secondary Structure 
TRPVASTETPQVVAKLSTLDRLLPLWIGIAMAAGLLLGRWVPGLNTVVESIAVDGVSLP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHH
IALGLLIMMYPVLAKVRYDRLDTVTGDRKLLVSSLLLNWVLGPALMFALAWLLLPDLPEY
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
RTGLIIVGLARCIAMVIIWNDLACGDREAAAVLVALNSIFQVVMFAVLGWFYLSVLPGWI
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLAQTTIATSPWDIAKSVLIFLGIPLLAGYLSRRFGEKARGREWYESRFLPTVGPWALYG
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHCCCCCCCHHHHHH
LLFTIVILFALQGDQITNRPLDVVRIALPLLAYFAIMWGGGYLLGALLGLGYERTTTLAF
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHEEEEE
TAAGNNFELAIAVAIATYGATSGQALAGVVGPLIEVPVLVALVYVSLALRRRFSRPVGVV
EECCCCEEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
RPPE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7704261; 8969508; 9384377; 7489895; 9537360 [H]