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The map label for this gene is ziaR [H]

Identifier: 108801486

GI number: 108801486

Start: 4800629

End: 4801006

Strand: Reverse

Name: ziaR [H]

Synonym: Mmcs_4523

Alternate gene names: 108801486

Gene position: 4801006-4800629 (Counterclockwise)

Preceding gene: 108801487

Following gene: 108801485

Centisome position: 84.15

GC content: 69.31

Gene sequence:

>378_bases
ATGTCGAATTCGACGCCCATGGAATCGGCGGACCGCTGTGATGTCGCCCCGCTGCTGCGCGAGCCACTGACCCCGGATGC
CGCCGCGCAGATGGCGTCGACGCTCAAGGCGCTCGCCGACCCCGTCCGCCTGCGCCTGTTCAGCGCCATCGCCAGCCGCG
CCGGTGGCGAGGCCTGCGTATGCGACGTCTCCGACGGCATCGACGTCAAGCAGCCGACCATCTCGCACCACCTGAAGGTT
CTGCGCGACGCCGGCCTGCTGACCTCCCAGCGCCGCGCGTCCTGGGTGTACTACGCCGTGGCCCCTGAGGCGCTGCGCAG
TCTTGCGATGCTGTTCGCGATCGATACCCTCGACGCGACAGCAGGGGCGAACGCATGA

Upstream 100 bases:

>100_bases
TGGGATTCGACGTGTCCTCGGTCGACGCCGCGTACGCCGCCGTCGCCGACTGACAAGCCCCCGGTTTGCCTTCTGCATTG
ATCAACGTCAATATCGATGT

Downstream 100 bases:

>100_bases
CTCGGCCGGTCGCGTCCACCGAGACGCCTCAGGTCGTCGCCAAACTCTCGACGCTGGACCGGTTGCTGCCACTGTGGATC
GGCATCGCGATGGCCGCGGG

Product: ArsR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 125; Mature: 124

Protein sequence:

>125_residues
MSNSTPMESADRCDVAPLLREPLTPDAAAQMASTLKALADPVRLRLFSAIASRAGGEACVCDVSDGIDVKQPTISHHLKV
LRDAGLLTSQRRASWVYYAVAPEALRSLAMLFAIDTLDATAGANA

Sequences:

>Translated_125_residues
MSNSTPMESADRCDVAPLLREPLTPDAAAQMASTLKALADPVRLRLFSAIASRAGGEACVCDVSDGIDVKQPTISHHLKV
LRDAGLLTSQRRASWVYYAVAPEALRSLAMLFAIDTLDATAGANA
>Mature_124_residues
SNSTPMESADRCDVAPLLREPLTPDAAAQMASTLKALADPVRLRLFSAIASRAGGEACVCDVSDGIDVKQPTISHHLKVL
RDAGLLTSQRRASWVYYAVAPEALRSLAMLFAIDTLDATAGANA

Specific function: Transcriptional repressor of the expression of the ziaA gene. Controls zinc homeostasis by triggering ziaA-mediated efflux of excess zinc into the periplasm [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH arsR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789916, Length=69, Percent_Identity=40.5797101449275, Blast_Score=61, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001845
- InterPro:   IPR018334
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01022 HTH_5 [H]

EC number: NA

Molecular weight: Translated: 13212; Mature: 13081

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50987 HTH_ARSR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSTPMESADRCDVAPLLREPLTPDAAAQMASTLKALADPVRLRLFSAIASRAGGEACV
CCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
CDVSDGIDVKQPTISHHLKVLRDAGLLTSQRRASWVYYAVAPEALRSLAMLFAIDTLDAT
EECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCC
AGANA
CCCCC
>Mature Secondary Structure 
SNSTPMESADRCDVAPLLREPLTPDAAAQMASTLKALADPVRLRLFSAIASRAGGEACV
CCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
CDVSDGIDVKQPTISHHLKVLRDAGLLTSQRRASWVYYAVAPEALRSLAMLFAIDTLDAT
EECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCC
AGANA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231; 9724772 [H]