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The map label for this gene is moaE2 [H]

Identifier: 108801443

GI number: 108801443

Start: 4759061

End: 4759489

Strand: Reverse

Name: moaE2 [H]

Synonym: Mmcs_4480

Alternate gene names: 108801443

Gene position: 4759489-4759061 (Counterclockwise)

Preceding gene: 108801444

Following gene: 108801438

Centisome position: 83.42

GC content: 70.86

Gene sequence:

>429_bases
ATGACCGCCGTCGTGCACCGTGCCGCCGTGACCGAGGACCCGATCGACCTGACCGAGCACGAAGACCTCGTGTCCCACGA
ATCCGCCGGGGCCGTCGTCAGTTTCGCCGGTGTGGTCCGCGACCACGACGGCGGGCGCGGGGTGGCCCGCCTCGAATACT
CCGCGCATCCCAGCGCCGCGCAGGTCCTCGCGGAGGTCGCCGCCGAGATCGCCGCGGAGTCCGACGGTGTGCGCGCGATC
GCCGTCAGCCACCGCGTGGGACCCCTCGAAATAGGCGACGCCGCCCTGGTGGCCGCTGTGGCAGCGGACCATCGCAGGGC
GGCGTTCGACACCTGTTCCCGGCTCGTCGACGCCGTCAAGGACCGGATACCGGTGTGGAAGCACCAGTTCTTCGGTGACG
GCTCCGACGAGTGGGTGAACTCGGCCTGA

Upstream 100 bases:

>100_bases
ACCTGCCCGGCTCGCCCGGCGGCGTCAGGGACGGACTGTCGGTGCTCGCCGACGTGCTCGACCACGCCCTGGACCAGCTC
GCCGGAAAGGACCATCCGCG

Downstream 100 bases:

>100_bases
CCCGACTCAGGCGGGCGGCAGGACCGGAGCCGGCGCGGGCGCCGGGGCCGGGGCCGGGGCCGGGGCGACAGGAAGGTTCG
GCGGCGGCCCACCCGGGGTG

Product: molybdopterin synthase subunit MoaE

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E 2; Molybdopterin-converting factor large subunit 2; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 142; Mature: 141

Protein sequence:

>142_residues
MTAVVHRAAVTEDPIDLTEHEDLVSHESAGAVVSFAGVVRDHDGGRGVARLEYSAHPSAAQVLAEVAAEIAAESDGVRAI
AVSHRVGPLEIGDAALVAAVAADHRRAAFDTCSRLVDAVKDRIPVWKHQFFGDGSDEWVNSA

Sequences:

>Translated_142_residues
MTAVVHRAAVTEDPIDLTEHEDLVSHESAGAVVSFAGVVRDHDGGRGVARLEYSAHPSAAQVLAEVAAEIAAESDGVRAI
AVSHRVGPLEIGDAALVAAVAADHRRAAFDTCSRLVDAVKDRIPVWKHQFFGDGSDEWVNSA
>Mature_141_residues
TAVVHRAAVTEDPIDLTEHEDLVSHESAGAVVSFAGVVRDHDGGRGVARLEYSAHPSAAQVLAEVAAEIAAESDGVRAIA
VSHRVGPLEIGDAALVAAVAADHRRAAFDTCSRLVDAVKDRIPVWKHQFFGDGSDEWVNSA

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=126, Percent_Identity=30.1587301587302, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1787003, Length=124, Percent_Identity=33.8709677419355, Blast_Score=65, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17509279, Length=127, Percent_Identity=35.4330708661417, Blast_Score=96, Evalue=6e-21,
Organism=Drosophila melanogaster, GI21356259, Length=132, Percent_Identity=30.3030303030303, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 14944; Mature: 14812

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAVVHRAAVTEDPIDLTEHEDLVSHESAGAVVSFAGVVRDHDGGRGVARLEYSAHPSAA
CCCHHHHHHCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHEECCCCCCEEEEECCCCCHHH
QVLAEVAAEIAAESDGVRAIAVSHRVGPLEIGDAALVAAVAADHRRAAFDTCSRLVDAVK
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRIPVWKHQFFGDGSDEWVNSA
HCCCHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TAVVHRAAVTEDPIDLTEHEDLVSHESAGAVVSFAGVVRDHDGGRGVARLEYSAHPSAA
CCHHHHHHCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHEECCCCCCEEEEECCCCCHHH
QVLAEVAAEIAAESDGVRAIAVSHRVGPLEIGDAALVAAVAADHRRAAFDTCSRLVDAVK
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRIPVWKHQFFGDGSDEWVNSA
HCCCHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]