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The map label for this gene is pdxH

Identifier: 108801421

GI number: 108801421

Start: 4740508

End: 4741170

Strand: Reverse

Name: pdxH

Synonym: Mmcs_4458

Alternate gene names: 108801421

Gene position: 4741170-4740508 (Counterclockwise)

Preceding gene: 108801425

Following gene: 108801420

Centisome position: 83.1

GC content: 69.68

Gene sequence:

>663_bases
GTGAAAAAGGCCGACAACGAGCACTTGGCGAGGATGCGCGTGGAGTACGGATCGGTGGAGAAGGACGGCAGCGCCGACCT
CGATGTCGACTGGCTGGCCGACGGCTGGGTTGCCCTGCTGCGCAGGTGGTTAGCCGATGCCGAGGCCGCCGGGATCGCCG
AGCCGAATGCGATCGTGCTCGGGACGGTGGACGCCGGGGGACGGCCGGTCACCCGCACGGTGCTGTGTAAGAGCGTCGAC
GACACCGGCATCACGTTCTTCACCAACTACGGTTCGGCCAAGGGCGAGGATCTGGCGAGCACGCCGTACGCCTCGGCGAC
CTTCCCGTGGTTCGCGCTGGGCCGTCAGGTCCACGTGCGCGGACCGGTGACGAAGGTGTCGGCCGAGGAGACCGCCGACT
ATTGGTCGAAGCGGCCCCGCGGATCGCAGCTCGGCGCGTGGGCATCGCAGCAGTCCAGGCCGATCGCCTCGCGGGCGGAG
CTGCTCGACCAGCTCGCCGAGGTGACCGAGCGGTTCGCTGACCACGACACGGTGCCGGTGCCGCCGGACTGGGGCGGCTA
CCGCATCACGGCCGAGGTCGTGGAGTTCTGGCAGGGCCGGGAGAGCCGCGTCCACAACAGGATCCGCGTCCACGACGGCC
GCATCGAGCGGCTGCAACCGTAG

Upstream 100 bases:

>100_bases
CGACGAAATTCTCCGGCACCGACGGCGACGTCTGAGTCATGGCCAGATTCTCGCACCCACAGCAAGTGCCGGACGGACCG
GTCGGCGTAGCGTTGGCGCG

Downstream 100 bases:

>100_bases
GGATTCCCGCCGGGTAGCGGATCAGGCCGCGATGGTGACCGGCCGCGACAGATGGTTAACATCGGCGAATTTCACCGGAT
GTCAAGATCAACTGCTTTTT

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MKKADNEHLARMRVEYGSVEKDGSADLDVDWLADGWVALLRRWLADAEAAGIAEPNAIVLGTVDAGGRPVTRTVLCKSVD
DTGITFFTNYGSAKGEDLASTPYASATFPWFALGRQVHVRGPVTKVSAEETADYWSKRPRGSQLGAWASQQSRPIASRAE
LLDQLAEVTERFADHDTVPVPPDWGGYRITAEVVEFWQGRESRVHNRIRVHDGRIERLQP

Sequences:

>Translated_220_residues
MKKADNEHLARMRVEYGSVEKDGSADLDVDWLADGWVALLRRWLADAEAAGIAEPNAIVLGTVDAGGRPVTRTVLCKSVD
DTGITFFTNYGSAKGEDLASTPYASATFPWFALGRQVHVRGPVTKVSAEETADYWSKRPRGSQLGAWASQQSRPIASRAE
LLDQLAEVTERFADHDTVPVPPDWGGYRITAEVVEFWQGRESRVHNRIRVHDGRIERLQP
>Mature_220_residues
MKKADNEHLARMRVEYGSVEKDGSADLDVDWLADGWVALLRRWLADAEAAGIAEPNAIVLGTVDAGGRPVTRTVLCKSVD
DTGITFFTNYGSAKGEDLASTPYASATFPWFALGRQVHVRGPVTKVSAEETADYWSKRPRGSQLGAWASQQSRPIASRAE
LLDQLAEVTERFADHDTVPVPPDWGGYRITAEVVEFWQGRESRVHNRIRVHDGRIERLQP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=172, Percent_Identity=41.8604651162791, Blast_Score=138, Evalue=3e-33,
Organism=Escherichia coli, GI1787926, Length=227, Percent_Identity=40.0881057268723, Blast_Score=160, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17553712, Length=179, Percent_Identity=36.3128491620112, Blast_Score=114, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6319509, Length=185, Percent_Identity=40, Blast_Score=134, Evalue=1e-32,
Organism=Drosophila melanogaster, GI45551845, Length=206, Percent_Identity=42.2330097087379, Blast_Score=153, Evalue=9e-38,
Organism=Drosophila melanogaster, GI24644901, Length=206, Percent_Identity=42.2330097087379, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24644903, Length=167, Percent_Identity=29.940119760479, Blast_Score=81, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_MYCSK (A1ULM8)

Other databases:

- EMBL:   CP000518
- RefSeq:   YP_940526.1
- ProteinModelPortal:   A1ULM8
- SMR:   A1ULM8
- STRING:   A1ULM8
- EnsemblBacteria:   EBMYCT00000054959
- GeneID:   4612489
- GenomeReviews:   CP000518_GR
- KEGG:   mkm:Mkms_4545
- eggNOG:   COG0259
- GeneTree:   EBGT00050000017296
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- ProtClustDB:   PRK05679
- BioCyc:   MSP189918:MKMS_4545-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 24387; Mature: 24387

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 72-72 BINDING 75-75 BINDING 77-77 BINDING 94-94 BINDING 134-134 BINDING 138-138 BINDING 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKADNEHLARMRVEYGSVEKDGSADLDVDWLADGWVALLRRWLADAEAAGIAEPNAIVL
CCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
GTVDAGGRPVTRTVLCKSVDDTGITFFTNYGSAKGEDLASTPYASATFPWFALGRQVHVR
EECCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHCCEEEEC
GPVTKVSAEETADYWSKRPRGSQLGAWASQQSRPIASRAELLDQLAEVTERFADHDTVPV
CCCEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
PPDWGGYRITAEVVEFWQGRESRVHNRIRVHDGRIERLQP
CCCCCCEEEHHHHHHHHCCHHHHHHCEEEECCCCCCCCCC
>Mature Secondary Structure
MKKADNEHLARMRVEYGSVEKDGSADLDVDWLADGWVALLRRWLADAEAAGIAEPNAIVL
CCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
GTVDAGGRPVTRTVLCKSVDDTGITFFTNYGSAKGEDLASTPYASATFPWFALGRQVHVR
EECCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHHHCCEEEEC
GPVTKVSAEETADYWSKRPRGSQLGAWASQQSRPIASRAELLDQLAEVTERFADHDTVPV
CCCEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
PPDWGGYRITAEVVEFWQGRESRVHNRIRVHDGRIERLQP
CCCCCCEEEHHHHHHHHCCHHHHHHCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA