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The map label for this gene is tcmR [H]

Identifier: 108801420

GI number: 108801420

Start: 4739733

End: 4740380

Strand: Reverse

Name: tcmR [H]

Synonym: Mmcs_4457

Alternate gene names: 108801420

Gene position: 4740380-4739733 (Counterclockwise)

Preceding gene: 108801421

Following gene: 108801419

Centisome position: 83.09

GC content: 68.67

Gene sequence:

>648_bases
GTGGTTGATCTCGACGGCGCCCCGGTTCTCGGGCTGCGCGAGCGCAAGAAACAGCGCACCCGAACCACCCTGATCAACGC
CGCCGTCGAACTGTGCGACCGGCAGGGTTTCGAGAACACCACCGTCGACCAGATCGCCGCGGTCGCCGACGTCTCGCCGC
GGACCTTCAGCCGGTACTTCGCGACCAAGGAAGCGGTGGTGCTGGCCGTCATCGACGACATCATCGAGATCGTCGCGGTC
GAACTCCGCAGGCAACCGCCGGACATCAGCCACCTCGAGGCGATCTTCCGCAGCCACATCCACGCGTTCAACGCCACCAA
GCGGGCCCCGCCGACGGGGCTGACCGAGGAGCGGCTGCTCGCGTCGGCGCGCATCGTGACGTCGTCGGAAACCCTCATAC
ACGCGGCCACCCGGTTCCGGCTGGACGCGGTGAACGCCGCGCTCGTCGAGCGTATGGGTACCGCACCCGACGACCGGCGG
CTGCAACTGGTGGCCGCGGTGTGGGGCGCGATCATGATGGCCGCACTCGCCGACCTCGGGCCCGTCGCCGACTGGGGCAC
GATGACCGCCGACGGCATCGTGTCCCGGATCGAGCTGGCGTATGCCCAGTTCCTCGACGTGACCGCCGACGTCAAGCAGC
TGGTCTGA

Upstream 100 bases:

>100_bases
CGCGATGGTGACCGGCCGCGACAGATGGTTAACATCGGCGAATTTCACCGGATGTCAAGATCAACTGCTTTTTGTCCCAG
CTCGGACTAGCATCCGAGGA

Downstream 100 bases:

>100_bases
GCAACTGCCCGCCCCCCGCAAGCACGTCCGTCACGATGGGGCTACCTTTTGTAGACGAGGGTCTGCACCTGCGGAGCGAC
GATGAAGGGATTCCCGTGGC

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Tetracenomycin C transcriptional repressor [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MVDLDGAPVLGLRERKKQRTRTTLINAAVELCDRQGFENTTVDQIAAVADVSPRTFSRYFATKEAVVLAVIDDIIEIVAV
ELRRQPPDISHLEAIFRSHIHAFNATKRAPPTGLTEERLLASARIVTSSETLIHAATRFRLDAVNAALVERMGTAPDDRR
LQLVAAVWGAIMMAALADLGPVADWGTMTADGIVSRIELAYAQFLDVTADVKQLV

Sequences:

>Translated_215_residues
MVDLDGAPVLGLRERKKQRTRTTLINAAVELCDRQGFENTTVDQIAAVADVSPRTFSRYFATKEAVVLAVIDDIIEIVAV
ELRRQPPDISHLEAIFRSHIHAFNATKRAPPTGLTEERLLASARIVTSSETLIHAATRFRLDAVNAALVERMGTAPDDRR
LQLVAAVWGAIMMAALADLGPVADWGTMTADGIVSRIELAYAQFLDVTADVKQLV
>Mature_215_residues
MVDLDGAPVLGLRERKKQRTRTTLINAAVELCDRQGFENTTVDQIAAVADVSPRTFSRYFATKEAVVLAVIDDIIEIVAV
ELRRQPPDISHLEAIFRSHIHAFNATKRAPPTGLTEERLLASARIVTSSETLIHAATRFRLDAVNAALVERMGTAPDDRR
LQLVAAVWGAIMMAALADLGPVADWGTMTADGIVSRIELAYAQFLDVTADVKQLV

Specific function: Represses transcription of the divergently oriented tcmR and tcmA (tetracenomycin C resistance and export) genes by binding to an intergenic operator region. This binding is inhibited by tetracenomycin C [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23501; Mature: 23501

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDLDGAPVLGLRERKKQRTRTTLINAAVELCDRQGFENTTVDQIAAVADVSPRTFSRYF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHH
ATKEAVVLAVIDDIIEIVAVELRRQPPDISHLEAIFRSHIHAFNATKRAPPTGLTEERLL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
ASARIVTSSETLIHAATRFRLDAVNAALVERMGTAPDDRRLQLVAAVWGAIMMAALADLG
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
PVADWGTMTADGIVSRIELAYAQFLDVTADVKQLV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVDLDGAPVLGLRERKKQRTRTTLINAAVELCDRQGFENTTVDQIAAVADVSPRTFSRYF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHH
ATKEAVVLAVIDDIIEIVAVELRRQPPDISHLEAIFRSHIHAFNATKRAPPTGLTEERLL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
ASARIVTSSETLIHAATRFRLDAVNAALVERMGTAPDDRRLQLVAAVWGAIMMAALADLG
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
PVADWGTMTADGIVSRIELAYAQFLDVTADVKQLV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1592819; 1592820 [H]