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The map label for this gene is gltA [H]

Identifier: 108801419

GI number: 108801419

Start: 4738333

End: 4739637

Strand: Reverse

Name: gltA [H]

Synonym: Mmcs_4456

Alternate gene names: 108801419

Gene position: 4739637-4738333 (Counterclockwise)

Preceding gene: 108801420

Following gene: 108801418

Centisome position: 83.07

GC content: 64.67

Gene sequence:

>1305_bases
GTGGCCGATAATCCGTCCAGTGCAACTGAGCACGCCAAGCTGAGCTACCCCGGCGGCGAGCTCGAGCTGGATATCGTCCC
GGCCACCGACGGTGCCGACGGCATCGCGCTGGGGTCGCTGCTGGCGAAGACCGGCTACACCACTTTCGACGGCGGATTCG
TCAACACCGCATCGACGAAGAGTGCGATCACCTACATCGACGGCGACGCCGGCATCCTGCGCTACCGGGGTTATCCCATC
GAGCAGCTGGCCGAGAAGTCGACGTTCATCGAGGTGAGCTACCTGCTCATCTACGGTGAGCTGCCGACCGCCGACCAGCT
CGAGGACTTCACCACCAAGATCCAGCGGCACACCCTGCTGCACGAGGATCTCAAGCGGTTCTTCGACGGGTTCCCGCGCA
ACGCCCACCCGATGCCGGTGCTCTCGAGTGCGGTCAACGCGTTGAGCGCGTACTACCAGGACTCGCTCGACCCGATGGAC
AAGAACCAGGTCGAACTGTCCACGATCCGGCTGCTGGCCAAGCTGCCGACCATCGCGGCCTACGCGTACAAGAAGTCCGA
GGGGCAGCCGTTCCTGTACCCGGACAACTCGCTGACGCTGGTCGAGAACTTCCTGCGGATGACGTTCGGCTTCCCGGCCG
AGCCCTACGAGGTCGACCCGGAGATCGTGCGGGCACTCGACATGCTGCTGATCCTGCACGCCGACCACGAGCAGAACTGC
TCGACGTCGACGGTCCGGCTGGTGGGTTCCTCGCAGGCCAACCTGTTCACCTCGATCTCGGGCGGCATCAATGCGCTGTG
GGGCCCGCTGCACGGCGGCGCCAACCAGGCGGTGCTGGAGATGTTGACCAAGATCCAGAAGTCCGATGGTGACGTCCGCG
AGTTCGTGCGCAAGGTCAAGGACCGCGAGGACGGCGTGAAGCTGATGGGCTTCGGTCACCGCGTCTACAAGAACTACGAT
CCGCGCGCCCGCATCGTCAAGGAGCAGGCCGACAAGATCCTCGGCAAGATGGGCGTCGAGGACGAACTGCTCGACATCGC
GAAGTCGCTCGAAGAGGTGGCGCTGACCGACGACTTCTTCGTCGAGCGCAAGCTGTACCCGAACGTCGACTTCTACACCG
GCGTGATCTACCGGGCGATGGGCTTCCCGACGCGGATGTTCACCGTGCTGTTCGCGCTGGGCCGGCTGCCCGGCTGGATC
GCGCACTGGCGGGAGATGCACTCCGAGCCCGGCAAGATCGGCCGCCCCCGGCAGATCTACACCGGCTACACCGAGCGCGA
CTACATCGACACCGACAAGCGCTGA

Upstream 100 bases:

>100_bases
TCTGAGCAACTGCCCGCCCCCCGCAAGCACGTCCGTCACGATGGGGCTACCTTTTGTAGACGAGGGTCTGCACCTGCGGA
GCGACGATGAAGGGATTCCC

Downstream 100 bases:

>100_bases
CCTCGCCACTTCCGTCGATTTCGGCGCTGGTTTGCCTTGCGAACAGTTGTAGTTTCACAATGGTTGGGTGATTGAAACCG
TCGGCATGAGCGCACGGCGC

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MADNPSSATEHAKLSYPGGELELDIVPATDGADGIALGSLLAKTGYTTFDGGFVNTASTKSAITYIDGDAGILRYRGYPI
EQLAEKSTFIEVSYLLIYGELPTADQLEDFTTKIQRHTLLHEDLKRFFDGFPRNAHPMPVLSSAVNALSAYYQDSLDPMD
KNQVELSTIRLLAKLPTIAAYAYKKSEGQPFLYPDNSLTLVENFLRMTFGFPAEPYEVDPEIVRALDMLLILHADHEQNC
STSTVRLVGSSQANLFTSISGGINALWGPLHGGANQAVLEMLTKIQKSDGDVREFVRKVKDREDGVKLMGFGHRVYKNYD
PRARIVKEQADKILGKMGVEDELLDIAKSLEEVALTDDFFVERKLYPNVDFYTGVIYRAMGFPTRMFTVLFALGRLPGWI
AHWREMHSEPGKIGRPRQIYTGYTERDYIDTDKR

Sequences:

>Translated_434_residues
MADNPSSATEHAKLSYPGGELELDIVPATDGADGIALGSLLAKTGYTTFDGGFVNTASTKSAITYIDGDAGILRYRGYPI
EQLAEKSTFIEVSYLLIYGELPTADQLEDFTTKIQRHTLLHEDLKRFFDGFPRNAHPMPVLSSAVNALSAYYQDSLDPMD
KNQVELSTIRLLAKLPTIAAYAYKKSEGQPFLYPDNSLTLVENFLRMTFGFPAEPYEVDPEIVRALDMLLILHADHEQNC
STSTVRLVGSSQANLFTSISGGINALWGPLHGGANQAVLEMLTKIQKSDGDVREFVRKVKDREDGVKLMGFGHRVYKNYD
PRARIVKEQADKILGKMGVEDELLDIAKSLEEVALTDDFFVERKLYPNVDFYTGVIYRAMGFPTRMFTVLFALGRLPGWI
AHWREMHSEPGKIGRPRQIYTGYTERDYIDTDKR
>Mature_433_residues
ADNPSSATEHAKLSYPGGELELDIVPATDGADGIALGSLLAKTGYTTFDGGFVNTASTKSAITYIDGDAGILRYRGYPIE
QLAEKSTFIEVSYLLIYGELPTADQLEDFTTKIQRHTLLHEDLKRFFDGFPRNAHPMPVLSSAVNALSAYYQDSLDPMDK
NQVELSTIRLLAKLPTIAAYAYKKSEGQPFLYPDNSLTLVENFLRMTFGFPAEPYEVDPEIVRALDMLLILHADHEQNCS
TSTVRLVGSSQANLFTSISGGINALWGPLHGGANQAVLEMLTKIQKSDGDVREFVRKVKDREDGVKLMGFGHRVYKNYDP
RARIVKEQADKILGKMGVEDELLDIAKSLEEVALTDDFFVERKLYPNVDFYTGVIYRAMGFPTRMFTVLFALGRLPGWIA
HWREMHSEPGKIGRPRQIYTGYTERDYIDTDKR

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=391, Percent_Identity=30.4347826086957, Blast_Score=132, Evalue=5e-31,
Organism=Escherichia coli, GI1786939, Length=428, Percent_Identity=53.9719626168224, Blast_Score=486, Evalue=1e-138,
Organism=Escherichia coli, GI1786527, Length=381, Percent_Identity=32.8083989501312, Blast_Score=191, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI17555174, Length=394, Percent_Identity=29.6954314720812, Blast_Score=124, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6319850, Length=343, Percent_Identity=28.2798833819242, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324328, Length=388, Percent_Identity=28.0927835051546, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6325257, Length=411, Percent_Identity=24.8175182481752, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24640126, Length=413, Percent_Identity=30.7506053268765, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24640124, Length=413, Percent_Identity=30.7506053268765, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21356863, Length=386, Percent_Identity=27.979274611399, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48595; Mature: 48464

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADNPSSATEHAKLSYPGGELELDIVPATDGADGIALGSLLAKTGYTTFDGGFVNTASTK
CCCCCCCCCCCCEEECCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCC
SAITYIDGDAGILRYRGYPIEQLAEKSTFIEVSYLLIYGELPTADQLEDFTTKIQRHTLL
CEEEEEECCCCEEEECCCCHHHHHCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
HEDLKRFFDGFPRNAHPMPVLSSAVNALSAYYQDSLDPMDKNQVELSTIRLLAKLPTIAA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHH
YAYKKSEGQPFLYPDNSLTLVENFLRMTFGFPAEPYEVDPEIVRALDMLLILHADHEQNC
HHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEECCCCCCC
STSTVRLVGSSQANLFTSISGGINALWGPLHGGANQAVLEMLTKIQKSDGDVREFVRKVK
CCCEEEEECCCCCCEEEECCCCHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
DREDGVKLMGFGHRVYKNYDPRARIVKEQADKILGKMGVEDELLDIAKSLEEVALTDDFF
CCCCCEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHH
VERKLYPNVDFYTGVIYRAMGFPTRMFTVLFALGRLPGWIAHWREMHSEPGKIGRPRQIY
HHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEE
TGYTERDYIDTDKR
ECCCCCCCCCCCCC
>Mature Secondary Structure 
ADNPSSATEHAKLSYPGGELELDIVPATDGADGIALGSLLAKTGYTTFDGGFVNTASTK
CCCCCCCCCCCEEECCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCC
SAITYIDGDAGILRYRGYPIEQLAEKSTFIEVSYLLIYGELPTADQLEDFTTKIQRHTLL
CEEEEEECCCCEEEECCCCHHHHHCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHH
HEDLKRFFDGFPRNAHPMPVLSSAVNALSAYYQDSLDPMDKNQVELSTIRLLAKLPTIAA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHH
YAYKKSEGQPFLYPDNSLTLVENFLRMTFGFPAEPYEVDPEIVRALDMLLILHADHEQNC
HHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEECCCCCCC
STSTVRLVGSSQANLFTSISGGINALWGPLHGGANQAVLEMLTKIQKSDGDVREFVRKVK
CCCEEEEECCCCCCEEEECCCCHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
DREDGVKLMGFGHRVYKNYDPRARIVKEQADKILGKMGVEDELLDIAKSLEEVALTDDFF
CCCCCEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHH
VERKLYPNVDFYTGVIYRAMGFPTRMFTVLFALGRLPGWIAHWREMHSEPGKIGRPRQIY
HHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEE
TGYTERDYIDTDKR
ECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]