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The map label for this gene is oxc [H]

Identifier: 108801359

GI number: 108801359

Start: 4674119

End: 4675834

Strand: Reverse

Name: oxc [H]

Synonym: Mmcs_4396

Alternate gene names: 108801359

Gene position: 4675834-4674119 (Counterclockwise)

Preceding gene: 108801360

Following gene: 108801358

Centisome position: 81.95

GC content: 67.54

Gene sequence:

>1716_bases
ATGGGTGTCCCCGTCTACAAACGCATTCTCGACCTGTTCGAGGCCGAGGGTGTGAACACGTTGTTCGGCATCCCGGATCC
GAACTTCGTGCACATGTTCACCGAGGCCGAGGCGCGCGGATGGTCGGTGGTGGCACCGCATCACGAGCTGAGCGCCGGGT
TCATGGCCGAGGCGGCGTCCCGGATGACCGGTAAGCCGGGATTGTGCATCGGCACGCTTGGGCCGGGTGTGGCCAACATC
GCGGGCGCGATGATGTGCGCGCTGGTGGAGAACTCACCGGTGATCTTCCTCGGTGGGCAGCGCGCCCGCATCACCGAACG
GCGGGTGCGCCGCGGCCGCATCCAATTCGTCCAGCAGGAAGGCCTTTTCACGCCTTCGGTCAAGTTCAGCAGCTCGATCG
AATACGCCGACCAGACCGACGAGATCATCCGGGAGGCGATCCGCCGCTCGATGTCGGGCACACCGGGACCGAGCTACATC
GAGTACCCGTCGCACGTCATCCTCGAAGAGCTCGACGTGCCCGAGCCGTTGCCGCCCAACCGTTATCGTCTGGTCAACCA
GGGTGCCGGTGAGCGCGAGATCGCCGAGGCCGCCACCCTGATCCGCGAGGCGAAGAGCCCGATCCTGTTGGTGGGCCACG
GCGTTCACACCTCCCGCACCCAGGAACAGGTCAGGGAGCTGGCCGAGCTGATGGCGTGCCCGGTGATCCAGACCTCGGGT
GGGACCTCGTTCATCCCGGGCCTGGAGGACCGGACCTTCCCGTACCTGTTCTCCCCGGCCGCCAACGAGGCCGTCGAGCA
GTCCGACCTGTGCGTGGCGCTGGGCACCGAACTCGGTGAGCCGATGCACTACGGCCGCACGCAGCACTGGGCCGGCAACG
ACGCCAACCGCAAGTGGGTCTACGTCGAGCAGGATCCGACCGCGATCGGCGTGAACCGGCAGTTCGACGTCCCCCTGGTC
GGCGATCTGCGTGGGGTGGTGCCGCAACTGGTCGACGCGCTACGGGACGCCCCGCGCACCCCGTCGGCCACACTGGAGTC
CCTGGTCGAAGCCGACGCCGCCGAGATCGCCCGGGTGGCCGAGGAGGCTCCGAGCGGTCGCACCCCGGTCCATCCGGCCC
GCTTCGTCGTCGAGGCCACCAAGGCCTTCAACGAGTACGCCGAGGACGGCATCATGGTCCGCGACGGCGGCGCCACCGTG
ATCTTCCAGTGGACCTACTCGCAGGCCAAACCGCGCGACGTCATCTGGAACCAGAACTTCGGTCACCTCGGCACGGGCCT
GCCGTATGCCGTCGGTGCGTCGGTCGCCGAGGGCCGCAAGCGACCGGTCATGCTGCTCACCAGCGACTCGGCGTTCCTGT
TCCACATCGCCGAACTGGAGACCGCCGCCCGCGAGGGCCTGCCGCTGGTCTGCGTGGTCGGCGTCGACCACCAGTGGGGT
CTCGAAGTGGGCGTCTACAAGCGCACATTCGAGCAGCCGTCGCCGCAGCCCGGTGTGCACTGGAGCAAGGACGTCCGGAT
GGACAAGATCGCCGAGGGCTTCGGCTGCCACGGCGAGTTCGTCGAGAAGGACGACGAGATCGGCCCGGCGATCCAGCGGG
CGTACGCCAGCGGGAAGACCGCCGTCGTGCACGTCTGCATCGATCCGAAGGCCAACTCCGAGGAGATGCCGAAGTACGAC
CGATTCCGCACCTGGTATGCAGAAGGCACCCAGTAG

Upstream 100 bases:

>100_bases
TATCTCAAACGTGCCGCGCTCAACCGCTCGCTGTTCGGATCCCCTGCGGCACACCGCAGACAACTCGCTCAACGCTATCG
GAATCAAGGAGAGTAATTCC

Downstream 100 bases:

>100_bases
GCAGGCGATCTAGGGGAGAGTGAACCCATGCGCGAGTATCTGAAGTTCTACATCGACGGCCAATGGGTCGACCCGCTCCG
TCCGAACGCCCTCGAGGTCG

Product: thiamine pyrophosphate enzyme-like TPP-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 571; Mature: 570

Protein sequence:

>571_residues
MGVPVYKRILDLFEAEGVNTLFGIPDPNFVHMFTEAEARGWSVVAPHHELSAGFMAEAASRMTGKPGLCIGTLGPGVANI
AGAMMCALVENSPVIFLGGQRARITERRVRRGRIQFVQQEGLFTPSVKFSSSIEYADQTDEIIREAIRRSMSGTPGPSYI
EYPSHVILEELDVPEPLPPNRYRLVNQGAGEREIAEAATLIREAKSPILLVGHGVHTSRTQEQVRELAELMACPVIQTSG
GTSFIPGLEDRTFPYLFSPAANEAVEQSDLCVALGTELGEPMHYGRTQHWAGNDANRKWVYVEQDPTAIGVNRQFDVPLV
GDLRGVVPQLVDALRDAPRTPSATLESLVEADAAEIARVAEEAPSGRTPVHPARFVVEATKAFNEYAEDGIMVRDGGATV
IFQWTYSQAKPRDVIWNQNFGHLGTGLPYAVGASVAEGRKRPVMLLTSDSAFLFHIAELETAAREGLPLVCVVGVDHQWG
LEVGVYKRTFEQPSPQPGVHWSKDVRMDKIAEGFGCHGEFVEKDDEIGPAIQRAYASGKTAVVHVCIDPKANSEEMPKYD
RFRTWYAEGTQ

Sequences:

>Translated_571_residues
MGVPVYKRILDLFEAEGVNTLFGIPDPNFVHMFTEAEARGWSVVAPHHELSAGFMAEAASRMTGKPGLCIGTLGPGVANI
AGAMMCALVENSPVIFLGGQRARITERRVRRGRIQFVQQEGLFTPSVKFSSSIEYADQTDEIIREAIRRSMSGTPGPSYI
EYPSHVILEELDVPEPLPPNRYRLVNQGAGEREIAEAATLIREAKSPILLVGHGVHTSRTQEQVRELAELMACPVIQTSG
GTSFIPGLEDRTFPYLFSPAANEAVEQSDLCVALGTELGEPMHYGRTQHWAGNDANRKWVYVEQDPTAIGVNRQFDVPLV
GDLRGVVPQLVDALRDAPRTPSATLESLVEADAAEIARVAEEAPSGRTPVHPARFVVEATKAFNEYAEDGIMVRDGGATV
IFQWTYSQAKPRDVIWNQNFGHLGTGLPYAVGASVAEGRKRPVMLLTSDSAFLFHIAELETAAREGLPLVCVVGVDHQWG
LEVGVYKRTFEQPSPQPGVHWSKDVRMDKIAEGFGCHGEFVEKDDEIGPAIQRAYASGKTAVVHVCIDPKANSEEMPKYD
RFRTWYAEGTQ
>Mature_570_residues
GVPVYKRILDLFEAEGVNTLFGIPDPNFVHMFTEAEARGWSVVAPHHELSAGFMAEAASRMTGKPGLCIGTLGPGVANIA
GAMMCALVENSPVIFLGGQRARITERRVRRGRIQFVQQEGLFTPSVKFSSSIEYADQTDEIIREAIRRSMSGTPGPSYIE
YPSHVILEELDVPEPLPPNRYRLVNQGAGEREIAEAATLIREAKSPILLVGHGVHTSRTQEQVRELAELMACPVIQTSGG
TSFIPGLEDRTFPYLFSPAANEAVEQSDLCVALGTELGEPMHYGRTQHWAGNDANRKWVYVEQDPTAIGVNRQFDVPLVG
DLRGVVPQLVDALRDAPRTPSATLESLVEADAAEIARVAEEAPSGRTPVHPARFVVEATKAFNEYAEDGIMVRDGGATVI
FQWTYSQAKPRDVIWNQNFGHLGTGLPYAVGASVAEGRKRPVMLLTSDSAFLFHIAELETAAREGLPLVCVVGVDHQWGL
EVGVYKRTFEQPSPQPGVHWSKDVRMDKIAEGFGCHGEFVEKDDEIGPAIQRAYASGKTAVVHVCIDPKANSEEMPKYDR
FRTWYAEGTQ

Specific function: Oxalic acid catabolism; second step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=565, Percent_Identity=23.8938053097345, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI21361361, Length=561, Percent_Identity=24.9554367201426, Blast_Score=127, Evalue=3e-29,
Organism=Escherichia coli, GI1788716, Length=554, Percent_Identity=25.9927797833935, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1790104, Length=563, Percent_Identity=25.2220248667851, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1786717, Length=546, Percent_Identity=26.3736263736264, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87081685, Length=498, Percent_Identity=24.2971887550201, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1787096, Length=564, Percent_Identity=21.2765957446809, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17542570, Length=589, Percent_Identity=24.1086587436333, Blast_Score=135, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17531301, Length=582, Percent_Identity=24.5704467353952, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17531299, Length=582, Percent_Identity=24.5704467353952, Blast_Score=125, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6320816, Length=558, Percent_Identity=24.1935483870968, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6323755, Length=561, Percent_Identity=23.1729055258467, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19922626, Length=577, Percent_Identity=24.263431542461, Blast_Score=146, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017660
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =4.1.1.8 [H]

Molecular weight: Translated: 62591; Mature: 62459

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVPVYKRILDLFEAEGVNTLFGIPDPNFVHMFTEAEARGWSVVAPHHELSAGFMAEAAS
CCCHHHHHHHHHHHCCCCCEEECCCCCCEEEEEECCCCCCCEEECCCHHHHHHHHHHHHH
RMTGKPGLCIGTLGPGVANIAGAMMCALVENSPVIFLGGQRARITERRVRRGRIQFVQQE
HHCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHC
GLFTPSVKFSSSIEYADQTDEIIREAIRRSMSGTPGPSYIEYPSHVILEELDVPEPLPPN
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCC
RYRLVNQGAGEREIAEAATLIREAKSPILLVGHGVHTSRTQEQVRELAELMACPVIQTSG
CEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEECC
GTSFIPGLEDRTFPYLFSPAANEAVEQSDLCVALGTELGEPMHYGRTQHWAGNDANRKWV
CCCCCCCCCCCCCCEEECCCHHHHHHHCCEEEEECHHCCCCHHCCCCCCCCCCCCCCEEE
YVEQDPTAIGVNRQFDVPLVGDLRGVVPQLVDALRDAPRTPSATLESLVEADAAEIARVA
EEECCCCEECCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
EEAPSGRTPVHPARFVVEATKAFNEYAEDGIMVRDGGATVIFQWTYSQAKPRDVIWNQNF
HHCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEEECCCCCCCCEEECCCC
GHLGTGLPYAVGASVAEGRKRPVMLLTSDSAFLFHIAELETAAREGLPLVCVVGVDHQWG
CCCCCCCCHHHCCHHHCCCCCCEEEEECCCEEEEEHHHHHHHHHCCCCEEEEEECCCCCC
LEVGVYKRTFEQPSPQPGVHWSKDVRMDKIAEGFGCHGEFVEKDDEIGPAIQRAYASGKT
CEEHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHCCCCCCCHHHHHHHCCCCE
AVVHVCIDPKANSEEMPKYDRFRTWYAEGTQ
EEEEEEECCCCCCCCCCCHHHHEEHCCCCCC
>Mature Secondary Structure 
GVPVYKRILDLFEAEGVNTLFGIPDPNFVHMFTEAEARGWSVVAPHHELSAGFMAEAAS
CCHHHHHHHHHHHCCCCCEEECCCCCCEEEEEECCCCCCCEEECCCHHHHHHHHHHHHH
RMTGKPGLCIGTLGPGVANIAGAMMCALVENSPVIFLGGQRARITERRVRRGRIQFVQQE
HHCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHC
GLFTPSVKFSSSIEYADQTDEIIREAIRRSMSGTPGPSYIEYPSHVILEELDVPEPLPPN
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCC
RYRLVNQGAGEREIAEAATLIREAKSPILLVGHGVHTSRTQEQVRELAELMACPVIQTSG
CEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEECC
GTSFIPGLEDRTFPYLFSPAANEAVEQSDLCVALGTELGEPMHYGRTQHWAGNDANRKWV
CCCCCCCCCCCCCCEEECCCHHHHHHHCCEEEEECHHCCCCHHCCCCCCCCCCCCCCEEE
YVEQDPTAIGVNRQFDVPLVGDLRGVVPQLVDALRDAPRTPSATLESLVEADAAEIARVA
EEECCCCEECCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
EEAPSGRTPVHPARFVVEATKAFNEYAEDGIMVRDGGATVIFQWTYSQAKPRDVIWNQNF
HHCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEEECCCCCCCCEEECCCC
GHLGTGLPYAVGASVAEGRKRPVMLLTSDSAFLFHIAELETAAREGLPLVCVVGVDHQWG
CCCCCCCCHHHCCHHHCCCCCCEEEEECCCEEEEEHHHHHHHHHCCCCEEEEEECCCCCC
LEVGVYKRTFEQPSPQPGVHWSKDVRMDKIAEGFGCHGEFVEKDDEIGPAIQRAYASGKT
CEEHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHCCCCCCCHHHHHHHCCCCE
AVVHVCIDPKANSEEMPKYDRFRTWYAEGTQ
EEEEEEECCCCCCCCCCCHHHHEEHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8157618 [H]