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The map label for this gene is purH [H]

Identifier: 108801283

GI number: 108801283

Start: 4591358

End: 4592941

Strand: Reverse

Name: purH [H]

Synonym: Mmcs_4319

Alternate gene names: 108801283

Gene position: 4592941-4591358 (Counterclockwise)

Preceding gene: 108801284

Following gene: 108801280

Centisome position: 80.5

GC content: 69.95

Gene sequence:

>1584_bases
ATGAGCGGTGACCAAGGGCAGGCCGGGGCGAAGAGGCCGATCCGGCGCGCACTGATCAGCGTCTACGACAAGACCGGGCT
GATCGACCTGGCGCGCGGACTGCACGAGGCCGGCGTCGACATCGTGTCGACCGGCTCCACCGCGAAAACCATTGCCGACA
AAGGCATTCCGGTCACACCGGTCGAATTCGTGACCGGGTTCCCCGAGGTGCTCGACGGCCGCGTCAAGACGCTGCATCCG
CACATCCACGCCGGCCTGCTCGCCGACACCCGTAAACCCGAGCACGTCGAGGCGCTGGCGAAACTCGGCATCGCGCCGTT
CGACCTCGTGGTGGTCAACCTCTACCCGTTCAGCGAGACCGTCGAATCCGGTGCGTCGGTCGACGAGTGCGTGGAGCAGA
TCGACATCGGCGGCCCGTCGATGGTGCGCGCGGCCGCCAAGAACCACCCGAGCGTGGCGGTCGTCGTCGAACCGAACGGT
TACGACGGTGTGCTGGCCGCGGTCCGGACCGGCGGCTTCACGCTTGCCGAACGAAAGATCCTGGCGTCGTTGGCATTCCG
GCACACCGCCGAATACGACGTGGCGGTGGCGTCGTGGATGGGTTCGACGCTGGCGCCCGAGGAGCCCGCGCAGAAGCTGC
CCGCCTGGGTGGGCGGCACCTGGCGGCGTGCAGCGGTGCTGCGCTACGGCGAGAACCCCCATCAGCAGGCGGCGCTCTAC
CGCGACGCCACCGCGTGGCCGGGGCTGGCGCAGGCCGAGCAGTTGCACGGCAAGGAGATGTCGTACAACAACTACACCGA
CGCCGATGCGGCGTGGCGGGCGGCGTTCGACCACGAGGAGATCTGCGTCGCGATCATCAAGCACGCCAACCCGTGCGGTA
TCGCGATCTCGTCGGTGTCGGTCGCCGACGCGCACCGCAAGGCCCACGAATGTGACCCGCTGTCGGCGTTCGGCGGGGTG
ATCGCGACGAACAGCTCCGTGAGCGTCGAGATGGCCGAGACCGTCGCCGACATCTTCACCGAGGTCATCGTCGCCCCGGC
CTACGAGCCCGGCGCCGTCGAGATCCTGTCCCGCAAGAAGAACATCCGCATCCTGGTGGCGGCGCAACCGCCGACCACCG
GCACCGAACTCCGGCCGATCAGCGGCGGTCTGCTGCTGCAGCAGCGCGACGCGCTCGACGCCGACGGCGACGACCCGGTC
AACTGGACCCTCGCGACGGGTGAGCCCGCCGATCCGGCGACGCTGGCCAACTTGAAGTTCGCGTGGCGCAGCTGCCGCGC
GGTGAAGTCCAACGCCATCGTCGTGGTCGCCGACGGCGCCACCGTGGGCGTCGGGATGGGGCAGGTCAACCGCGTCGACG
CGGCGCGGCTGGCGGTGCAGCGGGCCGGTGACCGGGTGCGCGGCGCGGTCGCGGCGTCGGATGCGTTCTTCCCGTTCCCC
GACGGGCTGGAGACGCTCACCGAGGCGGGGGTGAAGGCGATCGTGCACCCCGGCGGATCCATGCGCGACGACGTGGTGAC
CGAGGCGGCGGCCAAGGCCGGTATCTCGCTCTACCTGACCGGCGCGCGGCACTTCGCGCACTGA

Upstream 100 bases:

>100_bases
ACGAGCGCATCAAGGTGGTCGAACGACGACTGCTGGTGGATGTCCTGGCCGCGATGGCGCAGCGCGGCGTGACCTGGACC
GGACGAAAGGCGACCATAGG

Downstream 100 bases:

>100_bases
CTCGCTCGCCGAGACTGCGGTCAGCGCACGCTTCGCGGCCGCGAACACGATCCCCGAGCAGTCTCGGCGCAAGGGCTTAG
AGCGGTGGTTCGTCGTCTTC

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MSGDQGQAGAKRPIRRALISVYDKTGLIDLARGLHEAGVDIVSTGSTAKTIADKGIPVTPVEFVTGFPEVLDGRVKTLHP
HIHAGLLADTRKPEHVEALAKLGIAPFDLVVVNLYPFSETVESGASVDECVEQIDIGGPSMVRAAAKNHPSVAVVVEPNG
YDGVLAAVRTGGFTLAERKILASLAFRHTAEYDVAVASWMGSTLAPEEPAQKLPAWVGGTWRRAAVLRYGENPHQQAALY
RDATAWPGLAQAEQLHGKEMSYNNYTDADAAWRAAFDHEEICVAIIKHANPCGIAISSVSVADAHRKAHECDPLSAFGGV
IATNSSVSVEMAETVADIFTEVIVAPAYEPGAVEILSRKKNIRILVAAQPPTTGTELRPISGGLLLQQRDALDADGDDPV
NWTLATGEPADPATLANLKFAWRSCRAVKSNAIVVVADGATVGVGMGQVNRVDAARLAVQRAGDRVRGAVAASDAFFPFP
DGLETLTEAGVKAIVHPGGSMRDDVVTEAAAKAGISLYLTGARHFAH

Sequences:

>Translated_527_residues
MSGDQGQAGAKRPIRRALISVYDKTGLIDLARGLHEAGVDIVSTGSTAKTIADKGIPVTPVEFVTGFPEVLDGRVKTLHP
HIHAGLLADTRKPEHVEALAKLGIAPFDLVVVNLYPFSETVESGASVDECVEQIDIGGPSMVRAAAKNHPSVAVVVEPNG
YDGVLAAVRTGGFTLAERKILASLAFRHTAEYDVAVASWMGSTLAPEEPAQKLPAWVGGTWRRAAVLRYGENPHQQAALY
RDATAWPGLAQAEQLHGKEMSYNNYTDADAAWRAAFDHEEICVAIIKHANPCGIAISSVSVADAHRKAHECDPLSAFGGV
IATNSSVSVEMAETVADIFTEVIVAPAYEPGAVEILSRKKNIRILVAAQPPTTGTELRPISGGLLLQQRDALDADGDDPV
NWTLATGEPADPATLANLKFAWRSCRAVKSNAIVVVADGATVGVGMGQVNRVDAARLAVQRAGDRVRGAVAASDAFFPFP
DGLETLTEAGVKAIVHPGGSMRDDVVTEAAAKAGISLYLTGARHFAH
>Mature_526_residues
SGDQGQAGAKRPIRRALISVYDKTGLIDLARGLHEAGVDIVSTGSTAKTIADKGIPVTPVEFVTGFPEVLDGRVKTLHPH
IHAGLLADTRKPEHVEALAKLGIAPFDLVVVNLYPFSETVESGASVDECVEQIDIGGPSMVRAAAKNHPSVAVVVEPNGY
DGVLAAVRTGGFTLAERKILASLAFRHTAEYDVAVASWMGSTLAPEEPAQKLPAWVGGTWRRAAVLRYGENPHQQAALYR
DATAWPGLAQAEQLHGKEMSYNNYTDADAAWRAAFDHEEICVAIIKHANPCGIAISSVSVADAHRKAHECDPLSAFGGVI
ATNSSVSVEMAETVADIFTEVIVAPAYEPGAVEILSRKKNIRILVAAQPPTTGTELRPISGGLLLQQRDALDADGDDPVN
WTLATGEPADPATLANLKFAWRSCRAVKSNAIVVVADGATVGVGMGQVNRVDAARLAVQRAGDRVRGAVAASDAFFPFPD
GLETLTEAGVKAIVHPGGSMRDDVVTEAAAKAGISLYLTGARHFAH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family [H]

Homologues:

Organism=Homo sapiens, GI20127454, Length=482, Percent_Identity=34.6473029045643, Blast_Score=223, Evalue=3e-58,
Organism=Escherichia coli, GI1790439, Length=532, Percent_Identity=43.2330827067669, Blast_Score=422, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI71985564, Length=477, Percent_Identity=34.3815513626834, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI71985574, Length=308, Percent_Identity=25.6493506493506, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71985556, Length=141, Percent_Identity=34.0425531914894, Blast_Score=69, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323056, Length=481, Percent_Identity=35.1351351351351, Blast_Score=226, Evalue=9e-60,
Organism=Saccharomyces cerevisiae, GI6323768, Length=489, Percent_Identity=33.7423312883436, Blast_Score=219, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24649832, Length=477, Percent_Identity=33.3333333333333, Blast_Score=215, Evalue=7e-56,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607 [H]

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]

EC number: =2.1.2.3; =3.5.4.10 [H]

Molecular weight: Translated: 55533; Mature: 55402

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGDQGQAGAKRPIRRALISVYDKTGLIDLARGLHEAGVDIVSTGSTAKTIADKGIPVTP
CCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCCHHHHHCCCCCCCH
VEFVTGFPEVLDGRVKTLHPHIHAGLLADTRKPEHVEALAKLGIAPFDLVVVNLYPFSET
HHHHCCCHHHHCCCCEEECCHHHHCHHCCCCCCHHHHHHHHCCCCCEEEEEEEEECCHHH
VESGASVDECVEQIDIGGPSMVRAAAKNHPSVAVVVEPNGYDGVLAAVRTGGFTLAERKI
HHCCCCHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCCHHHHHHH
LASLAFRHTAEYDVAVASWMGSTLAPEEPAQKLPAWVGGTWRRAAVLRYGENPHQQAALY
HHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHCCHHHCCCHHHHHHHHCCCCHHHHHHHH
RDATAWPGLAQAEQLHGKEMSYNNYTDADAAWRAAFDHEEICVAIIKHANPCGIAISSVS
HCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCEEEECEE
VADAHRKAHECDPLSAFGGVIATNSSVSVEMAETVADIFTEVIVAPAYEPGAVEILSRKK
HHHHHHHHCCCCCHHHHCCEEECCCCCEEHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCC
NIRILVAAQPPTTGTELRPISGGLLLQQRDALDADGDDPVNWTLATGEPADPATLANLKF
CEEEEEEECCCCCCCCEEECCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHH
AWRSCRAVKSNAIVVVADGATVGVGMGQVNRVDAARLAVQRAGDRVRGAVAASDAFFPFP
HHHHHHHHCCCEEEEEECCCEEECCCCCCCHHHHHHHHHHHCCCHHHHEEEECCCCCCCC
DGLETLTEAGVKAIVHPGGSMRDDVVTEAAAKAGISLYLTGARHFAH
CHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCEEEEEECCHHCCC
>Mature Secondary Structure 
SGDQGQAGAKRPIRRALISVYDKTGLIDLARGLHEAGVDIVSTGSTAKTIADKGIPVTP
CCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCCHHHHHCCCCCCCH
VEFVTGFPEVLDGRVKTLHPHIHAGLLADTRKPEHVEALAKLGIAPFDLVVVNLYPFSET
HHHHCCCHHHHCCCCEEECCHHHHCHHCCCCCCHHHHHHHHCCCCCEEEEEEEEECCHHH
VESGASVDECVEQIDIGGPSMVRAAAKNHPSVAVVVEPNGYDGVLAAVRTGGFTLAERKI
HHCCCCHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCCHHHHHHH
LASLAFRHTAEYDVAVASWMGSTLAPEEPAQKLPAWVGGTWRRAAVLRYGENPHQQAALY
HHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHCCHHHCCCHHHHHHHHCCCCHHHHHHHH
RDATAWPGLAQAEQLHGKEMSYNNYTDADAAWRAAFDHEEICVAIIKHANPCGIAISSVS
HCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCEEEECEE
VADAHRKAHECDPLSAFGGVIATNSSVSVEMAETVADIFTEVIVAPAYEPGAVEILSRKK
HHHHHHHHCCCCCHHHHCCEEECCCCCEEHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCC
NIRILVAAQPPTTGTELRPISGGLLLQQRDALDADGDDPVNWTLATGEPADPATLANLKF
CEEEEEEECCCCCCCCEEECCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHH
AWRSCRAVKSNAIVVVADGATVGVGMGQVNRVDAARLAVQRAGDRVRGAVAASDAFFPFP
HHHHHHHHCCCEEEEEECCCEEECCCCCCCHHHHHHHHHHHCCCHHHHEEEECCCCCCCC
DGLETLTEAGVKAIVHPGGSMRDDVVTEAAAKAGISLYLTGARHFAH
CHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCEEEEEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA