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The map label for this gene is purN [H]

Identifier: 108801284

GI number: 108801284

Start: 4592938

End: 4593567

Strand: Reverse

Name: purN [H]

Synonym: Mmcs_4320

Alternate gene names: 108801284

Gene position: 4593567-4592938 (Counterclockwise)

Preceding gene: 108801285

Following gene: 108801283

Centisome position: 80.51

GC content: 71.75

Gene sequence:

>630_bases
GTGCAGCAACCGCTTCGTGTGCCTCCGAGCGCACCTGCACGGCTGGTCGTGCTCGCATCGGGCACCGGATCGCTGCTCGC
CTCGCTGCTCGAATCCACCGTCGACGACTATCCGGCGCGCGTGGTCGCCGTCGGGACCGACCGGACCTGCGCCGCGCTCG
ACATCGCCGCCGCCGCGCAGGTGCCCACCTACACCGTCCGGCTCGGGGAGTACCCCGACCGCACCGCGTGGGACGCCGCG
GTCACCGCGGCGACCGCCGAACACGAACCCGACCTCGTGGTGTCCGCCGGCTTCATGAAGATCCTCGGCCCCGAGTTCCT
CAACCGCTTCCCCGGCCGGGTGGTCAACACCCACCCAGCCCTGCTGCCCGCATTCCCCGGCGCCCACGCCGTCGCCGACT
CGCTGGCCTACGGTGTCCGGGTCACCGGCTGCACCGTGCACCTGGTCGACGCGGGGATGGACACCGGGCCGATCCTCGCC
CAGGAAGCCGTCGCGGTGCGCGACGGCGACGACGAGGCGACCCTGCACGAGCGCATCAAGGTGGTCGAACGACGACTGCT
GGTGGATGTCCTGGCCGCGATGGCGCAGCGCGGCGTGACCTGGACCGGACGAAAGGCGACCATAGGATGA

Upstream 100 bases:

>100_bases
GGCAGTCCCCCCAACGACAGTGCCCCCAACGACAGTCCCCCCAACGACAGTGCCCCCACCGACGGCGAGCCGCGGCGCTG
AGCCGACTAGGCTGCTGCGC

Downstream 100 bases:

>100_bases
GCGGTGACCAAGGGCAGGCCGGGGCGAAGAGGCCGATCCGGCGCGCACTGATCAGCGTCTACGACAAGACCGGGCTGATC
GACCTGGCGCGCGGACTGCA

Product: phosphoribosylglycinamide formyltransferase

Products: NA

Alternate protein names: 5'-phosphoribosylglycinamide transformylase; GAR transformylase; GART [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MQQPLRVPPSAPARLVVLASGTGSLLASLLESTVDDYPARVVAVGTDRTCAALDIAAAAQVPTYTVRLGEYPDRTAWDAA
VTAATAEHEPDLVVSAGFMKILGPEFLNRFPGRVVNTHPALLPAFPGAHAVADSLAYGVRVTGCTVHLVDAGMDTGPILA
QEAVAVRDGDDEATLHERIKVVERRLLVDVLAAMAQRGVTWTGRKATIG

Sequences:

>Translated_209_residues
MQQPLRVPPSAPARLVVLASGTGSLLASLLESTVDDYPARVVAVGTDRTCAALDIAAAAQVPTYTVRLGEYPDRTAWDAA
VTAATAEHEPDLVVSAGFMKILGPEFLNRFPGRVVNTHPALLPAFPGAHAVADSLAYGVRVTGCTVHLVDAGMDTGPILA
QEAVAVRDGDDEATLHERIKVVERRLLVDVLAAMAQRGVTWTGRKATIG
>Mature_209_residues
MQQPLRVPPSAPARLVVLASGTGSLLASLLESTVDDYPARVVAVGTDRTCAALDIAAAAQVPTYTVRLGEYPDRTAWDAA
VTAATAEHEPDLVVSAGFMKILGPEFLNRFPGRVVNTHPALLPAFPGAHAVADSLAYGVRVTGCTVHLVDAGMDTGPILA
QEAVAVRDGDDEATLHERIKVVERRLLVDVLAAMAQRGVTWTGRKATIG

Specific function: De novo purine biosynthesis; third step. [C]

COG id: COG0299

COG function: function code F; Folate-dependent phosphoribosylglycinamide formyltransferase PurN

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GART family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=177, Percent_Identity=41.2429378531073, Blast_Score=136, Evalue=1e-32,
Organism=Homo sapiens, GI209869995, Length=177, Percent_Identity=41.2429378531073, Blast_Score=136, Evalue=1e-32,
Organism=Homo sapiens, GI209869993, Length=177, Percent_Identity=41.2429378531073, Blast_Score=136, Evalue=1e-32,
Organism=Escherichia coli, GI1788846, Length=184, Percent_Identity=33.695652173913, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI1787483, Length=204, Percent_Identity=29.9019607843137, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17567511, Length=186, Percent_Identity=38.7096774193548, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24582400, Length=175, Percent_Identity=39.4285714285714, Blast_Score=121, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002376
- InterPro:   IPR001555
- InterPro:   IPR004607 [H]

Pfam domain/function: PF00551 Formyl_trans_N [H]

EC number: =2.1.2.2 [H]

Molecular weight: Translated: 21955; Mature: 21955

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQPLRVPPSAPARLVVLASGTGSLLASLLESTVDDYPARVVAVGTDRTCAALDIAAAAQ
CCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCC
VPTYTVRLGEYPDRTAWDAAVTAATAEHEPDLVVSAGFMKILGPEFLNRFPGRVVNTHPA
CCEEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEECCHHHHHCHHHHHHCCCCEECCCCC
LLPAFPGAHAVADSLAYGVRVTGCTVHLVDAGMDTGPILAQEAVAVRDGDDEATLHERIK
EECCCCCHHHHHHHHHHCEEEECEEEEEEECCCCCCCHHHHHHEEEECCCCHHHHHHHHH
VVERRLLVDVLAAMAQRGVTWTGRKATIG
HHHHHHHHHHHHHHHHCCCEECCCEECCC
>Mature Secondary Structure
MQQPLRVPPSAPARLVVLASGTGSLLASLLESTVDDYPARVVAVGTDRTCAALDIAAAAQ
CCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCC
VPTYTVRLGEYPDRTAWDAAVTAATAEHEPDLVVSAGFMKILGPEFLNRFPGRVVNTHPA
CCEEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEECCHHHHHCHHHHHHCCCCEECCCCC
LLPAFPGAHAVADSLAYGVRVTGCTVHLVDAGMDTGPILAQEAVAVRDGDDEATLHERIK
EECCCCCHHHHHHHHHHCEEEECEEEEEEECCCCCCCHHHHHHEEEECCCCHHHHHHHHH
VVERRLLVDVLAAMAQRGVTWTGRKATIG
HHHHHHHHHHHHHHHHCCCEECCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]