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The map label for this gene is cbs [H]

Identifier: 108801113

GI number: 108801113

Start: 4414516

End: 4415910

Strand: Reverse

Name: cbs [H]

Synonym: Mmcs_4149

Alternate gene names: 108801113

Gene position: 4415910-4414516 (Counterclockwise)

Preceding gene: 108801114

Following gene: 108801112

Centisome position: 77.4

GC content: 69.03

Gene sequence:

>1395_bases
ATGCGCATCGCCCAGCACGTCAGTGAGCTCATCGGCAACACCCCTCTGGTACAGCTGAATTCTGTTGTCCCCGAGGGGGC
TGGCACGGTCGCGGCGAAGATCGAATACCTCAACCCCGGCGGCAGCTCCAAGGACCGGATCGCGGTCAAGATGATCGACG
CCGCCGAGGCCAGCGGTGAGCTCAAACCGGGCGGCACCCTTGTCGAACCGACATCGGGCAACACCGGCGTCGGGCTCGCG
CTGGTCGCCCAGCAGCGCGGCTACAAGTGCATCTTCGTCTGCCCCGACAAGGTCAGCGAGGACAAGCGCAACGTGTTGCG
CGCCTACGGCGCCGACGTGGTGGTGTGCCCGACGGCCGTGGCCCCCGACGATCCGGACAGCTACTACAGCGTCTCCAACC
GCCTCGTCACCGAGATCGAGGGCGCGTGGAAGCCCGACCAGTACTCCAACCCGATGGGGCCGGAGTCCCACTACGAGACC
ACCGGGCCGGAGATCTGGCGCGACACCGACGGCAAGGTCACCCACTTCGTGGCCGGCGTCGGCACCGGCGGCACCATCAC
CGGCGCCGGGAGGTACCTCAAGGAGGTCTCCGGCGGGAAGGTCCGCGTCATCGGCGCCGACCCCGAGGGCTCGGTGTACT
CCGGAGGCACCGGTCGCCCGTATCTGGTCGAGGGTGTCGGCGAGGACTTCTGGCCGTCGGCCTACGACCCCGCCGTGCCG
GACGAGATCATCGCCGTCTCGGACGCCGACTCGTTCGACATGACGCGCCGGTTGGCCCGCGAGGAGGGCCTGCTGGTGGG
CGGCTCGTGCGGGATGGCCGTGGTGGCCGCGATCGAGGTCGCGCAGAAGGCCGGTCCGGACGCGTTGGTGGTGGTGTTGC
TGCCCGACGGCGGCCGCGGCTACCTGTCGAAGATCTTCAACGACTCGTGGATGTCGTCCTACGGATTCCTGCGCAACCGG
CTGGACGGGTCGATCGAACAGCCGACCGTCGGAGATGTGTTGCGCGGCAAGTCCGGTGAGCTGCCCGACCTGGTGCACAC
CCATCCGTCGGAGACGGTGCGCGACGCCATCGGGATCCTGCGCGAGTACGGCGTCTCGCAGATGCCCGTCGTCGGCGCCG
AACCACCCGTGATGGCCGGTGAGGTCGCGGGCAGCGTGTCGGAACGCGAGCTGCTGTCGGCGGTCTTCGAAGGCCGCGCC
AAGCTGGCCGATGCGGTGGCCGAGCACATGAGCCCGCCCATGCCGCTCATCGGTGCGGGCGAGTTGGTCAGCACCGCCGC
CAAGACCCTGCGCGAGTGCGATGCGCTGATGGTGGTCGAGGAGGGCAAACCGGTCGGTGTGGTCACCCGCCACGACCTGC
TCGGCTTCCTGTCGGACGGCAGCACGCGGCGTTAG

Upstream 100 bases:

>100_bases
CGCCGCTGGTGTCGGAGGCGCAGCGTTCGCTGCGCCAGATCGGTGAGTACATACGAGAGGCCACCTGGTAGTCGTTCAGC
GCGCCTGGGACGATGGAGTC

Downstream 100 bases:

>100_bases
TGGGATGCCATGGCGGCCATGCCTTCTGCCGTTGTGGTGAATCCGGTGCGCCGGGCGTGATCTTCGGTACTGTTAGCTCG
CTCGTTCACAGCTGACCGCA

Product: cystathionine beta-synthase

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MRIAQHVSELIGNTPLVQLNSVVPEGAGTVAAKIEYLNPGGSSKDRIAVKMIDAAEASGELKPGGTLVEPTSGNTGVGLA
LVAQQRGYKCIFVCPDKVSEDKRNVLRAYGADVVVCPTAVAPDDPDSYYSVSNRLVTEIEGAWKPDQYSNPMGPESHYET
TGPEIWRDTDGKVTHFVAGVGTGGTITGAGRYLKEVSGGKVRVIGADPEGSVYSGGTGRPYLVEGVGEDFWPSAYDPAVP
DEIIAVSDADSFDMTRRLAREEGLLVGGSCGMAVVAAIEVAQKAGPDALVVVLLPDGGRGYLSKIFNDSWMSSYGFLRNR
LDGSIEQPTVGDVLRGKSGELPDLVHTHPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVFEGRA
KLADAVAEHMSPPMPLIGAGELVSTAAKTLRECDALMVVEEGKPVGVVTRHDLLGFLSDGSTRR

Sequences:

>Translated_464_residues
MRIAQHVSELIGNTPLVQLNSVVPEGAGTVAAKIEYLNPGGSSKDRIAVKMIDAAEASGELKPGGTLVEPTSGNTGVGLA
LVAQQRGYKCIFVCPDKVSEDKRNVLRAYGADVVVCPTAVAPDDPDSYYSVSNRLVTEIEGAWKPDQYSNPMGPESHYET
TGPEIWRDTDGKVTHFVAGVGTGGTITGAGRYLKEVSGGKVRVIGADPEGSVYSGGTGRPYLVEGVGEDFWPSAYDPAVP
DEIIAVSDADSFDMTRRLAREEGLLVGGSCGMAVVAAIEVAQKAGPDALVVVLLPDGGRGYLSKIFNDSWMSSYGFLRNR
LDGSIEQPTVGDVLRGKSGELPDLVHTHPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVFEGRA
KLADAVAEHMSPPMPLIGAGELVSTAAKTLRECDALMVVEEGKPVGVVTRHDLLGFLSDGSTRR
>Mature_464_residues
MRIAQHVSELIGNTPLVQLNSVVPEGAGTVAAKIEYLNPGGSSKDRIAVKMIDAAEASGELKPGGTLVEPTSGNTGVGLA
LVAQQRGYKCIFVCPDKVSEDKRNVLRAYGADVVVCPTAVAPDDPDSYYSVSNRLVTEIEGAWKPDQYSNPMGPESHYET
TGPEIWRDTDGKVTHFVAGVGTGGTITGAGRYLKEVSGGKVRVIGADPEGSVYSGGTGRPYLVEGVGEDFWPSAYDPAVP
DEIIAVSDADSFDMTRRLAREEGLLVGGSCGMAVVAAIEVAQKAGPDALVVVLLPDGGRGYLSKIFNDSWMSSYGFLRNR
LDGSIEQPTVGDVLRGKSGELPDLVHTHPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVFEGRA
KLADAVAEHMSPPMPLIGAGELVSTAAKTLRECDALMVVEEGKPVGVVTRHDLLGFLSDGSTRR

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=478, Percent_Identity=39.3305439330544, Blast_Score=294, Evalue=1e-79,
Organism=Homo sapiens, GI295821200, Length=478, Percent_Identity=39.3305439330544, Blast_Score=294, Evalue=1e-79,
Organism=Homo sapiens, GI4557415, Length=478, Percent_Identity=39.3305439330544, Blast_Score=294, Evalue=1e-79,
Organism=Escherichia coli, GI2367138, Length=310, Percent_Identity=39.6774193548387, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1788754, Length=331, Percent_Identity=38.6706948640483, Blast_Score=189, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17534315, Length=329, Percent_Identity=46.5045592705167, Blast_Score=234, Evalue=7e-62,
Organism=Caenorhabditis elegans, GI17535051, Length=322, Percent_Identity=40.3726708074534, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI25147552, Length=323, Percent_Identity=43.343653250774, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI115535073, Length=331, Percent_Identity=42.2960725075529, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17562970, Length=283, Percent_Identity=44.1696113074205, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI32566674, Length=283, Percent_Identity=44.1696113074205, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17561720, Length=311, Percent_Identity=40.8360128617363, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI32566672, Length=220, Percent_Identity=36.8181818181818, Blast_Score=132, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6321594, Length=503, Percent_Identity=35.5864811133201, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6321449, Length=332, Percent_Identity=36.144578313253, Blast_Score=162, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24643623, Length=482, Percent_Identity=36.9294605809129, Blast_Score=255, Evalue=5e-68,
Organism=Drosophila melanogaster, GI20129101, Length=482, Percent_Identity=36.9294605809129, Blast_Score=255, Evalue=5e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 48795; Mature: 48795

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAQHVSELIGNTPLVQLNSVVPEGAGTVAAKIEYLNPGGSSKDRIAVKMIDAAEASGE
CCHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEEEECCCCCCCCEEEEEEEEHHCCCCC
LKPGGTLVEPTSGNTGVGLALVAQQRGYKCIFVCPDKVSEDKRNVLRAYGADVVVCPTAV
CCCCCEEECCCCCCCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEECCCC
APDDPDSYYSVSNRLVTEIEGAWKPDQYSNPMGPESHYETTGPEIWRDTDGKVTHFVAGV
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEEEEEC
GTGGTITGAGRYLKEVSGGKVRVIGADPEGSVYSGGTGRPYLVEGVGEDFWPSAYDPAVP
CCCCCCCHHHHHHHHCCCCEEEEEECCCCCCEECCCCCCCEEEECCCCCCCCCCCCCCCC
DEIIAVSDADSFDMTRRLAREEGLLVGGSCGMAVVAAIEVAQKAGPDALVVVLLPDGGRG
CCEEEECCCCHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCH
YLSKIFNDSWMSSYGFLRNRLDGSIEQPTVGDVLRGKSGELPDLVHTHPSETVRDAIGIL
HHHHHHCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHH
REYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVFEGRAKLADAVAEHMSPPMPLIGAG
HHCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
ELVSTAAKTLRECDALMVVEEGKPVGVVTRHDLLGFLSDGSTRR
HHHHHHHHHHHHCCEEEEEECCCCEEEEEHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRIAQHVSELIGNTPLVQLNSVVPEGAGTVAAKIEYLNPGGSSKDRIAVKMIDAAEASGE
CCHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEEEEECCCCCCCCEEEEEEEEHHCCCCC
LKPGGTLVEPTSGNTGVGLALVAQQRGYKCIFVCPDKVSEDKRNVLRAYGADVVVCPTAV
CCCCCEEECCCCCCCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEECCCC
APDDPDSYYSVSNRLVTEIEGAWKPDQYSNPMGPESHYETTGPEIWRDTDGKVTHFVAGV
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEEEEEEEC
GTGGTITGAGRYLKEVSGGKVRVIGADPEGSVYSGGTGRPYLVEGVGEDFWPSAYDPAVP
CCCCCCCHHHHHHHHCCCCEEEEEECCCCCCEECCCCCCCEEEECCCCCCCCCCCCCCCC
DEIIAVSDADSFDMTRRLAREEGLLVGGSCGMAVVAAIEVAQKAGPDALVVVLLPDGGRG
CCEEEECCCCHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCH
YLSKIFNDSWMSSYGFLRNRLDGSIEQPTVGDVLRGKSGELPDLVHTHPSETVRDAIGIL
HHHHHHCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHH
REYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVFEGRAKLADAVAEHMSPPMPLIGAG
HHCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
ELVSTAAKTLRECDALMVVEEGKPVGVVTRHDLLGFLSDGSTRR
HHHHHHHHHHHHCCEEEEEECCCCEEEEEHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]