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The map label for this gene is dosT [H]

Identifier: 108801089

GI number: 108801089

Start: 4390983

End: 4392689

Strand: Reverse

Name: dosT [H]

Synonym: Mmcs_4125

Alternate gene names: 108801089

Gene position: 4392689-4390983 (Counterclockwise)

Preceding gene: 108801090

Following gene: 108801087

Centisome position: 76.99

GC content: 71.82

Gene sequence:

>1707_bases
ATGACCGAGCCGATCGGTCCCGACGAGCCGCGCGGGCCGGGTCCGCTGCGCGACACGCTGTCGGGGCTGCGGCTGCGCGA
ACTGCTCACCGAGGTGCAGGACCGCATCGAGATGATCGTCGAGGGACGCGACCGCCTCGACGGCCTGGTCGACGCGATGC
TCGTCGTCACGGCGGGCCTCGAACTCGACGTCACACTGCGCACCATCGTGCACACCGCCATCCAGCTCGTCGATGCCCGC
TACGGCGCGCTCGGGGTGCGCGGGCACGGCCACGATCTCGTCCAATTCATCTACGAGGGCATCGACGACGGCACCCGCGA
CCTGATCGGGCACCTCCCCGAGGGGCGCGGCGTGCTCGGCGTGCTCATCGACGATCCGCGCCCGATCCGGCTCGACGACA
TCCGCCACCACAGCGCGTCGGTCGGGTTCCCGGCCAACCATCCGCCGATGCGGACGTTCCTCGGTGTGCCGGTGCGGATC
CGCGACGAGGTGTACGGCAACCTCTACCTGACCGACAAGGTCGGCGGGCAGCCGTTCACCGAGGAGGACGAGGTGCTCGT
GCAGGCGCTCGCCGCCGCGGCGGGTATCGCCATCGACAACGCCCGCCTCTACGAACAGGCCAGGGCGCGGCAGGCGTGGA
TCGCCGCGACGCGCGACATCGCCACCGAGATGCTCTCCGGGGCCAGCCCGGCCACCGTGTTCCGCAGGGTGGTCGATCAG
GCGCTGACGCTCACCGGCGCGGACGGCACGCTGGTCGCGGTGCCCGGCGACACCGAGGCCCCACCCGACCAGGTCCACGA
CCTGGTGGTGGTCGAGTCCGCGGGAATGTTCACCGGTGCCGCGGTCACCGTCGCGCTCGACGAATCCCCGATCGGGCTGG
CGTTCCGCAAGCGCACGCCGGTGCGGGTGGACCGGCTCACCCTGGGATCGGCGGAATGCGGTGCGGCCCTTGTGCTCCCG
CTTCGCGCCGCTGACACGGTCGCCGGTGTGCTGGTGGCGGCGCGGGTTCCCGGCGCCCAGGAGTTCACCGCCGAACAACT
CGACGTGACGGCCGCGTTCGCCGACCAGATGGCGCTGGCATGGCAGCTGGCGAGTTCGCAGCGGCGCATGCAGGAACTCG
AGATCCTCACCGACCGCGACCGCATCGCCCGCGACCTGCACGACCACGTCATCCAACGGCTGTTCGCGGTCGGTCTGTCG
CTGCAGGGCACCTTGGCCCGGGTGCGCGACGCCGACGTGCAGCAGCGGTTGGCGGGCAACGTCGACGACCTCCAGGCGGT
GATCCAGGAGATCCGCACCACGATCTTCGACCTGCACGGCGGTTCGTCGGGGGCGACCCGTCTGCGCCAACGCCTCGACG
AGGCGATCGGGCAGTTCGCCGGCGCCGGGCTGCACACCACCGCGCAGTTCGTCGGACCGCTGTCGGTGGTCGACGCGACG
CTGGCCGACCATGCCGAGGCGGTGGTGCGCGAAGCGGTCAGCAACGCCGTCCGGCACGCCAGGGCGACCGAGTTGACGGT
GCGGGTCACCGTCGCCGACGACCTGTGCATCGAGGTGGCCGACAACGGCTGCGGGATCGACGGGTCGATCACCGAGAGCG
GCCTGGGCAACCTGCGCGCGAGGGCCGAGGACGCCGGCGGCACGTTGACCCTCGGTGAGAGCGCCGGCGGCGGAACGCTG
CTGCGGTGGTGTGCGCCGCTGGCGTGA

Upstream 100 bases:

>100_bases
CCGGCTGCTGGCCAAACTGGGGATGGAGCGGCGCACCCAGGCCGCGGTGTTCGTATCGAAGCTCGACCGCCCCGGGCAGC
GTGACAGCTAGGTTGGCGGG

Downstream 100 bases:

>100_bases
TCAGTCCGGCAGCGGGCGGCGCGGGGTGGCGGGCAGTGCGACCGCGTCGCGGGGCAGCCAGCCGATGCGCAGCAGCATCT
GCGGATGCGCCTGCGCTTCG

Product: putative signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 568; Mature: 567

Protein sequence:

>568_residues
MTEPIGPDEPRGPGPLRDTLSGLRLRELLTEVQDRIEMIVEGRDRLDGLVDAMLVVTAGLELDVTLRTIVHTAIQLVDAR
YGALGVRGHGHDLVQFIYEGIDDGTRDLIGHLPEGRGVLGVLIDDPRPIRLDDIRHHSASVGFPANHPPMRTFLGVPVRI
RDEVYGNLYLTDKVGGQPFTEEDEVLVQALAAAAGIAIDNARLYEQARARQAWIAATRDIATEMLSGASPATVFRRVVDQ
ALTLTGADGTLVAVPGDTEAPPDQVHDLVVVESAGMFTGAAVTVALDESPIGLAFRKRTPVRVDRLTLGSAECGAALVLP
LRAADTVAGVLVAARVPGAQEFTAEQLDVTAAFADQMALAWQLASSQRRMQELEILTDRDRIARDLHDHVIQRLFAVGLS
LQGTLARVRDADVQQRLAGNVDDLQAVIQEIRTTIFDLHGGSSGATRLRQRLDEAIGQFAGAGLHTTAQFVGPLSVVDAT
LADHAEAVVREAVSNAVRHARATELTVRVTVADDLCIEVADNGCGIDGSITESGLGNLRARAEDAGGTLTLGESAGGGTL
LRWCAPLA

Sequences:

>Translated_568_residues
MTEPIGPDEPRGPGPLRDTLSGLRLRELLTEVQDRIEMIVEGRDRLDGLVDAMLVVTAGLELDVTLRTIVHTAIQLVDAR
YGALGVRGHGHDLVQFIYEGIDDGTRDLIGHLPEGRGVLGVLIDDPRPIRLDDIRHHSASVGFPANHPPMRTFLGVPVRI
RDEVYGNLYLTDKVGGQPFTEEDEVLVQALAAAAGIAIDNARLYEQARARQAWIAATRDIATEMLSGASPATVFRRVVDQ
ALTLTGADGTLVAVPGDTEAPPDQVHDLVVVESAGMFTGAAVTVALDESPIGLAFRKRTPVRVDRLTLGSAECGAALVLP
LRAADTVAGVLVAARVPGAQEFTAEQLDVTAAFADQMALAWQLASSQRRMQELEILTDRDRIARDLHDHVIQRLFAVGLS
LQGTLARVRDADVQQRLAGNVDDLQAVIQEIRTTIFDLHGGSSGATRLRQRLDEAIGQFAGAGLHTTAQFVGPLSVVDAT
LADHAEAVVREAVSNAVRHARATELTVRVTVADDLCIEVADNGCGIDGSITESGLGNLRARAEDAGGTLTLGESAGGGTL
LRWCAPLA
>Mature_567_residues
TEPIGPDEPRGPGPLRDTLSGLRLRELLTEVQDRIEMIVEGRDRLDGLVDAMLVVTAGLELDVTLRTIVHTAIQLVDARY
GALGVRGHGHDLVQFIYEGIDDGTRDLIGHLPEGRGVLGVLIDDPRPIRLDDIRHHSASVGFPANHPPMRTFLGVPVRIR
DEVYGNLYLTDKVGGQPFTEEDEVLVQALAAAAGIAIDNARLYEQARARQAWIAATRDIATEMLSGASPATVFRRVVDQA
LTLTGADGTLVAVPGDTEAPPDQVHDLVVVESAGMFTGAAVTVALDESPIGLAFRKRTPVRVDRLTLGSAECGAALVLPL
RAADTVAGVLVAARVPGAQEFTAEQLDVTAAFADQMALAWQLASSQRRMQELEILTDRDRIARDLHDHVIQRLFAVGLSL
QGTLARVRDADVQQRLAGNVDDLQAVIQEIRTTIFDLHGGSSGATRLRQRLDEAIGQFAGAGLHTTAQFVGPLSVVDATL
ADHAEAVVREAVSNAVRHARATELTVRVTVADDLCIEVADNGCGIDGSITESGLGNLRARAEDAGGTLTLGESAGGGTLL
RWCAPLA

Specific function: Interacts with the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. May act as a direct hypoxia sensor (rather than a redox sensor); the normal state is the oxygenated form, while the deoxy form is probably

COG id: COG2203

COG function: function code T; FOG: GAF domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788812, Length=211, Percent_Identity=32.2274881516588, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1787474, Length=256, Percent_Identity=27.34375, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR011712 [H]

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: 2.7.3.- [C]

Molecular weight: Translated: 60503; Mature: 60372

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPIGPDEPRGPGPLRDTLSGLRLRELLTEVQDRIEMIVEGRDRLDGLVDAMLVVTAGL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
ELDVTLRTIVHTAIQLVDARYGALGVRGHGHDLVQFIYEGIDDGTRDLIGHLPEGRGVLG
CEEHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHCCCCCHHHHHHCCCCCCCEEE
VLIDDPRPIRLDDIRHHSASVGFPANHPPMRTFLGVPVRIRDEVYGNLYLTDKVGGQPFT
EEECCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHCCCEEEECCCCCCEEEEECCCCCCCC
EEDEVLVQALAAAAGIAIDNARLYEQARARQAWIAATRDIATEMLSGASPATVFRRVVDQ
CHHHHHHHHHHHHHCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ALTLTGADGTLVAVPGDTEAPPDQVHDLVVVESAGMFTGAAVTVALDESPIGLAFRKRTP
HHEEECCCCEEEEECCCCCCCHHHHCCEEEEECCCCEECCEEEEEECCCCCCEEEECCCC
VRVDRLTLGSAECGAALVLPLRAADTVAGVLVAARVPGAQEFTAEQLDVTAAFADQMALA
CEEEEEECCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
WQLASSQRRMQELEILTDRDRIARDLHDHVIQRLFAVGLSLQGTLARVRDADVQQRLAGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
VDDLQAVIQEIRTTIFDLHGGSSGATRLRQRLDEAIGQFAGAGLHTTAQFVGPLSVVDAT
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHH
LADHAEAVVREAVSNAVRHARATELTVRVTVADDLCIEVADNGCGIDGSITESGLGNLRA
HHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEECCEEEEECCCCCCCCCCCCCCCCCHHHH
RAEDAGGTLTLGESAGGGTLLRWCAPLA
HCCCCCCEEEECCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
TEPIGPDEPRGPGPLRDTLSGLRLRELLTEVQDRIEMIVEGRDRLDGLVDAMLVVTAGL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
ELDVTLRTIVHTAIQLVDARYGALGVRGHGHDLVQFIYEGIDDGTRDLIGHLPEGRGVLG
CEEHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHCCCCCHHHHHHCCCCCCCEEE
VLIDDPRPIRLDDIRHHSASVGFPANHPPMRTFLGVPVRIRDEVYGNLYLTDKVGGQPFT
EEECCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHCCCEEEECCCCCCEEEEECCCCCCCC
EEDEVLVQALAAAAGIAIDNARLYEQARARQAWIAATRDIATEMLSGASPATVFRRVVDQ
CHHHHHHHHHHHHHCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ALTLTGADGTLVAVPGDTEAPPDQVHDLVVVESAGMFTGAAVTVALDESPIGLAFRKRTP
HHEEECCCCEEEEECCCCCCCHHHHCCEEEEECCCCEECCEEEEEECCCCCCEEEECCCC
VRVDRLTLGSAECGAALVLPLRAADTVAGVLVAARVPGAQEFTAEQLDVTAAFADQMALA
CEEEEEECCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
WQLASSQRRMQELEILTDRDRIARDLHDHVIQRLFAVGLSLQGTLARVRDADVQQRLAGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
VDDLQAVIQEIRTTIFDLHGGSSGATRLRQRLDEAIGQFAGAGLHTTAQFVGPLSVVDAT
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHH
LADHAEAVVREAVSNAVRHARATELTVRVTVADDLCIEVADNGCGIDGSITESGLGNLRA
HHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEECCEEEEECCCCCCCCCCCCCCCCCHHHH
RAEDAGGTLTLGESAGGGTLLRWCAPLA
HCCCCCCEEEECCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups; Phosphotransferases with a nitrogenous group as acceptor [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]