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The map label for this gene is devR [H]

Identifier: 108801090

GI number: 108801090

Start: 4392699

End: 4393361

Strand: Reverse

Name: devR [H]

Synonym: Mmcs_4126

Alternate gene names: 108801090

Gene position: 4393361-4392699 (Counterclockwise)

Preceding gene: 108801091

Following gene: 108801089

Centisome position: 77.0

GC content: 68.02

Gene sequence:

>663_bases
GTGAGACTGTCGACCATGGTCAGGGTCTTTCTCGTCGACGATCACGAGGTGGTGCGTCGCGGGCTCATAGACCTGCTGAG
CGCCGATCCCGAACTGGACGTGGTGGGCGAGGCCGACTCGGTGGCCTCGGCGCTGGCCCGCATCCCCACCCTGCAACCCG
ACGTCGCGGTCCTCGACGTGCGGCTGCCCGACGGTAACGGCATCGAACTGTGCCGCGACCTGCTGTCCCGGCTGCCCGAC
CTGCGGTGCCTGATGCTGACGTCGTTCACCTCCGACGAGGCGATGCTCGATGCGATCCTGGCCGGGGCCAGCGGATTCGT
CGTCAAGGACATCAAGGGGATGGAGTTGGCGCAGGCGATCAAGGACGTCGGGGCCGGCCGTTCGCTGCTGGACAACCGCG
CCGCGGCGGCGCTGATGTCCAAGCTGCGCGGCGACGTCGAACGCTCCGATCCGCTCTCGGGACTGTCCGCCCAGGAGCGG
GTGCTGCTCGACCTGCTCGGGGAGGGTCTGACCAACAAGCAGATCGCCGCGCGGATGTTCCTGGCCGAGAAGACGGTCAA
GAACTACGTGTCCCGGCTGCTGGCCAAACTGGGGATGGAGCGGCGCACCCAGGCCGCGGTGTTCGTATCGAAGCTCGACC
GCCCCGGGCAGCGTGACAGCTAG

Upstream 100 bases:

>100_bases
AAAGAGCGCGCGGCCCAGGCGAGTTCACCGACCCGCGCGGACGGTCGGTGCTGCGGGAGGCCGGATGCACGCTGCTCACT
TGCCATCGGCAGCATCGGTT

Downstream 100 bases:

>100_bases
GTTGGCGGGATGACCGAGCCGATCGGTCCCGACGAGCCGCGCGGGCCGGGTCCGCTGCGCGACACGCTGTCGGGGCTGCG
GCTGCGCGAACTGCTCACCG

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MRLSTMVRVFLVDDHEVVRRGLIDLLSADPELDVVGEADSVASALARIPTLQPDVAVLDVRLPDGNGIELCRDLLSRLPD
LRCLMLTSFTSDEAMLDAILAGASGFVVKDIKGMELAQAIKDVGAGRSLLDNRAAAALMSKLRGDVERSDPLSGLSAQER
VLLDLLGEGLTNKQIAARMFLAEKTVKNYVSRLLAKLGMERRTQAAVFVSKLDRPGQRDS

Sequences:

>Translated_220_residues
MRLSTMVRVFLVDDHEVVRRGLIDLLSADPELDVVGEADSVASALARIPTLQPDVAVLDVRLPDGNGIELCRDLLSRLPD
LRCLMLTSFTSDEAMLDAILAGASGFVVKDIKGMELAQAIKDVGAGRSLLDNRAAAALMSKLRGDVERSDPLSGLSAQER
VLLDLLGEGLTNKQIAARMFLAEKTVKNYVSRLLAKLGMERRTQAAVFVSKLDRPGQRDS
>Mature_220_residues
MRLSTMVRVFLVDDHEVVRRGLIDLLSADPELDVVGEADSVASALARIPTLQPDVAVLDVRLPDGNGIELCRDLLSRLPD
LRCLMLTSFTSDEAMLDAILAGASGFVVKDIKGMELAQAIKDVGAGRSLLDNRAAAALMSKLRGDVERSDPLSGLSAQER
VLLDLLGEGLTNKQIAARMFLAEKTVKNYVSRLLAKLGMERRTQAAVFVSKLDRPGQRDS

Specific function: Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. When phosphorylated binds the promoter of at least its own and Acr (hspX) gene in response to hypoxia. Activates its own transcription under hy

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790102, Length=202, Percent_Identity=35.6435643564356, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788222, Length=196, Percent_Identity=30.1020408163265, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788521, Length=205, Percent_Identity=32.6829268292683, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1787473, Length=206, Percent_Identity=32.0388349514563, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1788712, Length=190, Percent_Identity=28.9473684210526, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1786747, Length=192, Percent_Identity=26.5625, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR011990
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23841; Mature: 23841

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLSTMVRVFLVDDHEVVRRGLIDLLSADPELDVVGEADSVASALARIPTLQPDVAVLDV
CCHHHEEEEEEECCHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCCCCCCEEEEEE
RLPDGNGIELCRDLLSRLPDLRCLMLTSFTSDEAMLDAILAGASGFVVKDIKGMELAQAI
ECCCCCCHHHHHHHHHHCCCCEEHHHHHCCCHHHHHHHHHHCCCCCEECCCCHHHHHHHH
KDVGAGRSLLDNRAAAALMSKLRGDVERSDPLSGLSAQERVLLDLLGEGLTNKQIAARMF
HHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHH
LAEKTVKNYVSRLLAKLGMERRTQAAVFVSKLDRPGQRDS
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRLSTMVRVFLVDDHEVVRRGLIDLLSADPELDVVGEADSVASALARIPTLQPDVAVLDV
CCHHHEEEEEEECCHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHCCCCCCCEEEEEE
RLPDGNGIELCRDLLSRLPDLRCLMLTSFTSDEAMLDAILAGASGFVVKDIKGMELAQAI
ECCCCCCHHHHHHHHHHCCCCEEHHHHHCCCHHHHHHHHHHCCCCCEECCCCHHHHHHHH
KDVGAGRSLLDNRAAAALMSKLRGDVERSDPLSGLSAQERVLLDLLGEGLTNKQIAARMF
HHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHH
LAEKTVKNYVSRLLAKLGMERRTQAAVFVSKLDRPGQRDS
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]