Click here to switch to the map view.

The map label for this gene is mutT2 [H]

Identifier: 108801007

GI number: 108801007

Start: 4315953

End: 4316351

Strand: Reverse

Name: mutT2 [H]

Synonym: Mmcs_4043

Alternate gene names: 108801007

Gene position: 4316351-4315953 (Counterclockwise)

Preceding gene: 108801009

Following gene: 108801004

Centisome position: 75.65

GC content: 72.18

Gene sequence:

>399_bases
ATGGCAGAGCAGATCGTCGTGGCCGGAGCCTTGATCACCGGGTCGCAACTGTTGGTCGCGCAGCGCGACCGGCCACCCGA
GCTGGCCGGGTTGTGGGAACTCCCGGGCGGGAAGGTCGCGCGTGGGGAGAGCGACTCGGCGGCGCTGACGCGGGAGTTGC
AGGAGGAGTTGGGCATCGACGTCGCGGTGGGTCCACGCATCGGCGACGACATCGCCCTGAGCGCGACGACCGTGCTGCGC
GCGTATTTGGTCACCCACCTCGGCGGGGACCTGCGGCCGATCGACCACCGCGCCCTGCGCTGGGTCGCGGTGCACGAACT
CGACGACCTGCCGTGGGTTCCCGCGGACCGGGCCTGGCTCGCGGCGCTCGGTCACGCGCTGCGCAACGGCGCCGGATAG

Upstream 100 bases:

>100_bases
CCCCGTCGGCGCGCTCCCAGCCGCCCAGCTCCGGCAGTGCGGCGTCCACCTGATCGTCGGTCAACACAGCCATGCCTTCG
ACGGTATACCGTCACCGCTG

Downstream 100 bases:

>100_bases
CGGGCGGTCAGTACCGCAGGCGGTCGTCGATCACCCGCACGCGTTCGGGGCCGCGCGCGTGATGTACCGCATACAACGGA
TGCGTCAACACCGGATGGCG

Product: NUDIX hydrolase

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 132; Mature: 131

Protein sequence:

>132_residues
MAEQIVVAGALITGSQLLVAQRDRPPELAGLWELPGGKVARGESDSAALTRELQEELGIDVAVGPRIGDDIALSATTVLR
AYLVTHLGGDLRPIDHRALRWVAVHELDDLPWVPADRAWLAALGHALRNGAG

Sequences:

>Translated_132_residues
MAEQIVVAGALITGSQLLVAQRDRPPELAGLWELPGGKVARGESDSAALTRELQEELGIDVAVGPRIGDDIALSATTVLR
AYLVTHLGGDLRPIDHRALRWVAVHELDDLPWVPADRAWLAALGHALRNGAG
>Mature_131_residues
AEQIVVAGALITGSQLLVAQRDRPPELAGLWELPGGKVARGESDSAALTRELQEELGIDVAVGPRIGDDIALSATTVLRA
YLVTHLGGDLRPIDHRALRWVAVHELDDLPWVPADRAWLAALGHALRNGAG

Specific function: May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo- dGTP is inserted opposite dA and dC residues of template DNA with almost equa

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788056, Length=120, Percent_Identity=38.3333333333333, Blast_Score=69, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 14049; Mature: 13918

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQIVVAGALITGSQLLVAQRDRPPELAGLWELPGGKVARGESDSAALTRELQEELGID
CCCCEEEEEEEECCCEEEEECCCCCCCCCCEEECCCCCEECCCCCHHHHHHHHHHHHCCE
VAVGPRIGDDIALSATTVLRAYLVTHLGGDLRPIDHRALRWVAVHELDDLPWVPADRAWL
EEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHH
AALGHALRNGAG
HHHHHHHHCCCC
>Mature Secondary Structure 
AEQIVVAGALITGSQLLVAQRDRPPELAGLWELPGGKVARGESDSAALTRELQEELGID
CCCEEEEEEEECCCEEEEECCCCCCCCCCEEECCCCCEECCCCCHHHHHHHHHHHHCCE
VAVGPRIGDDIALSATTVLRAYLVTHLGGDLRPIDHRALRWVAVHELDDLPWVPADRAWL
EEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHH
AALGHALRNGAG
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]