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The map label for this gene is ydgK [H]

Identifier: 108800935

GI number: 108800935

Start: 4234843

End: 4236162

Strand: Reverse

Name: ydgK [H]

Synonym: Mmcs_3971

Alternate gene names: 108800935

Gene position: 4236162-4234843 (Counterclockwise)

Preceding gene: 108800938

Following gene: 108800934

Centisome position: 74.25

GC content: 72.5

Gene sequence:

>1320_bases
ATGGCAACATCCCCGCACGTGGACGAGAACCCTGCCCTCAGCGCGCCGGTGCCCGTCGCGCCGAGCCGGGCGCGGATGAT
CGTGGTGCTCGGCGCTCTCGTCGCGCTCGGTCCGCTCACCATCGACATGTATCTGCCCGCGTTGCCGAGCATCGCCGACG
AACTGAGCGTGTCCTCGTCGGTCGCGCAGCTCACGCTCACCGGAACCCTGGCGGGCCTGGCGCTCGGCCAGCTGCTCGTG
GGTGCGCTGTCGGATTCCCTCGGGCGGCGACGCCCGCTGATGGCCGGGATCGTGCTGCACATGCTGGCGTCGGTGCTGTG
CATGCTGGCACCCGACATCACCGTGTTGGGTGTGGCGCGCGGATTGCAGGGGATGGGCGCTGCCGCCGCGACAGTGGTGG
CGATCGCCGTCGTCGGGGACCTGTTCTCCGGGACCGCCGCGGCGACGGTGATGTCGCGGCTGATGCTCGTCCTGGGCGTC
GCGCCGGTGCTGGCGCCGTCGCTGGGCGCGGCGGTGCTGCTGCACGCGTCGTGGCAGTGGGTGTTCGCCGCGCTGGTCGT
CCTCGCCGGCGGGTTGCTCCTGGTGGCGGCCCTGGTGCTGCCGGAGACCCTGCCGGTGGCGCACCGCCGTCCGCTGAAGG
TGCGCGGCATCGCCGACACCTACGCCTCGCTGCTGCGCGACCCGCGGTTCGTGGTGCTGGTGCTGGTGGCGGCACTGGGC
ATGTCCGGACTGTTCGCCTACATCGCCGGCGCGGCGTTCGTGCTGCAGGGTGACTACGGGCTGGACCAGCAGACCTTCGC
GCTGGTGTTCGGCGCCGGGGCGGTCGCCCTGATCGGCACCACGCAGTTCAACGTGGTGCTGCTGCGCCGGTTCGCACCGC
AGCAGATCATGGTGTGGGCGCTGGCCGTGGCGTCGCTGGCCGGTGTCGTCTTCGTCGGTCTGACGGTCGCCCACATCGGT
GGTCTGACCGGGTTCCTGGTGTCGGTGTGGACCATCCTCGCCGCGATGGGCCTGGTGCTGCCGAATGCGCCGGCCGTCGC
GCTGTCGCGGCACAACGAGGCCGCCGGCACGGCGGCGGCCCTGCTCGGCGCCGGGCAGTTCGGGCTCGGTGCGGCGGTGG
CGCCGTTGGTCGGCGTGCTCGGCAACGACGAGTTCGCGCTCGCCCTGGTCATGACGGTCGGTACGGTCGTGGCGCTGGTC
GCGCTGATGGCGGTAGGGCTGCGCGGCAACCGCGAGGACTCCGACAACCCCGACGAGGTCACCGACGACGCCGTCGAGGT
CGCCGACGGGGCCCTGGCGAGCGCCGCCGAACCCGCCTGA

Upstream 100 bases:

>100_bases
GTCAACGAACGGCCACCGCCGCGGGGTGCCGAGCAGTGACCGCGGTCACTGTTGGGGGGCTGATGGAAGAAAATATCGAC
GCGACTCGCTGACCTAGTCC

Downstream 100 bases:

>100_bases
GAACCCGGCCACCTTTGGACTTGTTTCCTCGGGTGCCGGGTACGTAGCGTCGGCTGGCTGGATCCTTCGATAGGCGAGTC
GACCCGATATGTTCTCCACG

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MATSPHVDENPALSAPVPVAPSRARMIVVLGALVALGPLTIDMYLPALPSIADELSVSSSVAQLTLTGTLAGLALGQLLV
GALSDSLGRRRPLMAGIVLHMLASVLCMLAPDITVLGVARGLQGMGAAAATVVAIAVVGDLFSGTAAATVMSRLMLVLGV
APVLAPSLGAAVLLHASWQWVFAALVVLAGGLLLVAALVLPETLPVAHRRPLKVRGIADTYASLLRDPRFVVLVLVAALG
MSGLFAYIAGAAFVLQGDYGLDQQTFALVFGAGAVALIGTTQFNVVLLRRFAPQQIMVWALAVASLAGVVFVGLTVAHIG
GLTGFLVSVWTILAAMGLVLPNAPAVALSRHNEAAGTAAALLGAGQFGLGAAVAPLVGVLGNDEFALALVMTVGTVVALV
ALMAVGLRGNREDSDNPDEVTDDAVEVADGALASAAEPA

Sequences:

>Translated_439_residues
MATSPHVDENPALSAPVPVAPSRARMIVVLGALVALGPLTIDMYLPALPSIADELSVSSSVAQLTLTGTLAGLALGQLLV
GALSDSLGRRRPLMAGIVLHMLASVLCMLAPDITVLGVARGLQGMGAAAATVVAIAVVGDLFSGTAAATVMSRLMLVLGV
APVLAPSLGAAVLLHASWQWVFAALVVLAGGLLLVAALVLPETLPVAHRRPLKVRGIADTYASLLRDPRFVVLVLVAALG
MSGLFAYIAGAAFVLQGDYGLDQQTFALVFGAGAVALIGTTQFNVVLLRRFAPQQIMVWALAVASLAGVVFVGLTVAHIG
GLTGFLVSVWTILAAMGLVLPNAPAVALSRHNEAAGTAAALLGAGQFGLGAAVAPLVGVLGNDEFALALVMTVGTVVALV
ALMAVGLRGNREDSDNPDEVTDDAVEVADGALASAAEPA
>Mature_438_residues
ATSPHVDENPALSAPVPVAPSRARMIVVLGALVALGPLTIDMYLPALPSIADELSVSSSVAQLTLTGTLAGLALGQLLVG
ALSDSLGRRRPLMAGIVLHMLASVLCMLAPDITVLGVARGLQGMGAAAATVVAIAVVGDLFSGTAAATVMSRLMLVLGVA
PVLAPSLGAAVLLHASWQWVFAALVVLAGGLLLVAALVLPETLPVAHRRPLKVRGIADTYASLLRDPRFVVLVLVAALGM
SGLFAYIAGAAFVLQGDYGLDQQTFALVFGAGAVALIGTTQFNVVLLRRFAPQQIMVWALAVASLAGVVFVGLTVAHIGG
LTGFLVSVWTILAAMGLVLPNAPAVALSRHNEAAGTAAALLGAGQFGLGAAVAPLVGVLGNDEFALALVMTVGTVVALVA
LMAVGLRGNREDSDNPDEVTDDAVEVADGALASAAEPA

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=364, Percent_Identity=32.967032967033, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI48994889, Length=394, Percent_Identity=28.6802030456853, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1790146, Length=275, Percent_Identity=30.1818181818182, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI87082312, Length=340, Percent_Identity=28.2352941176471, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1790794, Length=340, Percent_Identity=23.8235294117647, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1787065, Length=192, Percent_Identity=27.0833333333333, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319657, Length=314, Percent_Identity=21.3375796178344, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321838, Length=206, Percent_Identity=27.6699029126214, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319480, Length=215, Percent_Identity=27.906976744186, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319517, Length=195, Percent_Identity=27.1794871794872, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324264, Length=163, Percent_Identity=26.9938650306748, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44212; Mature: 44081

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCCHHCCCCCCC
>Mature Secondary Structure 
ATSPHVDENPALSAPVPVAPSRARMIVVLGALVALGPLTIDMYLPALPSIADELSVSSS
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VAQLTLTGTLAGLALGQLLVGALSDSLGRRRPLMAGIVLHMLASVLCMLAPDITVLGVAR
HHHEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
GLQGMGAAAATVVAIAVVGDLFSGTAAATVMSRLMLVLGVAPVLAPSLGAAVLLHASWQW
HHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFAALVVLAGGLLLVAALVLPETLPVAHRRPLKVRGIADTYASLLRDPRFVVLVLVAALG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCHHHHHHHHHCCCHHHHHHHHHHHH
MSGLFAYIAGAAFVLQGDYGLDQQTFALVFGAGAVALIGTTQFNVVLLRRFAPQQIMVWA
HHHHHHHHHHHHEEEECCCCCCHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCHHHHHHH
LAVASLAGVVFVGLTVAHIGGLTGFLVSVWTILAAMGLVLPNAPAVALSRHNEAAGTAAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHH
LLGAGQFGLGAAVAPLVGVLGNDEFALALVMTVGTVVALVALMAVGLRGNREDSDNPDEV
HHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
TDDAVEVADGALASAAEPA
HHHHHHHHCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]