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The map label for this gene is hom [H]

Identifier: 108800860

GI number: 108800860

Start: 4148466

End: 4149803

Strand: Reverse

Name: hom [H]

Synonym: Mmcs_3896

Alternate gene names: 108800860

Gene position: 4149803-4148466 (Counterclockwise)

Preceding gene: 108800861

Following gene: 108800859

Centisome position: 72.73

GC content: 68.83

Gene sequence:

>1338_bases
ATGAACAGTGACAAATCGGTAGGCGACACACCGGTGGGCGTAGCCGTCCTGGGCCTCGGCAATGTGGGCAGTGAAGTGGT
CCACATCATCGAGCAGAGCGCGACCGACCTGGCGGCGCGTGTCGGCGCCCCGCTCGTACTGCGCGGGGTTGGGGTGCGCC
GGGTGGCCGGCGACCGCGGGGTGCCGGTCGACATGCTCACCGACAACATCGAAGAACTGGTCTCGCGCGAGGACGTCGAC
ATCGTCGTCGAGGTGATGGGTCCAGTCGAACCGGCCCGCAAGGCGATCCTCTCCGCGCTCGAACAGGGCAAGTCGGTGGT
GACCGCGAACAAGGCGCTGATGGCCCAGTCGACCGGTGAGCTGGCGCAGGCCGCCGAGGCCGCCCGGGTCGACCTGTACT
TCGAGGCCGCGGTGGCCGGTGCCATCCCGGTGATCCGCCCGCTGACCCAGTCGCTGGCCGGCGACACGGTGCTGCGGGTG
GCCGGGATCGTCAACGGCACAACGAATTACATCCTGTCGGCGATGAACGACACCGGCGCCGACTACGACAGTGCGCTGGC
CGATGCCAGTGCGCTCGGCTACGCGGAGGCGGATCCGACCGCCGACGTGGAGGGTTTCGACGCCGCGGCCAAGGCCGCGA
TCCTGGCGTCCATCGCGTTCCACACGCGGGTGACGGCCGACGACGTCTACCGCGAAGGCATCACCAAGGTCACCGCCGAG
GACTTCGAATCCGCCCGCTCGCTCGGGTGCACCATCAAGTTGCTCGCCATCTGTGAGCGGCTGACCACCGACGACGGCCA
ACAGCGCGTCTCGGCCCGGGTCTACCCGGCGCTGGTTCCGCTCGACCACCCGCTGGCATCGGTCAACGGCGCGTTCAACG
CCGTGGTGGTCGAGGCCGAGGCGGCCGGCCGCTTGATGTTCTACGGCCAGGGCGCCGGTGGCGCGCCGACCGCATCGGCG
GTCATGGGCGATCTCGTGATGGCCGCGCGCAACCGCGTCCAGGGCGGGCGCGGACCGCGGGAGTCGAAGTACGCCAAGCT
GCCGGTGTCGCCGATCGGGTTCATCCCCACGCGGTACTACGTCAACATGAACGTCGCCGACCGTCCTGGCGTGTTGTCCA
CGGTCGCAGCCGAATTCGCCAGGCATGAGGTCAGCATCGCCGAGGTGCGCCAGGAGGGTGTGGTCGACGAGGGCGGACAG
CCCTGCGGTGCGCGCATCGTCGTCGTCACCCACCGTGCGACCGATGCGGCGTTGTCCGAAACCGTCTCGGCCCTGGCCGA
ACTCGACGTCGTGCAGAGCGTCAACAGCGTGCTGCGCATGGAAGGAACAAGCGAATGA

Upstream 100 bases:

>100_bases
TCGGCCGCCCCGCGGTGGTGGCGGTGCGCGACGGGCACGCGCGCCTGATCCTGCGCCGCGAGACGGTCGACGATCTGTTG
AGTCTGGAAGTGAGTGGTCA

Downstream 100 bases:

>100_bases
GCACGCCCGTGAACGCGGTGCACCGGCGCTGGCCGGGGCTGATCGAGGCCTACCGCGACCGGCTTCCCGTCGGCGACGAC
TGGACGCCGGTCACCCTGCT

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MNSDKSVGDTPVGVAVLGLGNVGSEVVHIIEQSATDLAARVGAPLVLRGVGVRRVAGDRGVPVDMLTDNIEELVSREDVD
IVVEVMGPVEPARKAILSALEQGKSVVTANKALMAQSTGELAQAAEAARVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRV
AGIVNGTTNYILSAMNDTGADYDSALADASALGYAEADPTADVEGFDAAAKAAILASIAFHTRVTADDVYREGITKVTAE
DFESARSLGCTIKLLAICERLTTDDGQQRVSARVYPALVPLDHPLASVNGAFNAVVVEAEAAGRLMFYGQGAGGAPTASA
VMGDLVMAARNRVQGGRGPRESKYAKLPVSPIGFIPTRYYVNMNVADRPGVLSTVAAEFARHEVSIAEVRQEGVVDEGGQ
PCGARIVVVTHRATDAALSETVSALAELDVVQSVNSVLRMEGTSE

Sequences:

>Translated_445_residues
MNSDKSVGDTPVGVAVLGLGNVGSEVVHIIEQSATDLAARVGAPLVLRGVGVRRVAGDRGVPVDMLTDNIEELVSREDVD
IVVEVMGPVEPARKAILSALEQGKSVVTANKALMAQSTGELAQAAEAARVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRV
AGIVNGTTNYILSAMNDTGADYDSALADASALGYAEADPTADVEGFDAAAKAAILASIAFHTRVTADDVYREGITKVTAE
DFESARSLGCTIKLLAICERLTTDDGQQRVSARVYPALVPLDHPLASVNGAFNAVVVEAEAAGRLMFYGQGAGGAPTASA
VMGDLVMAARNRVQGGRGPRESKYAKLPVSPIGFIPTRYYVNMNVADRPGVLSTVAAEFARHEVSIAEVRQEGVVDEGGQ
PCGARIVVVTHRATDAALSETVSALAELDVVQSVNSVLRMEGTSE
>Mature_445_residues
MNSDKSVGDTPVGVAVLGLGNVGSEVVHIIEQSATDLAARVGAPLVLRGVGVRRVAGDRGVPVDMLTDNIEELVSREDVD
IVVEVMGPVEPARKAILSALEQGKSVVTANKALMAQSTGELAQAAEAARVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRV
AGIVNGTTNYILSAMNDTGADYDSALADASALGYAEADPTADVEGFDAAAKAAILASIAFHTRVTADDVYREGITKVTAE
DFESARSLGCTIKLLAICERLTTDDGQQRVSARVYPALVPLDHPLASVNGAFNAVVVEAEAAGRLMFYGQGAGGAPTASA
VMGDLVMAARNRVQGGRGPRESKYAKLPVSPIGFIPTRYYVNMNVADRPGVLSTVAAEFARHEVSIAEVRQEGVVDEGGQ
PCGARIVVVTHRATDAALSETVSALAELDVVQSVNSVLRMEGTSE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=357, Percent_Identity=25.4901960784314, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786183, Length=121, Percent_Identity=36.3636363636364, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46196; Mature: 46196

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSDKSVGDTPVGVAVLGLGNVGSEVVHIIEQSATDLAARVGAPLVLRGVGVRRVAGDRG
CCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEECCCCC
VPVDMLTDNIEELVSREDVDIVVEVMGPVEPARKAILSALEQGKSVVTANKALMAQSTGE
CCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEHHHHHHHCCHHH
LAQAAEAARVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGTTNYILSAMNDTGA
HHHHHHHHHHEEEEHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHCCCCCC
DYDSALADASALGYAEADPTADVEGFDAAAKAAILASIAFHTRVTADDVYREGITKVTAE
CHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
DFESARSLGCTIKLLAICERLTTDDGQQRVSARVYPALVPLDHPLASVNGAFNAVVVEAE
HHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHCEEECCCCCCHHHCCCCCEEEEEEEC
AAGRLMFYGQGAGGAPTASAVMGDLVMAARNRVQGGRGPRESKYAKLPVSPIGFIPTRYY
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCEEE
VNMNVADRPGVLSTVAAEFARHEVSIAEVRQEGVVDEGGQPCGARIVVVTHRATDAALSE
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHHH
TVSALAELDVVQSVNSVLRMEGTSE
HHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNSDKSVGDTPVGVAVLGLGNVGSEVVHIIEQSATDLAARVGAPLVLRGVGVRRVAGDRG
CCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEECCCCC
VPVDMLTDNIEELVSREDVDIVVEVMGPVEPARKAILSALEQGKSVVTANKALMAQSTGE
CCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEHHHHHHHCCHHH
LAQAAEAARVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGTTNYILSAMNDTGA
HHHHHHHHHHEEEEHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHCCCCCC
DYDSALADASALGYAEADPTADVEGFDAAAKAAILASIAFHTRVTADDVYREGITKVTAE
CHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
DFESARSLGCTIKLLAICERLTTDDGQQRVSARVYPALVPLDHPLASVNGAFNAVVVEAE
HHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHCEEECCCCCCHHHCCCCCEEEEEEEC
AAGRLMFYGQGAGGAPTASAVMGDLVMAARNRVQGGRGPRESKYAKLPVSPIGFIPTRYY
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCEEE
VNMNVADRPGVLSTVAAEFARHEVSIAEVRQEGVVDEGGQPCGARIVVVTHRATDAALSE
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCHHHHHHH
TVSALAELDVVQSVNSVLRMEGTSE
HHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]