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The map label for this gene is thrB [H]

Identifier: 108800858

GI number: 108800858

Start: 4146430

End: 4147374

Strand: Reverse

Name: thrB [H]

Synonym: Mmcs_3894

Alternate gene names: 108800858

Gene position: 4147374-4146430 (Counterclockwise)

Preceding gene: 108800859

Following gene: 108800857

Centisome position: 72.69

GC content: 70.9

Gene sequence:

>945_bases
GTGACCCAGACTCTTCCCGCCGGTCTGACGGCGACGGCCACGGTCGCGGCGTCGAGCGCCAACCTCGGCCCCGGCTTCGA
CAGCCTCGGCCTTGCGCTCAGCCTCTACGACGAAATCGTCGTGGAGACAGTCGATTCCGGCTTGACCGTCACCGTCGAGG
GGGAGGGTGCCGGTCAGGTCGCGCTGGACTCGTCGCACCTGGTGGTGCGGGCGATCGAAGCCGGTCTGCGCGCGACCGGA
TGCATCGCGCCGGGGCTCGTGGTGCGGTGCCGCAACGACATTCCGCACTCCCGGGGGCTGGGTTCCTCGGCAGCGGCCGT
CGTCGGCGGACTTGCTGCCGCCAATGGCCTTGTCTCCCAAACTGATTGGACGCCACTCACGGTGGAGCAGCTGATCCAGC
TGTCGTCGGCGTTCGAGGGTCACCCCGACAACGCCGCGGCCGCCGTGCTGGGCGGGGCGGTCGTCACGTGGACCGACGGT
GCGGGTGCCCAGGCGCGCTACGCGGCCGCACCGTTGCGGGTGCATCCTGACATCCACCTCTTCCCGGCCATCCCACAGCA
GCGGTCCTCCACCGCCGAGACCCGGGTGTTGCTGCCCGACACGGTCAGCCACACCGATGCGCGGTTCAACCTCAGTCGGG
CGGCACTGCTGGTGGTGGCGCTGACCGAGCGCCCCGACCTGCTGATGGCCGCCACCGAGGATGTCCTGCACCAACCGCAG
CGGGCGGCGGCGATGCCGGCGTCGGCGGAATTTCTGCGGGTGCTTCGTGGTTGCGGTGTGGCAGCGGTGTTGTCCGGCGC
CGGACCTGCGGTGATCGCACTGAGCACCGAGCCGGTGCTGCCCGCCGAGGCGGTCGAGTTCGGCATCGCGAACGGGTTCA
CCATCGCCGAGATGGCGGTGGGGGACGGTGTGCGCTGGTCAACCGGCGTGGCCGCCGGCCGCTGA

Upstream 100 bases:

>100_bases
TCCCGACACCGCGCTCAAGGGAATGCCCACCGTCACACCGCTCGCCGTGGATCCGGTGGCGGTGGCGGCCGAACTCGGTC
TGGTCTGACGGGACGTGTCG

Downstream 100 bases:

>100_bases
GGGTTGACACGCGTCACTCGGGTTGCGGAGGTTTCTTGCTTCCGACACGTAAGCGGGTTATTCTCGCTTTCGTCCAGCAA
TTGCAGCGTCTCTGCCTGCG

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MTQTLPAGLTATATVAASSANLGPGFDSLGLALSLYDEIVVETVDSGLTVTVEGEGAGQVALDSSHLVVRAIEAGLRATG
CIAPGLVVRCRNDIPHSRGLGSSAAAVVGGLAAANGLVSQTDWTPLTVEQLIQLSSAFEGHPDNAAAAVLGGAVVTWTDG
AGAQARYAAAPLRVHPDIHLFPAIPQQRSSTAETRVLLPDTVSHTDARFNLSRAALLVVALTERPDLLMAATEDVLHQPQ
RAAAMPASAEFLRVLRGCGVAAVLSGAGPAVIALSTEPVLPAEAVEFGIANGFTIAEMAVGDGVRWSTGVAAGR

Sequences:

>Translated_314_residues
MTQTLPAGLTATATVAASSANLGPGFDSLGLALSLYDEIVVETVDSGLTVTVEGEGAGQVALDSSHLVVRAIEAGLRATG
CIAPGLVVRCRNDIPHSRGLGSSAAAVVGGLAAANGLVSQTDWTPLTVEQLIQLSSAFEGHPDNAAAAVLGGAVVTWTDG
AGAQARYAAAPLRVHPDIHLFPAIPQQRSSTAETRVLLPDTVSHTDARFNLSRAALLVVALTERPDLLMAATEDVLHQPQ
RAAAMPASAEFLRVLRGCGVAAVLSGAGPAVIALSTEPVLPAEAVEFGIANGFTIAEMAVGDGVRWSTGVAAGR
>Mature_313_residues
TQTLPAGLTATATVAASSANLGPGFDSLGLALSLYDEIVVETVDSGLTVTVEGEGAGQVALDSSHLVVRAIEAGLRATGC
IAPGLVVRCRNDIPHSRGLGSSAAAVVGGLAAANGLVSQTDWTPLTVEQLIQLSSAFEGHPDNAAAAVLGGAVVTWTDGA
GAQARYAAAPLRVHPDIHLFPAIPQQRSSTAETRVLLPDTVSHTDARFNLSRAALLVVALTERPDLLMAATEDVLHQPQR
AAAMPASAEFLRVLRGCGVAAVLSGAGPAVIALSTEPVLPAEAVEFGIANGFTIAEMAVGDGVRWSTGVAAGR

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6321814, Length=333, Percent_Identity=33.033033033033, Blast_Score=122, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 31814; Mature: 31683

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTLPAGLTATATVAASSANLGPGFDSLGLALSLYDEIVVETVDSGLTVTVEGEGAGQV
CCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEE
ALDSSHLVVRAIEAGLRATGCIAPGLVVRCRNDIPHSRGLGSSAAAVVGGLAAANGLVSQ
EECCCCCEEHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
TDWTPLTVEQLIQLSSAFEGHPDNAAAAVLGGAVVTWTDGAGAQARYAAAPLRVHPDIHL
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCEEEEEECCCCCCCEEEECCEEECCCEEE
FPAIPQQRSSTAETRVLLPDTVSHTDARFNLSRAALLVVALTERPDLLMAATEDVLHQPQ
ECCCCCCCCCCCCEEEECCCCCCCCCCCEECCCEEEEEEEECCCCCEEEEECHHHHCCCH
RAAAMPASAEFLRVLRGCGVAAVLSGAGPAVIALSTEPVLPAEAVEFGIANGFTIAEMAV
HHHCCCCCHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHCCCCCEEEEEHH
GDGVRWSTGVAAGR
CCCCEECCCCCCCC
>Mature Secondary Structure 
TQTLPAGLTATATVAASSANLGPGFDSLGLALSLYDEIVVETVDSGLTVTVEGEGAGQV
CCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEE
ALDSSHLVVRAIEAGLRATGCIAPGLVVRCRNDIPHSRGLGSSAAAVVGGLAAANGLVSQ
EECCCCCEEHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
TDWTPLTVEQLIQLSSAFEGHPDNAAAAVLGGAVVTWTDGAGAQARYAAAPLRVHPDIHL
CCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCEEEEEECCCCCCCEEEECCEEECCCEEE
FPAIPQQRSSTAETRVLLPDTVSHTDARFNLSRAALLVVALTERPDLLMAATEDVLHQPQ
ECCCCCCCCCCCCEEEECCCCCCCCCCCEECCCEEEEEEEECCCCCEEEEECHHHHCCCH
RAAAMPASAEFLRVLRGCGVAAVLSGAGPAVIALSTEPVLPAEAVEFGIANGFTIAEMAV
HHHCCCCCHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHCCCCCEEEEEHH
GDGVRWSTGVAAGR
CCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA