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The map label for this gene is caiC [H]

Identifier: 108800855

GI number: 108800855

Start: 4141762

End: 4143345

Strand: Reverse

Name: caiC [H]

Synonym: Mmcs_3891

Alternate gene names: 108800855

Gene position: 4143345-4141762 (Counterclockwise)

Preceding gene: 108800857

Following gene: 108800853

Centisome position: 72.62

GC content: 69.0

Gene sequence:

>1584_bases
GTGCCGGACACTCTCCAGGGATTGCTGCGCGAGCGCGCCGACTCCGACGCGATCGCGGTCCGCTACGGCGACTGCAGCTG
GACCTGGCGCGAACACCTCGCCGAGGCGTCCCGGCAGGCTGCCGCCGTCATCGCCGCCGCCGATCCGGCCCGCCCCCTGC
ACGTCGGTGTGCTGCTGGGCAACAGCCCCGACATGCTCACCGCGCTGGCCGCCGCCGCGCTCGGCGGCTATGTGCTGTGC
GGTGTCAACACGACCCGTCGGGGAGAGGCGCTTGCCCGCGACATCGCGCGGGTGGACTGTCAGATCCTGCTGGTCAACCC
GGAGTATCGGGCGTTGATCGACGGGCTGGACCTGCCCGGCGTCACCGTCTTCGATGTCTCCACCGACGACTGGGCCCAGC
GCGTGGCCGATGCGCCGGAGCTCACCCCGCACCGCGAGGTGGGTCCCGACGACACCTTCATGATGATCTTCACCTCGGGC
ACCAGCGGTGAACCCAAGGCCGTCCAGGTGCCCCATGCGATGGTGCTGTTCGCCGGTGGCGCGCTGGTGGAGCGCTACGG
GCTCACAGAGGCCGACGTCTGCTACCTGGCCATGCCGCTGTTCCACTCCAACGCCGTCTACGCGGGGTGGAGCGTCGCGG
TCGGCGCCGGCGCGGCGATGGCCCCGGCGACGTTCTCGGCGTCACGTTTCCTGTCCGACATCCGCCGGTACGGCGCCACC
TACATGAACTACGTGGGCAAACCGCTGGCCTACATTCTGGCGACCACCGAGAAGCCCGACGATCACGACAACCCGCTGCG
CATCGCATTCGGCAACGAAGCAGCCGACCGTGACATCGAGGCGTTCGGCCGACGGTTCGGCTGCACGGTCTGGGACGGCT
TCGGGTCGACCGAGACCGCGGTCATCATCACCCGGCCCGACGACTGCCCACAGGGTTCGATCGGCAAGGGTTTTCCGGGT
GTGGCGATCTACGACCCCGACACGGTCCGCGAATGCGAGGTGGCCCGCTTCGACGAGAACGGGGCGTTGCTCAACGCCGA
CACGGCGGTGGGGGAGCTGGTCAACACCGCCGGCGGCGGACTGTTCCGCGGCTACTACAACGATCCGAACGCCACCGGCG
ACCGGATGCGCCACGGCATGTACTGGTCCGGTGATCTCGCCTACCGCGACGCCGAGGGATGGATATACCTGGCCGGCCGC
ACGGGTGACTGGATGCGTGTCGACGGGGAGAACCTCACCGCGGCGCCGATCGAGCGGATCCTGTTGCGCCTGCCCGCGAT
CAACCGGGTGGCGGTCTACCCGGTGCCCGACGAACACGTCGGCGACCAGGTGATGGCGGCCGTCGTGCTGCAGGACGACG
CGAAACTGACGCCGGAGGAGTTCGAGGAGTTCCTGGCCGCCCAGCGCGATCTCTCGACGAAGGGCTGGCCGCGGTACGTG
TGGATCGCCGCCGATCTGCCGAGCACCGCGACCAACAAGATCCTCAAACGCGAACTGGTCGCCATGGGCACCGATCCGCG
CGGACGCCACATCTGGATCCGCGACCGGACCTCGTATCGGGTGCTCAGCGGTACGGGTCGGTGA

Upstream 100 bases:

>100_bases
CGACGAGTGCATTCTGCCAACAGGCGCGCCGGTCCGGAGCGCCGGGCGAACATGGTAGACAGATTCAGAGATCTGTTCAC
TGAACGAACGAGGTGGATCC

Downstream 100 bases:

>100_bases
TCTCGCGCAGCGACACCATCGCATCGCGCAACCGGTCGAACGTCTCCGCGCCCAGGTGCGCCCGCCACTCCCGTTCGACC
TCGGCGAGTTCGGCCGCGGC

Product: acyl-CoA synthetase

Products: D-carnitinyl-CoA; crotonobetainyl-CoA; L-carnitinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MPDTLQGLLRERADSDAIAVRYGDCSWTWREHLAEASRQAAAVIAAADPARPLHVGVLLGNSPDMLTALAAAALGGYVLC
GVNTTRRGEALARDIARVDCQILLVNPEYRALIDGLDLPGVTVFDVSTDDWAQRVADAPELTPHREVGPDDTFMMIFTSG
TSGEPKAVQVPHAMVLFAGGALVERYGLTEADVCYLAMPLFHSNAVYAGWSVAVGAGAAMAPATFSASRFLSDIRRYGAT
YMNYVGKPLAYILATTEKPDDHDNPLRIAFGNEAADRDIEAFGRRFGCTVWDGFGSTETAVIITRPDDCPQGSIGKGFPG
VAIYDPDTVRECEVARFDENGALLNADTAVGELVNTAGGGLFRGYYNDPNATGDRMRHGMYWSGDLAYRDAEGWIYLAGR
TGDWMRVDGENLTAAPIERILLRLPAINRVAVYPVPDEHVGDQVMAAVVLQDDAKLTPEEFEEFLAAQRDLSTKGWPRYV
WIAADLPSTATNKILKRELVAMGTDPRGRHIWIRDRTSYRVLSGTGR

Sequences:

>Translated_527_residues
MPDTLQGLLRERADSDAIAVRYGDCSWTWREHLAEASRQAAAVIAAADPARPLHVGVLLGNSPDMLTALAAAALGGYVLC
GVNTTRRGEALARDIARVDCQILLVNPEYRALIDGLDLPGVTVFDVSTDDWAQRVADAPELTPHREVGPDDTFMMIFTSG
TSGEPKAVQVPHAMVLFAGGALVERYGLTEADVCYLAMPLFHSNAVYAGWSVAVGAGAAMAPATFSASRFLSDIRRYGAT
YMNYVGKPLAYILATTEKPDDHDNPLRIAFGNEAADRDIEAFGRRFGCTVWDGFGSTETAVIITRPDDCPQGSIGKGFPG
VAIYDPDTVRECEVARFDENGALLNADTAVGELVNTAGGGLFRGYYNDPNATGDRMRHGMYWSGDLAYRDAEGWIYLAGR
TGDWMRVDGENLTAAPIERILLRLPAINRVAVYPVPDEHVGDQVMAAVVLQDDAKLTPEEFEEFLAAQRDLSTKGWPRYV
WIAADLPSTATNKILKRELVAMGTDPRGRHIWIRDRTSYRVLSGTGR
>Mature_526_residues
PDTLQGLLRERADSDAIAVRYGDCSWTWREHLAEASRQAAAVIAAADPARPLHVGVLLGNSPDMLTALAAAALGGYVLCG
VNTTRRGEALARDIARVDCQILLVNPEYRALIDGLDLPGVTVFDVSTDDWAQRVADAPELTPHREVGPDDTFMMIFTSGT
SGEPKAVQVPHAMVLFAGGALVERYGLTEADVCYLAMPLFHSNAVYAGWSVAVGAGAAMAPATFSASRFLSDIRRYGATY
MNYVGKPLAYILATTEKPDDHDNPLRIAFGNEAADRDIEAFGRRFGCTVWDGFGSTETAVIITRPDDCPQGSIGKGFPGV
AIYDPDTVRECEVARFDENGALLNADTAVGELVNTAGGGLFRGYYNDPNATGDRMRHGMYWSGDLAYRDAEGWIYLAGRT
GDWMRVDGENLTAAPIERILLRLPAINRVAVYPVPDEHVGDQVMAAVVLQDDAKLTPEEFEEFLAAQRDLSTKGWPRYVW
IAADLPSTATNKILKRELVAMGTDPRGRHIWIRDRTSYRVLSGTGR

Specific function: Could catalyze the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI227499619, Length=486, Percent_Identity=28.8065843621399, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI62865631, Length=518, Percent_Identity=26.2548262548263, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI13325055, Length=518, Percent_Identity=26.2548262548263, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI38524616, Length=385, Percent_Identity=29.8701298701299, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI13325057, Length=462, Percent_Identity=26.8398268398268, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI40807357, Length=546, Percent_Identity=25.2747252747253, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI13236579, Length=491, Percent_Identity=26.4765784114053, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI156151445, Length=532, Percent_Identity=22.7443609022556, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI187761345, Length=480, Percent_Identity=26.4583333333333, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI187761343, Length=480, Percent_Identity=26.4583333333333, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI157311624, Length=497, Percent_Identity=22.5352112676056, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI157311622, Length=497, Percent_Identity=22.5352112676056, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI58082049, Length=503, Percent_Identity=22.6640159045726, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI38505220, Length=374, Percent_Identity=25.9358288770053, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI42544132, Length=502, Percent_Identity=24.1035856573705, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI115511026, Length=386, Percent_Identity=25.1295336787565, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI122937307, Length=514, Percent_Identity=25.4863813229572, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI28416953, Length=523, Percent_Identity=23.3269598470363, Blast_Score=77, Evalue=6e-14,
Organism=Escherichia coli, GI221142682, Length=465, Percent_Identity=25.8064516129032, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI145693145, Length=377, Percent_Identity=26.525198938992, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1786810, Length=520, Percent_Identity=25.9615384615385, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788107, Length=364, Percent_Identity=25, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1789201, Length=396, Percent_Identity=23.4848484848485, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790505, Length=392, Percent_Identity=23.2142857142857, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17551278, Length=491, Percent_Identity=25.6619144602851, Blast_Score=122, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI115534440, Length=490, Percent_Identity=23.8775510204082, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17558820, Length=353, Percent_Identity=24.6458923512748, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI32563687, Length=385, Percent_Identity=24.4155844155844, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17559526, Length=397, Percent_Identity=23.9294710327456, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17538037, Length=415, Percent_Identity=23.6144578313253, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560308, Length=403, Percent_Identity=27.7915632754342, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319699, Length=351, Percent_Identity=28.4900284900285, Blast_Score=124, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6319264, Length=536, Percent_Identity=23.8805970149254, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319515, Length=291, Percent_Identity=27.1477663230241, Blast_Score=77, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6323182, Length=411, Percent_Identity=24.330900243309, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI281364798, Length=555, Percent_Identity=26.6666666666667, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24583465, Length=555, Percent_Identity=26.6666666666667, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24583463, Length=555, Percent_Identity=26.6666666666667, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI45550496, Length=539, Percent_Identity=26.1595547309833, Blast_Score=145, Evalue=1e-34,
Organism=Drosophila melanogaster, GI45552801, Length=539, Percent_Identity=26.1595547309833, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI20130353, Length=476, Percent_Identity=25.6302521008403, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI28573631, Length=476, Percent_Identity=25.6302521008403, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI18859661, Length=512, Percent_Identity=24.0234375, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21355181, Length=401, Percent_Identity=25.4364089775561, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21356947, Length=364, Percent_Identity=25, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24648260, Length=357, Percent_Identity=24.0896358543417, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24653035, Length=402, Percent_Identity=24.1293532338308, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI20130357, Length=362, Percent_Identity=22.6519337016575, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI161076582, Length=409, Percent_Identity=23.7163814180929, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21356441, Length=369, Percent_Identity=25.4742547425474, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24648257, Length=364, Percent_Identity=23.3516483516484, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24656500, Length=370, Percent_Identity=23.7837837837838, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.3.2.- [C]

Molecular weight: Translated: 57309; Mature: 57178

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDTLQGLLRERADSDAIAVRYGDCSWTWREHLAEASRQAAAVIAAADPARPLHVGVLLG
CCHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHEEEEEECCCCCCEEEEEEEC
NSPDMLTALAAAALGGYVLCGVNTTRRGEALARDIARVDCQILLVNPEYRALIDGLDLPG
CCCHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHCCEEEEEECCCHHHHHCCCCCCC
VTVFDVSTDDWAQRVADAPELTPHREVGPDDTFMMIFTSGTSGEPKAVQVPHAMVLFAGG
EEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEECCCEEEEEECC
ALVERYGLTEADVCYLAMPLFHSNAVYAGWSVAVGAGAAMAPATFSASRFLSDIRRYGAT
HHHHHCCCCCCCHHEEEEHHHCCCCEEECCEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
YMNYVGKPLAYILATTEKPDDHDNPLRIAFGNEAADRDIEAFGRRFGCTVWDGFGSTETA
HHHHCCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCEEEECCCCCCEE
VIITRPDDCPQGSIGKGFPGVAIYDPDTVRECEVARFDENGALLNADTAVGELVNTAGGG
EEEECCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEECCCCCEEECCHHHHHHHHHCCCC
LFRGYYNDPNATGDRMRHGMYWSGDLAYRDAEGWIYLAGRTGDWMRVDGENLTAAPIERI
EEECCCCCCCCCHHHHHCCCEECCCEEEEECCCEEEEEECCCCEEEECCCCCCHHHHHHH
LLRLPAINRVAVYPVPDEHVGDQVMAAVVLQDDAKLTPEEFEEFLAAQRDLSTKGWPRYV
HHHCCCCCEEEEEECCCHHCCHHHEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEE
WIAADLPSTATNKILKRELVAMGTDPRGRHIWIRDRTSYRVLSGTGR
EEEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCCCC
>Mature Secondary Structure 
PDTLQGLLRERADSDAIAVRYGDCSWTWREHLAEASRQAAAVIAAADPARPLHVGVLLG
CHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHEEEEEECCCCCCEEEEEEEC
NSPDMLTALAAAALGGYVLCGVNTTRRGEALARDIARVDCQILLVNPEYRALIDGLDLPG
CCCHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHCCEEEEEECCCHHHHHCCCCCCC
VTVFDVSTDDWAQRVADAPELTPHREVGPDDTFMMIFTSGTSGEPKAVQVPHAMVLFAGG
EEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEECCCEEEEEECC
ALVERYGLTEADVCYLAMPLFHSNAVYAGWSVAVGAGAAMAPATFSASRFLSDIRRYGAT
HHHHHCCCCCCCHHEEEEHHHCCCCEEECCEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
YMNYVGKPLAYILATTEKPDDHDNPLRIAFGNEAADRDIEAFGRRFGCTVWDGFGSTETA
HHHHCCCCEEEEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHCCCEEEECCCCCCEE
VIITRPDDCPQGSIGKGFPGVAIYDPDTVRECEVARFDENGALLNADTAVGELVNTAGGG
EEEECCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEECCCCCEEECCHHHHHHHHHCCCC
LFRGYYNDPNATGDRMRHGMYWSGDLAYRDAEGWIYLAGRTGDWMRVDGENLTAAPIERI
EEECCCCCCCCCHHHHHCCCEECCCEEEEECCCEEEEEECCCCEEEECCCCCCHHHHHHH
LLRLPAINRVAVYPVPDEHVGDQVMAAVVLQDDAKLTPEEFEEFLAAQRDLSTKGWPRYV
HHHCCCCCEEEEEECCCHHCCHHHEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEE
WIAADLPSTATNKILKRELVAMGTDPRGRHIWIRDRTSYRVLSGTGR
EEEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; D-carnitine; Coenzyme A; crotono-betaine; L-carnitine [C]

Specific reaction: Coenzyme A + D-carnitine = D-carnitinyl-CoA Coenzyme A + crotono-betaine = crotonobetainyl-CoA Coenzyme A + L-carnitine = L-carnitinyl-CoA [C]

General reaction: Ligases; Forming Carbon-Sulfur Bonds; Acid-Thiol Ligases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA