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The map label for this gene is wecA [H]

Identifier: 108800848

GI number: 108800848

Start: 4136395

End: 4137594

Strand: Reverse

Name: wecA [H]

Synonym: Mmcs_3884

Alternate gene names: 108800848

Gene position: 4137594-4136395 (Counterclockwise)

Preceding gene: 108800849

Following gene: 108800847

Centisome position: 72.52

GC content: 68.5

Gene sequence:

>1200_bases
GTGCAGTACCGTTTCGCGGTGATGGTCGAGTACCTTGCGCTCTCCGATCGCGGCGCGGGCGTGCCGCTGCGCGAGCTCGT
CCTCGTCGGCCTGACGGCCGCGATCATCACCTACTTCGCCACCGGGTGGGTCCGTGTCCTCGCCACGCGGCTGGGTGCGG
TGGCCTACCCGCGTGAGCGCGACGTGCATGTGGAGCCCACTCCGCGGATGGGCGGGCTGGCGATGTACGTCGGCGTCGCC
GCGGCGGTACTGCTGGCCTCCCAACTGCCCGCGCTCACCCGCGGTTTCGTCTACTCCACCGGTATGCCCGCGGTCGTGGT
CGCCGGCGGGCTCATCATGGCGATCGGGCTGATCGACGACCGGTGGGGACTCGACGCGCTCACCAAGTTCGCCGGCCAGC
TCACCGCGGCCAGCGTGATGGTCACCATGGGGGTGGCGTGGAGCGTGCTGTACATCCCCATCGGCGGCGTCGGCACCATC
GTGCTCGACCAGGTCGCCTCGATCCTGCTGACGCTGGCGCTCACGGTGGCGATCGTCAACGCGATGAACTTCGTCGACGG
ACTCGACGGGCTCGCGGCCGGGCTGGGGTTGATCACGGCGCTGGCCATCTGCCTGTTCTCCGTCGGGCTGTTGCGTGATC
ACGGCGGCGATGTGCTGTTCTACCCGCCCGCGGTCATCTCGGTGGTGCTCGCCGGGGCCTGTCTTGGCTTTCTGCCGCAC
AACTTCCACAAGGCCAGGATCTTCATGGGGGACTCGGGGTCGATGCTGATCGGCCTCATGCTGGCCGCGGCCTCGACCAC
GGCGGCCGGGCCCATTTCCCAGACGGCGTACGGCGCCCGCGACGTGTTCGCGTTGCTGTCGCCCTTCCTGCTGGTCGTCG
CCGTCATGTTCGTCCCGGCGCTGGACATGTTGCTGGCGATCATCCGGCGCACCCGCGCGGGCCTCAGCCCGTTCAGCCCC
GACAAGATGCATCTGCACCACCGGTTGCTGGAGATCGGCCACTCCCACCGCCGCGTGGTGCTGCTGATCTACATGTGGGT
CGGCATCGTCGCCCTCGGTGCGGCGAGCACCATATTCTTCGATCCCCGGCACACCGGAATGGTCATGCTCGGCGCGACCG
CGGTGGCCGTCGTGGTGACCCTCGTTCCACTGGTCCGGCGCCGAGAAGTGGCAGCGGAGAGCGTGTACGACGAAAAGTAG

Upstream 100 bases:

>100_bases
CACCCACGCATCCTGCGCACCGGGCCCGTCACCGCCGAGGCCGTCGCCGAGGTCCTCGGGGTCAACACCGAAAGCCTGCT
CACGCAGTGACCACAGCTGC

Downstream 100 bases:

>100_bases
TAGGCCCCGTTTAGGGCTGCCTACCATGTGGTAACGTGCTGCTAGAACCCAGCCAGGGCAAGTTTCACACCTCGCGGGTT
GCCGGCCACCGGCCCGTCGG

Product: glycosyl transferase family protein

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-Phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MQYRFAVMVEYLALSDRGAGVPLRELVLVGLTAAIITYFATGWVRVLATRLGAVAYPRERDVHVEPTPRMGGLAMYVGVA
AAVLLASQLPALTRGFVYSTGMPAVVVAGGLIMAIGLIDDRWGLDALTKFAGQLTAASVMVTMGVAWSVLYIPIGGVGTI
VLDQVASILLTLALTVAIVNAMNFVDGLDGLAAGLGLITALAICLFSVGLLRDHGGDVLFYPPAVISVVLAGACLGFLPH
NFHKARIFMGDSGSMLIGLMLAAASTTAAGPISQTAYGARDVFALLSPFLLVVAVMFVPALDMLLAIIRRTRAGLSPFSP
DKMHLHHRLLEIGHSHRRVVLLIYMWVGIVALGAASTIFFDPRHTGMVMLGATAVAVVVTLVPLVRRREVAAESVYDEK

Sequences:

>Translated_399_residues
MQYRFAVMVEYLALSDRGAGVPLRELVLVGLTAAIITYFATGWVRVLATRLGAVAYPRERDVHVEPTPRMGGLAMYVGVA
AAVLLASQLPALTRGFVYSTGMPAVVVAGGLIMAIGLIDDRWGLDALTKFAGQLTAASVMVTMGVAWSVLYIPIGGVGTI
VLDQVASILLTLALTVAIVNAMNFVDGLDGLAAGLGLITALAICLFSVGLLRDHGGDVLFYPPAVISVVLAGACLGFLPH
NFHKARIFMGDSGSMLIGLMLAAASTTAAGPISQTAYGARDVFALLSPFLLVVAVMFVPALDMLLAIIRRTRAGLSPFSP
DKMHLHHRLLEIGHSHRRVVLLIYMWVGIVALGAASTIFFDPRHTGMVMLGATAVAVVVTLVPLVRRREVAAESVYDEK
>Mature_399_residues
MQYRFAVMVEYLALSDRGAGVPLRELVLVGLTAAIITYFATGWVRVLATRLGAVAYPRERDVHVEPTPRMGGLAMYVGVA
AAVLLASQLPALTRGFVYSTGMPAVVVAGGLIMAIGLIDDRWGLDALTKFAGQLTAASVMVTMGVAWSVLYIPIGGVGTI
VLDQVASILLTLALTVAIVNAMNFVDGLDGLAAGLGLITALAICLFSVGLLRDHGGDVLFYPPAVISVVLAGACLGFLPH
NFHKARIFMGDSGSMLIGLMLAAASTTAAGPISQTAYGARDVFALLSPFLLVVAVMFVPALDMLLAIIRRTRAGLSPFSP
DKMHLHHRLLEIGHSHRRVVLLIYMWVGIVALGAASTIFFDPRHTGMVMLGATAVAVVVTLVPLVRRREVAAESVYDEK

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55), the lipid intermediate involved in the synthesis of various bacter

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=307, Percent_Identity=28.6644951140065, Blast_Score=98, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000715 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 42175; Mature: 42175

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYRFAVMVEYLALSDRGAGVPLRELVLVGLTAAIITYFATGWVRVLATRLGAVAYPRER
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DVHVEPTPRMGGLAMYVGVAAAVLLASQLPALTRGFVYSTGMPAVVVAGGLIMAIGLIDD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCHHCCCCCHHHHHHHHHHHHHHHCC
RWGLDALTKFAGQLTAASVMVTMGVAWSVLYIPIGGVGTIVLDQVASILLTLALTVAIVN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
AMNFVDGLDGLAAGLGLITALAICLFSVGLLRDHGGDVLFYPPAVISVVLAGACLGFLPH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCCC
NFHKARIFMGDSGSMLIGLMLAAASTTAAGPISQTAYGARDVFALLSPFLLVVAVMFVPA
CCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LDMLLAIIRRTRAGLSPFSPDKMHLHHRLLEIGHSHRRVVLLIYMWVGIVALGAASTIFF
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHEEE
DPRHTGMVMLGATAVAVVVTLVPLVRRREVAAESVYDEK
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQYRFAVMVEYLALSDRGAGVPLRELVLVGLTAAIITYFATGWVRVLATRLGAVAYPRER
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DVHVEPTPRMGGLAMYVGVAAAVLLASQLPALTRGFVYSTGMPAVVVAGGLIMAIGLIDD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCHHCCCCCHHHHHHHHHHHHHHHCC
RWGLDALTKFAGQLTAASVMVTMGVAWSVLYIPIGGVGTIVLDQVASILLTLALTVAIVN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
AMNFVDGLDGLAAGLGLITALAICLFSVGLLRDHGGDVLFYPPAVISVVLAGACLGFLPH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCCC
NFHKARIFMGDSGSMLIGLMLAAASTTAAGPISQTAYGARDVFALLSPFLLVVAVMFVPA
CCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LDMLLAIIRRTRAGLSPFSPDKMHLHHRLLEIGHSHRRVVLLIYMWVGIVALGAASTIFF
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHEEE
DPRHTGMVMLGATAVAVVVTLVPLVRRREVAAESVYDEK
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]