Click here to switch to the map view.

The map label for this gene is echA8 [H]

Identifier: 108800782

GI number: 108800782

Start: 4064211

End: 4064978

Strand: Reverse

Name: echA8 [H]

Synonym: Mmcs_3818

Alternate gene names: 108800782

Gene position: 4064978-4064211 (Counterclockwise)

Preceding gene: 108800783

Following gene: 108800781

Centisome position: 71.25

GC content: 66.67

Gene sequence:

>768_bases
ATGTACGACATGCCTGACGAAATCCAAGTGACCGCGGACGGTCCGCTGCGGATCATCACGCTGAACCGGCCGGATGCGCT
CAACGCGGTCAACGACTCGTTGCACTGTGGCCTGGCGCAGTTGTGGCCGCGCCTCAACGAGGATCTCGACGCGCGGGCGG
CGGTGATCACCGGTGCGGGACGGGCGTTTTCGGCCGGCGGTGACTTCGCCTACCTCGACGAGCTGGGTAAGGATGCGAGG
CTGCGGGCCAAGACCATCCTGCACGGTCGCGAGATCGTGCTCGGCATGACTCGCACCCGGATTCCGGTGGTGGCCGCGGT
GAACGGACCCGCCGTCGGATTGGGTTGCAGCCTGGTCGCCTTGAGCGACATCGTCTACATGGCGCCGACGGCGTACTTCG
CCGATCCGCACGTGCAGGTGGGCCTGGTGGCCGCCGACGGCGGTCCGCTGACGTGGCCGCTGCACATCAGCCTGCTGCTG
GCCAAGGAGTTCGCCATGACGGGAACCCGCATCCCGGCGCAGCGCGCCGCCGAGTTGGGCCTGGCCAACCACATCGTCGA
GGATCCGCTCGCCGAGGCCATCGCCTGCGCCGAGAAGATGATGCAGATGCCGCGCCAGGCGCTCGAGTCGACGAAGCGGC
TGCTCAACATCCACCTCGAGCGGGCCGTGCTGGCAAGCCTCGACTACGCCAACACCGCAGAAGAGCAGTCGTTCCAGACG
GAGGACTTCCGCACGATCGTCGGAAAGCTCAACGCCAAGAACAACTGA

Upstream 100 bases:

>100_bases
GATGGGTGGGACGTCGCAGATCCAGAAGAACATCATCGCGTCACGAATCCTGGGACTGGGAGTGCGATGAGCGCCCGCGC
GAAGAGCAGAGGAGCCTGAC

Downstream 100 bases:

>100_bases
CGCGCCGCGGATTTCGCAGCAGTTGCGCACCCGCGCTGACTCTCGAAACCTCTTTTGTCACAGTGGTTTCCATAGTCACA
ACCTCAGCGGTTTTGTCAGA

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MYDMPDEIQVTADGPLRIITLNRPDALNAVNDSLHCGLAQLWPRLNEDLDARAAVITGAGRAFSAGGDFAYLDELGKDAR
LRAKTILHGREIVLGMTRTRIPVVAAVNGPAVGLGCSLVALSDIVYMAPTAYFADPHVQVGLVAADGGPLTWPLHISLLL
AKEFAMTGTRIPAQRAAELGLANHIVEDPLAEAIACAEKMMQMPRQALESTKRLLNIHLERAVLASLDYANTAEEQSFQT
EDFRTIVGKLNAKNN

Sequences:

>Translated_255_residues
MYDMPDEIQVTADGPLRIITLNRPDALNAVNDSLHCGLAQLWPRLNEDLDARAAVITGAGRAFSAGGDFAYLDELGKDAR
LRAKTILHGREIVLGMTRTRIPVVAAVNGPAVGLGCSLVALSDIVYMAPTAYFADPHVQVGLVAADGGPLTWPLHISLLL
AKEFAMTGTRIPAQRAAELGLANHIVEDPLAEAIACAEKMMQMPRQALESTKRLLNIHLERAVLASLDYANTAEEQSFQT
EDFRTIVGKLNAKNN
>Mature_255_residues
MYDMPDEIQVTADGPLRIITLNRPDALNAVNDSLHCGLAQLWPRLNEDLDARAAVITGAGRAFSAGGDFAYLDELGKDAR
LRAKTILHGREIVLGMTRTRIPVVAAVNGPAVGLGCSLVALSDIVYMAPTAYFADPHVQVGLVAADGGPLTWPLHISLLL
AKEFAMTGTRIPAQRAAELGLANHIVEDPLAEAIACAEKMMQMPRQALESTKRLLNIHLERAVLASLDYANTAEEQSFQT
EDFRTIVGKLNAKNN

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=227, Percent_Identity=34.3612334801762, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI70995211, Length=238, Percent_Identity=30.672268907563, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI116235487, Length=139, Percent_Identity=31.6546762589928, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI45643119, Length=211, Percent_Identity=27.0142180094787, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI260275230, Length=211, Percent_Identity=27.0142180094787, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI260274832, Length=211, Percent_Identity=27.0142180094787, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI221307494, Length=138, Percent_Identity=28.9855072463768, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI25453481, Length=234, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI51538573, Length=234, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI4757966, Length=234, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI51538581, Length=234, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI221136756, Length=138, Percent_Identity=28.9855072463768, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI221136753, Length=138, Percent_Identity=28.9855072463768, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4757968, Length=234, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI49355787, Length=234, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI37594469, Length=229, Percent_Identity=27.5109170305677, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI37594471, Length=229, Percent_Identity=27.5109170305677, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1787659, Length=225, Percent_Identity=31.5555555555556, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI221142681, Length=203, Percent_Identity=33.0049261083744, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1787660, Length=241, Percent_Identity=29.8755186721992, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25145438, Length=231, Percent_Identity=31.1688311688312, Blast_Score=110, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17554946, Length=232, Percent_Identity=31.4655172413793, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17535521, Length=226, Percent_Identity=29.2035398230088, Blast_Score=90, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17560910, Length=226, Percent_Identity=27.4336283185841, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17536985, Length=244, Percent_Identity=27.4590163934426, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI20129971, Length=239, Percent_Identity=30.1255230125523, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24653477, Length=239, Percent_Identity=30.1255230125523, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24654903, Length=260, Percent_Identity=25.3846153846154, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19920382, Length=251, Percent_Identity=25.4980079681275, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19922422, Length=152, Percent_Identity=30.2631578947368, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357171, Length=239, Percent_Identity=28.0334728033473, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24650670, Length=244, Percent_Identity=26.2295081967213, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 27491; Mature: 27491

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDMPDEIQVTADGPLRIITLNRPDALNAVNDSLHCGLAQLWPRLNEDLDARAAVITGAG
CCCCCCCEEEECCCCEEEEEECCCCHHHHHCCHHCCCHHHHHHHCCCCCCCCEEEEECCC
RAFSAGGDFAYLDELGKDARLRAKTILHGREIVLGMTRTRIPVVAAVNGPAVGLGCSLVA
CEECCCCCCHHHHHCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHH
LSDIVYMAPTAYFADPHVQVGLVAADGGPLTWPLHISLLLAKEFAMTGTRIPAQRAAELG
HHHHHHHCCCCEECCCCEEEEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LANHIVEDPLAEAIACAEKMMQMPRQALESTKRLLNIHLERAVLASLDYANTAEEQSFQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCH
EDFRTIVGKLNAKNN
HHHHHHHHHCCCCCC
>Mature Secondary Structure
MYDMPDEIQVTADGPLRIITLNRPDALNAVNDSLHCGLAQLWPRLNEDLDARAAVITGAG
CCCCCCCEEEECCCCEEEEEECCCCHHHHHCCHHCCCHHHHHHHCCCCCCCCEEEEECCC
RAFSAGGDFAYLDELGKDARLRAKTILHGREIVLGMTRTRIPVVAAVNGPAVGLGCSLVA
CEECCCCCCHHHHHCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCCHHHHH
LSDIVYMAPTAYFADPHVQVGLVAADGGPLTWPLHISLLLAKEFAMTGTRIPAQRAAELG
HHHHHHHCCCCEECCCCEEEEEEEECCCCEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LANHIVEDPLAEAIACAEKMMQMPRQALESTKRLLNIHLERAVLASLDYANTAEEQSFQT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCH
EDFRTIVGKLNAKNN
HHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]