Click here to switch to the map view.

The map label for this gene is pepQ [H]

Identifier: 108800730

GI number: 108800730

Start: 4019711

End: 4020979

Strand: Reverse

Name: pepQ [H]

Synonym: Mmcs_3765

Alternate gene names: 108800730

Gene position: 4020979-4019711 (Counterclockwise)

Preceding gene: 108800731

Following gene: 108800729

Centisome position: 70.48

GC content: 68.32

Gene sequence:

>1269_bases
ATGACGACGTCGACTCACACCGGCGTCACCCAGATCGCCCGGACCGGGTACACGTGGCTGGACATCCCGCAGGAGCCCGA
CTTCACCCGGCTGCGCAGTGAGGTCGGTGCACGTCTGCACGCCGCGATGGCCGAACAGGGTGTCGACGCGCTGGTTCTGC
TGGGCAACGGAAACGTCATGTACGCCACCGGTATCAGCTGGCCGCTGGCCGATGCCGGCCTGTCACACGTCGAGCGGCCG
GTGGCGGTCGTGCTGGCCGACGACGAGCACCCGCACCTGTTCCTGCCCTTCCGCGAGGGTGCGGCGATGGAGTCGGACCT
GCCCGACGACCACCTGCACGGGCCGGTCTATCTGGAGTTCGACGAAGGCGTCGCCGAATTCGCGAAGATCCTGGCCCGCC
TGATCCCGGCCGGCGCGACAGTCGCGACCGACGAGTTGACCGGGGCGATGCGGCGGGCCGGCAGCGCGCTGTTCCCCGAC
GCGCCGATCGATGCGGCCCCGGTGATCGGCGCGGCCAAGATCGTGAAGACCATCGACCAGATCGCCTGCATCCGGCGGGC
GTGTCAGATCACCGAACAGGCCGTCGCCGAGATCCAGAAATCGCTCGCCCCGGGTGCGCGTCAGATCGACCTGTCCGCCG
AATTCGTGCGCCGCACCTTCGAACTCGGCGCCACCACCAACATGTTCGACTCGATCTGGCAGGCCATGCCGGCGTCGAAG
GCCGAGGGCACCTGGACCACCACCGGCGATCTGGCCCTGCCCCTGCTGACGACCGAACGTGAGATCCAGCAGGGCGACGT
CCTGTGGACCGACGTGTCCATCGCCTACCAGGGCTATTGCTCCGATCACGGACGCACCTGGATCGTCGGTCAGGATCCGA
CGCCGGCCCAGCAGAAGCAGTTCGACAGGTGGAGCGAGATCGTCGACGCGGTGCTCGCGGTGACCAAGGCCGGTGCGACC
TGCGGCGACCTCGGGCGCGCGGCCACCGCGGCAGCGGGCGGTCAGAAGCCGTGGCTGCCGCACTTCTACCTGGGCCACGG
AATCGGAACCAGCGCGGCCGAAATGCCGATGATCGGAACGGATCTCGGTCAGGAGTGGGACGACAACTTCGTCTTCCCGG
CCGGCATGCTCCTGGTGTTCGAGCCGGTGGTCTGGGAGGACGGCACCGGCGGCTACCGGGGCGAGGAGATCGTGGTCGTC
ACCGAGGGCGGCTGGATGCCGCTGACCGAGTATCCCTACGACCCGTACGAGGTGACCCGTGGGAATTGA

Upstream 100 bases:

>100_bases
GGTATTCGGAGAAGTCGCTGGCCACCGTCGTCGACGCGGTCGGCCCGGAGAACGCCGTCAAGATCGTCAGCACCAATGTG
CGGAAGTTCCTGGGGGTCTG

Downstream 100 bases:

>100_bases
GATCGAGGCCGACGGCCGGGCGCTGCGCCACAGCCGTCGGGAGCGCGCCCTCGCGCAGATGAAGGCCTACGACCTCGACA
TGCTGGTGCTCGGCCGGCAA

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MTTSTHTGVTQIARTGYTWLDIPQEPDFTRLRSEVGARLHAAMAEQGVDALVLLGNGNVMYATGISWPLADAGLSHVERP
VAVVLADDEHPHLFLPFREGAAMESDLPDDHLHGPVYLEFDEGVAEFAKILARLIPAGATVATDELTGAMRRAGSALFPD
APIDAAPVIGAAKIVKTIDQIACIRRACQITEQAVAEIQKSLAPGARQIDLSAEFVRRTFELGATTNMFDSIWQAMPASK
AEGTWTTTGDLALPLLTTEREIQQGDVLWTDVSIAYQGYCSDHGRTWIVGQDPTPAQQKQFDRWSEIVDAVLAVTKAGAT
CGDLGRAATAAAGGQKPWLPHFYLGHGIGTSAAEMPMIGTDLGQEWDDNFVFPAGMLLVFEPVVWEDGTGGYRGEEIVVV
TEGGWMPLTEYPYDPYEVTRGN

Sequences:

>Translated_422_residues
MTTSTHTGVTQIARTGYTWLDIPQEPDFTRLRSEVGARLHAAMAEQGVDALVLLGNGNVMYATGISWPLADAGLSHVERP
VAVVLADDEHPHLFLPFREGAAMESDLPDDHLHGPVYLEFDEGVAEFAKILARLIPAGATVATDELTGAMRRAGSALFPD
APIDAAPVIGAAKIVKTIDQIACIRRACQITEQAVAEIQKSLAPGARQIDLSAEFVRRTFELGATTNMFDSIWQAMPASK
AEGTWTTTGDLALPLLTTEREIQQGDVLWTDVSIAYQGYCSDHGRTWIVGQDPTPAQQKQFDRWSEIVDAVLAVTKAGAT
CGDLGRAATAAAGGQKPWLPHFYLGHGIGTSAAEMPMIGTDLGQEWDDNFVFPAGMLLVFEPVVWEDGTGGYRGEEIVVV
TEGGWMPLTEYPYDPYEVTRGN
>Mature_421_residues
TTSTHTGVTQIARTGYTWLDIPQEPDFTRLRSEVGARLHAAMAEQGVDALVLLGNGNVMYATGISWPLADAGLSHVERPV
AVVLADDEHPHLFLPFREGAAMESDLPDDHLHGPVYLEFDEGVAEFAKILARLIPAGATVATDELTGAMRRAGSALFPDA
PIDAAPVIGAAKIVKTIDQIACIRRACQITEQAVAEIQKSLAPGARQIDLSAEFVRRTFELGATTNMFDSIWQAMPASKA
EGTWTTTGDLALPLLTTEREIQQGDVLWTDVSIAYQGYCSDHGRTWIVGQDPTPAQQKQFDRWSEIVDAVLAVTKAGATC
GDLGRAATAAAGGQKPWLPHFYLGHGIGTSAAEMPMIGTDLGQEWDDNFVFPAGMLLVFEPVVWEDGTGGYRGEEIVVVT
EGGWMPLTEYPYDPYEVTRGN

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788728, Length=249, Percent_Identity=27.710843373494, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1789275, Length=404, Percent_Identity=23.2673267326733, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 45568; Mature: 45437

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSTHTGVTQIARTGYTWLDIPQEPDFTRLRSEVGARLHAAMAEQGVDALVLLGNGNVM
CCCCCCCCHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEE
YATGISWPLADAGLSHVERPVAVVLADDEHPHLFLPFREGAAMESDLPDDHLHGPVYLEF
EEECCCCCCHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEE
DEGVAEFAKILARLIPAGATVATDELTGAMRRAGSALFPDAPIDAAPVIGAAKIVKTIDQ
CCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
IACIRRACQITEQAVAEIQKSLAPGARQIDLSAEFVRRTFELGATTNMFDSIWQAMPASK
HHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHCCCCHHHHHHHHHHCCCCC
AEGTWTTTGDLALPLLTTEREIQQGDVLWTDVSIAYQGYCSDHGRTWIVGQDPTPAQQKQ
CCCCEEECCCEEEEEECCHHHHHCCCEEEEEEEEEEEEEECCCCCEEEEECCCCCHHHHH
FDRWSEIVDAVLAVTKAGATCGDLGRAATAAAGGQKPWLPHFYLGHGIGTSAAEMPMIGT
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCHHCCCCCCC
DLGQEWDDNFVFPAGMLLVFEPVVWEDGTGGYRGEEIVVVTEGGWMPLTEYPYDPYEVTR
CCCCCCCCCEECCCCCEEEEECEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
GN
CC
>Mature Secondary Structure 
TTSTHTGVTQIARTGYTWLDIPQEPDFTRLRSEVGARLHAAMAEQGVDALVLLGNGNVM
CCCCCCCHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEE
YATGISWPLADAGLSHVERPVAVVLADDEHPHLFLPFREGAAMESDLPDDHLHGPVYLEF
EEECCCCCCHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEE
DEGVAEFAKILARLIPAGATVATDELTGAMRRAGSALFPDAPIDAAPVIGAAKIVKTIDQ
CCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
IACIRRACQITEQAVAEIQKSLAPGARQIDLSAEFVRRTFELGATTNMFDSIWQAMPASK
HHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHCCCCHHHHHHHHHHCCCCC
AEGTWTTTGDLALPLLTTEREIQQGDVLWTDVSIAYQGYCSDHGRTWIVGQDPTPAQQKQ
CCCCEEECCCEEEEEECCHHHHHCCCEEEEEEEEEEEEEECCCCCEEEEECCCCCHHHHH
FDRWSEIVDAVLAVTKAGATCGDLGRAATAAAGGQKPWLPHFYLGHGIGTSAAEMPMIGT
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCHHCCCCCCC
DLGQEWDDNFVFPAGMLLVFEPVVWEDGTGGYRGEEIVVVTEGGWMPLTEYPYDPYEVTR
CCCCCCCCCEECCCCCEEEEECEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
GN
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]