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The map label for this gene is pepQ [H]

Identifier: 108800729

GI number: 108800729

Start: 4018588

End: 4019721

Strand: Reverse

Name: pepQ [H]

Synonym: Mmcs_3764

Alternate gene names: 108800729

Gene position: 4019721-4018588 (Counterclockwise)

Preceding gene: 108800730

Following gene: 108800728

Centisome position: 70.45

GC content: 69.75

Gene sequence:

>1134_bases
GTGGGAATTGAGATCGAGGCCGACGGCCGGGCGCTGCGCCACAGCCGTCGGGAGCGCGCCCTCGCGCAGATGAAGGCCTA
CGACCTCGACATGCTGGTGCTCGGCCGGCAAGCCAACGTCCGCTACATCTCTGGTGCCCCGCAGCTGTGGGTGGTGGGCA
CCCGCCCGTTCGGGCCGATCTGCGAGTTCGTCCGCGCCACCGGGGAGATCCACCTCAACAGCACGTGGGACGAGGGCATC
CCGGAGGAGATCCCGCACGAGAATCTGTACGGGTTCGCGTGGAACCCGATGACCTTGGTCGGCATACTGCAGAACATCAA
GGGCGCCGACACCGTACGGCGGGTCGGAACCGATGCTCTGACACCGACGTTCGCGAAGCTGTTGCCGATGGCCTTCCCGA
ACGCCGAGCTGGTCGACGCCGAGCAGGCGATGCAGGCGGCTCGCCGGATCAAGACACCCGAGGAAGTGCAGGCGTTGCGT
CGGGCACTGGTCGTCGCCGAGGAGGGCCTGGCCGCAGGTGTTGCGGCGCTGGGCCCGGGCACCACGGAGAAGGCGCTCGC
CGGTGCCGTGCTCGAGGCCGAGGCCGCCGGTGGGGTGAGCACCCCGGCGACCCAGGACGCGGCCTGGGTGACCTCGAAGG
AGCATCCGTGGCGCCGAGCCGACAGTGACGGCCTGGTGCGCGAGGGTGACCTGGTGGCGTTGTCGGCCGGGGTACTGGCC
GACGGATATGTCGCCGAGGTGGCCCGAACGCTCTGTGTCGGGGAGCCGACAGACGCCGTGCGCGCGCTGTTCCGACGACG
AGATGACCTGTGGGACAGGCTGATCGAGGCCTGCCGACCCGGTATGACGACAAGCGGGTTGCTGGCCGCCTACGAGCAGG
CCGGTGAGCGTCTGCCTGCGATGCCGGTGGCGCACGGACTCGGGCTGGGGTTCGACCCGCCGGTGGTGTCACCGGCTCTG
CGGGCGACCGCGGAAGCCGATGTCCTCGAGGAGGGCATGGTGCTCGCGGTCACCGCCTACGTGTGGGAACAGGGGGTGGG
CGCGGTGTTCACCCGCGATGCCGTCTTGATCACCGTCGACGGCGCCGAAATCCTTTCGACCGCCCCCGCTTACGGGGAGG
CCGTCCATGGCTGA

Upstream 100 bases:

>100_bases
GACGGCACCGGCGGCTACCGGGGCGAGGAGATCGTGGTCGTCACCGAGGGCGGCTGGATGCCGCTGACCGAGTATCCCTA
CGACCCGTACGAGGTGACCC

Downstream 100 bases:

>100_bases
CCGGCCCAAGCCCCCTGCCGCGGAGCGGCCCAAGCCGGAGGAGATCATCCTCTACGAGAAGGACCCGAAGACCAAGATCG
CGACGATCACCTTCAACCGG

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MGIEIEADGRALRHSRRERALAQMKAYDLDMLVLGRQANVRYISGAPQLWVVGTRPFGPICEFVRATGEIHLNSTWDEGI
PEEIPHENLYGFAWNPMTLVGILQNIKGADTVRRVGTDALTPTFAKLLPMAFPNAELVDAEQAMQAARRIKTPEEVQALR
RALVVAEEGLAAGVAALGPGTTEKALAGAVLEAEAAGGVSTPATQDAAWVTSKEHPWRRADSDGLVREGDLVALSAGVLA
DGYVAEVARTLCVGEPTDAVRALFRRRDDLWDRLIEACRPGMTTSGLLAAYEQAGERLPAMPVAHGLGLGFDPPVVSPAL
RATAEADVLEEGMVLAVTAYVWEQGVGAVFTRDAVLITVDGAEILSTAPAYGEAVHG

Sequences:

>Translated_377_residues
MGIEIEADGRALRHSRRERALAQMKAYDLDMLVLGRQANVRYISGAPQLWVVGTRPFGPICEFVRATGEIHLNSTWDEGI
PEEIPHENLYGFAWNPMTLVGILQNIKGADTVRRVGTDALTPTFAKLLPMAFPNAELVDAEQAMQAARRIKTPEEVQALR
RALVVAEEGLAAGVAALGPGTTEKALAGAVLEAEAAGGVSTPATQDAAWVTSKEHPWRRADSDGLVREGDLVALSAGVLA
DGYVAEVARTLCVGEPTDAVRALFRRRDDLWDRLIEACRPGMTTSGLLAAYEQAGERLPAMPVAHGLGLGFDPPVVSPAL
RATAEADVLEEGMVLAVTAYVWEQGVGAVFTRDAVLITVDGAEILSTAPAYGEAVHG
>Mature_376_residues
GIEIEADGRALRHSRRERALAQMKAYDLDMLVLGRQANVRYISGAPQLWVVGTRPFGPICEFVRATGEIHLNSTWDEGIP
EEIPHENLYGFAWNPMTLVGILQNIKGADTVRRVGTDALTPTFAKLLPMAFPNAELVDAEQAMQAARRIKTPEEVQALRR
ALVVAEEGLAAGVAALGPGTTEKALAGAVLEAEAAGGVSTPATQDAAWVTSKEHPWRRADSDGLVREGDLVALSAGVLAD
GYVAEVARTLCVGEPTDAVRALFRRRDDLWDRLIEACRPGMTTSGLLAAYEQAGERLPAMPVAHGLGLGFDPPVVSPALR
ATAEADVLEEGMVLAVTAYVWEQGVGAVFTRDAVLITVDGAEILSTAPAYGEAVHG

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788728, Length=256, Percent_Identity=29.6875, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 40162; Mature: 40031

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIEIEADGRALRHSRRERALAQMKAYDLDMLVLGRQANVRYISGAPQLWVVGTRPFGPI
CCEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCEEEEEECCCCHHH
CEFVRATGEIHLNSTWDEGIPEEIPHENLYGFAWNPMTLVGILQNIKGADTVRRVGTDAL
HHHHHHCCCEEECCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHCCCHHHHHHHCCHHC
TPTFAKLLPMAFPNAELVDAEQAMQAARRIKTPEEVQALRRALVVAEEGLAAGVAALGPG
CHHHHHHHHHCCCCCHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCC
TTEKALAGAVLEAEAAGGVSTPATQDAAWVTSKEHPWRRADSDGLVREGDLVALSAGVLA
CHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCEECCCEEEEECCHHC
DGYVAEVARTLCVGEPTDAVRALFRRRDDLWDRLIEACRPGMTTSGLLAAYEQAGERLPA
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
MPVAHGLGLGFDPPVVSPALRATAEADVLEEGMVLAVTAYVWEQGVGAVFTRDAVLITVD
CHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHCCCCEEEECCEEEEEEC
GAEILSTAPAYGEAVHG
CHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
GIEIEADGRALRHSRRERALAQMKAYDLDMLVLGRQANVRYISGAPQLWVVGTRPFGPI
CEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEECCCCEEEEEECCCCHHH
CEFVRATGEIHLNSTWDEGIPEEIPHENLYGFAWNPMTLVGILQNIKGADTVRRVGTDAL
HHHHHHCCCEEECCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHCCCHHHHHHHCCHHC
TPTFAKLLPMAFPNAELVDAEQAMQAARRIKTPEEVQALRRALVVAEEGLAAGVAALGPG
CHHHHHHHHHCCCCCHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCC
TTEKALAGAVLEAEAAGGVSTPATQDAAWVTSKEHPWRRADSDGLVREGDLVALSAGVLA
CHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCEECCCEEEEECCHHC
DGYVAEVARTLCVGEPTDAVRALFRRRDDLWDRLIEACRPGMTTSGLLAAYEQAGERLPA
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
MPVAHGLGLGFDPPVVSPALRATAEADVLEEGMVLAVTAYVWEQGVGAVFTRDAVLITVD
CHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHCCCCEEEECCEEEEEEC
GAEILSTAPAYGEAVHG
CHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]