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The map label for this gene is echA8 [H]

Identifier: 108800718

GI number: 108800718

Start: 4005216

End: 4005998

Strand: Reverse

Name: echA8 [H]

Synonym: Mmcs_3753

Alternate gene names: 108800718

Gene position: 4005998-4005216 (Counterclockwise)

Preceding gene: 108800719

Following gene: 108800710

Centisome position: 70.21

GC content: 67.05

Gene sequence:

>783_bases
GTGTACATCGACTACGAGGTCGCCGACAAGATCGCGACCATATCGCTGAACCGCCCCGAGGTGGCCAACGCGCAGAACAC
CGAACTGCTCGACGAACTCGACGCCGCGTGGACGCGGGCCGCCGAGGATCCCGAGGTGGTGGTGATCGTGTTGCGCGCCA
ACGGGAAACACTTCTCGGCGGGTCACGACCTGCGGGGCGGCGGGCCGGTGCCGGACAAGATCACACTCGAGTTCATCATC
GCCCACGAGTCCAAGCGCTACCTCGAGTACACGCTGCGGTGGCGCAATACGCCCAAACCGTCGATCGCCGCGGTGCAGGG
CCGCTGCATCTCCGGTGGGCTGATGCTGTGCTGGCCCTGCGATCTGATCCTGGCCGCCGATGACGCGCTGTTCTCGGATC
CGGTGGCGCTGATGGGCATCGGCGGTGTCGAATACCACGGCCACACCTGGGAATTGGGGGCGCGCAAGGCCAAGGAGATC
CTGTTCACCGGCCGGCCGCTGACCGCCGAGGAGGCCGAACGCACCGGCATGGTGAACCGGGTCGTACCCCGTGACGATCT
CGACGCCGAGACCCGCGCGCTGGCCGAGCAGATCGCCGCGATGCCGCCGTTCGCCCTGCGTCAGGCCAAACGTGCGGTCA
ACCAGACCCTCGACGTACAGGGGTTCTACGCGGCGATCCAGTCGGTGTTCGACATCCACCAGACCGGGCACGGCAACGCG
CTGAGCGTGGGCGCATGGCCGGTGCTGGTCGACCTCGACAAGATGAAGGGCACCGTCCAGTAG

Upstream 100 bases:

>100_bases
CCGGACCTTCGCGGGGACCATCGCCGGCGGGACTTCCGAGATCCAACGCAACATCATCGCCCAGCGCCTGCTCGGGCTGC
CCAGGAACTAGAGGAGCAAC

Downstream 100 bases:

>100_bases
CGCCCCGAATTCTCGCTCGCGGAGCAATCAGAGGCTGACCAGCCTCGGCGCCGAGCCGCGGGCCCGCAGCCCCGCTCCGG
CCTTACGGGTGAGTTCCCTT

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MYIDYEVADKIATISLNRPEVANAQNTELLDELDAAWTRAAEDPEVVVIVLRANGKHFSAGHDLRGGGPVPDKITLEFII
AHESKRYLEYTLRWRNTPKPSIAAVQGRCISGGLMLCWPCDLILAADDALFSDPVALMGIGGVEYHGHTWELGARKAKEI
LFTGRPLTAEEAERTGMVNRVVPRDDLDAETRALAEQIAAMPPFALRQAKRAVNQTLDVQGFYAAIQSVFDIHQTGHGNA
LSVGAWPVLVDLDKMKGTVQ

Sequences:

>Translated_260_residues
MYIDYEVADKIATISLNRPEVANAQNTELLDELDAAWTRAAEDPEVVVIVLRANGKHFSAGHDLRGGGPVPDKITLEFII
AHESKRYLEYTLRWRNTPKPSIAAVQGRCISGGLMLCWPCDLILAADDALFSDPVALMGIGGVEYHGHTWELGARKAKEI
LFTGRPLTAEEAERTGMVNRVVPRDDLDAETRALAEQIAAMPPFALRQAKRAVNQTLDVQGFYAAIQSVFDIHQTGHGNA
LSVGAWPVLVDLDKMKGTVQ
>Mature_260_residues
MYIDYEVADKIATISLNRPEVANAQNTELLDELDAAWTRAAEDPEVVVIVLRANGKHFSAGHDLRGGGPVPDKITLEFII
AHESKRYLEYTLRWRNTPKPSIAAVQGRCISGGLMLCWPCDLILAADDALFSDPVALMGIGGVEYHGHTWELGARKAKEI
LFTGRPLTAEEAERTGMVNRVVPRDDLDAETRALAEQIAAMPPFALRQAKRAVNQTLDVQGFYAAIQSVFDIHQTGHGNA
LSVGAWPVLVDLDKMKGTVQ

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=225, Percent_Identity=32.4444444444444, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI260274832, Length=209, Percent_Identity=30.622009569378, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI45643119, Length=209, Percent_Identity=30.622009569378, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI260275230, Length=209, Percent_Identity=30.622009569378, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI31542718, Length=197, Percent_Identity=30.4568527918782, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI70995211, Length=210, Percent_Identity=31.4285714285714, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1788597, Length=226, Percent_Identity=35.8407079646018, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1787659, Length=215, Percent_Identity=31.1627906976744, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082183, Length=216, Percent_Identity=31.4814814814815, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI221142681, Length=228, Percent_Identity=34.2105263157895, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1787660, Length=233, Percent_Identity=30.9012875536481, Blast_Score=75, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI25145438, Length=216, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17554946, Length=213, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17535521, Length=209, Percent_Identity=27.7511961722488, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17534483, Length=228, Percent_Identity=28.0701754385965, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17549921, Length=207, Percent_Identity=25.1207729468599, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17540714, Length=214, Percent_Identity=28.5046728971963, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17540306, Length=186, Percent_Identity=30.1075268817204, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20129971, Length=222, Percent_Identity=34.6846846846847, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24653477, Length=222, Percent_Identity=34.6846846846847, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI19920382, Length=222, Percent_Identity=31.0810810810811, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19922422, Length=227, Percent_Identity=26.431718061674, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24650670, Length=227, Percent_Identity=29.9559471365639, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24653139, Length=219, Percent_Identity=31.5068493150685, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24654903, Length=211, Percent_Identity=26.0663507109005, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21357171, Length=225, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 28499; Mature: 28499

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIDYEVADKIATISLNRPEVANAQNTELLDELDAAWTRAAEDPEVVVIVLRANGKHFSA
CEECCEECCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEECC
GHDLRGGGPVPDKITLEFIIAHESKRYLEYTLRWRNTPKPSIAAVQGRCISGGLMLCWPC
CCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEEECCCCCCCEEEECCEEECCCEEEEECC
DLILAADDALFSDPVALMGIGGVEYHGHTWELGARKAKEILFTGRPLTAEEAERTGMVNR
CEEEECCCCHHCCCCCEEECCCEEECCCEEEHHHHHHHHHEEECCCCCHHHHHHCCCHHC
VVPRDDLDAETRALAEQIAAMPPFALRQAKRAVNQTLDVQGFYAAIQSVFDIHQTGHGNA
CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCE
LSVGAWPVLVDLDKMKGTVQ
EEECCCEEEEEHHHHCCCCC
>Mature Secondary Structure
MYIDYEVADKIATISLNRPEVANAQNTELLDELDAAWTRAAEDPEVVVIVLRANGKHFSA
CEECCEECCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEECC
GHDLRGGGPVPDKITLEFIIAHESKRYLEYTLRWRNTPKPSIAAVQGRCISGGLMLCWPC
CCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEEECCCCCCCEEEECCEEECCCEEEEECC
DLILAADDALFSDPVALMGIGGVEYHGHTWELGARKAKEILFTGRPLTAEEAERTGMVNR
CEEEECCCCHHCCCCCEEECCCEEECCCEEEHHHHHHHHHEEECCCCCHHHHHHCCCHHC
VVPRDDLDAETRALAEQIAAMPPFALRQAKRAVNQTLDVQGFYAAIQSVFDIHQTGHGNA
CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCE
LSVGAWPVLVDLDKMKGTVQ
EEECCCEEEEEHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]